(39 nodes) Negative regulation of ERK1 and ERK2 cascade network (Scleropages formosus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Z043_120772	Protein sprouty2-like. (360 aa)
	LOC108940714	Tyrosine-protein phosphatase non-receptor type. (404 aa)
	errfi1	ERBB receptor feedback inhibitor 1-like. (428 aa)
	dusp10	Dual specificity protein phosphatase 10-like. (472 aa)
	SMAD4	Mothers against decapentaplegic homolog. (551 aa)
	SPRY3	Protein sprouty2-like. (299 aa)
	Itgb1bp1	Integrin beta-1-binding protein 1-like. (198 aa)
	Z043_116999	Adiponectin-like. (301 aa)
	vrk3	Protein kinase domain-containing protein. (510 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1-like. (439 aa)
	LOC108931553	Metalloproteinase inhibitor 3-like. (216 aa)
	atf3	Cyclic AMP-dependent transcription factor ATF-3-like. (247 aa)
	LOC108938584	Disabled2-like. (732 aa)
	WNK2	Uncharacterized protein. (2688 aa)
	SPRY4	Protein sprouty4-like. (299 aa)
	LOC108920243	Uncharacterized protein. (881 aa)
	emilin1	EMILIN-1-like. (1050 aa)
	flcn	Folliculin-like. (559 aa)
	LOC108924096	EMILIN-1-like. (1065 aa)
	ENSSFOP00015032038	annotation not available (186 aa)
	c10h3orf33	Uncharacterized protein. (256 aa)
	LOC108919221	Tyrosine-protein phosphatase non-receptor type 2-like. (399 aa)
	ENSSFOP00015004954	Protein sprouty homolog 2-like. (292 aa)
	PTPRC	Receptor-type tyrosine-protein phosphatase C-like. (633 aa)
	PTPRC-2	Receptor-type tyrosine-protein phosphatase C-like. (744 aa)
	SPRY4-2	Uncharacterized protein. (327 aa)
	ENSSFOP00015074125	annotation not available (413 aa)
	LOC108941157	Sprouty-related, EVH1 domain-containing protein 3-like. (539 aa)
	LOC108925355	Uncharacterized protein. (891 aa)
	tnip1	CC2-LZ domain-containing protein. (671 aa)
	LOC108941913	Mothers against decapentaplegic homolog 4-like. (564 aa)
	TIMP3	NTR domain-containing protein. (220 aa)
	phb	Prohibitin. (271 aa)
	DAB2	DAB adaptor protein 2. (553 aa)
	Z043_120612	Adiponectin-like. (245 aa)
	LOC108942527	Mothers against decapentaplegic homolog. (559 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (194 aa)
	spry1	Protein sprouty1-like. (318 aa)
	LOC108939346	Tyrosine-protein phosphatase non-receptor type. (447 aa)

Your Current Organism:

Scleropages formosus

NCBI taxonomy Id: 113540
Other names: Asian arowana, Asian bonytongue, Osteoglossum formosum, S. formosus, golden arowana, golden dragon fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSFOP00015004954	spry1	ENSSFOP00015004954	ENSSFOP00015038492	Protein sprouty homolog 2-like.	Protein sprouty1-like.	0.661
LOC108920243	vrk3	ENSSFOP00015029207	ENSSFOP00015017205	Uncharacterized protein.	Protein kinase domain-containing protein.	0.410
LOC108925355	vrk3	ENSSFOP00015067742	ENSSFOP00015017205	Uncharacterized protein.	Protein kinase domain-containing protein.	0.410
PTPRC	PTPRC-2	ENSSFOP00015005552	ENSSFOP00015005610	Receptor-type tyrosine-protein phosphatase C-like.	Receptor-type tyrosine-protein phosphatase C-like.	0.900
PTPRC-2	PTPRC	ENSSFOP00015005610	ENSSFOP00015005552	Receptor-type tyrosine-protein phosphatase C-like.	Receptor-type tyrosine-protein phosphatase C-like.	0.900
SPRY3	spry1	ENSSFOP00015015302	ENSSFOP00015038492	Protein sprouty2-like.	Protein sprouty1-like.	0.576
SPRY4	spry1	ENSSFOP00015028879	ENSSFOP00015038492	Protein sprouty4-like.	Protein sprouty1-like.	0.557
SPRY4-2	spry1	ENSSFOP00015077607	ENSSFOP00015038492	Uncharacterized protein.	Protein sprouty1-like.	0.557
Z043_116999	Z043_120612	ENSSFOP00015016568	ENSSFOP00015049917	Adiponectin-like.	Adiponectin-like.	0.901
Z043_120612	Z043_116999	ENSSFOP00015049917	ENSSFOP00015016568	Adiponectin-like.	Adiponectin-like.	0.901
Z043_120772	spry1	ENSSFOP00015008313	ENSSFOP00015038492	Protein sprouty2-like.	Protein sprouty1-like.	0.553
dusp10	vrk3	ENSSFOP00015011431	ENSSFOP00015017205	Dual specificity protein phosphatase 10-like.	Protein kinase domain-containing protein.	0.410
spry1	ENSSFOP00015004954	ENSSFOP00015038492	ENSSFOP00015004954	Protein sprouty1-like.	Protein sprouty homolog 2-like.	0.661
spry1	SPRY3	ENSSFOP00015038492	ENSSFOP00015015302	Protein sprouty1-like.	Protein sprouty2-like.	0.576
spry1	SPRY4	ENSSFOP00015038492	ENSSFOP00015028879	Protein sprouty1-like.	Protein sprouty4-like.	0.557
spry1	SPRY4-2	ENSSFOP00015038492	ENSSFOP00015077607	Protein sprouty1-like.	Uncharacterized protein.	0.557
spry1	Z043_120772	ENSSFOP00015038492	ENSSFOP00015008313	Protein sprouty1-like.	Protein sprouty2-like.	0.553
vrk3	LOC108920243	ENSSFOP00015017205	ENSSFOP00015029207	Protein kinase domain-containing protein.	Uncharacterized protein.	0.410
vrk3	LOC108925355	ENSSFOP00015017205	ENSSFOP00015067742	Protein kinase domain-containing protein.	Uncharacterized protein.	0.410
vrk3	dusp10	ENSSFOP00015017205	ENSSFOP00015011431	Protein kinase domain-containing protein.	Dual specificity protein phosphatase 10-like.	0.410