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| | hisE | COG0140 Phosphoribosyl-ATP pyrophosphohydrolase. (90 aa) |
| | SU9_00175 | COG0456 Acetyltransferases. (141 aa) |
| | SU9_00220 | COG2188 Transcriptional regulators. (248 aa) |
| | SU9_00240 | GCN5-like N-acetyltransferase; COG0454 Histone acetyltransferase HPA2 and related acetyltransferases. (441 aa) |
| | SU9_00620 | COG3030 Protein affecting phage T7 exclusion by the F plasmid. (171 aa) |
| | SU9_01265 | Membrane protein. (399 aa) |
| | SU9_01690 | COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (481 aa) |
| | SU9_01925 | COG0174 Glutamine synthetase. (465 aa) |
| | SU9_02055 | N-acetyltransferase; COG3393 Predicted acetyltransferase. (285 aa) |
| | SU9_02337 | COG0191 Fructose/tagatose bisphosphate aldolase. (293 aa) |
| | SU9_02519 | COG1605 Chorismate mutase. (152 aa) |
| | SU9_02651 | Putative aminotransferase; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (404 aa) |
| | SU9_02696 | COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family; Belongs to the arginase family. (301 aa) |
| | SU9_02756 | Hypothetical protein; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (454 aa) |
| | SU9_03201 | COG2188 Transcriptional regulators. (231 aa) |
| | SU9_03216 | Putative soluble lytic transglycosylase; COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain. (275 aa) |
| | SU9_03501 | COG0019 Diaminopimelate decarboxylase. (398 aa) |
| | SU9_03596 | Hypothetical protein. (217 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (788 aa) |
| | SU9_03971 | Hypothetical protein; COG0367 Asparagine synthase (glutamine-hydrolyzing). (610 aa) |
| | SU9_04446 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa) |
| | SU9_04451 | COG0031 Cysteine synthase. (360 aa) |
| | SU9_04601 | Orn/DAP/Arg decarboxylase 2; COG0019 Diaminopimelate decarboxylase. (417 aa) |
| | SU9_04631 | COG0192 S-adenosylmethionine synthetase. (144 aa) |
| | SU9_04756 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (334 aa) |
| | SU9_04796 | COG0367 Asparagine synthase (glutamine-hydrolyzing). (618 aa) |
| | SU9_04896 | Phospho-2-dehydro-3-deoxyheptonate aldolase; COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the class-II DAHP synthase family. (389 aa) |
| | SU9_05136 | Acetolactate synthase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (593 aa) |
| | SU9_05371 | COG0372 Citrate synthase; Belongs to the citrate synthase family. (389 aa) |
| | SU9_05376 | Citrate synthase-like protein; COG0372 Citrate synthase. (415 aa) |
| | SU9_05491 | Hypothetical protein; COG0406 Fructose-2,6-bisphosphatase; Belongs to the phosphoglycerate mutase family. (219 aa) |
| | SU9_05551 | Class III aminotransferase; COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (464 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (291 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (250 aa) |
| | SU9_06030 | Acetyltransferase; COG3393 Predicted acetyltransferase. (281 aa) |
| | SU9_06195 | Hypothetical protein. (289 aa) |
| | SU9_06450 | COG3599 Cell division initiation protein. (386 aa) |
| | leuD | Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa) |
| | leuC | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (476 aa) |
| | SU9_06665 | Alpha-isopropylmalate/homocitrate synthase family transferase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. (544 aa) |
| | SU9_06705 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. (368 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (346 aa) |
| | SU9_06760 | COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (530 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa) |
| | ilvH | COG0440 Acetolactate synthase, small (regulatory) subunit. (174 aa) |
| | SU9_06775 | Acetolactate synthase 1 catalytic subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (622 aa) |
| | SU9_06915 | Hypothetical protein. (337 aa) |
| | vapC | PilT protein-like protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (142 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa) |
| | SU9_07090 | COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (461 aa) |
| | SU9_07290 | Hypothetical protein. (236 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa) |
| | SU9_07320 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (475 aa) |
