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| | pdxJ | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (231 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (390 aa) |
| | AIE72881.1 | Hypothetical protein; Sly1000790. (385 aa) |
| | por | Light-dependent protochlorophyllide reductase; Phototransformation of protochlorophyllide (Pchlide) to chlorophyllide (Chlide). (322 aa) |
| | cobW | CobW GTPase involved in cobalt insertion for B12 biosynthesis; Sly1000690. (352 aa) |
| | AIE72896.1 | Hydrolase (HAD superfamily), YqeK; Sly1000640. (192 aa) |
| | ribC | Riboflavin synthase eubacterial/eukaryotic; Sly1000530. (226 aa) |
| | exsB | Queuosine Biosynthesis QueC ATPase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (235 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (260 aa) |
| | AIE72936.1 | UDP-glucose dehydrogenase; Sly1000240. (453 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa) |
| | AIE72984.1 | Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family; Sly1024830. (382 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (296 aa) |
| | AIE73044.1 | Sirohydrochlorin cobaltochelatase; Sly1024470. (343 aa) |
| | AIE73064.1 | Creatinine amidohydrolase; Sly2002580. (246 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (385 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (237 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa) |
| | AIE73072.1 | Hypothetical protein; Sly2002500. (684 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ a [...] (224 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, PurS subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (91 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (362 aa) |
| | AIE73099.1 | Hypothetical protein; Sly2002230. (546 aa) |
| | hemL | Glutamate-1-semialdehyde aminotransferase; Sly2002080. (433 aa) |
| | purB | Adenylosuccinate lyase; Sly2001970; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa) |
| | dnaX | DNA polymerase III delta prime subunit; Sly2001930. (323 aa) |
| | AIE73133.1 | 5-formyltetrahydrofolate cyclo-ligase; Sly2001890; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (192 aa) |
| | sigF | Cyanobacterial SigF-related sigma factor; Sly2001880; Belongs to the sigma-70 factor family. (258 aa) |
| | lipA | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (291 aa) |
| | ppnK | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (305 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (303 aa) |
| | cya2 | Adenylate cyclase; Sly2001420. (756 aa) |
| | cobN-2 | CobN component of cobalt chelatase involved in B12 biosynthesis; Sly2001290. (191 aa) |
| | cinA | Molybdopterin binding motif, CinA N-terminal domain / C-terminal domain of CinA type S; Sly3000680; Belongs to the CinA family. (416 aa) |
| | folE | GTP cyclohydrolase I type 1; Sly3000700. (234 aa) |
| | pyrA | Carbamoyl-phosphate synthase large chain; Sly3000730; Belongs to the CarB family. (1071 aa) |
| | AIE73257.1 | Hypothetical protein; Sly3000740. (519 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa) |
| | chlG | Chlorophyll a synthase ChlG; Sly3001130. (324 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (177 aa) |
| | purL-2 | Phosphoribosylformylglycinamidine synthase, synthetase subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is t [...] (769 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (195 aa) |
| | dnaB | Replicative DNA helicase / intein-containing; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (1126 aa) |
| | bchE | Mg-protoporphyrin IX monomethyl ester oxidative cyclase (anaerobic); Sly3001590. (499 aa) |
| | AT103 | Mg protoporphyrin IX monomethyl ester oxidative cyclase (aerobic); Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME); Belongs to the AcsF family. (358 aa) |
| | hemN | Coproporphyrinogen III oxidase, oxygen-independent; Sly1030200; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (466 aa) |
| | trpE | Para-aminobenzoate synthase, aminase component; Sly1030180. (456 aa) |
| | rfbB-2 | dTDP-glucose 4,6-dehydratase; Sly1030070. (310 aa) |
| | AIE73380.1 | MoaD and/or ThiS families; Sly1029950. (91 aa) |
| | AIE73418.1 | Hypothetical protein; Sly1029550. (357 aa) |
| | cobA | Uroporphyrinogen-III methyltransferase; Sly1029500; Belongs to the precorrin methyltransferase family. (258 aa) |
| | chlI | Protoporphyrin IX Mg-chelatase subunit I; Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. (357 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (217 aa) |
