STRINGSTRING
AFH42038.1 AFH42038.1 AFH42103.1 AFH42103.1 AFH42106.1 AFH42106.1 AFH42108.1 AFH42108.1 AFH42111.1 AFH42111.1 eno eno AFH42130.1 AFH42130.1 AFH42168.1 AFH42168.1 AFH42179.1 AFH42179.1 AFH42180.1 AFH42180.1 AFH42191.1 AFH42191.1 AFH42216.1 AFH42216.1 gap gap pyrD pyrD AFH42270.1 AFH42270.1 AFH42271.1 AFH42271.1 pyrI pyrI pyrB pyrB pyrE pyrE AFH42275.1 AFH42275.1 AFH42309.1 AFH42309.1 AFH42310.1 AFH42310.1 AFH42311.1 AFH42311.1 AFH42316.1 AFH42316.1 AFH42317.1 AFH42317.1 AFH42318.1 AFH42318.1 AFH42319.1 AFH42319.1 AFH42326.1 AFH42326.1 AFH42330.1 AFH42330.1 AFH42333.1 AFH42333.1 sucD sucD sucC sucC AFH42371.1 AFH42371.1 AFH42372.1 AFH42372.1 AFH42373.1 AFH42373.1 AFH42381.1 AFH42381.1 gcvH gcvH AFH42392.1 AFH42392.1 pgk pgk AFH42408.1 AFH42408.1 AFH42412.1 AFH42412.1 AFH42413.1 AFH42413.1 AFH42414.1 AFH42414.1 AFH42415.1 AFH42415.1 AFH42418.1 AFH42418.1 AFH42419.1 AFH42419.1 AFH42428.1 AFH42428.1 AFH42479.1 AFH42479.1 AFH42541.1 AFH42541.1 AFH42542.1 AFH42542.1 purA purA AFH42545.1 AFH42545.1 purC purC AFH42547.1 AFH42547.1 AFH42548.1 AFH42548.1 purT purT purE purE AFH42551.1 AFH42551.1 purQ purQ purL purL purF purF AFH42555.1 AFH42555.1 AFH42556.1 AFH42556.1 AFH42557.1 AFH42557.1 purP purP AFH42559.1 AFH42559.1 AFH42580.1 AFH42580.1 AFH42585.1 AFH42585.1 AFH42596.1 AFH42596.1 AFH42597.1 AFH42597.1 AFH42603.1 AFH42603.1 AFH42667.1 AFH42667.1 AFH42705.1 AFH42705.1 AFH42715.1 AFH42715.1 AFH42722.1 AFH42722.1 AFH42756.1 AFH42756.1 AFH42769.1 AFH42769.1 ahcY ahcY AFH42776.1 AFH42776.1 AFH42789.1 AFH42789.1 mvk mvk AFH42821.1 AFH42821.1 AFH42835.1 AFH42835.1 AFH42840.1 AFH42840.1 AFH42845.1 AFH42845.1 AFH42850.1 AFH42850.1 AFH42875.1 AFH42875.1 AFH42876.1 AFH42876.1 AFH42878.1 AFH42878.1 AFH42884.1 AFH42884.1 tpiA tpiA AFH42894.1 AFH42894.1 AFH42895.1 AFH42895.1 AFH42920.1 AFH42920.1 AFH42921.1 AFH42921.1 AFH42922.1 AFH42922.1 fbp fbp AFH42962.1 AFH42962.1 AFH42968.1 AFH42968.1 prs prs AFH43010.1 AFH43010.1 AFH43011.1 AFH43011.1 AFH43012.1 AFH43012.1 glmS glmS AFH43027.1 AFH43027.1 AFH43095.1 AFH43095.1 AFH43119.1 AFH43119.1 AFH43129.1 AFH43129.1 AFH43157.1 AFH43157.1 AFH43161.1 AFH43161.1 AFH43177.1 AFH43177.1 AFH43180.1 AFH43180.1 AFH43192.1 AFH43192.1 AFH43193.1 AFH43193.1 AFH43194.1 AFH43194.1 AFH43195.1 AFH43195.1 htpX htpX AFH43201.1 AFH43201.1 AFH43216.1 AFH43216.1 lysA lysA AFH43225.1 AFH43225.1 AFH43226.1 AFH43226.1 AFH43236.1 AFH43236.1 AFH43254.1 AFH43254.1 AFH43288.1 AFH43288.1 AFH43364.1 AFH43364.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFH42038.1Putative asparagine synthetase. (259 aa)
AFH42103.1NADPH glutamate synthase. (335 aa)
AFH42106.1Haloacid dehalogenase-like (HAD) hydrolase. (198 aa)
AFH42108.1Putative ATP-fructose-6-phosphate kinase. (318 aa)
AFH42111.1Haloacid dehalogenase-like (HAD) hydrolase. (212 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
AFH42130.1Nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase. (506 aa)
AFH42168.14-aminobutyrate aminotransferase-related aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (440 aa)
AFH42179.1hydroxymethylglutaryl-CoA reductase, degradative; Belongs to the HMG-CoA reductase family. (427 aa)
AFH42180.1Gamma-glutamyltransferase. (514 aa)
AFH42191.1Arginine transporter. (302 aa)
AFH42216.1Dihydrodipicolinate synthase. (301 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase (phosphorylating). (347 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (308 aa)
AFH42270.1Dihydroorotase. (418 aa)
AFH42271.1Oxidoreductase FAD/NAD(P)-binding domain protein. (268 aa)
pyrIAspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (161 aa)