| | glyA-3 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (459 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (305 aa) |
| | SU9_07675 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (361 aa) |
| | SU9_07680 | COG0460 Homoserine dehydrogenase. (429 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (463 aa) |
| | SU9_08145 | COG2188 Transcriptional regulators. (251 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (454 aa) |
| | SU9_08252 | COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family. (267 aa) |
| | SU9_08624 | COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (363 aa) |
| | SU9_08639 | COG0436 Aspartate/tyrosine/aromatic aminotransferase. (377 aa) |
| | SU9_08649 | GCN5-like N-acetyltransferase; COG0454 Histone acetyltransferase HPA2 and related acetyltransferases. (345 aa) |
| | SU9_08744 | COG2188 Transcriptional regulators. (249 aa) |
| | SU9_08839 | COG2186 Transcriptional regulators. (250 aa) |
| | SU9_09344 | Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (403 aa) |
| | SU9_09579 | COG1171 Threonine dehydratase. (427 aa) |
| | SU9_09604 | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (357 aa) |
| | SU9_09679 | COG2186 Transcriptional regulators. (257 aa) |
| | SU9_09854 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (203 aa) |
| | SU9_10044 | Hypothetical protein. (105 aa) |
| | SU9_10319 | COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs. (77 aa) |
| | glyA-2 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa) |
| | SU9_10973 | Hypothetical protein; COG1605 Chorismate mutase. (101 aa) |
| | SU9_11103 | COG0372 Citrate synthase; Belongs to the citrate synthase family. (367 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa) |
| | SU9_11428 | COG1737 Transcriptional regulators. (304 aa) |
| | SU9_11483 | COG0498 Threonine synthase. (427 aa) |
| | SU9_11493 | COG2188 Transcriptional regulators. (251 aa) |
| | gpmA | Phosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (253 aa) |
| | SU9_11950 | Acetyltransferase-like protein; COG3393 Predicted acetyltransferase. (284 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa) |
| | ilvD | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (616 aa) |
| | SU9_12282 | COG1246 N-acetylglutamate synthase and related acetyltransferases; Belongs to the acetyltransferase family. (163 aa) |
| | SU9_12327 | Aromatic amino acid beta-eliminating lyase/threonine aldolase; COG2008 Threonine aldolase. (414 aa) |
| | SU9_12762 | Hypothetical protein. (185 aa) |
| | SU9_13109 | COG2186 Transcriptional regulators. (262 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (376 aa) |
| | SU9_13179 | COG0527 Aspartokinases; Belongs to the aspartokinase family. (423 aa) |
| | SU9_13219 | COG0367 Asparagine synthase (glutamine-hydrolyzing). (607 aa) |
| | SU9_13324 | COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase). (322 aa) |
| | SU9_13870 | COG0077 Prephenate dehydratase. (308 aa) |
| | lysA-2 | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (487 aa) |
| | pat | Aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (359 aa) |
| | SU9_14106 | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (375 aa) |
| | SU9_14131 | HAD-superfamily hydrolase; COG0560 Phosphoserine phosphatase. (210 aa) |
| | SU9_14156 | Hypothetical protein; COG0454 Histone acetyltransferase HPA2 and related acetyltransferases. (150 aa) |
| | SU9_14446 | Aminotransferase, class I and II; COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities. (408 aa) |
| | SU9_14691 | Aminoglycoside phosphotransferase; COG2334 Putative homoserine kinase type II (protein kinase fold). (347 aa) |
| | SU9_15267 | COG2188 Transcriptional regulators. (251 aa) |
| | SU9_15272 | COG2188 Transcriptional regulators. (246 aa) |
| | SU9_15302 | korSA, regulatory protein; COG2188 Transcriptional regulators. (245 aa) |
| | SU9_15457 | Aminotransferase; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (392 aa) |
| | SU9_15492 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa) |
| | SU9_15719 | Hypothetical protein. (285 aa) |
| | SU9_15904 | COG0367 Asparagine synthase (glutamine-hydrolyzing). (680 aa) |
| | rex | Redox-sensing transcriptional repressor Rex; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (256 aa) |
| | SU9_16592 | COG0436 Aspartate/tyrosine/aromatic aminotransferase. (411 aa) |
