STRINGSTRING
SU9_18341 SU9_18341 SU9_00275 SU9_00275 SU9_00975 SU9_00975 SU9_02951 SU9_02951 SU9_02966 SU9_02966 SU9_04516 SU9_04516 SU9_04771 SU9_04771 dut dut SU9_05311 SU9_05311 SU9_05316 SU9_05316 SU9_05511 SU9_05511 nrdR nrdR thyX thyX SU9_06150 SU9_06150 pyrH pyrH SU9_06560 SU9_06560 SU9_06930 SU9_06930 SU9_07895 SU9_07895 SU9_08165 SU9_08165 SU9_08170 SU9_08170 SU9_08619 SU9_08619 SU9_09034 SU9_09034 SU9_09384 SU9_09384 SU9_09789 SU9_09789 SU9_09929 SU9_09929 SU9_09984 SU9_09984 deoA deoA SU9_10109 SU9_10109 SU9_10529 SU9_10529 SU9_11775 SU9_11775 SU9_12879 SU9_12879 upp upp tadA tadA SU9_13593 SU9_13593 dcd dcd pyrE pyrE SU9_15497 SU9_15497 SU9_16202 SU9_16202 SU9_16562 SU9_16562 groES groES SU9_17395 SU9_17395 SU9_17660 SU9_17660 SU9_20364 SU9_20364 ndk ndk SU9_20898 SU9_20898 SU9_20908 SU9_20908 SU9_21073 SU9_21073 SU9_21083 SU9_21083 SU9_21427 SU9_21427 SU9_21762 SU9_21762 SU9_21845 SU9_21845 SU9_21910 SU9_21910 SU9_23797 SU9_23797 SU9_24072 SU9_24072 SU9_24602 SU9_24602 SU9_26114 SU9_26114 SU9_26559 SU9_26559 SU9_27664 SU9_27664 SU9_27754 SU9_27754 SU9_27904 SU9_27904 SU9_29521 SU9_29521 pyrF pyrF pyrD pyrD carB carB carA carA SU9_29756 SU9_29756 pyrC pyrC pyrB pyrB pyrR pyrR SU9_30156 SU9_30156 SU9_30161 SU9_30161 cmk cmk pyrG pyrG SU9_31496 SU9_31496 SU9_31738 SU9_31738 SU9_32183 SU9_32183 SU9_32913 SU9_32913 SU9_32983 SU9_32983 SU9_33508 SU9_33508 SU9_18935 SU9_18935 SU9_18995 SU9_18995 SU9_19185 SU9_19185 SU9_19190 SU9_19190 SU9_19215 SU9_19215 SU9_19484 SU9_19484 SU9_19540 SU9_19540 SU9_20187 SU9_20187
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SU9_18341Allantoate amidohydrolase; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (412 aa)
SU9_00275Hydrolase; COG2374 Predicted extracellular nuclease. (370 aa)
SU9_00975Hypothetical protein; COG0477 Permeases of the major facilitator superfamily. (457 aa)
SU9_02951Phenylhydantoinase; COG0044 Dihydroorotase and related cyclic amidohydrolases. (468 aa)
SU9_02966Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; COG0388 Predicted amidohydrolase. (280 aa)
SU9_04516Relaxase/mobilization nuclease family protein; COG0717 Deoxycytidine deaminase. (354 aa)
SU9_04771Hypothetical protein; COG1694 Predicted pyrophosphatase. (120 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (166 aa)
SU9_05311COG1435 Thymidine kinase. (182 aa)
SU9_05316COG1435 Thymidine kinase. (40 aa)
SU9_05511Vitamin B12-dependent ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (958 aa)
nrdRTranscriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (174 aa)
thyXFAD-dependent thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (252 aa)
SU9_06150Hypothetical protein; COG1611 Predicted Rossmann fold nucleotide-binding protein. (385 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (256 aa)
SU9_06560Hydrolase; COG1011 Predicted hydrolase (HAD superfamily). (264 aa)
SU9_06930Hypothetical protein; COG1611 Predicted Rossmann fold nucleotide-binding protein; Belongs to the LOG family. (180 aa)
SU9_07895Hypothetical protein. (1147 aa)
SU9_08165Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (800 aa)
SU9_08170Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (381 aa)
SU9_08619Hypothetical protein; COG1611 Predicted Rossmann fold nucleotide-binding protein; Belongs to the LOG family. (249 aa)
SU9_09034Malonic semialdehyde reductase; COG0778 Nitroreductase. (197 aa)
SU9_09384EmrB/QacA subfamily drug resistance transporter; COG0477 Permeases of the major facilitator superfamily. (544 aa)
SU9_09789Hypothetical protein. (411 aa)
SU9_09929Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (273 aa)
SU9_09984ATP-binding protein; COG0572 Uridine kinase. (200 aa)
deoACOG0213 Thymidine phosphorylase. (425 aa)
SU9_10109COG0295 Cytidine deaminase. (137 aa)
SU9_10529COG1403 Restriction endonuclease. (101 aa)
SU9_11775COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. (590 aa)
SU9_12879COG0125 Thymidylate kinase. (776 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (211 aa)
tadAZinc-binding CMP/dCMP deaminase protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (148 aa)
