STRINGSTRING
SU9_00950 SU9_00950 SU9_02337 SU9_02337 SU9_03141 SU9_03141 SU9_05491 SU9_05491 SU9_06515 SU9_06515 SU9_06760 SU9_06760 glyA glyA pfkA pfkA SU9_07310 SU9_07310 ackA ackA glyA-3 glyA-3 glpX glpX glyA-2 glyA-2 mdh mdh SU9_10853 SU9_10853 serC serC SU9_11428 SU9_11428 gpmA gpmA acsA acsA SU9_14131 SU9_14131 SU9_15392 SU9_15392 SU9_15492 SU9_15492 SU9_15664 SU9_15664 SU9_16957 SU9_16957 SU9_17085 SU9_17085 fbiC fbiC SU9_17665 SU9_17665 ppc ppc eno eno fbiB fbiB fbiA fbiA SU9_19862 SU9_19862 SU9_20022 SU9_20022 SU9_20713 SU9_20713 SU9_20863 SU9_20863 SU9_22095 SU9_22095 pfp pfp SU9_23675 SU9_23675 SU9_23907 SU9_23907 SU9_24532 SU9_24532 SU9_25524 SU9_25524 SU9_28289 SU9_28289 SU9_30429 SU9_30429 SU9_30754 SU9_30754 SU9_30859 SU9_30859 SU9_31001 SU9_31001 SU9_32068 SU9_32068 SU9_32478 SU9_32478 SU9_32483 SU9_32483 pfkA-2 pfkA-2 glyA-4 glyA-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SU9_00950COG3564 Uncharacterized protein conserved in bacteria. (141 aa)
SU9_02337COG0191 Fructose/tagatose bisphosphate aldolase. (293 aa)
SU9_03141COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. (490 aa)
SU9_05491Hypothetical protein; COG0406 Fructose-2,6-bisphosphatase; Belongs to the phosphoglycerate mutase family. (219 aa)
SU9_06515Hypothetical protein. (229 aa)
SU9_06760COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (530 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
SU9_07310Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (698 aa)
ackAAcetate kinase A/propionate kinase 2; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (406 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (459 aa)
glpXCOG1494 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins. (343 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (330 aa)
SU9_10853COG2425 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (356 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
SU9_11428COG1737 Transcriptional regulators. (304 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (253 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (654 aa)
SU9_14131HAD-superfamily hydrolase; COG0560 Phosphoserine phosphatase. (210 aa)
SU9_15392Hypothetical protein; COG0247 Fe-S oxidoreductase. (755 aa)
SU9_15492Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa)
SU9_15664DNA-binding protein; COG2452 Predicted site-specific integrase-resolvase. (68 aa)
SU9_169572-hydroxyacid family dehydrogenase; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (352 aa)
SU9_17085COG1062 Zn-dependent alcohol dehydrogenases, class III. (356 aa)
fbiCFO synthase; COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes. (848 aa)
SU9_17665COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (140 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (921 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
fbiBF420-0--gamma-glutamyl ligase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. (442 aa)
fbiALPPG:FO 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (318 aa)
SU9_19862Hypothetical protein. (295 aa)
SU9_20022COG1737 Transcriptional regulators. (289 aa)
SU9_20713Phosphoglycerate mutase; COG0406 Fructose-2,6-bisphosphatase; Belongs to the phosphoglycerate mutase family. (214 aa)
SU9_20863Mycothiol-dependent formaldehyde dehydrogenase; COG1062 Zn-dependent alcohol dehydrogenases, class III. (361 aa)
SU9_22095COG1062 Zn-dependent alcohol dehydrogenases, class III. (358 aa)
pfp6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa)
SU9_23675COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (766 aa)
SU9_23907Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (354 aa)
SU9_24532Putative phosphoserine phosphatase; COG3830 ACT domain-containing protein. (412 aa)
SU9_25524Mycothiol-dependent formaldehyde dehydrogenase; COG1062 Zn-dependent alcohol dehydrogenases, class III. (361 aa)
SU9_28289Mycothiol-dependent formaldehyde dehydrogenase; COG1062 Zn-dependent alcohol dehydrogenases, class III. (361 aa)
SU9_30429Lipoprotein; COG0560 Phosphoserine phosphatase. (422 aa)
SU9_30754Phosphoglycerate mutase; COG0406 Fructose-2,6-bisphosphatase. (232 aa)
SU9_30859Hypothetical protein; COG2864 Cytochrome b subunit of formate dehydrogenase. (234 aa)
SU9_31001COG1062 Zn-dependent alcohol dehydrogenases, class III. (366 aa)
SU9_32068COG1080 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria). (671 aa)
SU9_32478[NiFe] hydrogenase-specific C-terminal protease; COG0680 Ni,Fe-hydrogenase maturation factor. (188 aa)
SU9_32483Hypothetical protein. (473 aa)
pfkA-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
glyA-4Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (437 aa)
Your Current Organism:
Streptomyces auratus
NCBI taxonomy Id: 1160718
Other names: S. auratus AGR0001, Streptomyces auratus AGR0001, Streptomyces auratus str. AGR0001, Streptomyces auratus strain AGR0001
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.