STRINGSTRING
alaS alaS AFY99979.1 AFY99979.1 proS proS AFZ00011.1 AFZ00011.1 murQ murQ AFZ00062.1 AFZ00062.1 valS valS AFZ00081.1 AFZ00081.1 AFZ00086.1 AFZ00086.1 AFZ00099.1 AFZ00099.1 speA speA aroC aroC cobQ cobQ thrS thrS AFY99195.1 AFY99195.1 AFY99203.1 AFY99203.1 AFY99214.1 AFY99214.1 AFY99253.1 AFY99253.1 purQ purQ AFY99260.1 AFY99260.1 AFY99285.1 AFY99285.1 AFY99416.1 AFY99416.1 AFY99442.1 AFY99442.1 AFY99452.1 AFY99452.1 AFY99475.1 AFY99475.1 AFY99506.1 AFY99506.1 dapF dapF ilvA ilvA asnS asnS AFY99609.1 AFY99609.1 eno eno AFY99628.1 AFY99628.1 AFY99631.1 AFY99631.1 ilvC ilvC AFY99670.1 AFY99670.1 AFY99684.1 AFY99684.1 AFZ00155.1 AFZ00155.1 AFY99694.1 AFY99694.1 AFY99700.1 AFY99700.1 AFY99754.1 AFY99754.1 AFY99762.1 AFY99762.1 lipA lipA AFY99803.1 AFY99803.1 dxr dxr AFY99829.1 AFY99829.1 AFY99831.1 AFY99831.1 argC argC AFY99840.1 AFY99840.1 ispD ispD AFY99916.1 AFY99916.1 ispG ispG AFZ04485.1 AFZ04485.1 proC proC leuA-2 leuA-2 pgi pgi ilvE ilvE AFZ04365.1 AFZ04365.1 proB proB AFZ04349.1 AFZ04349.1 fabZ fabZ AFZ04239.1 AFZ04239.1 AFZ04234.1 AFZ04234.1 AFZ04199.1 AFZ04199.1 lysA lysA guaA guaA AFZ04177.1 AFZ04177.1 AFZ04165.1 AFZ04165.1 AFZ04121.1 AFZ04121.1 pheT pheT hisC hisC lipA-2 lipA-2 ispF ispF tyrS tyrS mtnB mtnB AFZ03930.1 AFZ03930.1 mtnD mtnD AFZ03895.1 AFZ03895.1 AFZ03892.1 AFZ03892.1 acpP acpP AFZ03890.1 AFZ03890.1 AFZ03880.1 AFZ03880.1 AFZ03833.1 AFZ03833.1 argJ argJ leuS leuS AFZ03783.1 AFZ03783.1 hisI hisI AFZ03756.1 AFZ03756.1 AFZ03755.1 AFZ03755.1 glyS glyS gpmI gpmI metG metG hisD-2 hisD-2 carB carB AFZ03525.1 AFZ03525.1 AFZ03522.1 AFZ03522.1 AFZ03501.1 AFZ03501.1 cysS cysS AFZ03481.1 AFZ03481.1 fabH fabH plsX plsX AFZ03408.1 AFZ03408.1 hisA hisA AFZ03383.1 AFZ03383.1 proA-2 proA-2 aroE aroE hisH hisH hisZ hisZ trpF trpF accA accA AFZ03277.1 AFZ03277.1 thrS-2 thrS-2 mtnP mtnP accD accD leuB leuB bioB bioB AFZ03206.1 AFZ03206.1 panD panD AFZ03201.1 AFZ03201.1 AFZ03196.1 AFZ03196.1 AFZ03181.1 AFZ03181.1 AFZ03168.1 AFZ03168.1 ileS ileS pheS pheS AFZ03141.1 AFZ03141.1 leuA leuA AFZ03104.1 AFZ03104.1 glk glk ispH ispH AFZ03002.1 AFZ03002.1 AFZ02990.1 AFZ02990.1 trpA trpA trpS trpS AFZ02941.1 AFZ02941.1 AFZ02916.1 AFZ02916.1 AFZ02891.1 AFZ02891.1 AFZ02842.1 AFZ02842.1 AFZ02817.1 AFZ02817.1 AFZ02782.1 AFZ02782.1 AFZ02761.1 AFZ02761.1 AFZ02758.1 AFZ02758.1 AFZ02752.1 AFZ02752.1 thrB thrB AFZ02738.1 AFZ02738.1 AFZ02726.1 AFZ02726.1 argD argD aroQ aroQ AFZ02690.1 AFZ02690.1 dapB dapB AFZ02681.1 AFZ02681.1 argS argS AFZ02645.1 AFZ02645.1 tpiA tpiA aroA aroA pyrG pyrG AFZ02572.1 AFZ02572.1 AFZ02570.1 AFZ02570.1 leuC leuC AFZ02568.1 AFZ02568.1 AFZ02565.1 AFZ02565.1 AFZ02478.1 AFZ02478.1 argB argB folD folD dapL dapL pdhA pdhA AFZ02395.1 AFZ02395.1 dapA dapA asd asd AFZ02345.1 AFZ02345.1 aspS aspS AFZ02307.1 AFZ02307.1 AFZ02306.1 AFZ02306.1 AFZ02289.1 AFZ02289.1 acsA acsA glmS glmS gltX gltX AFZ02258.1 AFZ02258.1 gcvP gcvP gcvH gcvH gcvT gcvT hisB hisB AFZ02219.1 AFZ02219.1 AFZ02212.1 AFZ02212.1 pgk pgk AFZ02163.1 AFZ02163.1 glyA glyA AFZ02111.1 AFZ02111.1 AFZ02068.1 AFZ02068.1 panB panB dtd3 dtd3 hisD hisD ilvD ilvD AFZ01930.1 AFZ01930.1 AFZ01919.1 AFZ01919.1 AFZ01913.1 AFZ01913.1 argG argG hisS hisS AFZ01859.1 AFZ01859.1 AFZ01821.1 AFZ01821.1 AFZ01695.1 AFZ01695.1 AFZ01577.1 AFZ01577.1 AFZ01576.1 AFZ01576.1 AFZ01468.1 AFZ01468.1 AFZ01416.1 AFZ01416.1 AFZ01371.1 AFZ01371.1 AFZ01370.1 AFZ01370.1 AFZ01349.1 AFZ01349.1 AFZ01242.1 AFZ01242.1 trpB trpB AFZ01117.1 AFZ01117.1 AFZ01112.1 AFZ01112.1 AFZ01080.1 AFZ01080.1 AFZ01035.1 AFZ01035.1 gloB gloB hisF hisF AFZ00989.1 AFZ00989.1 mtnA mtnA trpC trpC AFZ00971.1 AFZ00971.1 AFZ00962.1 AFZ00962.1 AFZ00951.1 AFZ00951.1 AFZ00939.1 AFZ00939.1 aroB aroB AFZ00906.1 AFZ00906.1 AFZ00845.1 AFZ00845.1 AFZ00842.1 AFZ00842.1 AFZ00837.1 AFZ00837.1 cbiA cbiA AFZ00804.1 AFZ00804.1 serS serS AFZ00733.1 AFZ00733.1 aroK aroK AFZ00731.1 AFZ00731.1 AFZ00730.1 AFZ00730.1 nadA nadA AFZ00711.1 AFZ00711.1 argH argH glyQ glyQ AFZ00580.1 AFZ00580.1 carA carA trpD trpD lysS lysS pheA pheA AFZ00551.1 AFZ00551.1 AFZ00536.1 AFZ00536.1 AFZ00530.1 AFZ00530.1 proA proA AFZ00495.1 AFZ00495.1 panC/cmk panC/cmk glsA glsA AFZ00477.1 AFZ00477.1 AFZ00467.1 AFZ00467.1 hisG hisG purF purF ppc ppc AFZ00294.1 AFZ00294.1 pyrB pyrB AFZ00292.1 AFZ00292.1 ispE ispE AFZ00221.1 AFZ00221.1 bioD bioD anmK anmK AFZ00208.1 AFZ00208.1 AFZ00174.1 AFZ00174.1 AFZ00167.1 AFZ00167.1 AFZ00165.1 AFZ00165.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
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alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (881 aa)
AFY99979.1Phosphoenolpyruvate synthase; PFAM: PEP-utilising enzyme, mobile domain; PEP-utilising enzyme, TIM barrel domain; Pyruvate phosphate dikinase, PEP/pyruvate binding domain; TIGRFAM: phosphoenolpyruvate synthase; COGs: COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; InterPro IPR002192:IPR008279:IPR000121; KEGG: ana:alr3397 phosphoenolpyruvate synthase; PFAM: PEP-utilising enzyme; PEP-utilising enzyme, mobile domain; Pyruvate phosphate dikinase, PEP/pyruvate-binding; PRIAM: Pyruvate, water dikinase; SPTR: Phosphoenolpyruvate synthase. (771 aa)
proSProlyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (602 aa)
AFZ00011.1Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (389 aa)
murQN-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (306 aa)
AFZ00062.13-mercaptopyruvate sulfurtransferase; PFAM: Rhodanese-like domain; COGs: COG2897 Rhodanese-related sulfurtransferase; InterPro IPR001763; KEGG: ava:Ava_1779 rhodanese-like protein; PFAM: Rhodanese-like; PRIAM: 3-mercaptopyruvate sulfurtransferase; SMART: Rhodanese-like; SPTR: Thiosulfate sulfurtransferase. (271 aa)
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (1021 aa)
AFZ00081.1PFAM: Methylenetetrahydrofolate reductase; COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: npu:Npun_R5069 methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (310 aa)
AFZ00086.1PFAM: Glycosyl transferase family, a/b domain; Glycosyl transferase family, helical bundle domain; COGs: COG0547 Anthranilate phosphoribosyltransferase; InterPro IPR017459; KEGG: npu:Npun_F1535 hypothetical protein; PFAM: Glycosyl transferase, family 3, N-terminal; SPTR: Glycosyl transferase, family 3. (358 aa)
AFZ00099.1PFAM: Orn/Lys/Arg decarboxylase, C-terminal domain; Orn/Lys/Arg decarboxylase, major domain; COGs: COG1982 Arginine/lysine/ornithine decarboxylase; InterPro IPR000310:IPR008286; KEGG: npu:Npun_F0489 Orn/Lys/Arg decarboxylase, major region; PFAM: Orn/Lys/Arg decarboxylase, major domain; Orn/Lys/Arg decarboxylase, C-terminal; PRIAM: Arginine decarboxylase; SPTR: Orn/Lys/Arg decarboxylase. (496 aa)
speAArginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (673 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (362 aa)
cobQAdenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (492 aa)
thrSSer-tRNA(Thr) hydrolase; PFAM: Anticodon binding domain; Threonyl and Alanyl tRNA synthetase second additional domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: threonyl-tRNA synthetase; COGs: COG0441 Threonyl-tRNA synthetase; InterPro IPR012947:IPR002314:IPR004154:IPR002320; KEGG: ava:Ava_B0226 threonyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; Threonyl/alanyl tRNA synthetase, SAD; Anticodon-binding; SMART: Threonyl/alanyl tRNA synthetase, SAD; SPTR: Threonyl-tRNA synthetase 2; TIGRFAM: Threonyl-tRNA synthetase, [...] (621 aa)
