STRINGSTRING
SU9_01140 SU9_01140 murB-2 murB-2 SU9_01945 SU9_01945 SU9_02282 SU9_02282 SU9_02811 SU9_02811 SU9_04281 SU9_04281 SU9_04381 SU9_04381 dxr dxr gpsA gpsA leuB leuB SU9_06760 SU9_06760 ilvC ilvC SU9_06790 SU9_06790 SU9_06855 SU9_06855 SU9_07535 SU9_07535 SU9_07680 SU9_07680 SU9_07960 SU9_07960 SU9_09429 SU9_09429 SU9_09439 SU9_09439 mdh mdh SU9_11930 SU9_11930 SU9_13374 SU9_13374 SU9_13439 SU9_13439 SU9_13930 SU9_13930 SU9_14366 SU9_14366 SU9_14621 SU9_14621 SU9_15834 SU9_15834 murB murB SU9_16957 SU9_16957 guaB guaB SU9_17002 SU9_17002 SU9_17015 SU9_17015 SU9_17290 SU9_17290 SU9_18433 SU9_18433 SU9_18920 SU9_18920 SU9_19329 SU9_19329 SU9_19787 SU9_19787 SU9_19822 SU9_19822 iolG iolG SU9_20349 SU9_20349 SU9_20873 SU9_20873 SU9_21068 SU9_21068 SU9_21572 SU9_21572 SU9_22090 SU9_22090 SU9_22605 SU9_22605 SU9_23020 SU9_23020 hisD hisD zwf zwf SU9_24914 SU9_24914 SU9_24949 SU9_24949 SU9_25039 SU9_25039 SU9_25064 SU9_25064 tdh tdh SU9_25619 SU9_25619 SU9_25919 SU9_25919 SU9_26124 SU9_26124 SU9_26464 SU9_26464 SU9_26889 SU9_26889 SU9_27309 SU9_27309 SU9_28811 SU9_28811 SU9_28946 SU9_28946 SU9_29301 SU9_29301 SU9_29376 SU9_29376 SU9_29381 SU9_29381 SU9_29581 SU9_29581 SU9_29641 SU9_29641 aroE aroE SU9_30329 SU9_30329 fcl fcl SU9_32333 SU9_32333 SU9_33363 SU9_33363 SU9_33733 SU9_33733
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SU9_01140COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (337 aa)
murB-2Putative UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (318 aa)
SU9_01945COG1250 3-hydroxyacyl-CoA dehydrogenase. (300 aa)
SU9_02282NAD-binding protein 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase. (734 aa)
SU9_02811COG1250 3-hydroxyacyl-CoA dehydrogenase. (604 aa)
SU9_04281Hypothetical protein; COG1985 Pyrimidine reductase, riboflavin biosynthesis. (274 aa)
SU9_04381Fatty acid oxidation complex alpha-subunit; COG1024 Enoyl-CoA hydratase/carnithine racemase. (711 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (424 aa)
gpsACOG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (333 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (346 aa)
SU9_06760COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (530 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
SU9_06790Oxidoreductase; COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases). (333 aa)
SU9_06855Aldo-keto reductase yakc; COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases). (334 aa)
SU9_07535COG1250 3-hydroxyacyl-CoA dehydrogenase. (282 aa)
SU9_07680COG0460 Homoserine dehydrogenase. (429 aa)
SU9_07960Malate oxidoreductase; COG0281 Malic enzyme. (407 aa)
SU9_09429Alcohol dehydrogenase GroES domain-containing protein; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (315 aa)
SU9_09439Dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (362 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (330 aa)
SU9_11930COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases). (330 aa)
SU9_13374Zinc-binding alcohol dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (359 aa)
SU9_13439COG1064 Zn-dependent alcohol dehydrogenases. (351 aa)
SU9_13930Putative aldoketoreductase. (61 aa)
SU9_143666-phosphogluconate dehydrogenase-like protein; COG1023 Predicted 6-phosphogluconate dehydrogenase. (292 aa)
SU9_14621COG1250 3-hydroxyacyl-CoA dehydrogenase. (503 aa)
SU9_15834Oxidoreductase; COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases). (318 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (351 aa)
SU9_169572-hydroxyacid family dehydrogenase; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (352 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (500 aa)
SU9_17002Inosine 5-monophosphate dehydrogenase; COG0516 IMP dehydrogenase/GMP reductase. (371 aa)
