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xdhA xdhA FAES_0106 FAES_0106 FAES_0107 FAES_0107 purH purH purD purD purQ purQ FAES_0428 FAES_0428 FAES_0488 FAES_0488 FAES_0491 FAES_0491 FAES_0675 FAES_0675 FAES_0683 FAES_0683 FAES_0753 FAES_0753 adk adk FAES_0835 FAES_0835 FAES_0939 FAES_0939 FAES_1222 FAES_1222 purN purN surE surE FAES_1872 FAES_1872 FAES_2038 FAES_2038 icc icc guaB guaB FAES_2257 FAES_2257 FAES_2494 FAES_2494 purE purE FAES_2525 FAES_2525 FAES_2526 FAES_2526 FAES_2527 FAES_2527 FAES_2581 FAES_2581 FAES_2648 FAES_2648 FAES_2649 FAES_2649 FAES_2650 FAES_2650 FAES_2832 FAES_2832 FAES_3070 FAES_3070 guaA guaA FAES_3316 FAES_3316 purC purC purL purL FAES_3825 FAES_3825 purS purS FAES_4141 FAES_4141 FAES_4144 FAES_4144 FAES_4171 FAES_4171 purA purA ade ade FAES_4508 FAES_4508 FAES_4610 FAES_4610 yagT yagT FAES_4687 FAES_4687 FAES_4688 FAES_4688 gmk gmk purK purK FAES_5384 FAES_5384 prsA prsA FAES_5487 FAES_5487
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
xdhAXanthine dehydrogenase YagR molybdenum-binding subunit. (753 aa)
FAES_0106Xanthine dehydrogenase YagS FAD-binding subunit. (331 aa)
FAES_0107Putative xanthine dehydrogenase yagT iron-sulfur-binding subunit. (210 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (523 aa)
purDPhosphoribosylamine/glycine ligase; Belongs to the GARS family. (427 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (229 aa)
FAES_0428Metallophosphoesterase; Belongs to the 5'-nucleotidase family. (310 aa)
FAES_0488Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (443 aa)
FAES_0491Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (825 aa)
FAES_0675Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (177 aa)
FAES_0683NUDIX hydrolase. (223 aa)
FAES_0753Metallophosphoesterase. (311 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (193 aa)
FAES_0835Pyruvate kinase; Belongs to the pyruvate kinase family. (479 aa)
FAES_0939Ribonucleoside-diphosphate reductase. (330 aa)
FAES_1222Non-canonical purine NTP pyrophosphatase,rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (200 aa)
purNPhosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (229 aa)
surEStationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (267 aa)
FAES_1872Adenylate/guanylate cyclase. (359 aa)
FAES_20385' nucleotidase. (215 aa)
iccIcc-like protein. (242 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)
FAES_2257MazG family protein. (262 aa)
FAES_2494Phosphoribosylformylglycinamidine cyclo-ligase. (412 aa)
purEPhosphoribosylaminoimidazole carboxylase,catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (157 aa)
FAES_2525Aldehyde oxidase and xanthine dehydrogenase molybdopterin binding protein. (746 aa)
FAES_2526Molybdopterin dehydrogenase FAD-binding protein. (339 aa)
FAES_2527Xanthine dehydrogenase YagT iron-sulfur-binding subunit. (211 aa)
FAES_2581Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I. (586 aa)
FAES_2648(2Fe-2S)-binding domain protein. (185 aa)
FAES_2649Molybdopterin dehydrogenase FAD-binding protein. (333 aa)
FAES_2650Aldehyde oxidase and xanthine dehydrogenase molybdopterin binding protein. (749 aa)
FAES_2832Ribose-phosphate pyrophosphokinase. (313 aa)
FAES_3070Ppx/GppA phosphatase. (318 aa)
guaAGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (510 aa)
FAES_3316Deoxynucleoside kinase. (204 aa)
purCPhosphoribosylaminoimidazolesuccinocarboxamidesy nthase; Belongs to the SAICAR synthetase family. (316 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (758 aa)
FAES_3825CMP/dCMP deaminase zinc-binding protein. (161 aa)
purSPhosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (83 aa)
FAES_4141Sulfate adenylyltransferase, small subunit. (298 aa)
FAES_4144Sulfate adenylyltransferase, large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (416 aa)
FAES_4171(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (752 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
adeAdenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (553 aa)
FAES_4508AMP nucleosidase. (257 aa)
FAES_4610Nucleoside-diphosphate kinase; Belongs to the NDK family. (139 aa)
yagTXanthine dehydrogenase YagT iron-sulfur-binding subunit. (262 aa)
FAES_4687Xanthine dehydrogenase YagS FAD-binding subunit. (335 aa)
FAES_4688Xanthine dehydrogenase YagR molybdenum-binding subunit. (706 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (199 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (411 aa)
FAES_5384Ppx/GppA phosphatase. (289 aa)
prsARibose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (302 aa)
FAES_5487Amidophosphoribosyltransferase. (682 aa)
Your Current Organism:
Fibrella aestuarina
NCBI taxonomy Id: 1166018
Other names: F. aestuarina BUZ 2, Fibrella aestuarina BUZ 2, Fibrella aestuarina str. BUZ 2, Fibrella aestuarina strain BUZ 2, Flexibacteraceae bacterium BUZ 2
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