STRINGSTRING
ABB56813.1 ABB56813.1 thiL thiL ABB58532.1 ABB58532.1 ndk ndk PSK PSK pnp pnp ABB58468.1 ABB58468.1 thiD thiD ABB58369.1 ABB58369.1 nadK-2 nadK-2 kdsB kdsB ABB58312.1 ABB58312.1 ABB58302.1 ABB58302.1 ABB58272.1 ABB58272.1 adk adk rpoA rpoA ABB58229.1 ABB58229.1 proB proB ABB58209.1 ABB58209.1 sasA sasA prs prs ABB58131.1 ABB58131.1 ackA ackA coaD coaD ABB58015.1 ABB58015.1 cugP cugP ABB57902.1 ABB57902.1 nadK nadK ABB57855.1 ABB57855.1 ABB57846.1 ABB57846.1 ABB57845.1 ABB57845.1 coaX coaX ABB57835.1 ABB57835.1 ABB57808.1 ABB57808.1 ABB57759.1 ABB57759.1 rpoZ rpoZ ABB57680.1 ABB57680.1 ABB57638.1 ABB57638.1 ABB57630.1 ABB57630.1 SEC0020 SEC0020 selO selO ppk ppk ABB57580.1 ABB57580.1 rpoC2 rpoC2 rpoC1 rpoC1 rpoB rpoB ABB57547.1 ABB57547.1 argB argB thrB thrB ABB57387.1 ABB57387.1 ABB57324.1 ABB57324.1 dnaG dnaG kaiC kaiC gmk gmk mobA mobA ABB57195.1 ABB57195.1 panC/cmk panC/cmk ABB57155.1 ABB57155.1 ABB57151.1 ABB57151.1 pgk pgk ABB57141.1 ABB57141.1 anmK anmK rph rph ABB57044.1 ABB57044.1 sphS sphS ABB57031.1 ABB57031.1 ABB57026.1 ABB57026.1 ABB57020.1 ABB57020.1 ABB57007.1 ABB57007.1 ABB57006.1 ABB57006.1 cysC cysC nblS nblS dnaX dnaX aroK aroK ABB56918.1 ABB56918.1 ABB56889.1 ABB56889.1 ABB56823.1 ABB56823.1 ABB56812.1 ABB56812.1 ABB56759.1 ABB56759.1 ispD ispD cikA cikA glgC glgC ABB56632.1 ABB56632.1 ABB56624.1 ABB56624.1 ABB56602.1 ABB56602.1 pyrH pyrH ABB56530.1 ABB56530.1 ABB56525.1 ABB56525.1 ABB56524.1 ABB56524.1 ABB56512.1 ABB56512.1 cobS cobS ABB56485.1 ABB56485.1 ABB56437.1 ABB56437.1 ABB56433.1 ABB56433.1 ABB56426.1 ABB56426.1 ABB56418.1 ABB56418.1 ispE ispE sat sat glmU glmU ABB56313.1 ABB56313.1 ABB56306.1 ABB56306.1 coaE coaE dacA dacA glk glk polA polA mraY mraY ABB56148.1 ABB56148.1 ABB56138.1 ABB56138.1 ABB56130.1 ABB56130.1 tmk tmk ABB56094.1 ABB56094.1 ABB56065.1 ABB56065.1 dnaN dnaN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABB56813.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (838 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (327 aa)
ABB58532.1Conserved hypothetical protein. (437 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (151 aa)
PSKProbable sugar kinase; Exhibits ATP hydrolysis without substrate. Phosphorylates D- ribulose. (426 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (716 aa)
ABB58468.1Putative CheA signal transduction histidine kinases, no good domain identification. (477 aa)
thiDPhosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. (263 aa)
ABB58369.1RfaE bifunctional protein, domain I. (344 aa)
nadK-2NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (305 aa)
kdsB3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (244 aa)
ABB58312.1GAF sensor signal transduction histidine kinase. (637 aa)
ABB58302.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (176 aa)
ABB58272.1Histidine kinase. (330 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (186 aa)
rpoADNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (309 aa)
ABB58229.1DNA polymerase III, alpha subunit / Intein. (870 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa)
ABB58209.1Conserved hypothetical protein. (304 aa)
sasAHistidine kinase; May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs. (387 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (331 aa)
ABB58131.1Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (294 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (393 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (166 aa)
ABB58015.1Conserved hypothetical protein; Belongs to the fructosamine kinase family. (297 aa)
cugPMannose-1-phosphate guanyltransferase; Catalyzes the formation of UDP-glucose, from UTP and glucose 1-phosphate. (389 aa)
ABB57902.1Histidine kinase. (482 aa)
nadKNAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (306 aa)
ABB57855.1CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (172 aa)
ABB57846.1Periplasmic sensor hybrid histidine kinase. (977 aa)
ABB57845.1Response regulator receiver domain protein (CheY-like). (411 aa)
coaXPutative transcriptional acitvator, Baf; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (247 aa)
ABB57835.1HetI protein-like; Belongs to the P-Pant transferase superfamily. (259 aa)
ABB57808.1Conserved hypothetical protein. (619 aa)
ABB57759.1Potassium-transporting ATPase D chain. (370 aa)
rpoZRNA polymerase subunit omega (rpoZ); Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (76 aa)
ABB57680.1Phosphorylase kinase alpha subunit. (1079 aa)
ABB57638.1Mannose-1-phosphate guanylyltransferase (GDP); Belongs to the mannose-6-phosphate isomerase type 2 family. (469 aa)
ABB57630.15',5'''-P-1,P-4-tetraphosphate phosphorylase II-like. (280 aa)
SEC0020Periplasmic sensor signal transduction histidine kinase. (436 aa)
selOConserved hypothetical protein; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). (492 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (731 aa)
ABB57580.1DNA-directed DNA polymerase. (418 aa)
rpoC2DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily. (1318 aa)
rpoC1DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (624 aa)
rpoBDNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1100 aa)
ABB57547.1Histidine kinase. (457 aa)
argBN-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (301 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (306 aa)
ABB57387.1Multi-sensor signal transduction histidine kinase. (1807 aa)
ABB57324.1Serine/threonine protein kinase. (522 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (694 aa)
kaiCCircadian clock protein KaiC; Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction; Belongs to the KaiC family. (519 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (183 aa)
mobAMolybdenum cofactor guanylyltransferase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (194 aa)
ABB57195.1Hypothetical protein. (131 aa)
panC/cmkPantothenate synthetase / cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. (527 aa)
ABB57155.1Putative CheA signal transduction histidine kinases, no good domain identification. (311 aa)
ABB57151.1Serine/threonine protein kinase. (719 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (402 aa)
ABB57141.1Serine/threonine protein kinase. (527 aa)
anmKConserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (378 aa)
rphRNAse PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (238 aa)
ABB57044.1CheA signal transduction histidine kinase. (928 aa)
sphSPAS/PAC sensor signal transduction histidine kinase; Member of the two-component regulatory system SphR/SphS. Sensory kinase. Is involved in inducible production of alkaline phosphatase in response to phosphate limitation as it is directly involved in the regulation of phoA transcription in response to phosphate limitation. SphS functions as a protein kinase that phosphorylates SphR. (413 aa)
ABB57031.1Aspartate kinase. (616 aa)
ABB57026.1Glycerate kinase. (328 aa)
ABB57020.1Adenosylcobinamide kinase. (180 aa)
ABB57007.1Phosphoribulokinase. (333 aa)
ABB57006.1CBS; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (909 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (208 aa)
nblSMulti-sensor signal transduction histidine kinase. (664 aa)
dnaXDNA polymerase III, tau subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (652 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (190 aa)
ABB56918.1Mannose-1-phosphate guanylyltransferase-like. (119 aa)
ABB56889.1CheA signal transduction histidine kinase. (952 aa)
ABB56823.1polyA polymerase. (412 aa)
ABB56812.1Serine/threonine protein kinase. (457 aa)
ABB56759.1Conserved hypothetical protein. (847 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (232 aa)
cikAGAF sensor hybrid histidine kinase. (754 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (430 aa)
ABB56632.1Serine/threonine protein kinase. (510 aa)
ABB56624.16-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (360 aa)
ABB56602.1DNA polymerase III, alpha subunit / Intein. (447 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (253 aa)
ABB56530.1Mannose-1-phosphate guanyltransferase. (837 aa)
ABB56525.1Conserved hypothetical protein. (494 aa)
ABB56524.1FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. (315 aa)
ABB56512.1GAF sensor signal transduction histidine kinase. (577 aa)
cobSCobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (251 aa)
ABB56485.1GAF sensor signal transduction histidine kinase. (404 aa)
ABB56437.1DNA polymerase III, delta subunit. (332 aa)
ABB56433.1Diacylglycerol kinase. (161 aa)
ABB56426.1Phosphatidate cytidylyltransferase; Belongs to the CDS family. (288 aa)
ABB56418.1Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (469 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (314 aa)
satSulfate adenylyltransferase; Belongs to the sulfate adenylyltransferase family. (395 aa)
glmUGlucosamine-1-phosphate N-acetyltransferase / UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the t [...] (452 aa)
ABB56313.1Probable glycosyltransferase. (357 aa)
ABB56306.1Conserved hypothetical protein. (112 aa)
coaEDephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (209 aa)
dacAProtein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (306 aa)
glkGlucokinase; Belongs to the bacterial glucokinase family. (345 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (953 aa)
mraYPhospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (365 aa)
ABB56148.1Fructokinase. (324 aa)
ABB56138.1Probable nicotinate-nucleotide adenylyltransferase; Belongs to the NadD family. (192 aa)
ABB56130.1Pyruvate kinase; Belongs to the pyruvate kinase family. (594 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (215 aa)
ABB56094.1Glucose-1-phosphate cytidylyltransferase. (257 aa)
ABB56065.1Conserved hypothetical protein. (110 aa)
dnaNDNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (390 aa)
Your Current Organism:
Synechococcus elongatus
NCBI taxonomy Id: 1140
Other names: Anacystis nidulans R2, S. elongatus PCC 7942, Synechococcus elongatus PCC 7942, Synechococcus leopoliensis UTEX 2434, Synechococcus leopoliensis strain PCC 7942, Synechococcus sp. IAM M-200, Synechococcus sp. PCC 7942
Server load: low (28%) [HD]