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| | hisF | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (265 aa) |
| | trpE-2 | Anthranilate synthase, aminase component; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] (508 aa) |
| | AIE75080.1 | Hypothetical protein; Sly1011170. (421 aa) |
| | hisH | Imidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (229 aa) |
| | ycf21 | Putative chorismate lyase; Sly1011380. (201 aa) |
| | cobA/hemD | Uroporphyrinogen-III methyltransferase / Uroporphyrinogen-III synthase; Sly1011940; Belongs to the precorrin methyltransferase family. (508 aa) |
| | vgb | Putative hydrolase; Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2- amino-butenoic acid. (352 aa) |
| | apcE | Phycobilisome core-membrane linker polypeptide; This protein is postulated to act both as terminal energy acceptor (by its phycobilin-like domains) and as a linker polypeptide (by its repeats and arms) that stabilizes the phycobilisome core architecture. Has intrinsic bilin lyase activity (By similarity). (896 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (231 aa) |
| | AIE74869.1 | O-succinylbenzoate synthase; Sly1013310; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (321 aa) |
| | phrA | Deoxyribodipyrimidine photolyase; Sly1013350; Belongs to the DNA photolyase family. (488 aa) |
| | napC | Carboxynorspermidine decarboxylase, putative; Sly1014710. (382 aa) |
| | AIE74658.1 | GDP-mannose 4,6-dehydratase; Sly1015470. (80 aa) |
| | ccmA | 2-keto-3-deoxy-D-arabino-heptulosonate-7- phosphate synthase I beta; Sly1015660. (351 aa) |
| | fda | Fructose-bisphosphate aldolase class I; Sly1016170; Belongs to the class I fructose-bisphosphate aldolase family. (299 aa) |
| | moaC | Probable molybdenum cofactor guanylyltransferase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (347 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (314 aa) |
| | cynS | Cyanate hydratase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide; Belongs to the cyanase family. (149 aa) |
| | AIE74562.1 | Hypothetical protein; Sly1016400. (246 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (139 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (225 aa) |
| | AIE74472.1 | 3-polyprenyl-4-hydroxybenzoate carboxy-lyase; Sly1017300; Belongs to the UbiD family. (501 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (264 aa) |
| | dcoH | Pterin-4-alpha-carbinolamine dehydratase; Sly1017390. (52 aa) |
| | AIE74410.1 | Lactoylglutathione lyase; Sly1017900. (126 aa) |
| | fpg | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (287 aa) |
| | cefD | Cysteine desulfurase; Sly1018220. (404 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa) |
| | AIE74250.1 | Glyoxalase family protein; Sly1021490. (150 aa) |
| | AIE74235.1 | UPF0272 protein; Sly1021640; Belongs to the LarC family. (421 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (1034 aa) |
| | cpcT | Hypothetical protein; Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins. (196 aa) |
| | yefA | GDP-mannose 4,6 dehydratase; Sly1023580. (317 aa) |
| | dacA | Diadenylate cyclase; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (303 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (464 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (432 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa) |
| | cya1 | Adenylate cyclase; Sly1026570. (308 aa) |
| | argH | Argininosuccinate lyase; Sly1025990. (489 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (161 aa) |
| | ribA | 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (551 aa) |
| | rfbD | GDP-D-mannose dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (362 aa) |
| | icfA | Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (285 aa) |
| | AIE73624.1 | Hypothetical protein; Sly2000650. (164 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (468 aa) |
| | speA-2 | Biosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (659 aa) |
| | thiC | Thiamin biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (459 aa) |
| | AIE73468.1 | Hypothetical protein; Sly1029020. (430 aa) |
| | rfbB-2 | dTDP-glucose 4,6-dehydratase; Sly1030070. (310 aa) |
| | trpE | Para-aminobenzoate synthase, aminase component; Sly1030180. (456 aa) |
| | cofG | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (328 aa) |
| | rfbB | dTDP-glucose 4,6-dehydratase; Sly3001360; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (342 aa) |