AFY99195.1PFAM: Proline dehydrogenase; Aldehyde dehydrogenase family; TIGRFAM: delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR002872:IPR015590:IPR005932; KEGG: ana:alr0540 1-pyrroline-5 carboxylate dehydrogenase; PFAM: Aldehyde dehydrogenase domain; Proline dehydrogenase; SPTR: 1-pyrroline-5 carboxylate dehydrogenase; TIGRFAM: Delta-1-pyrroline-5-carboxylate dehydrogenase 2; L-proline dehydrogenase. (990 aa)
AFY99203.1PFAM: FAD binding domain; FAD linked oxidases, C-terminal domain; COGs: COG0277 FAD/FMN-containing dehydrogenase; InterPro IPR006094:IPR004113; KEGG: npu:Npun_F0762 FAD linked oxidase domain-containing protein; PFAM: FAD linked oxidase, N-terminal; FAD-linked oxidase, C-terminal; SPTR: FAD linked oxidase domain protein. (432 aa)
AFY99214.1Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: ava:Ava_1347 cysteine synthase A; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cysteine synthase. (325 aa)
AFY99253.1PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; TIGRFAM: 4-hydroxyphenylpyruvate dioxygenase; COGs: COG3185 4-hydroxyphenylpyruvate dioxygenase and related hemolysins; InterPro IPR004360:IPR005956; KEGG: npu:Npun_R4104 4-hydroxyphenylpyruvate dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; PRIAM: 4-hydroxyphenylpyruvate dioxygenase; SPTR: 4-hydroxyphenylpyruvate dioxygenase; TIGRFAM: 4-hydroxyphenylpyruvate dioxygenase. (379 aa)
purQPhosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (223 aa)
AFY99260.1Hypothetical protein; PFAM: RNA ligase; TIGRFAM: RNA ligase, DRB0094 family; KEGG: hch:HCH_07016 hypothetical protein; SPTR: RNA ligase, DRB0094 family. (330 aa)
AFY99285.12-isopropylmalate synthase; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709:IPR005675; KEGG: npu:Npun_F4065 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; Pyruvate carboxyltransferase; PRIAM: (R)-citramalate synthase; SMART: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; SPTR: 2-isopropylmalate synt [...] (538 aa)
AFY99416.1KEGG: ana:alr3535 hypothetical protein; SPTR: Alr3535 protein. (32 aa)
AFY99442.1KEGG: clj:CLJU_c31420 hypothetical protein; SPTR: Putative uncharacterized protein. (70 aa)
AFY99452.1PFAM: Plasmid recombination enzyme; InterPro IPR001668; KEGG: npu:Npun_R3345 plasmid recombination enzyme; PFAM: Plasmid recombination enzyme; SPTR: Plasmid recombination enzyme. (531 aa)
AFY99475.1Cysteine desulfurase NifS; Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. (431 aa)
AFY99506.1KEGG: ana:all3315 hypothetical protein; SPTR: All3315 protein. (1461 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (279 aa)
ilvAL-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (503 aa)
asnSPFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; TIGRFAM: asparaginyl-tRNA synthetase; COGs: COG0017 Aspartyl/asparaginyl-tRNA synthetase; HAMAP: Asparaginyl-tRNA synthetase, class IIb; InterPro IPR004522:IPR004365:IPR004364; KEGG: ava:Ava_3630 asparaginyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (D/K/N); Nucleic acid binding, OB-fold, tRNA/helicase-type; PRIAM: Asparagine--tRNA ligase; SPTR: Asparaginyl-tRNA synthetase; TIGRFAM: Asparaginyl-tRNA synthetase, class IIb. (463 aa)
AFY99609.1GCN5-related N-acetyltransferase; PFAM: Acetyltransferase (GNAT) family; InterPro IPR000182; KEGG: geo:Geob_2059 GCN5-related N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase (GNAT) domain; SPTR: GCN5-related N-acetyltransferase. (162 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
AFY99628.1PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; COGs: COG0469 Pyruvate kinase; InterPro IPR001697:IPR015793:IPR015795:IPR008279; KEGG: ava:Ava_1694 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, C-terminal-like; PEP-utilising enzyme, mobile domain; PRIAM: Pyruvate kinase., Pyruvate, water dikinase; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase; Belongs to the pyruvate kinase family. (592 aa)
AFY99631.1Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (139 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa)
AFY99670.1Hypothetical protein; PFAM: Bacterial transferase hexapeptide (three repeats); COGs: COG1045 Serine acetyltransferase; InterPro IPR001451; KEGG: amr:AM1_5722 hypothetical protein; SPTR: Putative uncharacterized protein. (176 aa)
AFY99684.18-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (395 aa)
AFZ00155.1PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit; COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR004789:IPR002912:IPR019455; KEGG: npu:Npun_F1890 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT; PRIAM: Acetolactate synthase; SPTR: Acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit. (172 aa)
AFY99694.1Cysteine desulfurase; PFAM: Aminotransferase class-V; COGs: COG0520 Selenocysteine lyase; InterPro IPR000192; KEGG: npu:Npun_F1365 aminotransferase, class V; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Cysteine desulfurase; SPTR: L-cysteine/cystine lyase. (387 aa)
AFY99700.1Serine O-acetyltransferase; PFAM: Bacterial transferase hexapeptide (three repeats); TIGRFAM: serine O-acetyltransferase; COGs: COG1045 Serine acetyltransferase; InterPro IPR005881:IPR001451; KEGG: ana:all4037 serine acetyltransferase; PRIAM: Serine O-acetyltransferase; SPTR: Serine acetyltransferase; TIGRFAM: Serine O-acetyltransferase. (263 aa)
AFY99754.1Lactoylglutathione lyase; PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; TIGRFAM: lactoylglutathione lyase; COGs: COG0346 Lactoylglutathione lyase and related lyase; InterPro IPR004361:IPR004360; KEGG: npu:Npun_F3509 lactoylglutathione lyase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; PRIAM: Lactoylglutathione lyase; SPTR: Lactoylglutathione lyase; TIGRFAM: Glyoxalase I. (155 aa)
AFY99762.1KEGG: ana:all0864 carbon dioxide concentrating mechanism protein; SPTR: Carbon dioxide concentrating mechanism protein. (228 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (294 aa)
AFY99803.1Pyruvate dehydrogenase (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (415 aa)
AFY99829.1Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (416 aa)
AFY99831.1PFAM: Glutamine amidotransferases class-II; COGs: COG0121 glutamine amidotransferase; InterPro IPR000583; KEGG: ava:Ava_4720 glutamine amidotransferase, class-II; PFAM: Glutamine amidotransferase, class-II; SPTR: Glutamine amidotransferase, class-II; manually curated. (266 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (352 aa)
AFY99840.1Amidohydrolase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: amidohydrolase; COGs: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; InterPro IPR010168:IPR002933:IPR011650; KEGG: npu:Npun_F0970 amidohydrolase; PFAM: Peptidase M20; Peptidase M20, dimerisation; PRIAM: N-acetyldiaminopimelate deacetylase; SPTR: Amidohydrolase; TIGRFAM: Peptidase M20D, amidohydrolase. (392 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (226 aa)
