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| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (290 aa) |
| | hisS-2 | Histidyl tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity). (401 aa) |
| | leuC | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (468 aa) |
| | accA | acetyl-CoA carboxylase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (326 aa) |
| | slr1652 | Phytol kinase; Catalyzes the CTP-dependent phosphorylation of phytol to phytylmonophosphate (PMP). Can also use UTP as an alternative phosphate donor, but not ATP or GTP. Is involved in tocopherol biosynthesis, via the utilization of phytol generated by chlorophyll degradation. Also plays a significant but not critical role in the recycling of phytol for the biosynthesis of new chlorophyll molecules. (233 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (279 aa) |
| | ilvD | Dihydroxyacid dehydratase; ORF_ID:slr0452; Belongs to the IlvD/Edd family. (561 aa) |
| | argG | Argininosuccinate synthetase; ORF_ID:slr0585. (400 aa) |
| | slr0596 | Creatinine amidohydrolase; ORF_ID:slr0596. (273 aa) |
| | hisI | phosphoribosyl-ATP pyrophosphohydrolase:phosphoribosyl-AMP cyclohydrolase; ORF_ID:slr0608; In the C-terminal section; belongs to the PRA-PH family. (230 aa) |
| | napC | Carboxynorspermidine decarboxylase; ORF_ID:sll0873. (387 aa) |
| | cbiT | Precorrin decarbocylase; ORF_ID:slr1368; gene:cbiT or cobL. (227 aa) |
| | bioB | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (362 aa) |
| | ribH | Riboflavin synthase beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (164 aa) |
| | sll1348 | Epoxyqueuosine reductase; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (289 aa) |
| | menB | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). (275 aa) |
| | purC | Phosphoribosyl aminoidazole succinocarboxamide synthetase; ORF_ID:slr1226; Belongs to the SAICAR synthetase family. (264 aa) |
| | sll1634 | ORF_ID:sll1634; unknown protein. (349 aa) |
| | panC/kcy | Pantothenate synthetase/cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. (513 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (348 aa) |
| | cbiL | S-adenosyl-methionine: precorrin-2 methyltransferase; ORF_ID:slr1879; gene:cbiL or cobI; Belongs to the precorrin methyltransferase family. (242 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (306 aa) |
| | slr1880 | ORF_ID:slr1880; unknown protein. (377 aa) |
| | slr1882 | Bifunctional riboflavin kinase/FMN adenylyltransferase; Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD. (284 aa) |
| | sll2011 | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (208 aa) |
| | slr2141 | Methylenetetrahydrofolate reductase; ORF_ID:slr2141; unknown protein; Belongs to the methylenetetrahydrofolate reductase family. (340 aa) |
| | thrC | Threonine synthase; ORF_ID:sll1688. (433 aa) |
| | slr1736 | Homogentisate phytyltransferase; Involved in the synthesis of tocopherol (vitamin E). Catalyzes the condensation of homogentisate and phytyl diphosphate to form dimethylphytylhydrquinone. (308 aa) |
| | slr1742 | ORF_ID:slr1742; unknown protein. (256 aa) |
| | ndh | NADH dehydrogenase; Bifunctional oxidoreductase probably ables to act both on prenyl naphthoquinones and on prenyl benzoquinones. Catalyzes the penultimate step in the biosynthesis of vitamin K1. (404 aa) |
| | dcoH | Pterin-4a-carbinolamine dehydratase; ORF_ID:ssl2296. (96 aa) |
| | suhB | Extragenic suppressor; ORF_ID:sll1959; gene:suhB or ssyA. (267 aa) |
| | hisC-2 | Histidinol phosphate aminotransferase; ORF_ID:sll1958; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (367 aa) |
| | serA | Phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (554 aa) |
| | fabG-2 | 3-ketoacyl-acyl carrier protein reductase; Catalyzes the reduction of acetoacetyl-CoA to (R)-3- hydroxybutyryl-CoA. When expressed in E.coli with Synechocystis PhaA, PhaC and PhaE confers the ability to synthesize up to 12% (w/w) poly(3-hydroxybutyrate) (PHB) depending on the carbon source ; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (240 aa) |
| | folC | Folyl-polyglutamate synthetase; ORF_ID:sll1612; gene:folC or dedC; Belongs to the folylpolyglutamate synthase family. (428 aa) |
| | fabZ | (3R)-hydroxymyristol acyl carrier protein dehydrase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (166 aa) |
| | cobA | cob(I)alamin adenosyltransferase; ORF_ID:slr0260; gene:cobA or cobO. (203 aa) |
| | tyrA | Prephenate dehydrogenase; ORF_ID:slr2081. (279 aa) |
| | ilvG | Acetohydroxy acid synthase; ORF_ID:slr2088. (621 aa) |
| | ilvB | Acetolactate synthase; ORF_ID:sll1981; Belongs to the TPP enzyme family. (550 aa) |
| | glpX | GlpX protein; Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6- phosphate and sedoheptulose 7-phosphate, respectively; Belongs to the FBPase class 2 family. (345 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa) |
