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nrdA nrdA pyrB pyrB tmk tmk AIE72941.1 AIE72941.1 apt apt purL purL purS purS purB purB AIE73173.1 AIE73173.1 pyrR pyrR pyrA pyrA adk adk purL-2 purL-2 gmk gmk purN purN guaA guaA pyrC pyrC AIE73773.1 AIE73773.1 pyrC-2 pyrC-2 ndkR ndkR pyrG pyrG pyrE pyrE surE surE AIE74227.1 AIE74227.1 thiL thiL pyrD pyrD purE purE AIE74772.1 AIE74772.1 purC purC upp upp pyrF pyrF purA purA adk-2 adk-2 purD purD carA carA AIE75266.1 AIE75266.1 AIE75267.1 AIE75267.1 purK purK engC engC purH purH AIE75430.1 AIE75430.1 surE-2 surE-2 guaB-2 guaB-2 purF purF purM purM
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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nrdARibonucleotide reductase of class Ia (aerobic), alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (767 aa)
pyrBAspartate carbamoyltransferase; Sly1002510; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (347 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa)
AIE72941.1Nucleoside triphosphate pyrophosphohydrolase MazG; Sly1000190. (269 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa)
purLPhosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ a [...] (224 aa)
purSPhosphoribosylformylglycinamidine synthase, PurS subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (91 aa)
purBAdenylosuccinate lyase; Sly2001970; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa)
AIE73173.1Xanthosine/inosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (194 aa)
pyrRPhosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (178 aa)
pyrACarbamoyl-phosphate synthase large chain; Sly3000730; Belongs to the CarB family. (1071 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (177 aa)
purL-2Phosphoribosylformylglycinamidine synthase, synthetase subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is t [...] (769 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (195 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (217 aa)
guaAGMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. (527 aa)
pyrCDihydroorotase; Sly3001680. (435 aa)
AIE73773.1Thymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (216 aa)
pyrC-2Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (342 aa)
ndkRNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (149 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (552 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (198 aa)
surE5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (275 aa)
AIE74227.1Putative dihydropyrimidine dehydrogenase [NADP+], similar to dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (343 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (354 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (385 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (176 aa)
AIE74772.15'-nucleotidase; Sly1014280; Belongs to the 5'-nucleotidase family. (485 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Sly1014210; Belongs to the SAICAR synthetase family. (243 aa)
uppUracil phosphoribosyltransferase; Sly1013220; Belongs to the UPRTase family. (216 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (231 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (443 aa)
adk-2Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (193 aa)
purDPhosphoribosylamine--glycine ligase; Sly1009650; Belongs to the GARS family. (420 aa)
carACarbamoyl-phosphate synthase small chain; Sly1009050; Belongs to the CarA family. (388 aa)
AIE75266.1Ribonucleotide reductase of class Ia (aerobic), beta subunit; Sly1008860. (265 aa)
AIE75267.1Ribonucleotide reductase of class Ia (aerobic), beta subunit; Sly1008840. (64 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (388 aa)
engCRibosome small subunit-stimulated GTPase EngC; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (376 aa)
purHIMP cyclohydrolase / Phosphoribosylaminoimidazolecarboxamide formyltransferase; Sly1008370. (511 aa)
AIE75430.1Deoxycytidine triphosphate deaminase; Sly1007220. (193 aa)
surE-25-nucleotidase SurE; Sly1005000. (196 aa)
guaB-2Inosine-5'-monophosphate dehydrogenase, catalytic domain; Sly1021250. (387 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (495 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; Sly1010840. (341 aa)
Your Current Organism:
Synechocystis sp. PCC6714
NCBI taxonomy Id: 1147
Other names: Aphanocapsa sp. (strain 5.3A), Aphanocapsa sp. 5-3A, Aphanocapsa sp. 5.3A, S. sp. PCC 6714, Synechocystis sp. (ATCC 27178), Synechocystis sp. (PCC 6714), Synechocystis sp. (strain PCC 6714), Synechocystis sp. ATCC 27178, Synechocystis sp. PCC 6714, Synechocystis sp. SAG 92.79, Synechocystis sp. UTCC 98, Synechocystis sp. UTEX 2470
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