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SU9_22175 SU9_22175 SU9_22005 SU9_22005 SU9_21227 SU9_21227 SU9_21222 SU9_21222 SU9_20803 SU9_20803 SU9_20619 SU9_20619 SU9_20604 SU9_20604 SU9_19280 SU9_19280 SU9_18960 SU9_18960 whiB-6 whiB-6 SU9_17440 SU9_17440 fbiC fbiC whiB-5 whiB-5 nuoI-2 nuoI-2 nuoB-2 nuoB-2 nuoI nuoI SU9_16377 SU9_16377 SU9_16372 SU9_16372 SU9_16367 SU9_16367 nuoB nuoB mqnC mqnC mqnE mqnE purF purF SU9_15392 SU9_15392 SU9_14581 SU9_14581 SU9_14576 SU9_14576 SU9_14126 SU9_14126 SU9_14066 SU9_14066 SU9_14061 SU9_14061 SU9_13419 SU9_13419 whiB-4 whiB-4 nth nth SU9_12222 SU9_12222 ilvD ilvD SU9_11208 SU9_11208 sdhB sdhB SU9_10049 SU9_10049 SU9_09059 SU9_09059 whiB-3 whiB-3 ispH ispH SU9_08809 SU9_08809 SU9_08644 SU9_08644 SU9_08554 SU9_08554 whiB-2 whiB-2 whiB whiB SU9_07885 SU9_07885 SU9_07090 SU9_07090 SU9_06975 SU9_06975 SU9_06940 SU9_06940 leuC leuC rlmN rlmN ispG ispG rimO rimO miaB miaB SU9_05151 SU9_05151 SU9_05006 SU9_05006 SU9_04446 SU9_04446 SU9_03986 SU9_03986 SU9_03816 SU9_03816 SU9_03806 SU9_03806 SU9_03686 SU9_03686 SU9_03471 SU9_03471 SU9_03441 SU9_03441 SU9_03141 SU9_03141 SU9_02796 SU9_02796 SU9_02736 SU9_02736 SU9_02120 SU9_02120 SU9_02115 SU9_02115 SU9_01405 SU9_01405 SU9_01400 SU9_01400 SU9_01185 SU9_01185 SU9_00750 SU9_00750 bioB bioB lipA lipA SU9_33723 SU9_33723 SU9_33598 SU9_33598 SU9_33438 SU9_33438 mqnC-2 mqnC-2 SU9_33383 SU9_33383 mqnE-2 mqnE-2 SU9_32948 SU9_32948 SU9_32508 SU9_32508 SU9_32498 SU9_32498 SU9_32253 SU9_32253 SU9_32238 SU9_32238 SU9_32228 SU9_32228 SU9_31883 SU9_31883 SU9_31818 SU9_31818 whiB-7 whiB-7 SU9_31718 SU9_31718 SU9_30834 SU9_30834 SU9_30609 SU9_30609 SU9_28601 SU9_28601 SU9_28279 SU9_28279 SU9_27679 SU9_27679 SU9_27419 SU9_27419 SU9_26849 SU9_26849 SU9_26219 SU9_26219 gltD-2 gltD-2 SU9_25814 SU9_25814 SU9_25799 SU9_25799 SU9_25534 SU9_25534 SU9_25519 SU9_25519 SU9_25439 SU9_25439 SU9_24882 SU9_24882 moaA moaA SU9_24042 SU9_24042 SU9_24037 SU9_24037 SU9_24022 SU9_24022 SU9_23877 SU9_23877 SU9_23675 SU9_23675 gltD gltD SU9_23520 SU9_23520 SU9_23420 SU9_23420 SU9_23035 SU9_23035 SU9_22885 SU9_22885 SU9_22840 SU9_22840 SU9_22820 SU9_22820 nadA nadA SU9_22210 SU9_22210
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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SU9_22175Hypothetical protein; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (815 aa)
SU9_22005Iron-sulfur protein; COG1141 Ferredoxin. (77 aa)
SU9_21227Nitrite reductase (NAD(P)H) large subunit; COG1251 NAD(P)H-nitrite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (883 aa)
SU9_21222COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases. (141 aa)
SU9_20803Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (410 aa)
SU9_20619COG5011 Uncharacterized protein conserved in bacteria. (266 aa)
SU9_20604Hypothetical protein; COG1032 Fe-S oxidoreductase. (641 aa)
SU9_19280Oxidoreductase; COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit. (515 aa)
SU9_18960(2Fe-2S)-binding protein; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. (707 aa)
whiB-6WhiB family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (87 aa)
SU9_17440COG1032 Fe-S oxidoreductase. (640 aa)
fbiCFO synthase; COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes. (848 aa)
whiB-5WhiB family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (110 aa)
nuoI-2NADH dehydrogenase subunit NuoI2; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (196 aa)
nuoB-2NADH dehydrogenase subunit NuoB2; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (214 aa)
nuoINADH dehydrogenase subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (194 aa)
SU9_16377NADH dehydrogenase subunit G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (853 aa)
SU9_16372NADH-quinone oxidoreductase subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (460 aa)
SU9_16367COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. (294 aa)
nuoBNADH dehydrogenase subunit B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (184 aa)
mqnCHypothetical protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (399 aa)
