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dnaK_2 dnaK_2 grpE grpE dnaJ1 dnaJ1 hspR hspR APU27702.1 APU27702.1 groL2_2 groL2_2 APU26268.1 APU26268.1 htpG htpG dnaJ dnaJ APU27262.1 APU27262.1 groES groES
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaK_2Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (625 aa)
grpENucleotide exchange factor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] (235 aa)
dnaJ1Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
hspRMerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (126 aa)
APU27702.1ATP-dependent chaperone ClpB; Derived by automated computational analysis using gene prediction method: Protein Homology. (848 aa)
groL2_2Chaperonin GroL; Derived by automated computational analysis using gene prediction method: Protein Homology. (540 aa)
APU26268.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (581 aa)
htpGMolecular chaperone HtpG; Molecular chaperone. Has ATPase activity. (647 aa)
dnaJMolecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (382 aa)
APU27262.1Chaperonin GroL; Derived by automated computational analysis using gene prediction method: Protein Homology. (539 aa)
groESCo-chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (100 aa)
Your Current Organism:
Mycobacterium tuberculosis variant caprae
NCBI taxonomy Id: 115862
Other names: ATCC BAA-824, CIP 105776, M. tuberculosis variant caprae, Mycobacterium bovis subsp. caprae, Mycobacterium caprae, Mycobacterium tuberculosis subsp. caprae, strain gM-1, strain spc-1
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