AFY99916.1PFAM: Asparagine synthase; COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR001962; KEGG: rmr:Rmar_0967 asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; SPTR: Asparagine synthase (Glutamine-hydrolyzing). (617 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (408 aa)
AFZ04485.1Nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domain; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; TIGRFAM: nucleotide sugar dehydrogenase; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterPro IPR017476:IPR001732:IPR014026:IPR014027; KEGG: ana:alr0658 UDP-glucose dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal; PRIAM: UDP-glucose 6 [...] (461 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (556 aa)
pgiPFAM: Phosphoglucose isomerase; COGs: COG0166 Glucose-6-phosphate isomerase; HAMAP: Phosphoglucose isomerase (PGI); InterPro IPR001672; KEGG: ana:alr1050 glucose-6-phosphate isomerase; PFAM: Phosphoglucose isomerase (PGI); SPTR: Glucose-6-phosphate isomerase; Belongs to the GPI family. (528 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (304 aa)
AFZ04365.1Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (400 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (365 aa)
AFZ04349.1KEGG: ana:all4101 hypothetical protein; SPTR: Putative uncharacterized protein. (127 aa)
fabZ3-hydroxyacyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (169 aa)
AFZ04239.1Aspartoacylase; PFAM: Succinylglutamate desuccinylase / Aspartoacylase family; COGs: COG2988 Succinylglutamate desuccinylase; HAMAP: Aspartoacylase; InterPro IPR016708:IPR007036; KEGG: ava:Ava_1785 aspartoacylase; PFAM: Succinylglutamate desuccinylase/aspartoacylase; PRIAM: Aspartoacylase; SPTR: Probable aspartoacylase; Belongs to the AspA/AstE family. Aspartoacylase subfamily. (315 aa)
AFZ04234.1Assimilatory nitrite reductase (ferredoxin) precursor; PFAM: Nitrite and sulphite reductase 4Fe-4S domain; Nitrite/Sulfite reductase ferredoxin-like half domain; TIGRFAM: precorrin-3B synthase; COGs: COG0155 Sulfite reductase beta subunit (hemoprotein); InterPro IPR012798:IPR005117:IPR006067; KEGG: npu:Npun_F6481 precorrin-3B synthase; PFAM: Nitrite/sulphite reductase 4Fe-4S domain; Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like; PRIAM: Ferredoxin--nitrite reductase; SPTR: Precorrin-3B synthase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobG-like. (503 aa)
AFZ04199.1PFAM: Mandelate racemase / muconate lactonizing enzyme, C-terminal domain; Mandelate racemase / muconate lactonizing enzyme, N-terminal domain; COGs: COG4948 L-alanine-DL-glutamate epimerase; InterPro IPR013342:IPR013341; KEGG: ava:Ava_3512 mandelate racemase/muconate lactonizing protein; PFAM: Mandelate racemase/muconate lactonizing enzyme, C-terminal; Mandelate racemase/muconate lactonizing enzyme, N-terminal; SMART: Mandelate racemase/muconate lactonizing enzyme, C-terminal; SPTR: Mandelate racemase/muconate lactonizing enzyme. (350 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (465 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (540 aa)
AFZ04177.1Glycolate oxidase, subunit GlcD; PFAM: FAD binding domain; FAD linked oxidases, C-terminal domain; TIGRFAM: glycolate oxidase, subunit GlcD; COGs: COG0277 FAD/FMN-containing dehydrogenase; InterPro IPR006094:IPR004113:IPR004490; KEGG: ava:Ava_2520 glycolate oxidase subunit GlcD; PFAM: FAD-linked oxidase, C-terminal; FAD linked oxidase, N-terminal; PRIAM: D-lactate dehydrogenase (cytochrome); SPTR: Glycolate oxidase subunit GlcD; TIGRFAM: Glycolate oxidase subunit GlcD. (496 aa)
AFZ04165.1PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: ava:Ava_0949 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR: 7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. (165 aa)
AFZ04121.1KEGG: npu:Npun_R0010 hypothetical protein; SPTR: Putative uncharacterized protein. (519 aa)
pheTphenylalanyl-tRNA synthetase beta subunit; PFAM: tRNA synthetase B5 domain; B3/4 domain; Ferredoxin-fold anticodon binding domain; Putative tRNA binding domain; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; HAMAP: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; InterProIPR005146:IPR005147:IPR005121:IPR002547:IPR 004532; KEGG: ava:Ava_2221 phenylalanyl-tRNA synthetase subunit beta; PFAM: B3/B4 tRNA-binding domain; tRNA-binding domain; tRNA synthetase, B5; Phenylalanyl-tRNA synthet [...] (812 aa)
hisCPFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; HAMAP: Histidinol-phosphate aminotransferase; InterPro IPR004839:IPR005861; KEGG: ana:all4966 histidinol-phosphate aminotransferase; PFAM: Aminotransferase, class I/classII; PRIAM: Histidinol-phosphate transaminase; SPTR: Histidinol-phosphate aminotransferase 1; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (387 aa)
lipA-2Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (309 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (160 aa)
tyrStyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (398 aa)
mtnBMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (212 aa)
AFZ03930.1HAD-superfamily hydrolase, subfamily IB (PSPase-like); TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; COGs: COG4359 conserved hypothetical protein; InterPro IPR005834:IPR006384:IPR006383; KEGG: cyj:Cyan7822_3767 haloacid dehalogenase domain-containing protein hydrolase; PFAM: Haloacid dehalogenase-like hydrolase; SPTR: Hydrolase, haloacid dehalogenase-like protein; TIGRFAM: HAD-superfamily hydrolase, subfamily IB, PSPase-like; Pyridoxal phosphate phosphatase-related. (214 aa)
mtnDAcireductone dioxygenase apoprotein; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (184 aa)
AFZ03895.1Glyceraldehyde-3-phosphate dehydrogenase (NAD+); PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR020828:IPR020829:IPR006424; KEGG: ana:alr1095 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; PRIAM: Glyceraldehyde-3-phosphat [...] (339 aa)
AFZ03892.13-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (416 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (83 aa)
AFZ03890.1Succinate dehydrogenase subunit C; PFAM: Cysteine-rich domain; COGs: COG2048 Heterodisulfide reductase subunit B; InterPro IPR004017; KEGG: ava:Ava_3648 succinate dehydrogenase subunit C; PFAM: Cysteine-rich domain; PRIAM: CoB--CoM heterodisulfide reductase; SPTR: Succinate dehydrogenase subunit C. (304 aa)
AFZ03880.1Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (306 aa)
AFZ03833.1Cysteine desulfurase; PFAM: Aminotransferase class-V; TIGRFAM: cysteine desulfurases, SufSfamily; COGs: COG0520 Selenocysteine lyase; InterPro IPR000192:IPR010970; KEGG: npu:Npun_F4825 SufS subfamily cysteine desulfurase; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Cysteine desulfurase; SPTR: Cysteine desulfurase, SufS subfamily; TIGRFAM: Cysteine desulfurase, SufS; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (420 aa)
argJN-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (423 aa)
leuSPFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; TIGRFAM: leucyl-tRNA synthetase, eubacterial and mitochondrial family; COGs: COG0495 Leucyl-tRNA synthetase; InterPro IPR015413:IPR013155:IPR002302; KEGG: ana:alr3283 leucyl-tRNA synthetase; PFAM: Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding; Aminoacyl-tRNA synthetase, class I (M); PRIAM: Leucine--tRNA ligase; SPTR: Leucyl-tRNA synthetase; TIGRFAM: Leucyl-tRNA synthetase, class Ia, bacterial/mitochondrial. (861 aa)