mqnEHypothetical protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (387 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (519 aa)
SU9_15392Hypothetical protein; COG0247 Fe-S oxidoreductase. (755 aa)
SU9_14581Putative phenylacetic acid degradation protein; COG2151 Predicted metal-sulfur cluster biosynthetic enzyme; overlaps another CDS with the same product name. (165 aa)
SU9_14576Phenylacetic acid degradation NADH oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. (347 aa)
SU9_14126Flavohemoprotein; COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases. (672 aa)
SU9_14066Phosphomethylpyrimidine synthase ThiC; COG0422 Thiamine biosynthesis protein ThiC. (301 aa)
SU9_14061Phosphomethylpyrimidine synthase ThiC; COG0422 Thiamine biosynthesis protein ThiC. (294 aa)
SU9_13419COG1141 Ferredoxin. (66 aa)
whiB-4Regulatory protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (113 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (328 aa)
SU9_12222COG1194 A/G-specific DNA glycosylase. (319 aa)
ilvDCOG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (616 aa)
SU9_11208FAD linked oxidase domain-containing protein; COG0277 FAD/FMN-containing dehydrogenases. (981 aa)
sdhBCOG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (257 aa)
SU9_10049Hypothetical protein; COG1964 Predicted Fe-S oxidoreductases. (78 aa)
SU9_09059Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (557 aa)
whiB-3Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (79 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (343 aa)
SU9_08809COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit. (265 aa)
SU9_08644Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (106 aa)
SU9_08554ATP-binding protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (398 aa)
whiB-2Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (117 aa)
whiBWhiB-family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (85 aa)
SU9_07885Hypothetical protein; COG0641 Arylsulfatase regulator (Fe-S oxidoreductase). (384 aa)
SU9_07090COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (461 aa)
SU9_06975Class V aminotransferase; COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes. (389 aa)
SU9_06940Hypothetical protein. (230 aa)
leuCIsopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (476 aa)
rlmNRibosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (368 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (385 aa)
rimO30S ribosomal protein S12 methylthiotransferase RimO; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (503 aa)
miaB(dimethylallyl)adenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (495 aa)
SU9_05151TRAM domain-containing protein; COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (442 aa)
SU9_05006Radical SAM protein; COG0641 Arylsulfatase regulator (Fe-S oxidoreductase). (527 aa)
SU9_04446Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
SU9_03986COG1141 Ferredoxin. (65 aa)
SU9_03816Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (230 aa)
SU9_03806Nitrite and sulphite reductase 4Fe-4S region; COG0155 Sulfite reductase, beta subunit (hemoprotein); Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (565 aa)
SU9_03686(2Fe-2S)-binding domain-containing protein; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. (203 aa)
SU9_03471Hypothetical protein. (279 aa)
SU9_03441(2Fe-2S)-binding protein; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. (199 aa)
SU9_03141COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. (490 aa)
SU9_02796Radical SAM domain-containing protein; COG1533 DNA repair photolyase. (343 aa)
SU9_02736COG1141 Ferredoxin. (63 aa)
SU9_02120Hypothetical protein; COG0775 Nucleoside phosphorylase. (222 aa)
SU9_02115Hypothetical protein; COG0535 Predicted Fe-S oxidoreductases. (341 aa)
SU9_01405Iron-sulfur protein; COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain. (496 aa)
SU9_01400Hypothetical protein; COG0247 Fe-S oxidoreductase. (250 aa)
SU9_01185Xanthine dehydrogenase; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. (201 aa)