| | plsX | PlsX protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (348 aa) |
| | fabH | Beta-ketoacyl-acyl carrier protein synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (287 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity); Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (362 aa) |
| | menA | 1,4-dihydroxy-2-naphtoic acid prenyltransferase; Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4- naphthoquinone. (307 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (361 aa) |
| | fabF-2 | Beta ketoacyl-acyl carrier protein synthase; ORF_ID:slr1332; gene:fabF or fabJ; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (404 aa) |
| | cbiD | CbiD protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (364 aa) |
| | hisC | Histidinol-phosphate aminotransferase; ORF_ID:sll1713. (352 aa) |
| | cysK | Cysteine synthase; ORF_ID:slr1842. (331 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (362 aa) |
| | ilvA | L-threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (508 aa) |
| | aroQ | Carbonic 3-dehydroquinase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (152 aa) |
| | cobN | CobN protein; ORF_ID:slr1211. (1092 aa) |
| | sll1119 | ORF_ID:sll1119; unknown protein; Belongs to the pseudomonas-type ThrB family. (361 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (297 aa) |
| | acp | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (77 aa) |
| | fabF | Beta ketoacyl-acyl carrier protein synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (416 aa) |
| | argH | L-argininosuccinate lyase; ORF_ID:slr1133. (461 aa) |
| | folP | Dihydropteroate pyrophosphorylase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. Belongs to the DHPS family. (289 aa) |
| | fabD | Malonyl coenzyme A-acyl carrier protein transacylase; ORF_ID:slr2023; gene:fabD or tfpA; Belongs to the FabD family. (293 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (430 aa) |
| | argD | N-acetylornithine aminotransferase; ORF_ID:slr1022; gene:argD or dtu; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (429 aa) |
| | gylA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (427 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (375 aa) |
| | sll1945 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (640 aa) |
| | hisD-2 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | glnA | Glutamate--ammonia ligase; Involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. (473 aa) |
| | envM | Enoyl-[acyl-carrier-protein] reductase; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. (278 aa) |
| | cbiA | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (482 aa) |
| | gltB | Glutamate synthase (ferredoxin); ORF_ID:sll1502. (1550 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (289 aa) |
| | thiE | Thiamin biosynthetic bifunctional enzyme; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (343 aa) |
| | hisD | Histidinol dehydrogenase; ORF_ID:slr0682; Belongs to the histidinol dehydrogenase family. (409 aa) |
| | ccmA | Carboxysome formation protein; ORF_ID:sll0934. (351 aa) |
| | cbiH | Precorrin methylase; ORF_ID:slr0969; gene:cbiH or cobJ. (627 aa) |
| | sll0936 | ORF_ID:sll0936; hypothetical protein; Belongs to the UbiD family. (501 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (264 aa) |
| | slr1303 | ORF_ID:slr1303; unknown protein. (410 aa) |
| | ubiH | UbiH protein; ORF_ID:slr1300; gene:ubiH or visB. (414 aa) |
| | slr1299 | UDP-glucose dehydrogenase; ORF_ID:slr1299. (453 aa) |
| | gerCb | Spore germination protein c2; Methyltransferase required for the conversion of 2-phytyl- 1,4-beta-naphthoquinol to phylloquinol. (238 aa) |
| | pheA | Chorismate mutase /prephenate dehydratase; ORF_ID:sll1662. (297 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (189 aa) |
| | slr1787 | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (364 aa) |
| | pdxJ | Pyridoxal phosphate biosynthetic protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (221 aa) |
| | gltD | NADH-glutamate synthase small subunit; ORF_ID:sll1027. (494 aa) |
| | folK | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; ORF_ID:slr1093; Belongs to the HPPK family. (195 aa) |
| | slr0252 | Cobalt-precorrin-6A reductase; Catalyzes the reduction of the macrocycle of cobalt- precorrin-6A to cobalt-precorrin-6B. (261 aa) |
| | cbiF | Precorrin methylase; ORF_ID:slr0239; gene:cbiF or cobM. (264 aa) |
| | trpE | Anthranilate synthetase alpha-subunit; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high conc [...] (508 aa) |
| | cysM | Cysteine synthase; ORF_ID:sll0712. (325 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (275 aa) |
| | slr1467 | Precorrin isomerase; ORF_ID:slr1467. (222 aa) |
| | thrC-2 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (382 aa) |
| | leuD | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (230 aa) |