pyrBAspartate carbamoyltransferase catalytic subunit. (319 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (194 aa)
AFH42275.1Orotidine 5'-phosphate decarboxylase. (229 aa)
AFH42309.13-hydroxy-3-methylglutaryl CoA synthase; Belongs to the thiolase-like superfamily. UPF0219 family. (359 aa)
AFH42310.1Acetyl-CoA acetyltransferase. (386 aa)
AFH42311.1DUF35 domain containing protein. (133 aa)
AFH42316.12-oxoacid:ferredoxin oxidoreductase, beta subunit. (288 aa)
AFH42317.12-oxoacid:ferredoxin oxidoreductase, alpha subunit. (404 aa)
AFH42318.12-oxoacid:ferredoxin oxidoreductase, delta subunit. (98 aa)
AFH42319.12-oxoacid:ferredoxin oxidoreductase, gamma subunit. (195 aa)
AFH42326.1CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (225 aa)
AFH42330.1Pyruvate kinase; Belongs to the pyruvate kinase family. (461 aa)
AFH42333.1Pyruvate phosphate dikinase. (923 aa)
sucDSuccinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
sucCSuccinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (384 aa)
AFH42371.1Glycine dehydrogenase subunit 1. (452 aa)
AFH42372.1Hypothetical protein. (49 aa)
AFH42373.1Glycine dehydrogenase subunit 2. (445 aa)
AFH42381.1Glycine cleavage system aminomethyltransferase T. (371 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (137 aa)
AFH42392.1Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; Belongs to the phosphohexose mutase family. (452 aa)
pgk3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (415 aa)
AFH42408.1Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (320 aa)
AFH42412.1D-lactate dehydrogenase. (478 aa)
AFH42413.1Acyl-CoA synthetase (NDP forming), alpha subunit. (476 aa)
AFH42414.1Indolepyruvate:ferredoxin oxidoreductase subunit beta. (204 aa)
AFH42415.1Indolepyruvate:ferredoxin oxidoreductase subunit alpha; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (645 aa)
AFH42418.1Metalloexopeptidase, family M20. (422 aa)
AFH42419.1Transcriptional regulator, AbrB family. (141 aa)
AFH42428.1Nucleotidyl transferase. (427 aa)
AFH42479.1Bifunctional phosphoglucose/phosphomannose isomerase. (331 aa)
AFH42541.12-oxoacid:ferredoxin oxidoreductase, beta subunit. (311 aa)
AFH42542.12-oxoacid:ferredoxin oxidoreductase alpha subunit. (633 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (335 aa)
AFH42545.1FAD dependent oxidoreductase. (474 aa)
purCPhosphoribosylaminoimidazolesuccinocarboxamidesy nthase; Belongs to the SAICAR synthetase family. (245 aa)
AFH42547.1Amidophosphoribosyltransferase. (423 aa)
AFH42548.1Phosphoribosylamine--glycine ligase. (501 aa)
purTATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (404 aa)
purEPhosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (134 aa)
AFH42551.1Hypothetical protein. (78 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (224 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (730 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (476 aa)
AFH42555.1Phosphoribosylformylglycinamidine cyclo-ligase. (336 aa)
AFH42556.1IMP biosynthesis enzyme PurP-like protein. (369 aa)
AFH42557.1Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (451 aa)
purP5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (355 aa)
AFH42559.1Hypothetical protein. (68 aa)
AFH42580.1Nucleotidyl transferase. (235 aa)
AFH42585.1Pyruvate carboxylase subunit B. (456 aa)
AFH42596.1acetyl-CoA C-acyltransferase 7. (386 aa)
AFH42597.1DUF35 domain containing protein. (106 aa)
AFH42603.1Phosphoenolpyruvate carboxykinase-like protein. (594 aa)
AFH42667.1Aminotransferase, classes I and II. (398 aa)
AFH42705.1Putative phosphoserine phosphatase, SerB. (229 aa)
AFH42715.1Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (426 aa)