| | thiC | Thiamin biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (459 aa) |
| | kdtB | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) |
| | AIE73573.1 | Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family; Sly1027890. (323 aa) |
| | dnaE-2 | DNA polymerase III alpha subunit / Carboxy-terminal intein-mediated trans-splice; Sly2000970. (905 aa) |
| | chlN | Light-independent protochlorophyllide reductase subunit N; Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (ChlN-ChlB) is the catalytic component of the complex. (469 aa) |
| | chlL | Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein ChlL; Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP. (306 aa) |
| | guaA | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. (527 aa) |
| | pta | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (697 aa) |
| | panC | Pantoate--beta-alanine ligase / Cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the N-terminal section; belongs to the pantothenate synthetase family. (510 aa) |
| | AIE73649.1 | Hypothetical protein; Sly2000400. (188 aa) |
| | AIE73657.1 | Putative extracellular protein containing predicted 35aa signal peptide; Sly2000320. (175 aa) |
| | AIE73660.1 | Putative extracellular protein containing predicted 35aa signal peptide; Sly2000290. (181 aa) |
| | AIE73683.1 | Pterin-binding family; Sly2000070. (127 aa) |
| | nadB | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (554 aa) |
| | sigA, | Group 2 RNA polymerase sigma factor / RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (456 aa) |
| | pyrC | Dihydroorotase; Sly3001680. (435 aa) |
| | ycf59 | Mg protoporphyrin IX monomethyl ester oxidative cyclase (aerobic); Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME); Belongs to the AcsF family. (358 aa) |
| | fcl | Nucleoside-diphosphate-sugar epimerase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (312 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Sly1025160. (193 aa) |
| | ribA | 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (551 aa) |
| | chlP | Geranylgeranyl hydrogenase BchP; Sly1025340. (407 aa) |
| | sigG | RNA polymerase sigma-70 factor; Sly1025430; Belongs to the sigma-70 factor family. ECF subfamily. (223 aa) |
| | AIE73773.1 | Thymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (216 aa) |
| | AIE73778.1 | YrbA protein; Sly1025590; Belongs to the BolA/IbaG family. (85 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (299 aa) |
| | AIE73810.1 | Hypothetical protein; Sly1025910. (590 aa) |
| | ycf61 | DNA-directed RNA polymerase omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (76 aa) |
| | AIE73857.1 | Hypothetical protein; Sly1027700. (986 aa) |
| | pyrC-2 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (342 aa) |
| | AIE73930.1 | Radical SAM protein required for addition of adenosine to hopane skeleton, HpnH; Sly1027000. (338 aa) |
| | AIE73944.1 | Fe-S oxidoreductases of moaA/nifB/pqqE family; Sly1026850. (336 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (984 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (342 aa) |
| | ndkR | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (149 aa) |
| | proA-2 | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (420 aa) |
| | cya1 | Adenylate cyclase; Sly1026570. (308 aa) |
| | ribD | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (361 aa) |
| | AIE74003.1 | Nicotinamide phosphoribosyltransferase; Sly1022250; Belongs to the NAPRTase family. (460 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (552 aa) |
| | chlB | Light-independent protochlorophyllide reductase subunit B; Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (ChlN-ChlB) is the catalytic component of the complex. (508 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (376 aa) |
| | cbiE, | Precorrin-6Y C5,15-methyltransferase (decarboxylating); Sly1023310. (422 aa) |
| | dacA | Diadenylate cyclase; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (303 aa) |
| | AIE74129.1 | Hypothetical protein; Sly1023500. (745 aa) |
| | yefA | GDP-mannose 4,6 dehydratase; Sly1023580. (317 aa) |
| | AIE74169.1 | Acetyl-coenzyme A synthetase; Sly1023910. (81 aa) |
| | acs | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (653 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (198 aa) |
| | AIE74218.1 | Homogentisate prenyltransferase; Sly1024400. (308 aa) |
