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SU9_04446 SU9_04446 SU9_05371 SU9_05371 SU9_05376 SU9_05376 kgd kgd sdhA sdhA SU9_08809 SU9_08809 SU9_09059 SU9_09059 fumC fumC pckG pckG SU9_10249 SU9_10249 SU9_10254 SU9_10254 sdhA-2 sdhA-2 sdhB sdhB mdh mdh sucD sucD sucC sucC SU9_11103 SU9_11103 SU9_14636 SU9_14636 SU9_14641 SU9_14641 SU9_14646 SU9_14646 SU9_14706 SU9_14706 SU9_14711 SU9_14711 SU9_14716 SU9_14716 SU9_16457 SU9_16457 SU9_16462 SU9_16462 SU9_19075 SU9_19075 gltA gltA aceE aceE SU9_22295 SU9_22295 SU9_22710 SU9_22710 SU9_22725 SU9_22725 SU9_26884 SU9_26884 SU9_29301 SU9_29301 SU9_32273 SU9_32273 SU9_32278 SU9_32278
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SU9_04446Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
SU9_05371COG0372 Citrate synthase; Belongs to the citrate synthase family. (389 aa)
SU9_05376Citrate synthase-like protein; COG0372 Citrate synthase. (415 aa)
kgdAlpha-ketoglutarate decarboxylase; COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes. (1270 aa)
sdhACOG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (647 aa)
SU9_08809COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit. (265 aa)
SU9_09059Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (557 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (473 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (610 aa)
SU9_10249COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. (126 aa)
SU9_10254COG2142 Succinate dehydrogenase, hydrophobic anchor subunit. (162 aa)
sdhA-2COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (584 aa)
sdhBCOG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (257 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (330 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (391 aa)
SU9_11103COG0372 Citrate synthase; Belongs to the citrate synthase family. (367 aa)
SU9_14636COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (397 aa)
SU9_14641Transketolase; COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (344 aa)
SU9_14646Branched-chain alpha-keto acid dehydrogenase subunit E2; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (521 aa)
SU9_14706COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (404 aa)
SU9_14711Transketolase central region; COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (327 aa)
SU9_14716Branched-chain alpha-keto acid dehydrogenase subunit E2; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (490 aa)
SU9_16457COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit. (364 aa)
SU9_16462Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit. (650 aa)
SU9_19075Putative oxidoreductase; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (481 aa)
gltACOG0372 Citrate synthase; Belongs to the citrate synthase family. (429 aa)
aceEPyruvate dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (910 aa)
SU9_22295Hypothetical protein; COG0672 High-affinity Fe2+/Pb2+ permease. (330 aa)
SU9_227102-oxoacid dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (890 aa)
SU9_22725COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (462 aa)
SU9_26884Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1124 aa)
SU9_29301COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (739 aa)
SU9_32273oxidoreductase/HEAT repeat-containing protein; COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (832 aa)
SU9_32278oxidoreductase/HEAT repeat-containing protein. (69 aa)
Your Current Organism:
Streptomyces auratus
NCBI taxonomy Id: 1160718
Other names: S. auratus AGR0001, Streptomyces auratus AGR0001, Streptomyces auratus str. AGR0001, Streptomyces auratus strain AGR0001
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