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| | thrA | Aspartate kinase/homoserine dehydrogenase. (818 aa) |
| | prs1 | Putative ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (306 aa) |
| | ocd1 | Ornithine cyclodeaminase/mu-crystallin family protein. (320 aa) |
| | aatB | Class I aminotransferase. (431 aa) |
| | glnA | Glutamate--ammonia ligase. (479 aa) |
| | cysK1 | Putative cysteine synthase. (319 aa) |
| | gltB | Glutamate synthase small subunit. (486 aa) |
| | gltB1 | Glutamate synthase large subunit. (1523 aa) |
| | argE | Acetylornithine deacetylase. (380 aa) |
| | serB | ACT domain-containing protein/phosphoserine phosphatase SerB. (398 aa) |
| | aspC | Class I/II aminotransferase. (392 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (366 aa) |
| | acnA | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (911 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Belongs to the type-II 3-dehydroquinase family. (319 aa) |
| | ltaA | L-allo-threonine aldolase. (341 aa) |
| | AFE04031.1 | Homoserine O-acetyltransferase. (372 aa) |
| | AFE04067.1 | Fructose-bisphosphate aldolase class i. (354 aa) |
| | aspC2 | Class I aminotransferase. (412 aa) |
| | cysK | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (306 aa) |
| | srpH | Putative serine O-acetyltransferase. (281 aa) |
| | AFE04336.1 | Asparagine synthase. (520 aa) |
| | mdeA | Cys/Met metabolism PLP-dependent enzyme. (395 aa) |
| | metH | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1171 aa) |
| | gpmA | Putative 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (199 aa) |
| | tktB | Putative transketolase N-terminal section. (315 aa) |
| | dxs1 | Putative transketolase C-terminal section. (345 aa) |
| | lysX | alpha-aminoadipate--lysW ligase lysX; Belongs to the RimK family. (284 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (347 aa) |
| | argB | Putative acetylglutamate kinase-like protein. (289 aa) |
| | lysK | Acetyl-lysine deacetylase. (358 aa) |
| | alsS | Acetolactate synthase; Belongs to the TPP enzyme family. (543 aa) |
| | thrC1 | Threonine synthase. (390 aa) |
| | argC1 | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (356 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (395 aa) |
| | argH | Argininosuccinate lyase. (449 aa) |
| | argE1 | M20A family peptidase. (353 aa) |
| | argB1 | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (308 aa) |
| | argF | N-acetylornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (334 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (283 aa) |
| | ask | Aspartate kinase; Belongs to the aspartokinase family. (397 aa) |
| | rpiB | Ribose 5-phosphate isomerase B. (148 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa) |
| | cbs | Cysteine synthase A. (330 aa) |
| | AFE04822.1 | Aspartate aminotransferase. (550 aa) |
| | aroF | Putative phospho-2-dehydro-3-deoxyheptonate aldolase. (378 aa) |
| | pheA1 | Prephenate dehydratase. (277 aa) |
| | pheA | Chorismate mutase/prephenate dehydratase. (379 aa) |
| | cysE | Hexapeptide repeat-containing transferase. (176 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (404 aa) |
| | aatA | Putative aspartate aminotransferase. (397 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (432 aa) |
| | lysA1 | Diaminopimelate decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (466 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (285 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (433 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (345 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (197 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (238 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family. (181 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | hisIE | phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase; In the N-terminal section; belongs to the PRA-CH family. (205 aa) |
| | ilvB | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. (638 aa) |
| | hisC1 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (363 aa) |
| | pfkA1 | 6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (365 aa) |
| | ybdL | Class I/II aminotransferase. (399 aa) |
| | fba2 | Fructose-bisphosphate aldolase. (306 aa) |
| | aroH | 3-deoxy-7-phosphoheptulonate synthase. (426 aa) |
| | icd | Isocitrate dehydrogenase, NADP-dependent. (431 aa) |
| | aroF1 | Phospho-2-dehydro-3-deoxyheptonate aldolase. (263 aa) |
| | AFE05873.1 | Putative shikimate kinase. (158 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (339 aa) |
| | aroB | 3-dehydroquinate synthase. (356 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (431 aa) |
| | gltA | Citrate synthase; Belongs to the citrate synthase family. (431 aa) |
| | pyk1 | Pyruvate kinase; Belongs to the pyruvate kinase family. (466 aa) |
| | lysC | Aspartate kinase; Belongs to the aspartokinase family. (425 aa) |
| | thrC | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (443 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (283 aa) |
| | phhA | Phenylalanine 4-monooxygenase. (531 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (362 aa) |
| | hom | Homoserine dehydrogenase. (351 aa) |
| | argD1 | Acetylornithine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (407 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (316 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (253 aa) |
| | gapA | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (337 aa) |
| | asnB | Asparagine synthase. (656 aa) |
| | AFE06289.1 | Hypothetical protein. (250 aa) |
| | asd1 | Semialdehyde dehydrogenase family protein; Belongs to the aspartate-semialdehyde dehydrogenase family. (343 aa) |
| | thrB | Homoserine kinase; Belongs to the pseudomonas-type ThrB family. (322 aa) |
| | lysA2 | Pyridoxal-dependent decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (482 aa) |
| | citZ1 | Citrate synthase. (412 aa) |
| | cbs1 | Cystathionine beta-synthase. (455 aa) |
| | metB1 | Cys/Met metabolism PLP-dependent enzyme. (381 aa) |
| | glnA1 | Glutamine synthetase family protein. (487 aa) |
| | nifP | Putative serine acetyltransferase. (145 aa) |
| | ilvA | Threonine dehydratase. (406 aa) |
| | metX1 | Putative homoserine-O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (445 aa) |
| | thrA1 | Aspartate kinase/homoserine dehydrogenase. (837 aa) |
| | tal | Putative translaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (221 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (272 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (413 aa) |
| | aroF2 | Phospho-2-dehydro-3-deoxyheptonate aldolase. (341 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (272 aa) |
| | trpF | N-(5phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (210 aa) |
| | trpB | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (401 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa) |
| | trpG | Putative anthranilate synthase, glutamine amidotransferase component. (187 aa) |
| | trpE | Putative anthranilate synthase, component I. (498 aa) |
| | rpiA | Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (235 aa) |
| | sdaA | L-serine ammonia-lyase. (492 aa) |
| | tkt1 | Transketolase. (635 aa) |
| | tal2 | Transaldolase family protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (373 aa) |
| | cobC | Alpha-ribazole-5-phosphate phosphatase; Belongs to the phosphoglycerate mutase family. (209 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (219 aa) |
| | pyk | Pyruvate kinase; Belongs to the pyruvate kinase family. (476 aa) |
| | leuB2 | Putative isocitrate dehydrogenase, NAD-dependent. (335 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (398 aa) |
| | pfkA | 6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (345 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (396 aa) |
| | dapE2 | Succinyl-diaminopimelate desuccinylase. (362 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (275 aa) |
| | citZ | Citrate synthase. (431 aa) |
| | AFE07713.1 | Putative asparagine synthetase. (501 aa) |
| | tkt | Transketolase; Belongs to the transketolase family. (685 aa) |
| | cysE1 | Hexapeptide repeat-containing transferase. (178 aa) |
