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gnd gnd zwf zwf guaB-2 guaB-2 fabG fabG dfrA dfrA icd icd AIE72664.1 AIE72664.1 me me pdxA pdxA AIE72936.1 AIE72936.1 dxr dxr aroE aroE murB murB AIE73666.1 AIE73666.1 ilvC ilvC hisD hisD fcl fcl gldA gldA hisD-2 hisD-2 leuB leuB phaB phaB serA serA ribD ribD AIE73999.1 AIE73999.1 ddh ddh citH citH rfbD-2 rfbD-2 AIE74584.1 AIE74584.1 gpsA gpsA thrA thrA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
gnd6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (475 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (509 aa)
guaB-2Inosine-5'-monophosphate dehydrogenase, catalytic domain; Sly1021250. (387 aa)
fabG3-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa)
dfrADihydroflavonol 4-reductase; Sly1002570. (333 aa)
icdIsocitrate dehydrogenase [NADP]; Sly1003080. (475 aa)
AIE72664.1Dihydrofolate reductase; Sly1003100. (71 aa)
meNADP-dependent malic enzyme; Sly1010700. (463 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (358 aa)
AIE72936.1UDP-glucose dehydrogenase; Sly1000240. (453 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (413 aa)
aroEShikimate 5-dehydrogenase I alpha; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (290 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (330 aa)
AIE73666.1Alcohol dehydrogenase; Sly2000240. (336 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (348 aa)
hisDHistidinol dehydrogenase; Sly3001810; Belongs to the histidinol dehydrogenase family. (406 aa)
fclNucleoside-diphosphate-sugar epimerase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (312 aa)
gldAGlycerol dehydrogenase; Sly1025320. (389 aa)
hisD-2Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (362 aa)
phaBAcetoacetyl-CoA reductase; Sly1026610. (240 aa)
serAD-3-phosphoglycerate dehydrogenase; Sly1026540; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (526 aa)
ribDDiaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (361 aa)
AIE73999.1Hypothetical protein; Sly1022210. (330 aa)
ddhD-lactate dehydrogenase; Sly1023370; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (333 aa)
citHMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (336 aa)
rfbD-2dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (289 aa)
AIE74584.1Aldo-keto reductase family 1 member B10; Sly1016180. (318 aa)
gpsAGlycerol-3-phosphate dehydrogenase [NAD(P)+]; Sly1014420; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (338 aa)
thrAHomoserine dehydrogenase; Sly1013120. (433 aa)
Your Current Organism:
Synechocystis sp. PCC6714
NCBI taxonomy Id: 1147
Other names: Aphanocapsa sp. (strain 5.3A), Aphanocapsa sp. 5-3A, Aphanocapsa sp. 5.3A, S. sp. PCC 6714, Synechocystis sp. (ATCC 27178), Synechocystis sp. (PCC 6714), Synechocystis sp. (strain PCC 6714), Synechocystis sp. ATCC 27178, Synechocystis sp. PCC 6714, Synechocystis sp. SAG 92.79, Synechocystis sp. UTCC 98, Synechocystis sp. UTEX 2470
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