SU9_17015Nucleotide sugar dehydrogenase; COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (415 aa)
SU9_17290NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa)
SU9_18433COG1004 Predicted UDP-glucose 6-dehydrogenase. (446 aa)
SU9_18920NAD-binding malic protein; COG0281 Malic enzyme. (477 aa)
SU9_19329Oxidoreductase; COG0673 Predicted dehydrogenases and related proteins. (378 aa)
SU9_19787Oxidoreductase; COG0673 Predicted dehydrogenases and related proteins. (383 aa)
SU9_19822Inositol 2-dehydrogenase; COG0673 Predicted dehydrogenases and related proteins. (343 aa)
iolGInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase; Involved in the oxidation of myo-inositol (MI) to 2-keto-myo- inositol (2KMI or 2-inosose). (339 aa)
SU9_20349Glycoside hydrolase; COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases. (439 aa)
SU9_20873Glycoside hydrolase; COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases. (446 aa)
SU9_21068Oxidoreductase; COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases). (334 aa)
SU9_21572COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases). (338 aa)
SU9_22090Hypothetical protein; COG2030 Acyl dehydratase. (291 aa)
SU9_22605Oxidoreductase; COG0673 Predicted dehydrogenases and related proteins. (302 aa)
SU9_23020COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (338 aa)
hisDBifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (440 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (510 aa)
SU9_24914Alcohol dehydrogenase GroES domain protein; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (394 aa)
SU9_24949Oxidoreductase; COG0673 Predicted dehydrogenases and related proteins. (302 aa)
SU9_25039COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (296 aa)
SU9_25064Bifunctional deaminase-reductase-like protein; COG1985 Pyrimidine reductase, riboflavin biosynthesis. (307 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (342 aa)
SU9_25619Zinc-containing alcohol dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (332 aa)
SU9_25919COG1064 Zn-dependent alcohol dehydrogenases. (341 aa)
SU9_26124Putative alcohol dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (338 aa)
SU9_26464Putative dehydrogenase; COG0451 Nucleoside-diphosphate-sugar epimerases. (347 aa)
SU9_26889COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (88 aa)
SU9_27309Hypothetical protein; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (346 aa)
SU9_28811Putative zinc-binding dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (330 aa)
SU9_28946Putative UDP-glucose/GDP-mannose dehydrogenase; COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (419 aa)
SU9_29301COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (739 aa)
SU9_29376Methionine adenosyltransferase; COG1091 dTDP-4-dehydrorhamnose reductase. (278 aa)
SU9_29381L-iditol 2-dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (364 aa)
SU9_29581Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (375 aa)
SU9_29641Inosine 5-monophosphate dehydrogenase; COG0516 IMP dehydrogenase/GMP reductase. (471 aa)
aroECOG0169 Shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (275 aa)
SU9_30329COG1250 3-hydroxyacyl-CoA dehydrogenase. (271 aa)
fclNAD-dependent epimerase/dehydratase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (295 aa)
SU9_323334-hydroxythreonine-4-phosphate dehydrogenase; COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. (362 aa)
SU9_33363NDP-hexose 3-ketoreductase; COG0673 Predicted dehydrogenases and related proteins. (328 aa)
SU9_33733COG1250 3-hydroxyacyl-CoA dehydrogenase. (571 aa)
Your Current Organism:
Streptomyces auratus
NCBI taxonomy Id: 1160718
Other names: S. auratus AGR0001, Streptomyces auratus AGR0001, Streptomyces auratus str. AGR0001, Streptomyces auratus strain AGR0001
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