| | SU9_16957 | 2-hydroxyacid family dehydrogenase; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (352 aa) |
| | SU9_17420 | Phospho-2-dehydro-3-deoxyheptonate aldolase; COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the class-II DAHP synthase family. (437 aa) |
| | SU9_17630 | Amidohydrolase; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. (442 aa) |
| | SU9_17650 | COG2188 Transcriptional regulators. (266 aa) |
| | ksgA | 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (323 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa) |
| | SU9_18231 | Cystathionine beta-synthase; COG0031 Cysteine synthase. (462 aa) |
| | SU9_18311 | Orn/DAP/Arg decarboxylase 2; COG0019 Diaminopimelate decarboxylase. (444 aa) |
| | SU9_19344 | COG2188 Transcriptional regulators. (256 aa) |
| | SU9_19680 | COG2188 Transcriptional regulators. (259 aa) |
| | SU9_19685 | COG2188 Transcriptional regulators. (180 aa) |
| | SU9_19732 | Acetolactate synthase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (557 aa) |
| | SU9_19792 | Hypothetical protein. (400 aa) |
| | gltA | COG0372 Citrate synthase; Belongs to the citrate synthase family. (429 aa) |
| | SU9_19862 | Hypothetical protein. (295 aa) |
| | SU9_20022 | COG1737 Transcriptional regulators. (289 aa) |
| | SU9_20032 | COG0174 Glutamine synthetase. (435 aa) |
| | asd-2 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (343 aa) |
| | SU9_20474 | COG0698 Ribose 5-phosphate isomerase RpiB. (161 aa) |
| | proB | Gamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (365 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (422 aa) |
| | SU9_20713 | Phosphoglycerate mutase; COG0406 Fructose-2,6-bisphosphatase; Belongs to the phosphoglycerate mutase family. (214 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (592 aa) |
| | SU9_21332 | COG1171 Threonine dehydratase. (336 aa) |
| | SU9_21382 | Amidohydrolase; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (421 aa) |
| | SU9_21875 | COG0454 Histone acetyltransferase HPA2 and related acetyltransferases. (161 aa) |
| | SU9_22155 | Hypothetical protein. (228 aa) |
| | SU9_22350 | COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Belongs to the DapA family. (321 aa) |
| | SU9_22455 | COG0174 Glutamine synthetase. (453 aa) |
| | SU9_22600 | Glutamate--ammonia ligase; COG0174 Glutamine synthetase. (340 aa) |
| | SU9_22645 | COG0174 Glutamine synthetase. (469 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (354 aa) |
| | pfp | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa) |
| | SU9_23030 | Phospho-2-dehydro-3-deoxyheptonate aldolase; COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the class-II DAHP synthase family. (416 aa) |
| | hisD | Bifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (440 aa) |
| | hisC | COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (376 aa) |
| | hisB | COG0131 Imidazoleglycerol-phosphate dehydratase. (197 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa) |
| | priA | Phosphoribosyl isomerase A; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (240 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (134 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (514 aa) |
| | trpC | COG0134 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (269 aa) |
| | trpB | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (428 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (272 aa) |
| | SU9_23520 | COG0067 Glutamate synthase domain 1. (1513 aa) |
| | gltD | COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. (486 aa) |
| | SU9_23630 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (478 aa) |
| | SU9_23917 | COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa) |
| | pgk | COG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (400 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (258 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (380 aa) |
| | SU9_23967 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (699 aa) |
| | dapD | Transferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (337 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (321 aa) |
| | SU9_24162 | Diaminobutyrate--2-oxoglutarate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (422 aa) |