| | AIE74227.1 | Putative dihydropyrimidine dehydrogenase [NADP+], similar to dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (343 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (354 aa) |
| | ctaB | Heme O synthase, protoheme IX farnesyltransferase COX10-CtaB; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (316 aa) |
| | AIE74264.1 | Heme A synthase, cytochrome oxidase biogenesis protein Cox15-CtaA; Sly1019290. (313 aa) |
| | thiG | Glycine oxidase ThiO / Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (657 aa) |
| | hemN-2 | Putative radical SAM family enzyme in heat shock gene cluster, similarity with CPO of BS HemN-type; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (405 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (200 aa) |
| | folP | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (289 aa) |
| | sigD | Cyanobacteria-specific RpoD-like sigma factor, type-2 / Group 2 RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (318 aa) |
| | nusG | Transcription antitermination protein NusG; Participates in transcription elongation, termination and antitermination. (206 aa) |
| | AIE74352.1 | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Sly1018470; Belongs to the UPF0284 family. (368 aa) |
| | AIE74376.1 | GDP-L-fucose synthase; Sly1018240. (310 aa) |
| | nadE | NAD synthetase / Glutamine amidotransferase chain of NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (558 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (430 aa) |
| | cobL | Cobalt-precorrin-6y C15-methyltransferase [decarboxylating]; Sly1017650. (223 aa) |
| | cobS | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (260 aa) |
| | cobO | Cob(I)alamin adenosyltransferase; Sly1017480. (203 aa) |
| | dcoH | Pterin-4-alpha-carbinolamine dehydratase; Sly1017390. (52 aa) |
| | dnaN | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (391 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (264 aa) |
| | cobJ | Cobalamin biosynthesis protein CbiG / Cobalt-precorrin-3b C17-methyltransferase; Sly1017270. (615 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (334 aa) |
| | hemF | Coproporphyrinogen III oxidase, aerobic; Involved in the heme and chlorophyll biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. (340 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (166 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (385 aa) |
| | AIE74526.1 | Putative BioA alternative protein; Sly1016770. (331 aa) |
| | AIE74528.1 | Hypothetical protein; Sly1016760. (234 aa) |
| | rfbD-2 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (289 aa) |
| | moeA | Molybdopterin biosynthesis protein MoeA; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (390 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (314 aa) |
| | moaC | Probable molybdenum cofactor guanylyltransferase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (347 aa) |
| | AIE74573.1 | Molybdenum cofactor biosynthesis protein MoaD; Sly1016290. (81 aa) |
| | moaE | Molybdenum cofactor biosynthesis protein MoaE; Sly1016280. (145 aa) |
| | nadC | Quinolinate phosphoribosyltransferase [decarboxylating]; Sly1016270; Belongs to the NadC/ModD family. (301 aa) |
| | cobH | Cobalt-precorrin-8x methylmutase; Sly1016240. (218 aa) |
| | AIE74584.1 | Aldo-keto reductase family 1 member B10; Sly1016180. (318 aa) |
| | cbiJ | Cobalt-precorrin-6x reductase; Sly1016020. (260 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (176 aa) |
| | AIE74629.1 | Protoporphyrinogen IX oxidase, novel form, HemJ; Sly1015760. (193 aa) |
| | AIE74658.1 | GDP-mannose 4,6-dehydratase; Sly1015470. (80 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Sly1014210; Belongs to the SAICAR synthetase family. (243 aa) |
| | pcyA | Phycocyanobilin:ferredoxin oxidoreductase PcyA; Catalyzes the four-electron reduction of biliverdin IX-alpha (2-electron reduction at both the A and D rings); the reaction proceeds via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin. Belongs to the HY2 family. (248 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (391 aa) |
| | priA | Helicase PriA essential for oriC/DnaA-independent DNA replication; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (831 aa) |
| | sigC | Group 2 RNA polymerase sigma factor / Cyanobacteria-specific RpoD-like sigma factor, type-7; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (404 aa) |
| | AIE74834.1 | Phosphate-binding protein; Sly1013680. (419 aa) |