AFZ03783.1Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; COGs: COG0031 Cysteine synthase; InterPro IPR001926:IPR005856:IPR005859; KEGG: ava:Ava_2508 cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cysteine synthase; TIGRFAM: Cysteine synthase A; Cysteine synthase K/M; Belongs to the cysteine synthase/cystathionine beta- synthase family. (320 aa)
hisIPFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphohydrolase; Histidine biosynthesis bifunctional protein HisIE; InterPro IPR002496:IPR021130:IPR023019:IPR008179; KEGG: ava:Ava_4918 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; PRIAM: Phosphoribosyl-AMP cyclohydrolase., Phosphoribosyl-ATP dip [...] (216 aa)
AFZ03756.1Chorismate lyase; PFAM: Protein of unknown function (DUF98); COGs: COG3161 4-hydroxybenzoate synthetase (chorismate lyase); KEGG: ava:Ava_0515 hypothetical protein; SPTR: Putative uncharacterized protein. (206 aa)
AFZ03755.1acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (452 aa)
glySPFAM: Glycyl-tRNA synthetase beta subunit; DALR anticodon binding domain; TIGRFAM: glycyl-tRNA synthetase, tetrameric type, beta subunit; COGs: COG0751 Glycyl-tRNA synthetase beta subunit; HAMAP: Glycyl-tRNA synthetase, class IIc, beta subunit; InterPro IPR002311:IPR015944; KEGG: ana:alr4111 glycyl-tRNA synthetase subunit beta; PFAM: Glycyl-tRNA synthetase, class IIc, beta subunit, N-terminal; PRIAM: Glycine--tRNA ligase; SPTR: Glycyl-tRNA synthetase beta subunit; TIGRFAM: Glycyl-tRNA synthetase, class IIc, beta subunit. (716 aa)
gpmIPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (533 aa)
metGmethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (533 aa)
hisD-2Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (427 aa)
carBPFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; MGS-like domain; Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; TIGRFAM: carbamoyl-phosphate synthase, large subunit; COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR005481:IPR005479:IPR005480:IPR011607:IPR 006275; KEGG: npu:Npun_R5798 carbamoyl phosphate synthase large subunit; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthase, large subunit, N-terminal; Carbamoy [...] (1083 aa)
AFZ03525.1AMP-dependent synthetase and ligase; PFAM: AMP-binding enzyme; COGs: COG1022 Long-chain acyl-CoA synthetase (AMP-forming); InterPro IPR000873; KEGG: ava:Ava_3173 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase/ligase; SPTR: AMP-dependent synthetase and ligase. (658 aa)
AFZ03522.1Dihydrolipoyllysine-residue acetyltransferase; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requiring enzyme; TIGRFAM: pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089:IPR004167:IPR001078; KEGG: ana:alr3606 branched-chain alpha-keto acid dehydrogenase subunit E2; PFAM: 2-oxoacid dehydrogenase acyltransferase, catalytic domain; Biotin/lipoyl attachment; E3 binding; PRIAM: Dihydrolipoylly [...] (431 aa)
AFZ03501.1PFAM: Beta-ketoacyl synthase, N-terminal domain; Beta-ketoacyl synthase, C-terminal domain; COGs: COG0304 3-oxoacyl-(acyl-carrier-protein) synthase; InterPro IPR014030:IPR014031:IPR020841; KEGG: npu:Npun_F3640 3-oxoacyl-(acyl carrier protein) synthase II; PFAM: Beta-ketoacyl synthase, C-terminal; Beta-ketoacyl synthase, N-terminal; PRIAM: Beta-ketoacyl-acyl-carrier-protein synthase I; SMART: Polyketide synthase, beta-ketoacyl synthase domain; SPTR: Beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (373 aa)
cysSPFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase; COGs: COG0215 Cysteinyl-tRNA synthetase; InterPro IPR015803:IPR015273; KEGG: ana:all1092 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase, class Ia; Cysteinyl-tRNA synthetase, class Ia, DALR; PRIAM: Cysteine--tRNA ligase; SMART: Cysteinyl-tRNA synthetase, class Ia, DALR; SPTR: Cysteinyl-tRNA synthetase; TIGRFAM: Cysteinyl-tRNA synthetase, class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family. (488 aa)
AFZ03481.1PFAM: Acyl transferase domain; TIGRFAM: malonyl CoA-acyl carrier protein transacylase; COGs: COG0331 (acyl-carrier-protein) S-malonyltransferase; InterPro IPR014043:IPR020801:IPR004410; KEGG: ava:Ava_2730 acyl-carrier-protein S-malonyltransferase; PFAM: Acyl transferase; PRIAM: [Acyl-carrier-protein] S-malonyltransferase; SMART: Polyketide synthase, acyl transferase domain; SPTR: Malonyl CoA-acyl carrier protein transacylase; TIGRFAM: Malonyl CoA-acyl carrier protein transacylase. (296 aa)
fabH3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (330 aa)
plsXPhosphate:acyl-(acyl carrier protein) acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (341 aa)
AFZ03408.1PFAM: Domain of unknown function DUF39; COGs: COG1900 conserved hypothetical protein; InterPro IPR002708; KEGG: ava:Ava_0664 hypothetical protein; PFAM: Domain of unknown function DUF39; SPTR: Putative uncharacterized protein. (389 aa)
hisA1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; InterPro IPR006062:IPR006063:IPR023016; KEGG: ava:Ava_3372 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; [...] (257 aa)
AFZ03383.1o-succinylbenzoate--CoA ligase; PFAM: AMP-binding enzyme; COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR000873; KEGG: naz:Aazo_1392 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase/ligase; PRIAM: o-succinylbenzoate--CoA ligase; SPTR: AMP-dependent synthetase and ligase. (435 aa)
proA-2Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (435 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (306 aa)
hisHImidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (211 aa)
hisZATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (403 aa)
trpFPFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; COGs: COG0135 Phosphoribosylanthranilate isomerase; InterPro IPR001240; KEGG: naz:Aazo_3378 phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Phosphoribosylanthranilate isomerase; SPTR: N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (220 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (326 aa)
AFZ03277.1acyl-ACP reductase; PFAM: short chain dehydrogenase; TIGRFAM: long-chain fatty acyl-ACP reductase (aldehyde-forming); COGs: COG5322 dehydrogenase; InterPro IPR002198; KEGG: ana:alr5284 hypothetical protein; PFAM: Short-chain dehydrogenase/reductase SDR; SPTR: Putative uncharacterized protein. (339 aa)
thrS-2threonyl-tRNA synthetase; PFAM: Anticodon binding domain; Threonyl and Alanyl tRNA synthetase second additional domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: threonyl-tRNA synthetase; COGs: COG0441 Threonyl-tRNA synthetase; InterPro IPR012947:IPR002320:IPR002314:IPR004154; KEGG: npu:Npun_F5857 threonyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; Threonyl/alanyl tRNA synthetase, SAD; Anticodon-binding; SMART: Threonyl/alanyl tRNA synthetase, SAD; SPTR: Threonyl-tRNA synthetase; TIGRFAM: Threonyl-tRNA synthetase, [...] (609 aa)
mtnPMethylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (290 aa)
accDAcetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (341 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (364 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (334 aa)
