(7 nodes) Ketone body metabolism, and Thiolase network (Pleurotus ostreatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A067NFE3	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (485 aa)
	A0A067NMF2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (388 aa)
	A0A067NSS4	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
	A0A067NV45	Uncharacterized protein. (627 aa)
	A0A067NXS5	Pyruvate carboxyltransferase domain-containing protein. (346 aa)
	A0A067NZA2	AMP-binding domain-containing protein. (709 aa)
	A0A067PDE9	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (466 aa)

Your Current Organism:

Pleurotus ostreatus

NCBI taxonomy Id: 1137138
Other names: P. ostreatus PC15, Pleurotus ostreatus PC15

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A067NFE3	A0A067NMF2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.979
A0A067NFE3	A0A067NSS4	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.972
A0A067NFE3	A0A067NV45	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.852
A0A067NFE3	A0A067NXS5	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Pyruvate carboxyltransferase domain-containing protein.	0.872
A0A067NFE3	A0A067NZA2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	AMP-binding domain-containing protein.	0.853
A0A067NFE3	A0A067PDE9	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.865
A0A067NMF2	A0A067NFE3	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.979
A0A067NMF2	A0A067NSS4	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.928
A0A067NMF2	A0A067NV45	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.941
A0A067NMF2	A0A067NXS5	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Pyruvate carboxyltransferase domain-containing protein.	0.952
A0A067NMF2	A0A067NZA2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	AMP-binding domain-containing protein.	0.951
A0A067NMF2	A0A067PDE9	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.961
A0A067NSS4	A0A067NFE3	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.972
A0A067NSS4	A0A067NMF2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.928
A0A067NSS4	A0A067NV45	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.653
A0A067NSS4	A0A067NXS5	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Pyruvate carboxyltransferase domain-containing protein.	0.933
A0A067NSS4	A0A067NZA2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	AMP-binding domain-containing protein.	0.653
A0A067NSS4	A0A067PDE9	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.938
A0A067NV45	A0A067NFE3	Uncharacterized protein.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.852
A0A067NV45	A0A067NMF2	Uncharacterized protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.941