STRINGSTRING
egr1 egr1 med1 med1 sirt1 sirt1 prdm1 prdm1 ercc1 ercc1 LOC108918875 LOC108918875 taf10 taf10 PCGF1 PCGF1 LOC108929131 LOC108929131 kdm1a kdm1a myod1 myod1 LOC108923185 LOC108923185 irf3 irf3 rbl1 rbl1 nup98 nup98 ercc4 ercc4 EZH1 EZH1 mecp2 mecp2 Z043_110323 Z043_110323 setdb1 setdb1 tp53 tp53 LOC108934077 LOC108934077 polr2a polr2a Z043_124132 Z043_124132 dnmt1 dnmt1 ENSSFOP00015052991 ENSSFOP00015052991 wdr13 wdr13 LOC108927998 LOC108927998 EZH2-2 EZH2-2 EZH1-2 EZH1-2 gtf2b gtf2b myf5 myf5 dhx9 dhx9 LOC108940586 LOC108940586 PRDM15 PRDM15 rbl2 rbl2 EZH2 EZH2 LOC108937397 LOC108937397
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (507 aa)
med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1799 aa)
sirt1NAD-dependent protein deacetylase sirtuin-1-like. (710 aa)
prdm1PR domain zinc finger protein 1-like. (784 aa)
ercc1DNA excision repair protein ERCC-1-like. (335 aa)
LOC108918875Polycomb group RING finger protein 1-like. (266 aa)
taf10Transcription initiation factor TFIID subunit 10-like. (191 aa)
PCGF1Polycomb group RING finger protein 1-like. (275 aa)
LOC108929131PR domain zinc finger protein 1-like. (705 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (905 aa)
myod1Myogenic factor. (275 aa)
LOC108923185Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (400 aa)
irf3Interferon regulatory factor 3-like. (475 aa)
rbl1Retinoblastoma-like protein 1-like. (1070 aa)
nup98Nuclear pore complex protein Nup98-Nup96-like. (1836 aa)
ercc4DNA repair endonuclease XPF-like. (909 aa)
EZH1PRC2_HTH_1 domain-containing protein. (747 aa)
mecp2MBD domain-containing protein. (568 aa)
Z043_110323Uncharacterized protein. (700 aa)
setdb1Histone-lysine N-methyltransferase SETDB1-B-like. (1271 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (462 aa)
LOC108934077Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (490 aa)
polr2aDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1968 aa)
Z043_124132Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (510 aa)
dnmt1Dnmt1 protein-like; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1514 aa)
ENSSFOP00015052991annotation not available (570 aa)
wdr13WD repeat-containing protein 13-like. (503 aa)
LOC108927998Polycomb group RING finger protein 4. (327 aa)
EZH2-2Histone-lysine N-methyltransferase EZH2-like. (771 aa)
EZH1-2Uncharacterized protein. (728 aa)
gtf2bTranscription initiation factor IIB-like. (319 aa)
myf5Myogenic factor 5. (245 aa)
dhx9Uncharacterized protein. (1261 aa)
LOC108940586Polycomb group RING finger protein 4-like. (328 aa)
PRDM15PR domain zinc finger protein 15-like. (1080 aa)
rbl2Uncharacterized protein. (1095 aa)
EZH2Histone-lysine N-methyltransferase EZH2-like. (768 aa)
LOC108937397Zinc finger protein 750-like. (555 aa)
Your Current Organism:
Scleropages formosus
NCBI taxonomy Id: 113540
Other names: Asian arowana, Asian bonytongue, Osteoglossum formosum, S. formosus, golden arowana, golden dragon fish
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