AFZ03206.1Aspartate ammonia-lyase; PFAM: Lyase; Fumarase C C-terminus; TIGRFAM: aspartate ammonia-lyase; COGs: COG1027 Aspartate ammonia-lyase; InterPro IPR022761:IPR018951; KEGG: npu:Npun_F2551 aspartate ammonia-lyase; PFAM: Lyase 1, N-terminal; Fumarase C, C-terminal; PRIAM: Aspartate ammonia-lyase; SPTR: Fumarate lyase. (477 aa)
panDL-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (129 aa)
AFZ03201.1Hypothetical protein; COGs: COG1235 Metal-dependent hydrolase of the beta-lactamase superfamily I; KEGG: npu:Npun_F2555 hypothetical protein; SPTR: Putative uncharacterized protein. (301 aa)
AFZ03196.1InterPro IPR001258; KEGG: npu:Npun_R2952 NHL repeat-containing protein; PFAM: NHL repeat; SPTR: NHL repeat containing protein. (723 aa)
AFZ03181.1KEGG: azl:AZL_023800 hypothetical protein; SPTR: Putative uncharacterized protein. (284 aa)
AFZ03168.1COGs: COG2515 1-aminocyclopropane-1-carboxylate deaminase; KEGG: naz:Aazo_0431 1-aminocyclopropane-1-carboxylate deaminase; SPTR: 1-aminocyclopropane-1-carboxylate deaminase. (310 aa)
ileSIsoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (964 aa)
pheSphenylalanyl-tRNA synthetase, alpha subunit; PFAM: tRNA synthetases class II core domain (F); Aminoacyl tRNA synthetase class II, N-terminal domain; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; COGs: COG0016 Phenylalanyl-tRNA synthetase alpha subunit; HAMAP: Phenylalanyl-tRNA synthetase alpha chain 1, bacterial; InterPro IPR004529:IPR022911:IPR004188:IPR002319; KEGG: npu:Npun_R0940 phenylalanyl-tRNA synthetase subunit alpha; PFAM: Phenylalanyl-tRNA synthetase; Phenylalanyl-tRNA synthetase, class II, N-terminal; SPTR: Phenylalanyl-tRNA synthetase alpha chain; TIGRFAM: Phenylala [...] (333 aa)
AFZ03141.1Beta-lactamase domain protein; COGs: COG1235 Metal-dependent hydrolase of the beta-lactamase superfamily I; InterPro IPR001279; KEGG: ava:Ava_2117 beta-lactamase-like; PFAM: Beta-lactamase-like; SPTR: Putative uncharacterized protein. (294 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (534 aa)
AFZ03104.1PFAM: Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase/PNT, N-terminal domain; TIGRFAM: alanine dehydrogenase; COGs: COG0686 Alanine dehydrogenase; InterPro IPR008141:IPR007886:IPR007698; KEGG: ava:Ava_0176 L-alanine dehydrogenase; PFAM: Alanine dehydrogenase/PNT, C-terminal; Alanine dehydrogenase/PNT, N-terminal; PRIAM: Alanine dehydrogenase; SPTR: L-alanine dehydrogenase; TIGRFAM: Alanine dehydrogenase/pyridine nucleotide transhydrogenase; Belongs to the AlaDH/PNT family. (363 aa)
glkPFAM: Glucokinase; TIGRFAM: glucokinase, proteobacterial type; COGs: COG0837 Glucokinase; HAMAP: Glucokinase; InterPro IPR003836; KEGG: ana:alr2973 glucokinase; PFAM: Glucokinase; SPTR: Glucokinase; TIGRFAM: Glucokinase; Belongs to the bacterial glucokinase family. (344 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (402 aa)
AFZ03002.1PFAM: Protein of unknown function (DUF1565); S-layer homology domain; TIGRFAM: parallel beta-helix repeat (two copies); InterPro IPR006626:IPR011459:IPR001119; KEGG: ana:alr2090 hypothetical protein; PFAM: Domain of unknown function DUF1565; S-layer homology domain; SPTR: Alr2090 protein. (550 aa)
AFZ02990.1Arogenate dehydrogenase (NADP); PFAM: Prephenate dehydrogenase; COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099; KEGG: ava:Ava_4397 arogenate dehydrogenase; PFAM: Prephenate dehydrogenase; PRIAM: Prephenate dehydrogenase; SPTR: Arogenate dehydrogenase (NADP). (279 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (266 aa)
trpStryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (335 aa)
AFZ02941.1Hypothetical protein; COGs: COG2220 Zn-dependent hydrolase of the beta-lactamase fold; KEGG: npu:Npun_F1348 hypothetical protein; SPTR: Putative uncharacterized protein. (256 aa)
AFZ02916.1PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, prokaryotic type; COGs: COG0538 Isocitrate dehydrogenase; InterPro IPR004439:IPR001804; KEGG: ana:alr1827 isocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NADP(+)); SPTR: Isocitrate dehydrogenase [NADP]; TIGRFAM: Isocitrate dehydrogenase NADP-dependent, prokaryotic. (472 aa)
AFZ02891.1Cysteine desulfurase; PFAM: Aminotransferase class-V; COGs: COG0520 Selenocysteine lyase; InterPro IPR000192; KEGG: npu:Npun_R4000 aminotransferase, class V; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Cysteine desulfurase; SPTR: Aminotransferase, class V. (485 aa)
AFZ02842.1Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; COGs: COG0031 Cysteine synthase; InterPro IPR005856:IPR005859:IPR001926; KEGG: ava:Ava_0452 cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cysteine synthase; TIGRFAM: Cysteine synthase A; Cysteine synthase K/M; Belongs to the cysteine synthase/cystathionine beta- synthase family. (319 aa)
AFZ02817.1KEGG: npu:Npun_R4080 hypothetical protein; SPTR: Putative uncharacterized protein. (149 aa)
AFZ02782.1PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain; COGs: COG0460 Homoserine dehydrogenase; InterPro IPR005106:IPR001342:IPR002912; KEGG: naz:Aazo_4841 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; SPTR: Homoserine dehydrogenase. (463 aa)
AFZ02761.1PFAM: Protein of unknown function (DUF1565); TIGRFAM: parallel beta-helix repeat (two copies); InterPro IPR006633:IPR006626:IPR011459; KEGG: ana:all1342 hypothetical protein; PFAM: Domain of unknown function DUF1565; SMART: Carbohydrate-binding/sugar hydrolysis domain; Parallel beta-helix repeat; SPTR: All1342 protein. (594 aa)
AFZ02758.1PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit; D-3-phosphoglycerate dehydrogenase; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006236:IPR006139:IPR006140:IPR002912; KEGG: ana:alr1890 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Amino acid-binding ACT; PRIAM: [...] (526 aa)
AFZ02752.1PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; COGs: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenase; InterPro IPR013154:IPR013149; KEGG: npu:Npun_R2418 alcohol dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, C-terminal; SPTR: Alcohol dehydrogenase GroES domain protein. (398 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
AFZ02738.1Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1176 aa)
AFZ02726.1Succinate-semialdehyde dehydrogenase (NAD(P)(+)); PFAM: Aldehyde dehydrogenase family; COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590; KEGG: ana:all3556 succinate-semialdehyde dehydrogenase; PFAM: Aldehyde dehydrogenase domain; PRIAM: Succinate-semialdehyde dehydrogenase (NAD(P)(+)); SPTR: Succinate-semialdehyde dehydrogenase. (460 aa)
argDPFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine transaminases; COGs: COG4992 Ornithine/acetylornithine aminotransferase; HAMAP: Acetylornithine/succinyldiaminopimelate aminotransferase; InterPro IPR004636:IPR005814; KEGG: npu:Npun_R4958 acetylornithine aminotransferase; PFAM: Aminotransferase class-III; PRIAM: Acetylornithine transaminase; SPTR: Acetylornithine and succinylornithine aminotransferase; TIGRFAM: Acetylornithine/succinylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (425 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (161 aa)
