(31 nodes) Mixed, incl. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion, and Phospholipase C-activating serotonin receptor signaling pathway network (Scleropages formosus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HRH1	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (541 aa)
	Z043_104924	Alpha-1A adrenergic receptor-like. (468 aa)
	htr2a	G_PROTEIN_RECEP_F1_2 domain-containing protein. (465 aa)
	LOC108919913	Uncharacterized protein. (371 aa)
	ENSSFOP00015007445	G-protein coupled receptor family C group 6 member A-like. (825 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1229 aa)
	htr2b	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (460 aa)
	LOC108938653	Guanine nucleotide-binding protein subunit alpha-14-like. (351 aa)
	Z043_104096	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (554 aa)
	CYSLTR1	Cysteinyl leukotriene receptor 1-like. (346 aa)
	LOC108923025	5-hydroxytryptamine receptor 2C-like. (496 aa)
	Ptgfr	Prostaglandin F2-alpha receptor-like; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	gprc6a	G-protein coupled receptor family C group 6 member A-like. (878 aa)
	LOC108921572	Guanine nucleotide-binding protein G(Q) subunit alpha-like. (402 aa)
	LOC108921573	Guanine nucleotide-binding protein subunit alpha-11-like. (371 aa)
	cysltr1	Cysteinyl leukotriene receptor 1-like. (357 aa)
	LOC108937879	Leukotriene B4 receptor 1-like. (375 aa)
	LOC108941282	Leukotriene B4 receptor 1-like. (377 aa)
	ENSSFOP00015022800	annotation not available (347 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2. (1363 aa)
	LOC108940281	Thromboxane A2 receptor-like. (366 aa)
	LOC108924383	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (499 aa)
	Z043_105079	Uncharacterized protein. (354 aa)
	LOC108934154	Alpha-1B adrenergic receptor-like. (508 aa)
	Z043_107001	Phosphoinositide phospholipase C. (1184 aa)
	LOC108934223	5-hydroxytryptamine receptor 2C-like; Belongs to the G-protein coupled receptor 1 family. (485 aa)
	Z043_123728	Thromboxane A2 receptor-like; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	LOC108919906	Guanine nucleotide-binding protein subunit alpha-11-like. (375 aa)
	plcb3	Phosphoinositide phospholipase C. (1249 aa)
	HTR2B	5-hydroxytryptamine receptor 2B-like. (512 aa)
	ENSSFOP00015077663	annotation not available (469 aa)

Your Current Organism:

Scleropages formosus

NCBI taxonomy Id: 113540
Other names: Asian arowana, Asian bonytongue, Osteoglossum formosum, S. formosus, golden arowana, golden dragon fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYSLTR1	LOC108919906	ENSSFOP00015014677	ENSSFOP00015053909	Cysteinyl leukotriene receptor 1-like.	Guanine nucleotide-binding protein subunit alpha-11-like.	0.746
CYSLTR1	LOC108919913	ENSSFOP00015014677	ENSSFOP00015004256	Cysteinyl leukotriene receptor 1-like.	Uncharacterized protein.	0.746
CYSLTR1	LOC108921572	ENSSFOP00015014677	ENSSFOP00015018061	Cysteinyl leukotriene receptor 1-like.	Guanine nucleotide-binding protein G(Q) subunit alpha-like.	0.746
CYSLTR1	LOC108921573	ENSSFOP00015014677	ENSSFOP00015018076	Cysteinyl leukotriene receptor 1-like.	Guanine nucleotide-binding protein subunit alpha-11-like.	0.746
CYSLTR1	LOC108938653	ENSSFOP00015014677	ENSSFOP00015013399	Cysteinyl leukotriene receptor 1-like.	Guanine nucleotide-binding protein subunit alpha-14-like.	0.746
CYSLTR1	Z043_105079	ENSSFOP00015014677	ENSSFOP00015037284	Cysteinyl leukotriene receptor 1-like.	Uncharacterized protein.	0.746
ENSSFOP00015007445	PLCB2	ENSSFOP00015007445	ENSSFOP00015024521	G-protein coupled receptor family C group 6 member A-like.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2.	0.914
ENSSFOP00015007445	PLCB4	ENSSFOP00015007445	ENSSFOP00015012628	G-protein coupled receptor family C group 6 member A-like.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.912
ENSSFOP00015007445	gprc6a	ENSSFOP00015007445	ENSSFOP00015017083	G-protein coupled receptor family C group 6 member A-like.	G-protein coupled receptor family C group 6 member A-like.	0.903
ENSSFOP00015007445	plcb3	ENSSFOP00015007445	ENSSFOP00015068656	G-protein coupled receptor family C group 6 member A-like.	Phosphoinositide phospholipase C.	0.914
ENSSFOP00015022800	LOC108919906	ENSSFOP00015022800	ENSSFOP00015053909	annotation not available	Guanine nucleotide-binding protein subunit alpha-11-like.	0.470
ENSSFOP00015022800	LOC108919913	ENSSFOP00015022800	ENSSFOP00015004256	annotation not available	Uncharacterized protein.	0.470
ENSSFOP00015022800	LOC108921572	ENSSFOP00015022800	ENSSFOP00015018061	annotation not available	Guanine nucleotide-binding protein G(Q) subunit alpha-like.	0.470
ENSSFOP00015022800	LOC108921573	ENSSFOP00015022800	ENSSFOP00015018076	annotation not available	Guanine nucleotide-binding protein subunit alpha-11-like.	0.470
ENSSFOP00015022800	LOC108938653	ENSSFOP00015022800	ENSSFOP00015013399	annotation not available	Guanine nucleotide-binding protein subunit alpha-14-like.	0.470
ENSSFOP00015022800	Z043_105079	ENSSFOP00015022800	ENSSFOP00015037284	annotation not available	Uncharacterized protein.	0.470
ENSSFOP00015077663	LOC108919906	ENSSFOP00015077663	ENSSFOP00015053909	annotation not available	Guanine nucleotide-binding protein subunit alpha-11-like.	0.470
ENSSFOP00015077663	LOC108919913	ENSSFOP00015077663	ENSSFOP00015004256	annotation not available	Uncharacterized protein.	0.470
ENSSFOP00015077663	LOC108921572	ENSSFOP00015077663	ENSSFOP00015018061	annotation not available	Guanine nucleotide-binding protein G(Q) subunit alpha-like.	0.470
ENSSFOP00015077663	LOC108921573	ENSSFOP00015077663	ENSSFOP00015018076	annotation not available	Guanine nucleotide-binding protein subunit alpha-11-like.	0.470