AFH42722.1Acyl-CoA synthetase (NDP forming), alpha subunit. (471 aa)
AFH42756.1Deoxyribose-phosphate aldolase. (239 aa)
AFH42769.1Threonine dehydratase. (417 aa)
ahcYS-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (416 aa)
AFH42776.1Pyridoxal-5'-phosphate-dependent protein beta subunit. (379 aa)
AFH42789.1HAD-superfamily hydrolase, subfamily IA, variant 1. (238 aa)
mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (335 aa)
AFH42821.1Asparagine synthetase. (641 aa)
AFH42835.1Phospho-sugar mutase; Belongs to the phosphohexose mutase family. (473 aa)
AFH42840.1Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (337 aa)
AFH42845.12, 5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase. (228 aa)
AFH42850.1Ribose-5-phosphate isomerase. (233 aa)
AFH42875.1Aminotransferase. (398 aa)
AFH42876.1Dihydrolipoamide dehydrogenase. (464 aa)
AFH42878.1Carbamate kinase-like carbamoyl phosphate synthetase. (321 aa)
AFH42884.1Nucleotidyl transferase. (248 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (231 aa)
AFH42894.1Amidinotransferase. (432 aa)
AFH42895.1Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (336 aa)
AFH42920.12-oxoacid:ferredoxin oxidoreductase, fused gamma and delta subunits. (374 aa)
AFH42921.12-oxoacid:ferredoxin oxidoreductase, alpha subunit. (412 aa)
AFH42922.12-oxoacid:ferredoxin oxidoreductase, beta subunit. (319 aa)
fbpFructose-1,6-bisphosphate phosphatase (type V); Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (366 aa)
AFH42962.1Glycerate kinase, putative. (454 aa)
AFH42968.1Dihydropteroate synthase-related protein. (547 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (292 aa)
AFH43010.1Indolepyruvate:ferredoxin oxidoreductase subunit beta. (203 aa)
AFH43011.1Indolepyruvate:ferredoxin oxidoreductase subunit alpha; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (636 aa)
AFH43012.1Acyl-CoA synthetase (NDP forming), alpha subunit. (457 aa)
glmSD-fructose-6-phosphate amidotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (626 aa)
AFH43027.1Sugar phosphate nucleotidyltransferase. (385 aa)
AFH43095.14-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (453 aa)
AFH43119.1Phosphoglycerate mutase. (426 aa)
AFH43129.1Serine hydroxymethyltransferase. (436 aa)
AFH43157.1Threonine synthase. (340 aa)
AFH43161.1Acylphosphatase; Belongs to the acylphosphatase family. (63 aa)
AFH43177.1SPP-like hydrolase. (264 aa)
AFH43180.1Pyridoxal phosphate-dependent acyltransferase, putative. (396 aa)
AFH43192.12-oxoacid:ferredoxin oxidoreductase, beta subunit. (318 aa)
AFH43193.12-oxoacid:ferredoxin oxidoreductase, alpha subunit. (408 aa)
AFH43194.12-oxoacid:ferredoxin oxidoreductase, delta subunit. (107 aa)
AFH43195.12-oxoacid:ferredoxin oxidoreductase, gamma subunit. (198 aa)
htpXEndopeptidase, family M48B; Belongs to the peptidase M48B family. (378 aa)
AFH43201.1Acyl-CoA synthetase (NDP forming), beta subunit. (238 aa)
AFH43216.1Glutamine synthetase. (465 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (378 aa)
AFH43225.1Hypothetical protein. (504 aa)
AFH43226.1FAD dependent oxidoreductase. (387 aa)
AFH43236.1D-3-phosphoglycerate dehydrogenase (serA); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa)
AFH43254.1Plant-type l-asparaginase (l-asparagine amidohydrolase). (291 aa)
AFH43288.1Putative amidohydrolase. (306 aa)
AFH43364.1Hypothetical protein. (90 aa)
Your Current Organism:
Fervidicoccus fontis
NCBI taxonomy Id: 1163730
Other names: Desulfurococcales archaeon Kam940, F. fontis Kam940, Fervidicoccus fontis DSM 19380, Fervidicoccus fontis Kam940, Fervidicoccus fontis str. Kam940, Fervidicoccus fontis strain Kam940
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