STRINGSTRING
SU9_07350 SU9_07350 hutU hutU eno eno SU9_17190 SU9_17190 SU9_17105 SU9_17105 nnrD nnrD SU9_16572 SU9_16572 mqnA mqnA SU9_16052 SU9_16052 SU9_15769 SU9_15769 SU9_13870 SU9_13870 SU9_13314 SU9_13314 nth nth SU9_12989 SU9_12989 ilvD ilvD SU9_11483 SU9_11483 murQ murQ fumC fumC SU9_09059 SU9_09059 SU9_08854 SU9_08854 SU9_08599 SU9_08599 SU9_07675 SU9_07675 aroQ aroQ leuC leuC leuD leuD mutM mutM dapA dapA SU9_05716 SU9_05716 SU9_04886 SU9_04886 SU9_04741 SU9_04741 SU9_04446 SU9_04446 SU9_03656 SU9_03656 SU9_02836 SU9_02836 phhB phhB SU9_02207 SU9_02207 SU9_01380 SU9_01380 SU9_00745 SU9_00745 SU9_00325 SU9_00325 SU9_19792 SU9_19792 SU9_20479 SU9_20479 SU9_21702 SU9_21702 SU9_22090 SU9_22090 SU9_33578 SU9_33578 SU9_18890 SU9_18890 SU9_23155 SU9_23155 hisB hisB SU9_23410 SU9_23410 trpB trpB SU9_22350 SU9_22350 trpA trpA dapA-2 dapA-2 ectC ectC SU9_25044 SU9_25044 SU9_25164 SU9_25164 SU9_25824 SU9_25824 mqnA-2 mqnA-2 SU9_32938 SU9_32938 gmd gmd vgb vgb SU9_30971 SU9_30971 SU9_30724 SU9_30724 aroC aroC aroB aroB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SU9_07350NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (335 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (556 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
SU9_17190COG1024 Enoyl-CoA hydratase/carnithine racemase. (264 aa)
SU9_17105COG1024 Enoyl-CoA hydratase/carnithine racemase. (301 aa)
nnrDHypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...] (474 aa)
SU9_16572Hypothetical protein; COG2030 Acyl dehydratase; Belongs to the UPF0336 family. (150 aa)
mqnAHypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (276 aa)
SU9_16052COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (505 aa)
SU9_15769Hypothetical protein. (138 aa)
SU9_13870COG0077 Prephenate dehydratase. (308 aa)
SU9_13314Terpene synthase metal-binding domain-containing protein. (747 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (328 aa)
SU9_12989Hypothetical protein; COG0659 Sulfate permease and related transporters (MFS superfamily). (778 aa)
ilvDCOG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (616 aa)
SU9_11483COG0498 Threonine synthase. (427 aa)
murQN-acetylmuramic acid-6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (312 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (473 aa)
SU9_09059Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (557 aa)
SU9_08854COG0288 Carbonic anhydrase. (189 aa)
SU9_08599Acyl CoA isomerase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (266 aa)
SU9_07675Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (361 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (156 aa)
leuCIsopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (476 aa)
leuDIsopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
mutMFormamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (308 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa)
SU9_05716H2TH DNA-binding DNA glycosylase/AP lyase; COG0266 Formamidopyrimidine-DNA glycosylase. (269 aa)
SU9_04886Hypothetical protein; COG2030 Acyl dehydratase. (154 aa)
SU9_04741COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (275 aa)
SU9_04446Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
SU9_03656Hypothetical protein. (171 aa)
SU9_02836Hypothetical protein; COG2030 Acyl dehydratase. (174 aa)
phhBCOG2154 Pterin-4a-carbinolamine dehydratase. (103 aa)
SU9_02207COG1024 Enoyl-CoA hydratase/carnithine racemase. (256 aa)
SU9_01380Hypothetical protein. (140 aa)
SU9_00745COG0266 Formamidopyrimidine-DNA glycosylase. (263 aa)
SU9_00325Siderophore binding protein; COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily. (172 aa)
SU9_19792Hypothetical protein. (400 aa)
SU9_20479DNA glycosylase/AP lyase, H2TH DNA-binding protein; COG0266 Formamidopyrimidine-DNA glycosylase; Belongs to the FPG family. (273 aa)
SU9_21702Galactonate dehydratase; COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily. (381 aa)
SU9_22090Hypothetical protein; COG2030 Acyl dehydratase. (291 aa)
SU9_33578COG1088 dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (326 aa)
SU9_18890Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; COG1587 Uroporphyrinogen-III synthase. (394 aa)
SU9_23155COG0288 Carbonic anhydrase. (186 aa)
hisBCOG0131 Imidazoleglycerol-phosphate dehydratase. (197 aa)
SU9_23410Nitrile hydratase subunit alpha (Nitrilase) (NHase). (196 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (428 aa)
SU9_22350COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Belongs to the DapA family. (321 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (272 aa)
dapA-2Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (321 aa)
ectCL-ectoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (138 aa)
SU9_25044COG0720 6-pyruvoyl-tetrahydropterin synthase. (132 aa)
SU9_25164Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (200 aa)
SU9_25824COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Belongs to the DapA family. (298 aa)
mqnA-2Hypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (301 aa)
SU9_32938COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Belongs to the DapA family. (302 aa)
gmdGDP-D-mannose dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (337 aa)
vgbPutative hydrolase/lactonase; Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2- amino-butenoic acid. (297 aa)
SU9_30971Hypothetical protein; COG2030 Acyl dehydratase. (153 aa)
SU9_30724Mandelate racemase/muconate lactonizing protein; COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (458 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (363 aa)
Your Current Organism:
Streptomyces auratus
NCBI taxonomy Id: 1160718
Other names: S. auratus AGR0001, Streptomyces auratus AGR0001, Streptomyces auratus str. AGR0001, Streptomyces auratus strain AGR0001
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