STRINGSTRING
cysH cysH AFT99928.1 AFT99928.1 tyrS tyrS AFT99978.1 AFT99978.1 ileS ileS AFU00238.1 AFU00238.1 ileS-2 ileS-2 AFU00557.1 AFU00557.1 argG argG argS-2 argS-2 AFU01322.1 AFU01322.1 AFU01421.1 AFU01421.1 AFU01572.1 AFU01572.1 AFU01583.1 AFU01583.1 AFU01584.1 AFU01584.1 AFU01610.1 AFU01610.1 AFU01612.1 AFU01612.1 AFU01613.1 AFU01613.1 AFU01618.1 AFU01618.1 AFU01619.1 AFU01619.1 coaD coaD panC-2 panC-2 AFU01824.1 AFU01824.1 mshC mshC AFU02209.1 AFU02209.1 panC-3 panC-3 leuS leuS AFU02653.1 AFU02653.1 AFU03173.1 AFU03173.1 AFU03380.1 AFU03380.1 AFU04034.1 AFU04034.1 AFU04229.1 AFU04229.1 coaD-2 coaD-2 gltX gltX AFU04401.1 AFU04401.1 AFU04402.1 AFU04402.1 mnmA mnmA nadE nadE AFU04846.1 AFU04846.1 metG metG AFU05526.1 AFU05526.1 nadE-2 nadE-2 leuS-2 leuS-2 AFU06083.1 AFU06083.1 gluQ gluQ tilS tilS panC panC cysS cysS guaA guaA trpS trpS argS argS AFT99617.1 AFT99617.1 valS valS nadD nadD AFT99862.1 AFT99862.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cysHPhosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (239 aa)
AFT99928.1Hypothetical protein. (230 aa)
tyrStyrosyl-tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (425 aa)
AFT99978.1Hypothetical protein. (340 aa)
ileSisoleucyl-tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1049 aa)
AFU00238.1COG0367 Asparagine synthase (glutamine-hydrolyzing). (631 aa)
ileS-2isoleucyl-tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1051 aa)
AFU00557.1COG0589 Universal stress protein UspA and related nucleotide-binding proteins. (150 aa)
argGCOG0137 Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (400 aa)
argS-2COG0018 Arginyl-tRNA synthetase. (588 aa)
AFU01322.1COG0589 Universal stress protein UspA and related nucleotide-binding proteins. (157 aa)
AFU01421.1Sulfate adenylyltransferase subunit 2; COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes. (310 aa)
AFU01572.1COG0589 Universal stress protein UspA and related nucleotide-binding proteins. (299 aa)
AFU01583.1COG0589 Universal stress protein UspA and related nucleotide-binding proteins. (292 aa)
AFU01584.1COG0589 Universal stress protein UspA and related nucleotide-binding proteins. (305 aa)
AFU01610.1COG0589 Universal stress protein UspA and related nucleotide-binding proteins. (306 aa)
AFU01612.1COG0589 Universal stress protein UspA and related nucleotide-binding proteins. (291 aa)
AFU01613.1COG0589 Universal stress protein UspA and related nucleotide-binding proteins. (303 aa)
AFU01618.1COG0589 Universal stress protein UspA and related nucleotide-binding proteins. (290 aa)
AFU01619.1COG0589 Universal stress protein UspA and related nucleotide-binding proteins. (304 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (161 aa)
panC-2Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa)
AFU01824.1COG0367 Asparagine synthase (glutamine-hydrolyzing). (662 aa)
mshCcysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. (412 aa)
AFU02209.1Putative amidotransferase; COG0367 Asparagine synthase (glutamine-hydrolyzing). (620 aa)
panC-3Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (279 aa)
leuSCOG0495 Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (663 aa)
AFU02653.1Transcriptional regulator; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (239 aa)
AFU03173.1Hypothetical protein. (222 aa)
AFU03380.1Hypothetical protein. (290 aa)
AFU04034.1Bifunctional riboflavin kinase/FMN adenylyltransferase; COG0196 FAD synthase; Belongs to the ribF family. (313 aa)
AFU04229.1Sensor protein kdpD; COG2205 Osmosensitive K+ channel histidine kinase. (848 aa)
coaD-2Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (161 aa)
gltXglutamyl-tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (490 aa)
AFU04401.1COG2086 Electron transfer flavoprotein, beta subunit. (261 aa)
AFU04402.1COG2025 Electron transfer flavoprotein, alpha subunit. (318 aa)
mnmAtRNA-specific 2-thiouridylase MnmA; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (373 aa)
nadENAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (275 aa)
AFU04846.1Deoxyribodipyrimidine photo-lyase (DNA photolyase) (Photoreactivating enzyme); COG0415 Deoxyribodipyrimidine photolyase; Belongs to the DNA photolyase family. (441 aa)
metGmethionyl-tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (519 aa)
AFU05526.1COG0367 Asparagine synthase (glutamine-hydrolyzing). (611 aa)
nadE-2NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (687 aa)
leuS-2COG0495 Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (948 aa)
AFU06083.1COG0589 Universal stress protein UspA and related nucleotide-binding proteins. (162 aa)
gluQglutamyl-Q tRNA(Asp) ligase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (305 aa)
tilStRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (333 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (309 aa)
cysSCOG0215 Cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (476 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (527 aa)
trpStryptophanyl-tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (343 aa)
argSCOG0018 Arginyl-tRNA synthetase. (552 aa)
AFT99617.1Hypothetical protein. (337 aa)
valSvalyl-tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (864 aa)
nadDNicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (213 aa)
AFT99862.1Sulfate adenylyltransferase subunit 2; COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes. (316 aa)
Your Current Organism:
Nocardia brasiliensis
NCBI taxonomy Id: 1133849
Other names: N. brasiliensis ATCC 700358, Nocardia brasiliensis ATCC 700358, Nocardia brasiliensis HUJEG-1, Nocardia brasiliensis str. ATCC 700358, Nocardia brasiliensis strain ATCC 700358
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