AFZ02690.16-phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (476 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (278 aa)
AFZ02681.1KEGG: ava:Ava_0475 hypothetical protein; SPTR: Putative uncharacterized protein. (251 aa)
argSarginyl-tRNA synthetase; PFAM: DALR anticodon binding domain; Arginyl tRNA synthetase N terminal domain; tRNA synthetases class I (R); TIGRFAM: arginyl-tRNA synthetase; COGs: COG0018 Arginyl-tRNA synthetase; HAMAP: Arginyl-tRNA synthetase, class Ic; InterPro IPR008909:IPR005148:IPR015945:IPR001278; KEGG: naz:Aazo_2060 arginyl-tRNA synthetase; PFAM: Arginyl-tRNA synthetase, class Ic, core; Arginyl tRNA synthetase, class Ic, N-terminal; DALR anticodon binding; PRIAM: Arginine--tRNA ligase; SMART: DALR anticodon binding; SPTR: Arginyl-tRNA synthetase; TIGRFAM: Arginyl-tRNA synthetase, class Ic. (585 aa)
AFZ02645.1GCN5-related N-acetyltransferase; PFAM: Acetyltransferase (GNAT) family; InterPro IPR000182; KEGG: ana:alr2925 hypothetical protein; PFAM: GCN5-related N-acetyltransferase (GNAT) domain; SPTR: Alr2925 protein. (163 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (231 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (455 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (550 aa)
AFZ02572.1PFAM: Bacterial transferase hexapeptide (three repeats); COGs: COG1045 Serine acetyltransferase; InterPro IPR001451; KEGG: cyj:Cyan7822_3995 serine O-acetyltransferase; PFAM: Bacterial transferase hexapeptide repeat; SPTR: Bacterial transferase hexapeptide repeat protein. (193 aa)
AFZ02570.13-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (194 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (468 aa)
AFZ02568.1KEGG: amr:AM1_A0073 hypothetical protein; SPTR: Putative uncharacterized protein. (327 aa)
AFZ02565.1PFAM: Lipoxygenase; InterPro IPR013819; KEGG: npu:Npun_F6548 lipoxygenase-like protein; PFAM: Lipoxygenase, C-terminal; PRIAM: Arachidonate 15-lipoxygenase; SPTR: Lipoxygenase-like protein. (631 aa)
AFZ02478.1PFAM: Radical SAM superfamily; Domain of unknown function (DUF3463); TIGRFAM: hopanoid biosynthesis associated radical SAM protein HpnH; COGs: COG0535 Fe-S oxidoreductase; InterPro IPR007197:IPR017833; KEGG: ava:Ava_1219 radical SAM family protein; PFAM: Radical SAM; SPTR: Radical SAM; TIGRFAM: Hopanoid biosynthesis associated radical SAM protein HpnH. (339 aa)
argBN-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (298 aa)
folD5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa)
dapLLL-diaminopimelate aminotransferase apoenzyme; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (408 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (344 aa)
AFZ02395.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (359 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (347 aa)
AFZ02345.1Aspartate kinase; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; COGs: COG0527 Aspartokinase; InterPro IPR001048:IPR002912:IPR005260:IPR001341; KEGG: npu:Npun_R4597 aspartate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; SPTR: Aspartokinase; TIGRFAM: Aspartate kinase domain; Aspartate kinase, monofunctional class. (598 aa)
aspSaspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (595 aa)
AFZ02307.1Acetolactate synthase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001:IPR012000:IPR011766; KEGG: npu:Npun_F2094 thiamine pyrophosphate binding domain-containing protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; PRIAM: Acetolactate synthase; SPTR: Thiamine py [...] (598 aa)
AFZ02306.1PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; COGs: COG0332 3-oxoacyl-(acyl-carrier-protein); InterPro IPR013751:IPR013747; KEGG: npu:Npun_R5302 3-oxoacyl-(acyl-carrier-protein) synthase III; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal; PRIAM: Beta-ketoacyl-acyl-carrier-protein synthase III; SPTR: 3-Oxoacyl-(Acyl-carrier-protein (ACP)) synthase III. (367 aa)
AFZ02289.1L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (363 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa)
glmSGlucosamine--fructose-6-phosphate aminotransferase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (635 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (484 aa)
AFZ02258.1L-iditol 2-dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; COGs: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenase; InterPro IPR013154:IPR013149:IPR020843; KEGG: npu:Npun_F2709 alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like; PRIAM: L-iditol 2-dehydrogenase; SMART: Polyketide synthase, enoylreductase; SPTR: Alcohol dehydrogenase GroES domain protein. (342 aa)
gcvPGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (374 aa)
hisBPFAM: Imidazoleglycerol-phosphate dehydratase; COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807; KEGG: npu:Npun_R5509 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase. (209 aa)
AFZ02219.1Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001:IPR012000:IPR011766:IPR012846; KEGG: npu:Npun_R1735 acetolactate synthase 3 catalytic subunit; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enz [...] (633 aa)
AFZ02212.1Enoyl-(acyl-carrier-protein) reductase (NADH); PFAM: short chain dehydrogenase; COGs: COG0623 Enoyl-(acyl-carrier-protein); InterPro IPR002198; KEGG: npu:Npun_R5510 enoyl-(acyl carrier protein) reductase; PFAM: Short-chain dehydrogenase/reductase SDR; PRIAM: Enoyl-[acyl-carrier-protein] reductase (NADH); SPTR: Enoyl-(Acyl carrier protein) reductase. (258 aa)
pgkPFAM: Phosphoglycerate kinase; COGs: COG0126 3-phosphoglycerate kinase; HAMAP: Phosphoglycerate kinase; InterPro IPR001576; KEGG: ava:Ava_0772 phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa)
AFZ02163.1Ureidoglycolate lyase; PFAM: Domain of unknown function (DUF2437); Fumarylacetoacetate (FAA) hydrolase family; COGs: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1 7-dioic acid hydratase (catechol pathway); InterPro IPR002529; KEGG: ana:alr4803 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; PFAM: Fumarylacetoacetase, C-terminal-like; PRIAM: Ureidoglycolate lyase; SPTR: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase. (257 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (427 aa)
AFZ02111.1PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006096:IPR006097; KEGG: npu:Npun_F3641 Glu/Leu/Phe/Val dehydrogenase, C terminal; PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain; PRIAM: Glutamate dehydrogenase (NAD(P)(+)); SMART: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; SPTR: Glu/Leu/Phe/Val dehydrogenase, C terminal; Belongs to t [...] (428 aa)
AFZ02068.1Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (196 aa)
panBKetopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (257 aa)
dtd3Sec-independent protein translocase TatD; Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr). (261 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa)
ilvDPFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; HAMAP: Dihydroxy-acid dehydratase; InterPro IPR004404:IPR000581; KEGG: ana:alr2771 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (562 aa)
AFZ01930.1FAD linked oxidase domain protein; PFAM: FAD binding domain; COGs: COG0277 FAD/FMN-containing dehydrogenase; InterPro IPR006094; KEGG: ana:all4443 hypothetical protein; PFAM: FAD linked oxidase, N-terminal; SPTR: All4443 protein. (443 aa)