| | trpG | Anthranilate synthase component II; Sly3001120. (196 aa) |
| | ecaB | Carbonic anhydrase; Sly3001030. (234 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Sly2001060. (210 aa) |
| | cya2 | Adenylate cyclase; Sly2001420. (756 aa) |
| | purB | Adenylosuccinate lyase; Sly2001970; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa) |
| | eda | 4-Hydroxy-2-oxoglutarate aldolase / 2-dehydro-3-deoxyphosphogluconate aldolase; Sly1006930. (230 aa) |
| | AIE75576.1 | Sirohydrochlorin cobaltochelatase; Sly1005800. (276 aa) |
| | ycf58 | Phycoerythrin linker protein CpeS-like; Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins. (192 aa) |
| | AIE75717.1 | Hypothetical protein; Sly1022130. (730 aa) |
| | fabZ | (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (166 aa) |
| | repA | Rare lipoprotein A; Sly1020760. (110 aa) |
| | rbcL | Ribulose bisphosphate carboxylase large chain; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site. (470 aa) |
| | rbcS | Ribulose bisphosphate carboxylase small chain; Sly1020490. (113 aa) |
| | thrC | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (382 aa) |
| | rlpA | Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (222 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (215 aa) |
| | thrC-2 | Threonine synthase; Sly1019780. (392 aa) |
| | phr | Cryptochrome; Sly1019620; Belongs to the DNA photolyase family. (489 aa) |
| | AIE75965.1 | C-1'-hydroxylase CruF; Sly3000370. (303 aa) |
| | menB | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). (275 aa) |
| | hemH, | Ferrochelatase, protoheme ferro-lyase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (387 aa) |
| | cpcF-2 | Phycocyanobilin lyase beta subunit; Sly1010870. (214 aa) |
| | mltA | Membrane-bound lytic murein transglycosylase A precursor; Sly2002070. (384 aa) |
| | fbaA, | Fructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | nnrD | NAD(P)HX epimerase / NAD(P)HX dehydratase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] (530 aa) |
| | AIE73060.1 | Aldehyde decarbonylase; Catalyzes the decarbonylation of fatty aldehydes to alkanes. (231 aa) |
| | AIE73044.1 | Sirohydrochlorin cobaltochelatase; Sly1024470. (343 aa) |
| | mgsA | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (433 aa) |
| | pheA | Prephenate dehydratase; Sly1000410. (299 aa) |
| | dfp | Phosphopantothenoylcysteine decarboxylase / Phosphopantothenoylcysteine synthetase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (405 aa) |
| | queE | Queuosine Biosynthesis QueE Radical SAM; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (206 aa) |
| | speA | Biosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (693 aa) |
| | acnB | Aconitate hydratase 2; Sly1002900; Belongs to the aconitase/IPM isomerase family. (868 aa) |
| | ilvA | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (508 aa) |
| | fumC | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (455 aa) |
| | AIE72589.1 | Fumarate hydratase class II; Sly1003850. (42 aa) |
| | aroQ | 3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (157 aa) |
| | cpeS | Phycoerythrin-like linker protein CpeS; Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins. (178 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (379 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Sly1007340; Belongs to the IlvD/Edd family. (563 aa) |
| | AIE75416.1 | Xylulose-5-phosphate phosphoketolase; Sly1007360. (805 aa) |
| | gad | Glutamate decarboxylase; Sly1007520; Belongs to the group II decarboxylase family. (467 aa) |
| | cpcE | Phycocyanobilin lyase alpha subunit; Sly1007870. (279 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Sly1008550; Belongs to the TrpC family. (295 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (301 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (388 aa) |
| | hemB | Porphobilinogen synthase; Sly1009110; Belongs to the ALAD family. (327 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (361 aa) |
| | folB | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (140 aa) |
| | murQ | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (306 aa) |
| | AIE75143.1 | Porphobilinogen synthase; Sly1010050; Belongs to the ALAD family. (312 aa) |
| | AIE75129.1 | Queuosine biosynthesis QueD, PTPS-I; Sly1010190. (129 aa) |
| | hemE | Uroporphyrinogen III decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (350 aa) |
