(39 nodes) Tumor necrosis factor-mediated signaling pathway network (Scleropages formosus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108921806	SEFIR domain-containing protein. (123 aa)
	ilk	Integrin-linked protein kinase-like. (452 aa)
	LOC108933218	SEFIR domain-containing protein. (435 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa)
	Z043_120187	Protein kinase domain-containing protein. (471 aa)
	LOC108923979	IkappaBalpha2-like. (308 aa)
	card14	Caspase recruitment domain-containing protein 14-like. (984 aa)
	Z043_115319	Uncharacterized protein. (407 aa)
	LOC108918204	TNFR-Cys domain-containing protein. (402 aa)
	Z043_117232	Uncharacterized protein. (217 aa)
	Z043_104216	Tumor necrosis factor receptor superfamily member 19-like. (169 aa)
	eda2r	Tumor necrosis factor receptor superfamily member 27 isoform X1. (498 aa)
	Z043_111898	Suppression of tumorigenicity 18 protein-like. (962 aa)
	LOC108929927	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (517 aa)
	TNFRSF19	Uncharacterized protein. (407 aa)
	traf1	TNF receptor-associated factor 2-like. (548 aa)
	ENSSFOP00015017708	annotation not available (169 aa)
	Z043_104686	Inhibitor of nuclear factor kappa-B kinase subunit beta-like. (756 aa)
	Chuk	Protein kinase domain-containing protein. (752 aa)
	traf3	TNF receptor-associated factor 3-like. (568 aa)
	LOC108934700	TNF receptor-associated factor 6-like. (543 aa)
	tnfsf11	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (251 aa)
	LOC108928984	Tumor necrosis factor ligand superfamily member 11-like; Belongs to the tumor necrosis factor family. (270 aa)
	LOC108926003	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (260 aa)
	commd7	COMM domain-containing protein. (200 aa)
	relt	Uncharacterized protein. (404 aa)
	tnfrsf1a	Tumor necrosis factor receptor superfamily member 1A-like. (403 aa)
	LOC108935562	Tumor necrosis factor receptor superfamily member 11A. (552 aa)
	LOC108938148	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
	Z043_113566	BAFF protein-like; Belongs to the tumor necrosis factor family. (266 aa)
	cdip1	Cell death-inducing p53-target protein 1-like. (202 aa)
	TNFSF13B	Tumor necrosis factor ligand superfamily member 13B-like; Belongs to the tumor necrosis factor family. (255 aa)
	traf5	TNF receptor-associated factor. (567 aa)
	Z043_101222	Uncharacterized protein. (378 aa)
	LOC108919669	Tumor necrosis factor receptor superfamily member 11A-like. (526 aa)
	Z043_119999	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
	LOC108922584	Uncharacterized protein. (575 aa)
	Nfkbia	NF-kappa-B inhibitor alpha-like. (303 aa)
	LOC108924936	Tumor necrosis factor receptor superfamily member 1B-like isoform X1. (389 aa)

Your Current Organism:

Scleropages formosus

NCBI taxonomy Id: 113540
Other names: Asian arowana, Asian bonytongue, Osteoglossum formosum, S. formosus, golden arowana, golden dragon fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Chuk	LOC108922584	ENSSFOP00015058321	ENSSFOP00015020805	Protein kinase domain-containing protein.	Uncharacterized protein.	0.619
Chuk	LOC108923979	ENSSFOP00015058321	ENSSFOP00015006478	Protein kinase domain-containing protein.	IkappaBalpha2-like.	0.965
Chuk	LOC108929927	ENSSFOP00015058321	ENSSFOP00015014376	Protein kinase domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.619
Chuk	LOC108934700	ENSSFOP00015058321	ENSSFOP00015055609	Protein kinase domain-containing protein.	TNF receptor-associated factor 6-like.	0.959
Chuk	LOC108938148	ENSSFOP00015058321	ENSSFOP00015039928	Protein kinase domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.619
Chuk	Nfkbia	ENSSFOP00015058321	ENSSFOP00015018792	Protein kinase domain-containing protein.	NF-kappa-B inhibitor alpha-like.	0.965
Chuk	TRAF6	ENSSFOP00015058321	ENSSFOP00015005782	Protein kinase domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.986
Chuk	Z043_104686	ENSSFOP00015058321	ENSSFOP00015070582	Protein kinase domain-containing protein.	Inhibitor of nuclear factor kappa-B kinase subunit beta-like.	0.563
Chuk	tnfrsf1a	ENSSFOP00015058321	ENSSFOP00015043557	Protein kinase domain-containing protein.	Tumor necrosis factor receptor superfamily member 1A-like.	0.682
Chuk	traf1	ENSSFOP00015058321	ENSSFOP00015016271	Protein kinase domain-containing protein.	TNF receptor-associated factor 2-like.	0.619
Chuk	traf3	ENSSFOP00015058321	ENSSFOP00015056189	Protein kinase domain-containing protein.	TNF receptor-associated factor 3-like.	0.719
Chuk	traf5	ENSSFOP00015058321	ENSSFOP00015035086	Protein kinase domain-containing protein.	TNF receptor-associated factor.	0.719
ENSSFOP00015017708	TNFSF13B	ENSSFOP00015017708	ENSSFOP00015036233	annotation not available	Tumor necrosis factor ligand superfamily member 13B-like; Belongs to the tumor necrosis factor family.	0.951
ENSSFOP00015017708	Z043_113566	ENSSFOP00015017708	ENSSFOP00015039025	annotation not available	BAFF protein-like; Belongs to the tumor necrosis factor family.	0.951
LOC108918204	LOC108922584	ENSSFOP00015011871	ENSSFOP00015020805	TNFR-Cys domain-containing protein.	Uncharacterized protein.	0.969
LOC108918204	LOC108924936	ENSSFOP00015011871	ENSSFOP00015017745	TNFR-Cys domain-containing protein.	Tumor necrosis factor receptor superfamily member 1B-like isoform X1.	0.909
LOC108918204	LOC108928984	ENSSFOP00015011871	ENSSFOP00015054781	TNFR-Cys domain-containing protein.	Tumor necrosis factor ligand superfamily member 11-like; Belongs to the tumor necrosis factor family.	0.569
LOC108918204	LOC108929927	ENSSFOP00015011871	ENSSFOP00015014376	TNFR-Cys domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.969
LOC108918204	LOC108934700	ENSSFOP00015011871	ENSSFOP00015055609	TNFR-Cys domain-containing protein.	TNF receptor-associated factor 6-like.	0.533
LOC108918204	LOC108938148	ENSSFOP00015011871	ENSSFOP00015039928	TNFR-Cys domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.969