STRINGSTRING
SU9_17590 SU9_17590 SU9_17630 SU9_17630 ppc ppc SU9_18296 SU9_18296 SU9_18311 SU9_18311 hutU hutU SU9_18341 SU9_18341 hutI hutI SU9_18688 SU9_18688 SU9_18920 SU9_18920 SU9_19792 SU9_19792 SU9_20042 SU9_20042 asd-2 asd-2 SU9_21357 SU9_21357 SU9_21382 SU9_21382 SU9_21767 SU9_21767 SU9_21772 SU9_21772 SU9_22350 SU9_22350 nadA nadA SU9_23030 SU9_23030 SU9_23500 SU9_23500 SU9_23520 SU9_23520 gltD gltD dapD dapD dapA-2 dapA-2 SU9_24172 SU9_24172 aspA aspA SU9_25824 SU9_25824 gltD-2 gltD-2 SU9_27604 SU9_27604 SU9_27974 SU9_27974 SU9_28461 SU9_28461 SU9_28591 SU9_28591 aroQ aroQ SU9_29161 SU9_29161 SU9_29311 SU9_29311 aroB aroB aroK aroK aroC aroC aroE aroE SU9_30026 SU9_30026 SU9_31066 SU9_31066 SU9_31321 SU9_31321 SU9_32938 SU9_32938 glyA-4 glyA-4 SU9_33753 SU9_33753 SU9_33528 SU9_33528 SU9_02000 SU9_02000 SU9_02297 SU9_02297 SU9_02519 SU9_02519 SU9_03141 SU9_03141 SU9_03286 SU9_03286 SU9_03501 SU9_03501 SU9_04601 SU9_04601 SU9_04896 SU9_04896 dapF dapF dapA dapA dapB dapB SU9_06735 SU9_06735 glyA glyA glyA-3 glyA-3 lysA lysA SU9_07960 SU9_07960 glsA glsA aroA aroA SU9_08384 SU9_08384 SU9_08624 SU9_08624 fumC fumC hutH hutH SU9_10134 SU9_10134 glyA-2 glyA-2 SU9_10973 SU9_10973 SU9_12372 SU9_12372 SU9_12377 SU9_12377 SU9_12387 SU9_12387 SU9_12502 SU9_12502 asd asd SU9_13179 SU9_13179 lysA-2 lysA-2 kynU kynU hemA hemA SU9_17420 SU9_17420
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
SU9_17590L-carnitine dehydratase/bile acid-inducible protein F; COG1804 Predicted acyl-CoA transferases/carnitine dehydratase; Belongs to the CoA-transferase III family. (425 aa)
SU9_17630Amidohydrolase; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. (442 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (921 aa)
SU9_18296COG2986 Histidine ammonia-lyase. (507 aa)
SU9_18311Orn/DAP/Arg decarboxylase 2; COG0019 Diaminopimelate decarboxylase. (444 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (556 aa)
SU9_18341Allantoate amidohydrolase; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (412 aa)
hutICOG1228 Imidazolonepropionase and related amidohydrolases. (393 aa)
SU9_18688COG2902 NAD-specific glutamate dehydrogenase. (1653 aa)
SU9_18920NAD-binding malic protein; COG0281 Malic enzyme. (477 aa)
SU9_19792Hypothetical protein. (400 aa)
SU9_20042Aminoacylase; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. (386 aa)
asd-2Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (343 aa)
SU9_21357Hydrolase; COG1228 Imidazolonepropionase and related amidohydrolases. (358 aa)
SU9_21382Amidohydrolase; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (421 aa)
SU9_21767Peptidase M20; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (470 aa)
SU9_21772L-carnitine dehydratase/bile acid-inducible protein F; COG1804 Predicted acyl-CoA transferases/carnitine dehydratase; Belongs to the CoA-transferase III family. (408 aa)
SU9_22350COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Belongs to the DapA family. (321 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (396 aa)
SU9_23030Phospho-2-dehydro-3-deoxyheptonate aldolase; COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the class-II DAHP synthase family. (416 aa)
SU9_23500COG1804 Predicted acyl-CoA transferases/carnitine dehydratase; Belongs to the CoA-transferase III family. (418 aa)
SU9_23520COG0067 Glutamate synthase domain 1. (1513 aa)
gltDCOG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. (486 aa)
dapDTransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (337 aa)
dapA-2Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (321 aa)
SU9_24172Amidohydrolase; COG1228 Imidazolonepropionase and related amidohydrolases. (363 aa)
aspACOG1027 Aspartate ammonia-lyase. (470 aa)
SU9_25824COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Belongs to the DapA family. (298 aa)
gltD-2COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. (501 aa)
SU9_27604COG1804 Predicted acyl-CoA transferases/carnitine dehydratase; Belongs to the CoA-transferase III family. (588 aa)
