STRINGSTRING
FAES_0018 FAES_0018 FAES_0023 FAES_0023 gcvT gcvT FAES_0227 FAES_0227 FAES_0370 FAES_0370 FAES_0397 FAES_0397 FAES_0441 FAES_0441 FAES_0472 FAES_0472 FAES_0502 FAES_0502 FAES_0571 FAES_0571 FAES_0572 FAES_0572 FAES_0573 FAES_0573 FAES_0579 FAES_0579 FAES_0582 FAES_0582 FAES_0583 FAES_0583 FAES_0584 FAES_0584 FAES_0616 FAES_0616 FAES_0665 FAES_0665 FAES_0687 FAES_0687 FAES_0700 FAES_0700 FAES_0706 FAES_0706 paaE paaE FAES_0822 FAES_0822 FAES_0894 FAES_0894 accD accD fabH fabH FAES_0950 FAES_0950 FAES_0951 FAES_0951 FAES_0998 FAES_0998 proA proA FAES_1037 FAES_1037 qor2 qor2 pdhA pdhA purU purU FAES_1248 FAES_1248 proB proB merA1 merA1 FAES_1447 FAES_1447 FAES_1526 FAES_1526 FAES_1546 FAES_1546 merA3 merA3 fat fat FAES_1605 FAES_1605 FAES_1608 FAES_1608 FAES_1637 FAES_1637 FAES_1638 FAES_1638 FAES_1705 FAES_1705 FAES_1755 FAES_1755 FAES_1756 FAES_1756 FAES_1781 FAES_1781 FAES_1787 FAES_1787 FAES_1789 FAES_1789 FAES_1864 FAES_1864 FAES_1865 FAES_1865 FAES_1866 FAES_1866 FAES_1907 FAES_1907 sucD sucD FAES_1944 FAES_1944 FAES_1973 FAES_1973 FAES_2024 FAES_2024 FAES_2046 FAES_2046 FAES_2088 FAES_2088 accA accA pepA pepA FAES_2147 FAES_2147 FAES_2243 FAES_2243 FAES_2421 FAES_2421 mcnE mcnE FAES_2487 FAES_2487 FAES_2546 FAES_2546 FAES_2565 FAES_2565 FAES_2615 FAES_2615 icmF icmF FAES_2686 FAES_2686 coaE coaE FAES_2724 FAES_2724 FAES_2797 FAES_2797 FAES_2798 FAES_2798 FAES_2806 FAES_2806 FAES_2807 FAES_2807 FAES_2808 FAES_2808 FAES_2836 FAES_2836 birA birA FAES_2880 FAES_2880 fumC fumC mqo mqo FAES_2931 FAES_2931 FAES_2975 FAES_2975 FAES_3117 FAES_3117 FAES_3150 FAES_3150 FAES_3350 FAES_3350 FAES_3351 FAES_3351 qor3 qor3 FAES_3365 FAES_3365 FAES_3520 FAES_3520 FAES_3573 FAES_3573 FAES_3764 FAES_3764 FAES_3768 FAES_3768 alkH alkH FAES_3836 FAES_3836 fabH-2 fabH-2 FAES_4095 FAES_4095 FAES_4269 FAES_4269 FAES_4350 FAES_4350 FAES_4407 FAES_4407 FAES_4438 FAES_4438 FAES_4506 FAES_4506 gcvH gcvH mdh mdh FAES_4625 FAES_4625 FAES_4644 FAES_4644 FAES_4645 FAES_4645 FAES_4747 FAES_4747 FAES_4882 FAES_4882 FAES_4919 FAES_4919 fabF fabF sucC sucC FAES_5021 FAES_5021 FAES_5067 FAES_5067 FAES_5151 FAES_5151 FAES_5194 FAES_5194 FAES_5203 FAES_5203 pckA pckA FAES_5305 FAES_5305 gcvP gcvP FAES_5418 FAES_5418 FAES_5443 FAES_5443 FAES_5448 FAES_5448 FAES_5449 FAES_5449 FAES_5450 FAES_5450 mutA mutA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FAES_0018Beta-ketoacyl-acyl-carrier-protein synthase I. (312 aa)
FAES_0023Enoyl-CoA hydratase/isomerase. (272 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (377 aa)
FAES_0227acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
FAES_0370Putative czcO-like oxidoreductase. (424 aa)
FAES_0397Polyketide synthase. (1429 aa)
FAES_04414'-phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily. (311 aa)
FAES_0472Delta-1-pyrroline-5-carboxylate dehydrogenase. (542 aa)
FAES_0502Butyryl-CoA dehydrogenase. (389 aa)
FAES_0571Succinate dehydrogenase and fumarate reductase iron-sulfur protein. (258 aa)
FAES_0572Succinate dehydrogenase or fumarate reductase,flavoprotein subunit. (645 aa)
FAES_0573Succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family. (232 aa)
FAES_05793-hydroxyacyl-CoA dehydrogenase NAD-binding protein. (811 aa)
FAES_0582Short-chain dehydrogenase/reductase SDR; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa)
FAES_0583Enoyl-CoA hydratase. (156 aa)
FAES_0584Alpha/beta hydrolase fold protein. (266 aa)
FAES_0616Oxidoreductase FAD/NAD(P)-binding domain protein. (357 aa)
FAES_0665methylmalonyl-CoA mutase, large subunit. (749 aa)