SU9_13593COG0477 Permeases of the major facilitator superfamily. (513 aa)
dcdDeoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (180 aa)
SU9_15497Transmembrane efflux protein; COG0477 Permeases of the major facilitator superfamily. (525 aa)
SU9_16202Zinc-binding protein; COG0590 Cytosine/adenosine deaminases. (178 aa)
SU9_16562Hydrolase; COG0402 Cytosine deaminase and related metal-dependent hydrolases. (420 aa)
groESCo-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (102 aa)
SU9_17395MFS transporter methylenomycin A resistance protein; COG0477 Permeases of the major facilitator superfamily. (439 aa)
SU9_17660COG0477 Permeases of the major facilitator superfamily. (403 aa)
SU9_20364Endonuclease; COG1403 Restriction endonuclease. (178 aa)
ndkMulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-phosphodiesterase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa)
SU9_20898Transmembrane efflux protein; COG0477 Permeases of the major facilitator superfamily. (465 aa)
SU9_20908Hypothetical protein. (125 aa)
SU9_21073COG0477 Permeases of the major facilitator superfamily. (516 aa)
SU9_21083Efflux protein; COG0477 Permeases of the major facilitator superfamily. (468 aa)
SU9_21427COG0477 Permeases of the major facilitator superfamily. (555 aa)
SU9_21762COG0477 Permeases of the major facilitator superfamily. (410 aa)
SU9_21845Hypothetical protein. (214 aa)
SU9_21910Integral membrane transport protein; COG0477 Permeases of the major facilitator superfamily. (503 aa)
SU9_23797Hypothetical protein. (212 aa)
SU9_24072Endonuclease/exonuclease/phosphatase; COG2374 Predicted extracellular nuclease. (612 aa)
SU9_24602Endonuclease; COG1403 Restriction endonuclease. (167 aa)
SU9_26114Hypothetical protein; COG0477 Permeases of the major facilitator superfamily. (419 aa)
SU9_26559M6 family metalloprotease domain-containing protein. (397 aa)
SU9_27664COG1896 Predicted hydrolases of HD superfamily. (165 aa)
SU9_27754Hypothetical protein. (169 aa)
SU9_27904COG0295 Cytidine deaminase. (218 aa)
SU9_29521Hypothetical protein; COG0572 Uridine kinase. (211 aa)
pyrFCOG0284 Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (287 aa)
pyrDDihydroorotate dehydrogenase 2; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (369 aa)
carBCOG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. (1103 aa)
carACOG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (384 aa)
SU9_29756Hypothetical protein. (195 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (431 aa)
pyrBCOG0540 Aspartate carbamoyltransferase, catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (325 aa)
pyrRBifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (196 aa)
SU9_30156COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. (656 aa)
SU9_30161COG0477 Permeases of the major facilitator superfamily. (545 aa)
cmkCOG0283 Cytidylate kinase. (247 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (551 aa)
SU9_31496Hypothetical protein. (421 aa)
SU9_31738Hypothetical protein. (136 aa)
SU9_32183Peptidoglycan-binding protein; COG1388 FOG: LysM repeat. (229 aa)
SU9_32913M6 family metalloprotease domain-containing protein. (397 aa)
SU9_32983M6 family metalloprotease domain-containing protein. (391 aa)
SU9_33508COG0105 Nucleoside diphosphate kinase. (331 aa)
SU9_18935Hypothetical protein; COG1678 Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (226 aa)
SU9_18995COG1403 Restriction endonuclease. (285 aa)
SU9_19185Hypothetical protein. (332 aa)
SU9_19190General substrate transporter; COG0477 Permeases of the major facilitator superfamily. (512 aa)
SU9_19215GroES family molecular chaperone; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. (116 aa)
SU9_19484M6 family metalloprotease domain-containing protein. (413 aa)
SU9_19540Hypothetical protein. (387 aa)
SU9_20187COG0105 Nucleoside diphosphate kinase; Belongs to the NDK family. (169 aa)
Your Current Organism:
Streptomyces auratus
NCBI taxonomy Id: 1160718
Other names: S. auratus AGR0001, Streptomyces auratus AGR0001, Streptomyces auratus str. AGR0001, Streptomyces auratus strain AGR0001
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