AFZ01919.1PFAM: Radical SAM superfamily; Protein of unknown function (DUF3641); TIGRFAM: radical SAM/Cys-rich domain protein; COGs: COG0535 Fe-S oxidoreductase; InterPro IPR007197; KEGG: ava:Ava_3799 radical SAM family protein; PFAM: Radical SAM; SPTR: Radical SAM. (332 aa)
AFZ01913.13-deoxy-D-arabinoheptulosonate-7-phosphate synthase; PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006268:IPR006218; KEGG: npu:Npun_F0725 3-deoxy-7-phosphoheptulonate synthase; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; SPTR: Phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2. (351 aa)
argGPFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; COGs: COG0137 Argininosuccinate synthase; HAMAP: Argininosuccinate synthase; InterPro IPR001518; KEGG: ava:Ava_2068 argininosuccinate synthase; PFAM: Argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: Argininosuccinate synthase; TIGRFAM: Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (399 aa)
hisSPFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: histidyl-tRNA synthetase; COGs: COG0124 Histidyl-tRNA synthetase; HAMAP: Histidyl-tRNA synthetase, class IIa, subgroup; InterPro IPR015807:IPR002314:IPR004154; KEGG: npu:Npun_R5420 histidyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; Anticodon-binding; PRIAM: Histidine--tRNA ligase; SPTR: Histidyl-tRNA synthetase; TIGRFAM: Histidyl-tRNA synthetase, class IIa, subgroup. (468 aa)
AFZ01859.1LL-diaminopimelate aminotransferase apoenzyme; PFAM: Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: ava:Ava_0017 aspartate aminotransferase; PFAM: Aminotransferase, class I/classII; PRIAM: LL-diaminopimelate aminotransferase; SPTR: LL-diaminopimelate aminotransferase apoenzyme. (394 aa)
AFZ01821.1NADPH:quinone reductase; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; COGs: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductase; InterPro IPR020843:IPR013154:IPR013149; KEGG: amr:AM1_6100 zinc-binding oxidoreductase, putative; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like; PRIAM: NADPH:quinone reductase; SMART: Polyketide synthase, enoylreductase; SPTR: Zinc-binding oxidoreductase, putative. (335 aa)
AFZ01695.1PFAM: Plasmid recombination enzyme; InterPro IPR001668; KEGG: npu:Npun_R3345 plasmid recombination enzyme; PFAM: Plasmid recombination enzyme; SPTR: Plasmid recombination enzyme. (535 aa)
AFZ01577.1Diaminobutyrate aminotransferase apoenzyme; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (416 aa)
AFZ01576.16-deoxyerythronolide-B synthase, Aspartate racemase; PFAM: Phosphopantetheine attachment site; Acyl transferase domain; KR domain; Beta-ketoacyl synthase, N-terminal domain; Condensation domain; Beta-ketoacyl synthase, C-terminal domain; COGs: COG3321 Polyketide synthase modules and related protein; InterProIPR020841:IPR020801:IPR020842:IPR014030:IPR 014031:IPR014043:IPR013968:IPR006163:IPR001242; KEGG: npu:Npun_R3425 beta-ketoacyl synthase; PFAM: Beta-ketoacyl synthase, N-terminal; Beta-ketoacyl synthase, C-terminal; Acyl transferase; Polyketide synthase, KR; Phosphopantetheine-bindin [...] (2042 aa)
AFZ01468.1PFAM: Acetyltransferase (GNAT) family; InterPro IPR000182; KEGG: ana:alr3535 hypothetical protein; PFAM: GCN5-related N-acetyltransferase (GNAT) domain; SPTR: Alr3535 protein. (170 aa)
AFZ01416.1Long-chain-fatty-acid--CoA ligase; PFAM: AMP-binding enzyme; COGs: COG1022 Long-chain acyl-CoA synthetase (AMP-forming); InterPro IPR000873; KEGG: npu:Npun_F6411 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase/ligase; PRIAM: Long-chain-fatty-acid--CoA ligase; SPTR: AMP-binding enzyme, putative. (657 aa)
AFZ01371.1PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; COGs: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenase; InterPro IPR013154:IPR013149; KEGG: srm:SRM_00889 IMP dehydrogenase / GMP reductase domain, putative; PFAM: Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, C-terminal; SPTR: IMP dehydrogenase / GMP reductase domain, putative. (342 aa)
AFZ01370.1PFAM: Streptococcal 67 kDa myosin-cross-reactive antigen like family; COGs: COG4716 Myosin-crossreactive antigen; InterPro IPR010354; KEGG: bbt:BBta_4626 myosin-cross-reactive antigen; PFAM: Streptococcal 67kDa myosin-cross-reactive antigen-like; SPTR: Putative class II antigen. (523 aa)
AFZ01349.1PFAM: Acetyltransferase (GNAT) family; InterPro IPR000182; KEGG: ana:alr3535 hypothetical protein; PFAM: GCN5-related N-acetyltransferase (GNAT) domain; SPTR: Alr3535 protein. (170 aa)
AFZ01242.1KEGG: mmi:MMAR_4432 hypothetical protein; SPTR: Putative uncharacterized protein. (245 aa)
trpBTryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (411 aa)
AFZ01117.13-deoxy-D-arabinoheptulosonate-7-phosphate synthase; PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006268:IPR006218; KEGG: ana:alr3050 3-deoxy-7-phosphoheptulonate synthase; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; SPTR: 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2. (279 aa)
AFZ01112.1L-iditol 2-dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; COGs: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenase; InterPro IPR013154:IPR013149:IPR020843; KEGG: ava:Ava_0154 zinc-containing alcohol dehydrogenase superfamily protein; PFAM: Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, C-terminal; PRIAM: L-iditol 2-dehydrogenase; SMART: Polyketide synthase, enoylreductase; SPTR: Zinc-containing alcohol dehydrogenase superfamily. (353 aa)
AFZ01080.1PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; TIGRFAM: nucleotide sugar dehydrogenase; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterPro IPR001732:IPR014026; KEGG: cyj:Cyan7822_5295 nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; PRIAM: UDP-glucose 6-dehydrogenase; SPTR: Nucleotide sugar dehydrogenase. (251 aa)
AFZ01035.1PFAM: Acetyltransferase (GNAT) family; InterPro IPR000182; KEGG: ana:alr3535 hypothetical protein; PFAM: GCN5-related N-acetyltransferase (GNAT) domain; SPTR: Alr3535 protein. (168 aa)
gloBHydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (257 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (262 aa)
AFZ00989.1PFAM: Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR000583:IPR001962; KEGG: amr:AM1_1915 asparagine synthase, putative; PFAM: Asparagine synthase; Glutamine amidotransferase, class-II; SPTR: Asparagine synthase, putative. (679 aa)
mtnAMethylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (354 aa)
trpCPFAM: Indole-3-glycerol phosphate synthase; COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR013798; KEGG: ava:Ava_1926 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; PRIAM: Indole-3-glycerol-phosphate synthase; SPTR: Indole-3-glycerol phosphate synthase 1; Belongs to the TrpC family. (300 aa)
AFZ00971.1Serine--glyoxylate transaminase; PFAM: Aminotransferase class-V; COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; InterPro IPR000192; KEGG: npu:Npun_F4157 aminotransferase, class V; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Serine--glyoxylate transaminase; SPTR: Aminotransferase, class V. (385 aa)
