STRINGSTRING
ureA ureA cyaB_2 cyaB_2 mesJ mesJ hpt hpt truA truA guaB2 guaB2 APU27255.1 APU27255.1 APU27243.1 APU27243.1 iunH iunH yihX yihX add add APU27169.1 APU27169.1 purK_1 purK_1 purE purE APU27062.1 APU27062.1 APU28030.1 APU28030.1 pgm pgm nrdI nrdI nrdE nrdE nrdF-2 nrdF-2 fixA fixA APU26917.1 APU26917.1 APU26892.1 APU26892.1 APU26878.1 APU26878.1 APU26721.1 APU26721.1 nrdR nrdR APU26585.1 APU26585.1 APU26573.1 APU26573.1 apt apt relA relA APU26538.1 APU26538.1 APU26532.1 APU26532.1 APU26527.1 APU26527.1 APU26459.1 APU26459.1 APU26427.1 APU26427.1 ndkA ndkA APU26399.1 APU26399.1 rpfD rpfD corC corC dgt dgt APU26237.1 APU26237.1 APU26223.1 APU26223.1 APU26213.1 APU26213.1 nrdF nrdF lipJ lipJ rpfC rpfC ureC ureC ureB ureB purT purT APU24701.1 APU24701.1 APU24769.1 APU24769.1 adk adk hit_2 hit_2 APU27665.1 APU27665.1 APU24307.1 APU24307.1 APU24379.1 APU24379.1 yhhT yhhT nrdB nrdB purA purA mgtE mgtE cutS cutS purD purD APU24963.1 APU24963.1 purB purB purC purC purS purS purQ purQ APU24987.1 APU24987.1 cpdA cpdA purF purF purM purM APU27753.1 APU27753.1 rpfA rpfA purN purN purH_2 purH_2 prsA prsA mazG mazG APU25182.1 APU25182.1 APU25183.1 APU25183.1 APU25214.1 APU25214.1 ydiK ydiK engD engD APU25265.1 APU25265.1 APU25266.1 APU25266.1 yvdD yvdD APU25362.1 APU25362.1 APU25385.1 APU25385.1 APU25387.1 APU25387.1 cysD cysD cysNC cysNC APU25440.1 APU25440.1 cyaB_3 cyaB_3 cyaB_1 cyaB_1 rph rph rdgB rdgB APU25483.1 APU25483.1 gmk gmk pyk pyk cya_1 cya_1 APU25713.1 APU25713.1 APU27865.1 APU27865.1 nudF nudF tlyC_2 tlyC_2 tlyC_1 tlyC_1 APU25896.1 APU25896.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ureAUrease subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the urease gamma subunit family. (100 aa)
cyaB_2Adenylyl cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (529 aa)
mesJtRNA lysidine(34) synthetase TilS; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
hptHypothetical protein; Incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (202 aa)
truAtRNA pseudouridine(38,39,40) synthase TruA; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
guaB2IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (529 aa)
APU27255.1Inosine 5-monophosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
APU27243.1Glutamine-hydrolyzing GMP synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (509 aa)
iunHNucleoside hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (308 aa)
yihXAmidase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
addAdenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
APU27169.1Purine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
purK_15-(carboxyamino)imidazole ribonucleotide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (174 aa)
APU27062.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
APU28030.1tRNA-specific adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (176 aa)
pgmPhosphoglucomutase, alpha-D-glucose phosphate-specific; Catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (547 aa)
nrdIRibonucleotide reductase assembly protein NrdI; Probably involved in ribonucleotide reductase function. (150 aa)
nrdERibonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (693 aa)
nrdF-2Class 1b ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (324 aa)
fixAElectron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
APU26917.1Amino acid-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (221 aa)
APU26892.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
APU26878.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa)
APU26721.1Metallophosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
nrdRTranscriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (154 aa)
APU26585.1Zinc metalloprotease; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
APU26573.1Diadenosine tetraphosphate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
aptAdenine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (171 aa)
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (790 aa)
APU26538.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (529 aa)
APU26532.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (129 aa)
APU26527.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
APU26459.1TIGR00725 family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (207 aa)
APU26427.1Resuscitation-promoting factor RpfE; Derived by automated computational analysis using gene prediction method: Protein Homology. (172 aa)
ndkANucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (136 aa)
APU26399.1Fatty acid-binding protein DegV; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
rpfDResuscitation-promoting factor RpfD; Derived by automated computational analysis using gene prediction method: Protein Homology. (154 aa)
corCHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
dgtDeoxyguanosinetriphosphate triphosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
APU26237.1CHAD domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
APU26223.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
APU26213.1Ribokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
nrdFRibonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (322 aa)
lipJCyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
rpfCResuscitation-promoting factor RpfC; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
ureCUrease subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (577 aa)
ureBUrease subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the urease beta subunit family. (104 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Derived by automated computational analysis using gene prediction method: Protein Homology. (419 aa)
APU24701.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa)
APU24769.1Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Derived by automated computational analysis using gene prediction method: Protein Homology. (692 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (181 aa)
hit_2HIT family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (133 aa)
APU27665.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0301 (AlgH) family. (201 aa)
APU24307.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (352 aa)
APU24379.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (126 aa)
yhhTAI-2E family transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
nrdBRibonucleotide-diphosphate reductase subunit beta; Catalyzes the rate-limiting step in dNTP synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
mgtEMagnesium transporter; Acts as a magnesium transporter. (460 aa)
cutSCarbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
APU24963.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
purBAdenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (472 aa)
purCPhosphoribosylaminoimidazolesuccinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (297 aa)
purSPhosphoribosylformylglycinamidine synthase subunit PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (79 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (224 aa)
APU24987.1Phosphoribosylformylglycinamidine synthase II; Derived by automated computational analysis using gene prediction method: Protein Homology. (766 aa)
cpdAPhosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (318 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (509 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (364 aa)
APU27753.1Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (151 aa)
rpfAResuscitation-promoting factor RpfA; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
purNPhosphoribosylglycinamide formyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
purH_2Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PurH family. (523 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
mazGNucleoside triphosphate hydrolase; Functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
APU25182.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
APU25183.1Exopolyphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
APU25214.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
ydiKHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
engDRedox-regulated ATPase YchF; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
APU25265.1Guanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (49 aa)
APU25266.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
yvdDRossman fold protein, TIGR00730 family; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LOG family. (187 aa)
APU25362.1Magnesium transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
APU25385.1HIT family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
APU25387.1Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa)
cysDSulfate adenylyltransferase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
cysNCAdenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (614 aa)
APU25440.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (541 aa)
cyaB_3Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (535 aa)
cyaB_1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (567 aa)
rphRibonuclease PH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the RNase PH family. (259 aa)
rdgBNon-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (201 aa)
APU25483.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
gmkGuanylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
pykPyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (472 aa)
cya_1Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (443 aa)
APU25713.1Guanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)
APU27865.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (115 aa)
nudFADP-ribose pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (207 aa)
tlyC_2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (349 aa)
tlyC_1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
APU25896.1Inosine 5-monophosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
Your Current Organism:
Mycobacterium tuberculosis variant caprae
NCBI taxonomy Id: 115862
Other names: ATCC BAA-824, CIP 105776, M. tuberculosis variant caprae, Mycobacterium bovis subsp. caprae, Mycobacterium caprae, Mycobacterium tuberculosis subsp. caprae, strain gM-1, strain spc-1
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