FAES_0687Carbamoyl-phosphate synthase L chain ATP-binding protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (523 aa)
FAES_0700Amino acid adenylation domain protein. (1793 aa)
FAES_0706Amino acid adenylation domain protein. (2262 aa)
paaEPhenylacetic acid degradation NADH oxidoreductase. (351 aa)
FAES_0822Citrate synthase I; Belongs to the citrate synthase family. (427 aa)
FAES_0894Flavin-containing monooxygenase FMO. (371 aa)
accDacetyl-CoA carboxylase, carboxyl transferase,beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (350 aa)
fabH3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (327 aa)
FAES_0950acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (158 aa)
FAES_0951acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (469 aa)
FAES_0998Nitrilase. (315 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (416 aa)
FAES_1037Dihydrolipoamide dehydrogenase. (465 aa)
qor2NADPH2:quinone reductase. (324 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (348 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (286 aa)
FAES_1248Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (416 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (344 aa)
merA1Mercuric reductase. (482 aa)
FAES_1447Gamma-glutamyltransferase. (603 aa)
FAES_1526Glu/Leu/Phe/Val dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (426 aa)
FAES_1546Isocitrate dehydrogenase, NADP-dependent; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (424 aa)
merA3Mercuric reductase. (465 aa)
fatAcyl-ACP thioesterase. (260 aa)
FAES_1605acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
FAES_16083-hydroxyacyl-CoA dehydrogenase NAD-binding protein; Belongs to the enoyl-CoA hydratase/isomerase family. (716 aa)
FAES_1637Hypothetical protein. (338 aa)
FAES_1638Enoyl-(acyl-carrier-protein) reductase (NADH). (268 aa)
FAES_1705Short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (243 aa)
FAES_1755Electron transfer flavoprotein alpha subunit. (320 aa)
FAES_1756Electron transfer flavoprotein alpha/beta-subunit. (245 aa)
FAES_1781acyl-CoA dehydrogenase domain protein. (387 aa)
FAES_1787Isocitrate dehydrogenase. (478 aa)
FAES_1789Biotin/lipoyl attachment domain-containing protein. (165 aa)
FAES_1864Dihydrolipoamide dehydrogenase. (468 aa)
FAES_18652-oxoglutarate dehydrogenase, E2 subunit,dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (553 aa)
FAES_18662-oxoglutarate dehydrogenase, E1 subunit. (921 aa)
FAES_19073-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa)
FAES_1944Hydroxymethylglutaryl-CoA lyase. (271 aa)
FAES_1973Peptidase M1 membrane alanine aminopeptidase. (859 aa)
FAES_2024Catalytic domain of components of various dehydrogenase complexes. (475 aa)
FAES_2046acyl-CoA dehydrogenase domain protein. (598 aa)
FAES_2088Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (588 aa)
accAacetyl-CoA carboxylase, carboxyl transferase,alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa)
pepALeucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (488 aa)
FAES_2147Acyl-(acyl-carrier-protein) desaturase. (321 aa)
FAES_2243citronellyl-CoA dehydrogenase. (391 aa)
FAES_2421Enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (265 aa)
mcnEAmino acid adenylation domain protein. (880 aa)
FAES_2487acetoacetyl-CoA synthase. (661 aa)
FAES_2546Carboxyl transferase. (519 aa)
FAES_2565Fatty acid desaturase. (249 aa)
FAES_2615Fatty acid desaturase. (263 aa)
icmFMethylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1126 aa)
FAES_2686Aconitate hydratase. (754 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (200 aa)
FAES_2724acyl-CoA dehydrogenase domain protein. (408 aa)