| | AIE74840.1 | Putative amidotransferase similar to cobyric acid synthase; Sly1013620. (256 aa) |
| | sigH | RNA polymerase sigma factor RpoE; Sly1013380; Belongs to the sigma-70 factor family. ECF subfamily. (193 aa) |
| | upp | Uracil phosphoribosyltransferase; Sly1013220; Belongs to the UPRTase family. (216 aa) |
| | AIE74881.1 | Metallo-beta-lactamase superfamily protein; Sly1013190. (292 aa) |
| | AIE74884.1 | DNA primase; Sly1013160. (1009 aa) |
| | proB | Glutamate 5-kinase / RNA-binding C-terminal domain PUA; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (373 aa) |
| | dxs | 1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (638 aa) |
| | chlD | Protoporphyrin IX Mg-chelatase subunit D; Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. (676 aa) |
| | accC | Biotin carboxylase of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (231 aa) |
| | dnaX-2 | DNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (706 aa) |
| | lipA-2 | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (295 aa) |
| | cobA/hemD | Uroporphyrinogen-III methyltransferase / Uroporphyrinogen-III synthase; Sly1011940; Belongs to the precorrin methyltransferase family. (508 aa) |
| | holA | DNA polymerase III delta subunit; Sly1011860. (333 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (443 aa) |
| | rpoA | DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (306 aa) |
| | adk-2 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (193 aa) |
| | AIE75080.1 | Hypothetical protein; Sly1011170. (421 aa) |
| | accD, | Acetyl-coenzyme A carboxyl transferase beta chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (326 aa) |
| | nusA | Transcription termination protein NusA; Participates in both transcription termination and antitermination. (461 aa) |
| | AIE75129.1 | Queuosine biosynthesis QueD, PTPS-I; Sly1010190. (129 aa) |
| | rpoC2 | DNA-directed RNA polymerase delta (beta) subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily. (1318 aa) |
| | rpoB | DNA-directed RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1102 aa) |
| | AIE75143.1 | Porphobilinogen synthase; Sly1010050; Belongs to the ALAD family. (312 aa) |
| | atpB | ATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (483 aa) |
| | atpE | ATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (136 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Sly1009650; Belongs to the GARS family. (420 aa) |
| | chlM | Mg-protoporphyrin O-methyltransferase; Sly1009580. (230 aa) |
| | rfbC | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (189 aa) |
| | sigI | RNA polymerase sigma-70 factor; Sly1009450; Belongs to the sigma-70 factor family. ECF subfamily. (185 aa) |
| | queG | Iron-sulfur cluster-binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (310 aa) |
| | cbiD | Cobalt-precorrin-6 synthase, anaerobic; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (379 aa) |
| | hemB | Porphobilinogen synthase; Sly1009110; Belongs to the ALAD family. (327 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Sly1009050; Belongs to the CarA family. (388 aa) |
| | AIE75266.1 | Ribonucleotide reductase of class Ia (aerobic), beta subunit; Sly1008860. (265 aa) |
| | AIE75267.1 | Ribonucleotide reductase of class Ia (aerobic), beta subunit; Sly1008840. (64 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (388 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (209 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Sly1008550; Belongs to the TrpC family. (295 aa) |
| | glmU | N-acetylglucosamine-1-phosphate uridyltransferase / Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (456 aa) |
| | purH | IMP cyclohydrolase / Phosphoribosylaminoimidazolecarboxamide formyltransferase; Sly1008370. (511 aa) |
| | AIE75318.1 | Creatinine amidohydrolase; Sly1008360. (272 aa) |
| | thiE | Thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (343 aa) |
| | cobI | Cobalt-precorrin-2 C20-methyltransferase; Sly1007800; Belongs to the precorrin methyltransferase family. (235 aa) |
| | ribF | Riboflavin kinase / FMN adenylyltransferase; Sly1007780; Belongs to the ribF family. (314 aa) |
| | AIE75388.1 | Hypothetical protein; Sly1007640. (127 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (379 aa) |
| | AIE75430.1 | Deoxycytidine triphosphate deaminase; Sly1007220. (193 aa) |
| | atpC | ATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (314 aa) |
| | atpA | ATP synthase alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (503 aa) |
