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| | iscS | Pyridoxal-dependent decarboxylase. (499 aa) |
| | FAES_0073 | Aminotransferase class I and II. (385 aa) |
| | thrC | Threonine synthase. (454 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (261 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (399 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (214 aa) |
| | trpC | Indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (275 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (328 aa) |
| | FAES_0484 | Glutamine amidotransferase of anthranilate synthase. (188 aa) |
| | FAES_0485 | Anthranilate synthase. (479 aa) |
| | mtnK | Methylthioribose kinase. (333 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (359 aa) |
| | FAES_0724 | Aminotransferase class I and II. (406 aa) |
| | trpF-2 | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (216 aa) |
| | FAES_1010 | Methionine synthase vitamin-B12 independent. (345 aa) |
| | pdxJ | Pyridoxal phosphate biosynthetic protein PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (240 aa) |
| | FAES_1179 | Aspartate kinase; Belongs to the aspartokinase family. (448 aa) |
| | FAES_1216 | Cysteine synthase B. (328 aa) |
| | FAES_1297 | Hypothetical protein. (236 aa) |
| | FAES_1445 | Aspartate kinase. (822 aa) |
| | asnB | Asparagine synthase (glutamine-hydrolysing). (617 aa) |
| | FAES_1627 | Aminotransferase class IV. (274 aa) |
| | FAES_1696 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (340 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (424 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (286 aa) |
| | FAES_1856 | Hypothetical protein. (219 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (258 aa) |
| | FAES_1963 | Peptidase M20. (361 aa) |
| | FAES_2036 | Hypothetical protein. (152 aa) |
| | FAES_2043 | Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (384 aa) |
| | FAES_2044 | Aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (324 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (264 aa) |
| | ilvE | Branched-chain amino acid aminotransferase. (294 aa) |
| | FAES_2531 | DAHP synthetase I/KDSA. (366 aa) |
| | FAES_2666 | L-asparaginase, type I. (350 aa) |
| | mtnN | S-adenosylhomocysteine/5'- methylthioadenosinenucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (257 aa) |
| | pabB | Para-aminobenzoate synthetase component I. (431 aa) |
| | hisB | Histidinol-phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (386 aa) |
| | FAES_2750 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (566 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (213 aa) |
| | FAES_2845 | Cystathionine gamma-lyase. (385 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (245 aa) |
| | mtn | S-adenosylhomocysteine/5'- methylthioadenosinenucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (276 aa) |
| | pabA | Anthranilate synthase component II. (191 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2, 6-carboxylateN-succinyltransferase. (158 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa) |
| | FAES_3479 | Argininosuccinate lyase. (419 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (418 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (174 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (316 aa) |
| | FAES_3688 | Aminotransferase class V. (338 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (370 aa) |
| | FAES_3703 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (319 aa) |
| | FAES_3799 | N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (206 aa) |
| | FAES_3832 | Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa) |
| | FAES_3839 | Cystathionine beta-synthase. (458 aa) |
| | FAES_3840 | Hypothetical protein. (261 aa) |
| | FAES_4047 | DNA (cytosine-5-)-methyltransferase. (709 aa) |
| | FAES_4077 | Cystathionine gamma-synthase. (372 aa) |
| | metZ | Methionine gamma-lyase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (411 aa) |
| | FAES_4159 | Aminotransferase class V; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (360 aa) |
| | FAES_4160 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (643 aa) |
| | FAES_4164 | O-acetylhomoserine/O-acetylserinesulfhydrylase. (438 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (353 aa) |
| | FAES_4365 | Aminotransferase class I and II. (403 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (326 aa) |
| | FAES_4399 | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (405 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (425 aa) |
| | FAES_4478 | Prephenate dehydrogenase. (285 aa) |
| | FAES_4479 | Aminotransferase class I and II. (387 aa) |
| | FAES_4781 | Serine O-acetyltransferase. (314 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (412 aa) |
| | FAES_4819 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein. (315 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. (608 aa) |
| | FAES_4825 | Aminotransferase class I and II. (400 aa) |
| | FAES_4828 | Chorismate mutase. (381 aa) |
| | FAES_4886 | Peptidase M23. (232 aa) |
| | FAES_4905 | Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (379 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (364 aa) |
| | FAES_4907 | Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (505 aa) |
| | FAES_4908 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (203 aa) |
| | FAES_4909 | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (484 aa) |
| | FAES_4924 | Ketol-acid reductoisomerase. (347 aa) |
| | FAES_4925 | Acetolactate synthase, small subunit. (177 aa) |
| | FAES_4926 | Acetolactate synthase, large subunit,biosynthetic type. (587 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (566 aa) |
| | hisI | phosphoribosyl-ATP diphosphatase; In the N-terminal section; belongs to the PRA-CH family. (208 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamideisomerase. (243 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (225 aa) |
| | cysS | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (501 aa) |
| | FAES_5085 | Branched-chain amino acid aminotransferase. (356 aa) |
| | FAES_5227 | Aspartate kinase; Belongs to the aspartokinase family. (422 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (436 aa) |
| | FAES_5376 | Shikimate dehydrogenase substrate binding domain protein. (251 aa) |
| | FAES_5383 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1259 aa) |