SU9_00750Rieske (2Fe-2S) domain-containing protein; COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases. (296 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (391 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (316 aa)
SU9_33723COG1141 Ferredoxin. (76 aa)
SU9_33598COG1141 Ferredoxin. (67 aa)
SU9_33438Hypothetical protein. (246 aa)
mqnC-2Menaquinone biosynthesis protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (422 aa)
SU9_33383COG1141 Ferredoxin. (101 aa)
mqnE-2Hypothetical protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (387 aa)
SU9_32948Hypothetical protein; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. (104 aa)
SU9_32508COG1740 Ni,Fe-hydrogenase I small subunit. (362 aa)
SU9_32498Hypothetical protein. (202 aa)
SU9_32253COG1146 Ferredoxin. (75 aa)
SU9_32238Rieske (2Fe-2S) domain-containing protein; COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit. (383 aa)
SU9_32228Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit. (428 aa)
SU9_31883Methylesterase; COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit. (335 aa)
SU9_31818(2Fe-2S)-binding domain-containing protein; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. (163 aa)
whiB-7Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (85 aa)
SU9_31718COG0277 FAD/FMN-containing dehydrogenases. (984 aa)
SU9_30834Hypothetical protein. (87 aa)
SU9_30609COG1141 Ferredoxin. (97 aa)
SU9_28601Molybdopterin oxidoreductase; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (1402 aa)
SU9_28279COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases. (110 aa)
SU9_27679SUF system FeS assembly protein, NifU family; COG0822 NifU homolog involved in Fe-S cluster formation. (145 aa)
SU9_27419COG1141 Ferredoxin. (81 aa)
SU9_26849(2Fe-2S)-binding protein; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. (189 aa)
SU9_26219Radical SAM domain-containing protein; COG1032 Fe-S oxidoreductase. (643 aa)
gltD-2COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. (501 aa)
SU9_25814Hypothetical protein; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. (93 aa)
SU9_25799COG1573 Uracil-DNA glycosylase. (263 aa)
SU9_25534Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenase; COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit. (388 aa)
SU9_25519COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases. (106 aa)
SU9_25439Hypothetical protein; COG1141 Ferredoxin. (71 aa)
SU9_24882Rieske (2Fe-2S) domain-containing protein; COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases. (106 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa)
SU9_24042Hypothetical protein; COG2151 Predicted metal-sulfur cluster biosynthetic enzyme. (111 aa)
SU9_24037SUF system FeS assembly protein, NifU family; COG0822 NifU homolog involved in Fe-S cluster formation. (152 aa)
SU9_24022COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases. (105 aa)
SU9_23877Rieske (2Fe-2S) iron-sulfur domain protein; COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases. (137 aa)
SU9_23675COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (766 aa)
gltDCOG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. (486 aa)
SU9_23520COG0067 Glutamate synthase domain 1. (1513 aa)
SU9_23420Radical SAM protein; COG0535 Predicted Fe-S oxidoreductases. (268 aa)
SU9_23035Hypothetical protein; COG2906 Bacterioferritin-associated ferredoxin. (91 aa)
SU9_22885Ubiquinol-cytochrome C reductase iron-sulfur subunit; COG0201 Preprotein translocase subunit SecY. (328 aa)
SU9_22840Pyridoxal-phosphate-dependent aminotransferase; COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes; Belongs to the sulfur carrier protein TusA family. (481 aa)
SU9_22820Hypothetical protein; Belongs to the HesB/IscA family. (117 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (396 aa)
SU9_22210DNA polymerase related protein; COG1573 Uracil-DNA glycosylase. (224 aa)
Your Current Organism:
Streptomyces auratus
NCBI taxonomy Id: 1160718
Other names: S. auratus AGR0001, Streptomyces auratus AGR0001, Streptomyces auratus str. AGR0001, Streptomyces auratus strain AGR0001
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