STRINGSTRING
SU9_31171 SU9_31171 SU9_00570 SU9_00570 SU9_02182 SU9_02182 SU9_03826 SU9_03826 SU9_03831 SU9_03831 pnp pnp SU9_05960 SU9_05960 SU9_06225 SU9_06225 SU9_06260 SU9_06260 glnD glnD coaD coaD SU9_06515 SU9_06515 SU9_06780 SU9_06780 SU9_10379 SU9_10379 SU9_11603 SU9_11603 ispF ispF ispD ispD disA disA SU9_12612 SU9_12612 SU9_12867 SU9_12867 SU9_32023 SU9_32023 SU9_13199 SU9_13199 SU9_14271 SU9_14271 SU9_14361 SU9_14361 rpoB rpoB rpoC rpoC rpoA rpoA SU9_17722 SU9_17722 SU9_17974 SU9_17974 glmU glmU SU9_18498 SU9_18498 rph rph SU9_19479 SU9_19479 nadD nadD dnaG dnaG glnE glnE SU9_22770 SU9_22770 dnaE dnaE polA polA SU9_32393 SU9_32393 SU9_24627 SU9_24627 dinB dinB SU9_33583 SU9_33583 SU9_25279 SU9_25279 SU9_28626 SU9_28626 SU9_29361 SU9_29361 rpoZ rpoZ SU9_31166 SU9_31166
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SU9_31171COG0587 DNA polymerase III, alpha subunit; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. (1195 aa)
SU9_00570DNA polymerase LigD, polymerase domain-containing protein; COG3285 Predicted eukaryotic-type DNA primase. (315 aa)
SU9_02182Nucleotide sugar-1-phosphate transferase; COG1213 Predicted sugar nucleotidyltransferases. (245 aa)
SU9_03826Sulfate adenylyltransferase subunit 2; COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes. (316 aa)
SU9_03831Sulfate adenylyltransferase large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (450 aa)
pnpPolynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (743 aa)
SU9_05960Bifunctional riboflavin kinase/FMN adenylyltransferase; COG0196 FAD synthase; Belongs to the ribF family. (315 aa)
SU9_06225Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. (291 aa)
SU9_06260RNA polymerase sigma factor WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (278 aa)
glnDPII uridylyl-transferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (836 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)
SU9_06515Hypothetical protein. (229 aa)
SU9_06780PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase; COG2199 FOG: GGDEF domain. (973 aa)
SU9_10379COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains. (631 aa)
SU9_11603Guanyltransferase; COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon). (230 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (174 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (248 aa)
disADNA integrity scanning protein DisA; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. (374 aa)
SU9_12612COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains. (534 aa)
SU9_12867DNA polymerase III subunit delta; COG0470 ATPase involved in DNA replication. (416 aa)
SU9_32023Glycerol-3-phosphate cytidyltransferase; COG0615 Cytidylyltransferase. (101 aa)
SU9_13199COG2812 DNA polymerase III, gamma/tau subunits. (751 aa)
SU9_14271Polynucleotide adenylyltransferase; COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (491 aa)
SU9_14361DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (376 aa)
rpoBDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1161 aa)
rpoCDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1299 aa)
rpoADNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (340 aa)
SU9_17722UTP-glucose-1-phosphate uridylyltransferase; COG1210 UDP-glucose pyrophosphorylase. (300 aa)
SU9_17974COG1085 Galactose-1-phosphate uridylyltransferase. (352 aa)
glmUGlucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (485 aa)
SU9_18498Nucleotidyl transferase; COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon). (360 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (243 aa)
SU9_19479Sensory box/GGDEF family protein; COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. (604 aa)
nadDNicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (189 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (638 aa)
glnEBifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] (1008 aa)
SU9_22770Cobalbumin biosynthesis protein; COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I. (489 aa)
dnaECOG0587 DNA polymerase III, alpha subunit. (1185 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (912 aa)
SU9_32393Hypothetical protein; COG3285 Predicted eukaryotic-type DNA primase. (337 aa)
SU9_24627Mannose-1-phosphate guanyltransferase; COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon). (831 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (472 aa)
SU9_33583Glucose-1-phosphate thymidyltransferase; COG1209 dTDP-glucose pyrophosphorylase. (355 aa)
SU9_25279Hypothetical protein; COG1796 DNA polymerase IV (family X). (343 aa)
SU9_28626Hypothetical protein; COG3285 Predicted eukaryotic-type DNA primase. (316 aa)
SU9_29361Hypothetical protein. (430 aa)
rpoZDNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (90 aa)
SU9_31166Hypothetical protein; COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. (379 aa)
Your Current Organism:
Streptomyces auratus
NCBI taxonomy Id: 1160718
Other names: S. auratus AGR0001, Streptomyces auratus AGR0001, Streptomyces auratus str. AGR0001, Streptomyces auratus strain AGR0001
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