| | SU9_24212 | Hypothetical protein; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. (398 aa) |
| | SU9_24532 | Putative phosphoserine phosphatase; COG3830 ACT domain-containing protein. (412 aa) |
| | SU9_24827 | Acetyltransferase; COG3393 Predicted acetyltransferase. (245 aa) |
| | SU9_25224 | COG0454 Histone acetyltransferase HPA2 and related acetyltransferases. (294 aa) |
| | SU9_25324 | N-acetyltransferase GCN5; COG0454 Histone acetyltransferase HPA2 and related acetyltransferases. (181 aa) |
| | SU9_25474 | Cys; COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (400 aa) |
| | SU9_26014 | Transferase; COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities. (392 aa) |
| | SU9_26129 | COG0287 Prephenate dehydrogenase. (367 aa) |
| | gltD-2 | COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. (501 aa) |
| | SU9_26654 | COG0367 Asparagine synthase (glutamine-hydrolyzing). (656 aa) |
| | SU9_26884 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1124 aa) |
| | SU9_27569 | N-acetyltransferase GCN5; COG0454 Histone acetyltransferase HPA2 and related acetyltransferases. (253 aa) |
| | SU9_27874 | Hypothetical protein; COG0454 Histone acetyltransferase HPA2 and related acetyltransferases. (263 aa) |
| | SU9_27974 | COG0019 Diaminopimelate decarboxylase. (82 aa) |
| | SU9_28461 | COG1605 Chorismate mutase. (210 aa) |
| | SU9_28591 | COG0019 Diaminopimelate decarboxylase. (415 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (156 aa) |
| | SU9_29091 | Lyase; COG0031 Cysteine synthase. (385 aa) |
| | SU9_29231 | COG2008 Threonine aldolase. (356 aa) |
| | SU9_29301 | COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (739 aa) |
| | SU9_29476 | Asparagine synthetase, glutamine-hydrolysing; COG3209 Rhs family protein. (913 aa) |
| | SU9_29481 | Hypothetical protein. (236 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa) |
| | SU9_29661 | COG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (363 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (185 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa) |
| | aroE | COG0169 Shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (275 aa) |
| | SU9_30056 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. (274 aa) |
| | argH | COG0165 Argininosuccinate lyase. (480 aa) |
| | argG | COG0137 Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (397 aa) |
| | argD | COG4992 Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (401 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (309 aa) |
| | argJ | Bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (383 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (342 aa) |
| | SU9_30429 | Lipoprotein; COG0560 Phosphoserine phosphatase. (422 aa) |
| | SU9_30444 | COG0174 Glutamine synthetase. (462 aa) |
| | SU9_30459 | Peptidase C26; COG2071 Predicted glutamine amidotransferases. (229 aa) |
| | SU9_30654 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1175 aa) |
| | SU9_30754 | Phosphoglycerate mutase; COG0406 Fructose-2,6-bisphosphatase. (232 aa) |
| | SU9_30804 | Hypothetical protein; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (441 aa) |
| | SU9_31026 | COG2188 Transcriptional regulators. (248 aa) |
| | SU9_31121 | COG0367 Asparagine synthase (glutamine-hydrolyzing). (616 aa) |
| | SU9_31316 | COG0287 Prephenate dehydrogenase. (361 aa) |
| | SU9_31321 | COG4401 Chorismate mutase. (120 aa) |
| | SU9_31988 | COG0110 Acetyltransferase (isoleucine patch superfamily). (178 aa) |
| | SU9_32248 | COG2188 Transcriptional regulators. (260 aa) |
| | pfkA-2 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa) |
| | SU9_32908 | IS110 family transposase; COG3547 Transposase and inactivated derivatives. (112 aa) |
| | SU9_33003 | Aminotransferase; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (372 aa) |
| | glyA-4 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (437 aa) |
| | SU9_33293 | Hypothetical protein; COG1357 Uncharacterized low-complexity proteins. (517 aa) |
| | SU9_33693 | Aminotransferase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. (346 aa) |
| | SU9_33718 | Aminoglycoside phosphotransferase. (315 aa) |
| | SU9_33753 | Phospho-2-dehydro-3-deoxyheptonate aldolase; COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the class-II DAHP synthase family. (396 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (1003 aa) |
