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ABB57547.1 ABB57547.1 tmk tmk ABB56130.1 ABB56130.1 ABB56148.1 ABB56148.1 glk glk coaE coaE ispE ispE ABB56433.1 ABB56433.1 ABB56485.1 ABB56485.1 gpmI gpmI ABB56512.1 ABB56512.1 ABB56524.1 ABB56524.1 pyrH pyrH ABB56624.1 ABB56624.1 ABB56632.1 ABB56632.1 eno eno cikA cikA ABB56812.1 ABB56812.1 ABB56813.1 ABB56813.1 ABB56889.1 ABB56889.1 aroK aroK nblS nblS cysC cysC ABB57007.1 ABB57007.1 ABB57020.1 ABB57020.1 ABB57026.1 ABB57026.1 ABB57031.1 ABB57031.1 sphS sphS ABB57044.1 ABB57044.1 anmK anmK ABB57141.1 ABB57141.1 pgk pgk ABB57151.1 ABB57151.1 ABB57155.1 ABB57155.1 panC/cmk panC/cmk gmk gmk kaiC kaiC kaiA kaiA tpiA tpiA ABB57324.1 ABB57324.1 ABB57387.1 ABB57387.1 thrB thrB cbbA cbbA argB argB ppk ppk SEC0020 SEC0020 ABB57680.1 ABB57680.1 ABB57759.1 ABB57759.1 ABB57808.1 ABB57808.1 coaX coaX ABB57845.1 ABB57845.1 ABB57846.1 ABB57846.1 nadK nadK ABB57902.1 ABB57902.1 ABB58015.1 ABB58015.1 pgi pgi ackA ackA prs prs sasA sasA ABB58209.1 ABB58209.1 proB proB adk adk ABB58272.1 ABB58272.1 ABB58302.1 ABB58302.1 ABB58312.1 ABB58312.1 nadK-2 nadK-2 ABB58369.1 ABB58369.1 thiD thiD ABB58468.1 ABB58468.1 PSK PSK ndk ndk ABB58532.1 ABB58532.1 thiL thiL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABB57547.1Histidine kinase. (457 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (215 aa)
ABB56130.1Pyruvate kinase; Belongs to the pyruvate kinase family. (594 aa)
ABB56148.1Fructokinase. (324 aa)
glkGlucokinase; Belongs to the bacterial glucokinase family. (345 aa)
coaEDephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (209 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (314 aa)
ABB56433.1Diacylglycerol kinase. (161 aa)
ABB56485.1GAF sensor signal transduction histidine kinase. (404 aa)
gpmIPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (532 aa)
ABB56512.1GAF sensor signal transduction histidine kinase. (577 aa)
ABB56524.1FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. (315 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (253 aa)
ABB56624.16-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (360 aa)
ABB56632.1Serine/threonine protein kinase. (510 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
cikAGAF sensor hybrid histidine kinase. (754 aa)
ABB56812.1Serine/threonine protein kinase. (457 aa)
ABB56813.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (838 aa)
ABB56889.1CheA signal transduction histidine kinase. (952 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (190 aa)
nblSMulti-sensor signal transduction histidine kinase. (664 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (208 aa)
ABB57007.1Phosphoribulokinase. (333 aa)
ABB57020.1Adenosylcobinamide kinase. (180 aa)
ABB57026.1Glycerate kinase. (328 aa)
ABB57031.1Aspartate kinase. (616 aa)
sphSPAS/PAC sensor signal transduction histidine kinase; Member of the two-component regulatory system SphR/SphS. Sensory kinase. Is involved in inducible production of alkaline phosphatase in response to phosphate limitation as it is directly involved in the regulation of phoA transcription in response to phosphate limitation. SphS functions as a protein kinase that phosphorylates SphR. (413 aa)
ABB57044.1CheA signal transduction histidine kinase. (928 aa)
anmKConserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (378 aa)
ABB57141.1Serine/threonine protein kinase. (527 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (402 aa)
ABB57151.1Serine/threonine protein kinase. (719 aa)
ABB57155.1Putative CheA signal transduction histidine kinases, no good domain identification. (311 aa)
panC/cmkPantothenate synthetase / cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. (527 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (183 aa)
kaiCCircadian clock protein KaiC; Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction; Belongs to the KaiC family. (519 aa)
kaiACircadian clock protein KaiA; Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of KaiC. In contrast, the presence of KaiB in the complex decreases the phosphorylation status of KaiC, suggesting that KaiB acts by antagonizing the interaction between KaiA and KaiC. A KaiA dimer is sufficient to enhance KaiC he [...] (284 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (263 aa)
ABB57324.1Serine/threonine protein kinase. (522 aa)
ABB57387.1Multi-sensor signal transduction histidine kinase. (1807 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (306 aa)
cbbAFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (357 aa)
argBN-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (301 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (731 aa)
SEC0020Periplasmic sensor signal transduction histidine kinase. (436 aa)
ABB57680.1Phosphorylase kinase alpha subunit. (1079 aa)
ABB57759.1Potassium-transporting ATPase D chain. (370 aa)
ABB57808.1Conserved hypothetical protein. (619 aa)
coaXPutative transcriptional acitvator, Baf; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (247 aa)
ABB57845.1Response regulator receiver domain protein (CheY-like). (411 aa)
ABB57846.1Periplasmic sensor hybrid histidine kinase. (977 aa)
nadKNAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (306 aa)
ABB57902.1Histidine kinase. (482 aa)
ABB58015.1Conserved hypothetical protein; Belongs to the fructosamine kinase family. (297 aa)
pgiGlucose-6-phosphate isomerase. (528 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (393 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (331 aa)
sasAHistidine kinase; May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs. (387 aa)
ABB58209.1Conserved hypothetical protein. (304 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (186 aa)
ABB58272.1Histidine kinase. (330 aa)
ABB58302.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (176 aa)
ABB58312.1GAF sensor signal transduction histidine kinase. (637 aa)
nadK-2NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (305 aa)
ABB58369.1RfaE bifunctional protein, domain I. (344 aa)
thiDPhosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. (263 aa)
ABB58468.1Putative CheA signal transduction histidine kinases, no good domain identification. (477 aa)
PSKProbable sugar kinase; Exhibits ATP hydrolysis without substrate. Phosphorylates D- ribulose. (426 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (151 aa)
ABB58532.1Conserved hypothetical protein. (437 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (327 aa)
Your Current Organism:
Synechococcus elongatus
NCBI taxonomy Id: 1140
Other names: Anacystis nidulans R2, S. elongatus PCC 7942, Synechococcus elongatus PCC 7942, Synechococcus leopoliensis UTEX 2434, Synechococcus leopoliensis strain PCC 7942, Synechococcus sp. IAM M-200, Synechococcus sp. PCC 7942
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