FAES_2797acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (633 aa)
FAES_2798AMP-dependent synthetase and ligase. (638 aa)
FAES_2806Hypothetical protein. (223 aa)
FAES_2807Hypothetical protein. (131 aa)
FAES_2808acetyl-CoA hydrolase/transferase. (451 aa)
FAES_2836Hypothetical protein. (755 aa)
birABirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase. (254 aa)
FAES_2880Glutamate-ammonia ligase; Belongs to the glutamine synthetase family. (457 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
mqoMalate/quinone oxidoreductase. (536 aa)
FAES_2931Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase. (755 aa)
FAES_2975Aldehyde Dehydrogenase; Belongs to the aldehyde dehydrogenase family. (557 aa)
FAES_3117Aldehyde dehydrogenase (NAD(+)); Belongs to the aldehyde dehydrogenase family. (508 aa)
FAES_3150AMP-dependent synthetase and ligase. (562 aa)
FAES_3350Glutamate synthase (ferredoxin). (1533 aa)
FAES_3351Glutamate synthase, NADH/NADPH, small subunit. (496 aa)
qor3NADPH2:quinone reductase. (322 aa)
FAES_3365acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (431 aa)
FAES_3520Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1144 aa)
FAES_3573Peroxiredoxin; Belongs to the glutathione peroxidase family. (206 aa)
FAES_3764Glutamine synthetase catalytic region. (729 aa)
FAES_3768Glutamate-ammonia ligase; Belongs to the glutamine synthetase family. (340 aa)
alkHAldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (508 aa)
FAES_3836Glutamate-cysteine ligase GCS2; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (366 aa)
fabH-23-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (336 aa)
FAES_40954'-phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily. (216 aa)
FAES_4269Hypothetical protein. (744 aa)
FAES_4350Amidase; Belongs to the amidase family. (503 aa)
FAES_4407Methylcrotonoyl-CoA carboxylase. (539 aa)
FAES_4438AMP-dependent synthetase and ligase. (565 aa)
FAES_4506Enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (307 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (306 aa)
FAES_4625Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (325 aa)
FAES_4644MaoC domain protein dehydratase. (134 aa)
FAES_4645Metallophosphoesterase. (252 aa)
FAES_4747Gamma-glutamyltransferase. (568 aa)
FAES_4882Cytochrome P450. (450 aa)
FAES_4919Xylose isomerase domain protein TIM barrel. (301 aa)
fabF3-oxoacyl-(acyl-carrier-protein) synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (417 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (405 aa)
FAES_5021methylmalonyl-CoA epimerase. (138 aa)
FAES_5067AMP-dependent synthetase and ligase. (571 aa)
FAES_5151Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase. (267 aa)
FAES_5194acyl-CoA dehydrogenase domain protein. (599 aa)
FAES_5203Alcohol dehydrogenase GroES domain protein. (347 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (540 aa)
FAES_5305LAO/AO transport system ATPase. (332 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (975 aa)
FAES_5418Malonyl CoA-acyl carrier protein transacylase. (295 aa)
FAES_54435-oxoprolinase (ATP-hydrolyzing). (1253 aa)
FAES_5448Transketolase domain protein. (822 aa)
FAES_5449acyl-CoA dehydrogenase domain protein. (411 aa)
FAES_5450Acyl-CoA dehydrogenase family member 11 ACAD-11. (348 aa)
mutAmethylmalonyl-CoA mutase. (434 aa)
Your Current Organism:
Fibrella aestuarina
NCBI taxonomy Id: 1166018
Other names: F. aestuarina BUZ 2, Fibrella aestuarina BUZ 2, Fibrella aestuarina str. BUZ 2, Fibrella aestuarina strain BUZ 2, Flexibacteraceae bacterium BUZ 2
Server load: low (32%) [HD]