SU9_27974COG0019 Diaminopimelate decarboxylase. (82 aa)
SU9_28461COG1605 Chorismate mutase. (210 aa)
SU9_28591COG0019 Diaminopimelate decarboxylase. (415 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (156 aa)
SU9_29161Hypothetical protein; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (453 aa)
SU9_29311Amidohydrolase; COG1228 Imidazolonepropionase and related amidohydrolases. (394 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (363 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (185 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa)
aroECOG0169 Shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (275 aa)
SU9_30026Sporulation and cell division protein SsgA. (137 aa)
SU9_31066Amidohydrolase; COG1228 Imidazolonepropionase and related amidohydrolases. (244 aa)
SU9_31321COG4401 Chorismate mutase. (120 aa)
SU9_32938COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Belongs to the DapA family. (302 aa)
glyA-4Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (437 aa)
SU9_33753Phospho-2-dehydro-3-deoxyheptonate aldolase; COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the class-II DAHP synthase family. (396 aa)
SU9_33528Amidohydrolase; COG1228 Imidazolonepropionase and related amidohydrolases. (422 aa)
SU9_02000Hypothetical protein; COG0823 Periplasmic component of the Tol biopolymer transport system. (1066 aa)
SU9_02297Fatty acid-CoA racemase; COG1804 Predicted acyl-CoA transferases/carnitine dehydratase; Belongs to the CoA-transferase III family. (386 aa)
SU9_02519COG1605 Chorismate mutase. (152 aa)
SU9_03141COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. (490 aa)
SU9_03286Peptidase M20; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (467 aa)
SU9_03501COG0019 Diaminopimelate decarboxylase. (398 aa)
SU9_04601Orn/DAP/Arg decarboxylase 2; COG0019 Diaminopimelate decarboxylase. (417 aa)
SU9_04896Phospho-2-dehydro-3-deoxyheptonate aldolase; COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the class-II DAHP synthase family. (389 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (291 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (250 aa)
SU9_06735COG0506 Proline dehydrogenase. (308 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (459 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (463 aa)
SU9_07960Malate oxidoreductase; COG0281 Malic enzyme. (407 aa)
glsACOG2066 Glutaminase; Belongs to the glutaminase family. (308 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (454 aa)
SU9_08384Peptidase; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (466 aa)
SU9_08624COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (363 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (473 aa)
hutHCOG2986 Histidine ammonia-lyase. (514 aa)
SU9_10134COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. (418 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa)
SU9_10973Hypothetical protein; COG1605 Chorismate mutase. (101 aa)
SU9_123722-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (207 aa)
SU9_12377Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (119 aa)
SU9_12387Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (294 aa)
SU9_12502COG0076 Glutamate decarboxylase and related PLP-dependent proteins; Belongs to the group II decarboxylase family. (471 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (376 aa)
SU9_13179COG0527 Aspartokinases; Belongs to the aspartokinase family. (423 aa)
lysA-2Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (487 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (417 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (451 aa)
SU9_17420Phospho-2-dehydro-3-deoxyheptonate aldolase; COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the class-II DAHP synthase family. (437 aa)
Your Current Organism:
Streptomyces auratus
NCBI taxonomy Id: 1160718
Other names: S. auratus AGR0001, Streptomyces auratus AGR0001, Streptomyces auratus str. AGR0001, Streptomyces auratus strain AGR0001
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