STRINGSTRING
AFT99200.1 AFT99200.1 AFT99201.1 AFT99201.1 thrB thrB AFT99673.1 AFT99673.1 ilvA ilvA AFU00679.1 AFU00679.1 AFU01093.1 AFU01093.1 glyA-3 glyA-3 AFU01647.1 AFU01647.1 AFU02272.1 AFU02272.1 AFU04385.1 AFU04385.1 AFU04729.1 AFU04729.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AFT99200.1COG0460 Homoserine dehydrogenase. (429 aa)
AFT99201.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (353 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (321 aa)
AFT99673.1COG1171 Threonine dehydratase. (322 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (451 aa)
AFU00679.1COG1171 Threonine dehydratase. (411 aa)
AFU01093.1Pyridoxal-5'-phosphate-dependent protein subunit beta; COG0498 Threonine synthase. (382 aa)
glyA-3Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (440 aa)
AFU01647.1COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa)
AFU02272.1Pyridoxal-5'-phosphate-dependent protein subunit beta; COG0498 Threonine synthase. (396 aa)
AFU04385.1Phosphoserine phosphatase; COG3830 ACT domain-containing protein. (405 aa)
AFU04729.1COG1171 Threonine dehydratase. (311 aa)
Your Current Organism:
Nocardia brasiliensis
NCBI taxonomy Id: 1133849
Other names: N. brasiliensis ATCC 700358, Nocardia brasiliensis ATCC 700358, Nocardia brasiliensis HUJEG-1, Nocardia brasiliensis str. ATCC 700358, Nocardia brasiliensis strain ATCC 700358
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