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| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (391 aa) |
| | SU9_01050 | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. (367 aa) |
| | SU9_01135 | COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases. (389 aa) |
| | SU9_01640 | COG3321 Polyketide synthase modules and related proteins. (2370 aa) |
| | SU9_01940 | Hypothetical protein. (295 aa) |
| | SU9_02115 | Hypothetical protein; COG0535 Predicted Fe-S oxidoreductases. (341 aa) |
| | SU9_02337 | COG0191 Fructose/tagatose bisphosphate aldolase. (293 aa) |
| | SU9_03141 | COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. (490 aa) |
| | SU9_03221 | COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase. (222 aa) |
| | SU9_04736 | salicylyl-CoA 5-hydroxylase; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. (773 aa) |
| | SU9_04896 | Phospho-2-dehydro-3-deoxyheptonate aldolase; COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the class-II DAHP synthase family. (389 aa) |
| | SU9_05006 | Radical SAM protein; COG0641 Arylsulfatase regulator (Fe-S oxidoreductase). (527 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa) |
| | rlmN | Ribosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (368 aa) |
| | SU9_06665 | Alpha-isopropylmalate/homocitrate synthase family transferase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. (544 aa) |
| | SU9_07885 | Hypothetical protein; COG0641 Arylsulfatase regulator (Fe-S oxidoreductase). (384 aa) |
| | SU9_09944 | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (333 aa) |
| | SU9_10049 | Hypothetical protein; COG1964 Predicted Fe-S oxidoreductases. (78 aa) |
| | SU9_10144 | N-acetylneuraminic acid synthase domain-containing protein; COG2089 Sialic acid synthase. (308 aa) |
| | SU9_12307 | COG0157 Nicotinate-nucleotide pyrophosphorylase. (357 aa) |
| | SU9_15492 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa) |
| | SU9_16052 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (505 aa) |
| | mqnE | Hypothetical protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (387 aa) |
| | mqnC | Hypothetical protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (399 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (500 aa) |
| | SU9_17002 | Inosine 5-monophosphate dehydrogenase; COG0516 IMP dehydrogenase/GMP reductase. (371 aa) |
| | fbiC | FO synthase; COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes. (848 aa) |
| | SU9_17420 | Phospho-2-dehydro-3-deoxyheptonate aldolase; COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the class-II DAHP synthase family. (437 aa) |
| | SU9_19115 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (442 aa) |
| | SU9_19635 | Pyruvate carboxyltransferase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. (313 aa) |
| | SU9_19792 | Hypothetical protein. (400 aa) |
| | SU9_19862 | Hypothetical protein. (295 aa) |
| | SU9_20067 | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. (356 aa) |
| | SU9_20803 | Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (410 aa) |
| | SU9_20833 | COG2070 Dioxygenases related to 2-nitropropane dioxygenase. (363 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (592 aa) |
| | SU9_21088 | TIM-barrel protein, nifR3 family; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (375 aa) |
| | SU9_21697 | 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase. (206 aa) |
| | SU9_22130 | 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase. (214 aa) |
| | SU9_22350 | COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Belongs to the DapA family. (321 aa) |
| | SU9_22620 | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. (671 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (316 aa) |
| | SU9_23030 | Phospho-2-dehydro-3-deoxyheptonate aldolase; COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the class-II DAHP synthase family. (416 aa) |
| | thiG | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (279 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (216 aa) |
| | priA | Phosphoribosyl isomerase A; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (240 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa) |
| | SU9_23420 | Radical SAM protein; COG0535 Predicted Fe-S oxidoreductases. (268 aa) |
| | trpC | COG0134 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (269 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (272 aa) |
| | SU9_23520 | COG0067 Glutamate synthase domain 1. (1513 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (258 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (380 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (321 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa) |
| | SU9_25769 | enoyl-ACP reductase II; COG2070 Dioxygenases related to 2-nitropropane dioxygenase. (360 aa) |
| | SU9_25824 | COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Belongs to the DapA family. (298 aa) |
| | SU9_25879 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (448 aa) |
| | SU9_26144 | Putative oxidoreductase; COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases. (380 aa) |
| | SU9_26694 | Polyketide synthesis protein; COG0331 (acyl-carrier-protein) S-malonyltransferase. (751 aa) |
| | SU9_26884 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1124 aa) |
| | SU9_26894 | Oxidoreductase; COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. (357 aa) |
| | SU9_26929 | COG2070 Dioxygenases related to 2-nitropropane dioxygenase. (324 aa) |
| | SU9_28501 | COG2070 Dioxygenases related to 2-nitropropane dioxygenase. (367 aa) |
| | SU9_28511 | Ricin B lectin; COG3345 Alpha-galactosidase. (435 aa) |
| | thiG-2 | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (255 aa) |
| | SU9_29171 | Alpha-galactosidase; COG1361 S-layer domain. (658 aa) |
| | SU9_29446 | Modular polyketide synthase; COG2070 Dioxygenases related to 2-nitropropane dioxygenase. (2279 aa) |
| | SU9_29641 | Inosine 5-monophosphate dehydrogenase; COG0516 IMP dehydrogenase/GMP reductase. (471 aa) |
| | SU9_29661 | COG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa) |
| | pyrF | COG0284 Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (287 aa) |
| | pyrD | Dihydroorotate dehydrogenase 2; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (369 aa) |
| | pdxS | Pyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (303 aa) |
| | SU9_30956 | Hypothetical protein. (251 aa) |
| | SU9_32938 | COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Belongs to the DapA family. (302 aa) |
| | mqnE-2 | Hypothetical protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (387 aa) |
| | mqnC-2 | Menaquinone biosynthesis protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (422 aa) |
| | SU9_33753 | Phospho-2-dehydro-3-deoxyheptonate aldolase; COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the class-II DAHP synthase family. (396 aa) |
| | SU9_33763 | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. (692 aa) |