| | otsA | Alpha,alpha-trehalose-phosphate synthase; Involved in salt tolerance by producing GG-phosphate from ADP-glucose and glycerol-3-phosphate (G3P), an intermediate in the synthesis of the osmolyte glucosylglycerol (GG). Belongs to the glycosyltransferase 20 family. (499 aa) |
| | leuA | Alpha-isopropylmalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate. (547 aa) |
| | sll1559 | Soluble hydrogenase 42 kD subunit; ORF_ID:sll1559. (384 aa) |
| | cbiC | Precorrin isomerase; Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate. Belongs to the CobH/CbiC family. (217 aa) |
| | cysE | Serine acetyltransferase; ORF_ID:slr1348. (249 aa) |
| | pgi | Glucose-6-phosphate isomerase; ORF_ID:slr1349. (531 aa) |
| | desA | Fatty acid desaturase; Can introduce a second cis double bond at the Delta(12) position of fatty acid bound to membranes glycerolipids. This enzyme is involved in chilling tolerance because the phase transition temperature of lipids of cellular membranes depends on the degree of unsaturation of fatty acids of the membrane lipids. (351 aa) |
| | ribA | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. (556 aa) |
| | hisF | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). (261 aa) |
| | argJ | Ornithine acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (419 aa) |
| | trpE-2 | Anthranilate synthase component I; ORF_ID:slr1979. (485 aa) |
| | fabG | 3-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis (Probable). Is capable of reducing acetoacetyl-CoA, but less well than its paralog PhaB ; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | lipA-2 | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (303 aa) |
| | fbp-2 | Fructose 1,6-bisphosphatase; ORF_ID:slr0952; gene:fbp or fdp. (347 aa) |
| | slr1626 | Probable dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (150 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (447 aa) |
| | sll0418 | sterol-C-methyltransferase; Involved in a key methylation step in both tocopherol (vitamin E) and plastoquinone synthesis. Catalyzes the conversion of 2- methyl-6-phytyl-1,4-hydroquinol (MPBQ) to 2,3-dimethyl-6-phytyl-1,4- hydroquinol (DMPQ, a substrate for tocopherol cyclase), and 2-methyl-6- solanyl-1,4-benzoquinol (MSBQ) to plastoquinol. (318 aa) |
| | pgk | Phosphoglycerate kinase; ORF_ID:slr0394; Belongs to the phosphoglycerate kinase family. (374 aa) |
| | trpF | 5'-phosphoribosyl anthranilate isomerase; ORF_ID:sll0356; Belongs to the TrpF family. (218 aa) |
| | sll0135 | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (326 aa) |
| | cbiB | CbiB protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (342 aa) |
| | slr1938 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (351 aa) |
| | ribC | Riboflavin synthase alpha chain; ORF_ID:sll0300. (226 aa) |
| | leuA-2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (533 aa) |
| | accD | acetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (326 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa) |
| | tpi | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (242 aa) |
| | slr0355 | ORF_ID:slr0355; unknown protein. (331 aa) |
| | cobU | Cobinamide kinase/cobinamide phosphate guanylyltransferase; ORF_ID:slr0216; gene:cobU or cobP. (185 aa) |
| | sll0409 | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (320 aa) |
| | accB | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (154 aa) |
| | ilvN | Acetolactate synthase; ORF_ID:sll0065; Belongs to the acetolactate synthase small subunit family. (188 aa) |
| | trpG | Anthranilate synthase component II; ORF_ID:slr0055. (163 aa) |
| | ribG | Riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. (368 aa) |
| | accC | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (420 aa) |
| | thrA | Homoserine dehydrogenase; ORF_ID:sll0455; gene:thrA or hom; Belongs to the homoserine dehydrogenase family. (433 aa) |
| | slr0495 | Lipopeptide antibiotics iturin a biosynthesis protein; Probably transfers the 4'-phosphopantetheine moiety from coenzyme A (CoA) to a serine residue of a carrier protein domain. Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family. (246 aa) |
| | thiG | ThiG protein; Catalyzes the FAD-dependent oxidative deamination of glycine. Is essential for thiamine biosynthesis since the oxidation of glycine catalyzed by ThiO generates the glycine imine intermediate (dehydroglycine) required for the biosynthesis of the thiazole ring of thiamine pyrophosphate; In the N-terminal section; belongs to the DAO family. ThiO subfamily. (656 aa) |
| | slr0636 | Adenosylcobinamide-GDP ribazoletransferase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (260 aa) |
| | menD | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). (595 aa) |
| | cysG | uroporphyrin-III C-methyltransferase; Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin. (263 aa) |
