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purK purK purA purA purD purD purB purB purC purC purS purS purQ purQ purL purL purF purF purM purM adk adk guaB guaB guaA2 guaA2 purN purN purH purH add add purE purE BLASA_3842 BLASA_3842 BLASA_3737 BLASA_3737 BLASA_3472 BLASA_3472 BLASA_3471 BLASA_3471 purU purU apt apt guaA guaA hpt hpt
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (377 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa)
purDPhosphoribosylamine--glycine ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GARS family. (427 aa)
purBAdenylosuccinate lyase; Function of strongly homologous gene; enzyme; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Function of strongly homologous gene; enzyme; Belongs to the SAICAR synthetase family. (292 aa)
purSPhosphoribosylformylglycinamidine synthetase, PurS component; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is tho [...] (90 aa)
purQPhosphoribosylformylglycinamidine synthase I (FGAM synthase I); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is t [...] (223 aa)
purLPhosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (788 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (512 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (353 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (204 aa)
guaBInosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (504 aa)
guaA2GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. (520 aa)
purNPhosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (191 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (516 aa)
addAdenosine deaminase; Function of strongly homologous gene; enzyme. (357 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit (AIR carboxylase) (AIRC); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (171 aa)
BLASA_3842Putative GMP synthase family protein (glutamine-hydrolyzing); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (242 aa)
BLASA_3737Putative 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (224 aa)
BLASA_3472Homologs of previously reported genes of unknown function. (114 aa)
BLASA_3471Homologs of previously reported genes of unknown function. (70 aa)
purUFormyltetrahydrofolate deformylase (Formyl-FH(4) hydrolase); Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (290 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (195 aa)
guaAPutative GMP synthase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (242 aa)
hptHypoxanthine-guanine phosphoribosyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (194 aa)
Your Current Organism:
Blastococcus saxobsidens
NCBI taxonomy Id: 1146883
Other names: B. saxobsidens DD2, Blastococcus saxobsidens DD2, Blastococcus saxobsidens str. DD2, Blastococcus saxobsidens strain DD2
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