| | atpD | ATP synthase delta chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (185 aa) |
| | atpF | ATP synthase B chain; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (179 aa) |
| | atpG | ATP synthase B' chain; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria. Belongs to the ATPase B chain family. (143 aa) |
| | atpH | ATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (126 aa) |
| | atpI | ATP synthase A chain; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (248 aa) |
| | hemE | Uroporphyrinogen III decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (350 aa) |
| | ppnK-2 | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (307 aa) |
| | sigB | Cyanobacteria-specific RpoD-like sigma factor, type-3 / Group 2 RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (328 aa) |
| | odhB | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Sly1006420. (437 aa) |
| | AIE75522.1 | Hypothetical protein; Sly1006350. (58 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (214 aa) |
| | folC | Dihydrofolate synthase / Folylpolyglutamate synthase; Sly1006130; Belongs to the folylpolyglutamate synthase family. (428 aa) |
| | AIE75558.1 | PUCC protein:PUCC protein; Sly1005980. (484 aa) |
| | AIE75576.1 | Sirohydrochlorin cobaltochelatase; Sly1005800. (276 aa) |
| | accA | Acetyl-coenzyme A carboxyl transferase alpha chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (381 aa) |
| | pdhB | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (324 aa) |
| | chlH | Protoporphyrin IX Mg-chelatase subunit H; Sly1004620. (1332 aa) |
| | AIE75701.1 | Hypothetical protein; Sly1004550. (302 aa) |
| | comB | 2-phosphosulfolactate phosphatase; Sly1021290; Belongs to the ComB family. (241 aa) |
| | guaB-2 | Inosine-5'-monophosphate dehydrogenase, catalytic domain; Sly1021250. (387 aa) |
| | ycf40 | Sulfur carrier protein ThiS; Sly1020960. (71 aa) |
| | AIE75821.1 | Anthranilate phosphoribosyltransferase; Sly1020780. (372 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (495 aa) |
| | rpoC1 | DNA-directed RNA polymerase gamma subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (626 aa) |
| | cobM | Cobalt-precorrin-4 C11-methyltransferase; Sly1020080. (264 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Sly1019950; Belongs to the TrpF family. (216 aa) |
| | sigE, | Cyanobacteria-specific RpoD-like sigma factor, type-1; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (372 aa) |
| | coaX | Pantothenate kinase type III, CoaX-like; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (255 aa) |
| | bchB | Protochlorophyllide reductase BchB subunit; Sly3000120. (55 aa) |
| | nusB | Transcription termination protein NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (221 aa) |
| | cpmA | Circadian phase modifier; Sly1010780. (279 aa) |
| | hemH, | Ferrochelatase, protoheme ferro-lyase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (387 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; Sly1010840. (341 aa) |
| | pnp-2 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (294 aa) |
| | cobN | CobN component of cobalt chelatase involved in B12 biosynthesis; Sly1004350. (1091 aa) |
| | hemA | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (427 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (438 aa) |
| | nrdA | Ribonucleotide reductase of class Ia (aerobic), alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (767 aa) |
| | AIE72633.1 | Cobalt-precorrin-8x methylmutase; Sly1003420. (216 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (643 aa) |
| | AIE72664.1 | Dihydrofolate reductase; Sly1003100. (71 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (318 aa) |
| | queE | Queuosine Biosynthesis QueE Radical SAM; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (206 aa) |
| | cobP | Adenosylcobinamide-phosphate guanylyltransferase; Sly1002680. (185 aa) |
| | pyrB | Aspartate carbamoyltransferase; Sly1002510; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (347 aa) |
| | dfp | Phosphopantothenoylcysteine decarboxylase / Phosphopantothenoylcysteine synthetase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (405 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (433 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (493 aa) |
| | queF | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (137 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (358 aa) |