| | proA-2 | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (433 aa) |
| | carB | Carbamoyl-phosphate synthase, pyrimidine-specific, large chain; ORF_ID:sll0370; gene:carB or pyrA. (1105 aa) |
| | folE | GTP cyclohydrolase I; ORF_ID:slr0426; gene:folE or gchL. (234 aa) |
| | slr0199 | Putative glutamine amidotransferase slr0199; ORF_ID:slr0199; hypothetical protein. (304 aa) |
| | slr0204 | 1,4-dihydroxy-2-naphthoyl-CoA hydrolase; Catalyzes the specific hydrolysis of 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis. Is not active on benzoyl-CoA, phenylacetyl-CoA and aliphatic acyl-CoA thioesters. (138 aa) |
| | metH | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). (1195 aa) |
| | ssr1513 | ORF_ID:ssr1513; hypothetical protein. (65 aa) |
| | bioF | 7-keto-8-aminopelargonic acid synthetase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (437 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (145 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (400 aa) |
| | slr0078 | 6-carboxy-5,6,7,8-tetrahydropterin synthase; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. (129 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (351 aa) |
| | hisH | N-acetyl-glutamate-gamma-semialdehyde dehydrogenase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). (210 aa) |
| | hisB-2 | Imidazoleglycerol-phosphate dehydratase; ORF_ID:slr0500. (210 aa) |
| | cobW | CobW protein; ORF_ID:slr0502. (352 aa) |
| | sll0480 | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (412 aa) |
| | slr0523 | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (237 aa) |
| | slr1980 | ORF_ID:slr1980; unknown protein. (297 aa) |
| | queA | Queuosine biosynthesis protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (366 aa) |
| | sll0596 | ORF_ID:sll0596; unknown protein. (244 aa) |
| | cbiP | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); Belongs to the CobB/CobQ family. CobQ subfamily. (527 aa) |
| | aroH | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (127 aa) |
| | cbiE | Precorrin-6y methylase; ORF_ID:sll0099; gene:cbiE or cobL. (425 aa) |
| | thiC | ThiC protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (459 aa) |
| | ppsA | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (818 aa) |
| | merR | Mercuric resistance operon regulatory protein; ORF_ID:sll0794; gene:merR or cobH. (370 aa) |
| | gdhA | Glutamate dehydrogenase (NADP+); Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. (428 aa) |
| | slr0711 | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (137 aa) |
| | pdxA | Pyridoxal phosphate biosynthetic protein; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (349 aa) |
| | tgt | Transfer RNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to f [...] (374 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (305 aa) |
| | sll0037 | Sirohydrochlorin cobaltochelatase; Chelates cobalt to the cobalamin precursor as part of the anaerobic pathway to cobalamin biosynthesis. (336 aa) |
| | sll0036 | ORF_ID:sll0036; hypothetical protein; In the N-terminal section; belongs to the methylglyoxal synthase family. (433 aa) |
| | panB | Alpha-ketopantoate hydroxymethyl transferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (260 aa) |
| | exsB | ExsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (271 aa) |
| | sll0506 | Isoprenyl transferase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (249 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (469 aa) |
| | trpB | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (412 aa) |
| | argF | Ornithine carbamoyltransferase chain f; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (308 aa) |
| | ubiA | 4-hydroxybenzoate-octaprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of plastoquinone-9 (PQ-9) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 4-hydroxy-3-solanesylbenzoate. (292 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (210 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; ORF_ID:slr0546; Belongs to the TrpC family. (295 aa) |
| | asd | Aspartate beta-semialdehyde dehydrogenese; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (280 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (301 aa) |
| | sll1329 | Monophosphatase; ORF_ID:sll1329. (287 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (367 aa) |
| | hisA | Phosphorybosilformimino-5-amino-phosphorybosil- 4-imidazolecarboxamideisomerase; ORF_ID:slr0652. (256 aa) |
| | lysC | Aspartate kinase; ORF_ID:slr0657. (600 aa) |
| | proC | Pyrroline carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (267 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (318 aa) |
| | gltB-2 | Ferredoxin-dependent glutamate synthase; ORF_ID:sll1499; Belongs to the glutamate synthase family. (1556 aa) |
| | carA | Carbamoyl-phosphate synthetase subunit A; ORF_ID:sll1498; gene:carA or pyrA; Belongs to the CarA family. (424 aa) |