AFZ00962.1Hypothetical protein; COGs: COG2220 Zn-dependent hydrolase of the beta-lactamase fold; KEGG: ava:Ava_2296 hypothetical protein; SPTR: Putative uncharacterized protein. (258 aa)
AFZ00951.1PFAM: Radical SAM superfamily; COGs: COG0535 Fe-S oxidoreductase; InterPro IPR007197; KEGG: amr:AM1_4577 hypothetical protein; PFAM: Radical SAM; SPTR: Putative uncharacterized protein. (324 aa)
AFZ00939.1PFAM: Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR000583:IPR001962; KEGG: amr:AM1_1915 asparagine synthase, putative; PFAM: Asparagine synthase; Glutamine amidotransferase, class-II; SPTR: Asparagine synthase, putative. (675 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (365 aa)
AFZ00906.1L-threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase; COGs: COG0498 Threonine synthase; InterPro IPR004450:IPR001926; KEGG: npu:Npun_R0769 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Threonine synthase; SPTR: Threonine synthase; TIGRFAM: Threonine synthase. (434 aa)
AFZ00845.1PFAM: Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: ana:alr1260 hypothetical protein; PFAM: Aminotransferase, class IV; SPTR: Alr1260 protein; manually curated. (260 aa)
AFZ00842.1Glyceraldehyde-3-phosphate dehydrogenase (NAD+); PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR006424:IPR020828:IPR020829; KEGG: ava:Ava_0495 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; PRIAM: Glyceraldehyde-3-phospha [...] (340 aa)
AFZ00837.1Beta-lactamase domain protein; PFAM: Metallo-beta-lactamase superfamily; COGs: COG0491 Zn-dependent hydrolase including glyoxylase; InterPro IPR001279; KEGG: ava:Ava_3439 beta-lactamase-like; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like; SPTR: Beta-lactamase-like protein. (230 aa)
cbiAHydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (466 aa)
AFZ00804.1PFAM: DALR anticodon binding domain; InterPro IPR008909; KEGG: ava:Ava_1751 arginyl tRNA synthetase anticodon binding; PFAM: DALR anticodon binding; SMART: DALR anticodon binding; SPTR: Arginyl tRNA synthetase, anticodon binding. (268 aa)
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (427 aa)
AFZ00733.1Polyketide-type polyunsaturated fatty acid synthase PfaA; PFAM: Acyl transferase domain; Phosphopantetheine attachment site; Beta-ketoacyl synthase, N-terminal domain; Beta-ketoacyl synthase, C-terminal domain; TIGRFAM: polyketide-type polyunsaturated fatty acid synthase PfaA; COGs: COG3321 Polyketide synthase modules and related protein; InterProIPR004432:IPR020841:IPR020801:IPR014030:IPR 014031:IPR014043:IPR006163; KEGG: npu:Npun_R0043 polyketide synthase phosphopantetheine-binding HglE; PFAM: Beta-ketoacyl synthase, C-terminal; Beta-ketoacyl synthase, N-terminal; Acyl transferase; P [...] (1708 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (181 aa)
AFZ00731.1PFAM: KR domain; COGs: COG3321 Polyketide synthase modules and related protein; InterPro IPR020842:IPR013968; KEGG: naz:Aazo_3916 KR domain-containing protein; PFAM: Polyketide synthase, KR; SMART: Polyketide synthase/Fatty acid synthase, KR; SPTR: KR domain protein. (598 aa)
AFZ00730.1PfaB family protein; PFAM: Beta-ketoacyl synthase, N-terminal domain; Beta-ketoacyl synthase, C-terminal domain; TIGRFAM: PfaB family protein; COGs: COG3321 Polyketide synthase modules and related protein; InterPro IPR014181:IPR020841:IPR014030:IPR014031; KEGG: npu:Npun_R0041 beta-ketoacyl synthase HglC; PFAM: Beta-ketoacyl synthase, C-terminal; Beta-ketoacyl synthase, N-terminal; PRIAM: Beta-ketoacyl-acyl-carrier-protein synthase I; SMART: Polyketide synthase, beta-ketoacyl synthase domain; SPTR: Beta-ketoacyl synthase HglC; TIGRFAM: Omega-3 polyunsaturated fatty acid synthase-like; B [...] (1603 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (324 aa)
AFZ00711.1phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. (161 aa)
argHPFAM: Lyase; TIGRFAM: argininosuccinate lyase; COGs: COG0165 Argininosuccinate lyase; HAMAP: Argininosuccinate lyase; InterPro IPR009049:IPR022761; KEGG: ava:Ava_1807 argininosuccinate lyase; PFAM: Lyase 1, N-terminal; PRIAM: Argininosuccinate lyase; SPTR: Argininosuccinate lyase; TIGRFAM: Argininosuccinate lyase. (464 aa)
glyQPFAM: Glycyl-tRNA synthetase alpha subunit; TIGRFAM: glycyl-tRNA synthetase, tetrameric type, alpha subunit; COGs: COG0752 Glycyl-tRNA synthetase alpha subunit; HAMAP: Glycyl-tRNA synthetase, class IIc, alpha subunit; InterPro IPR002310; KEGG: naz:Aazo_0922 glycyl-tRNA synthetase subunit alpha; PFAM: Glycyl-tRNA synthetase, class IIc, alpha subunit; PRIAM: Glycine--tRNA ligase; SPTR: Glycyl-tRNA synthetase alpha subunit; TIGRFAM: Glycyl-tRNA synthetase, class IIc, alpha subunit. (296 aa)
AFZ00580.1Isopenicillin-N epimerase; PFAM: Aminotransferase class-V; COGs: COG0520 Selenocysteine lyase; InterPro IPR000192; KEGG: cyn:Cyan7425_0721 aminotransferase class V; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Isopenicillin-N epimerase; SPTR: Putative isopenicillin n epimerase protein. (399 aa)
carAPFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; COGs: COG0505 Carbamoylphosphate synthase small subunit; InterPro IPR006274:IPR002474:IPR000991; KEGG: ava:Ava_4410 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; PRIAM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing); SPTR: Carbamoyl-phosphate synthase small chain; TIGRFAM: Carbamoyl-phosphate synthase, small subunit; Belon [...] (392 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (346 aa)
lysSPFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; TIGRFAM: lysyl-tRNA synthetase, eukaryotic and non-spirochete bacterial; COGs: COG1190 Lysyl-tRNA synthetase (class II); HAMAP: Lysyl-tRNA synthetase, class II; InterPro IPR002313:IPR004365:IPR004364; KEGG: npu:Npun_R5202 lysyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (D/K/N); Nucleic acid binding, OB-fold, tRNA/helicase-type; PRIAM: Lysine--tRNA ligase; SPTR: Lysyl-tRNA synthetase; TIGRFAM: Lysyl-tRNA synthetase, class II; Belongs to the class-II aminoacyl-tRNA synthetase family. (511 aa)
pheAPFAM: Prephenate dehydratase; ACT domain; COGs: COG0077 Prephenate dehydratase; InterPro IPR001086:IPR002912; KEGG: npu:Npun_R3887 prephenate dehydratase; PFAM: Prephenate dehydratase; Amino acid-binding ACT; PRIAM: Prephenate dehydratase; SPTR: Prephenate dehydratase. (290 aa)
AFZ00551.1PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: ana:alr4344 ferredoxin-glutamate synthase; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Ferredoxin-glutamate synthase. (1566 aa)
AFZ00536.13-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (255 aa)
AFZ00530.1Hypothetical protein; PFAM: Saccharopine dehydrogenase; KEGG: ana:alr2440 hypothetical protein; SPTR: Alr2440 protein. (341 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (421 aa)
AFZ00495.1Delta-12 acyl-phospholipid desaturase; PFAM: Fatty acid desaturase; COGs: COG3239 Fatty acid desaturase; InterPro IPR005804; KEGG: naz:Aazo_3555 fatty acid desaturase; PFAM: Fatty acid desaturase, type 1; SPTR: Fatty acid desaturase. (359 aa)
panC/cmkCytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the N-terminal section; belongs to the pantothenate synthetase family. (534 aa)
glsAL-glutaminase; PFAM: Glutaminase; TIGRFAM: glutaminase A; COGs: COG2066 Glutaminase; HAMAP: Glutaminase; InterPro IPR015868; KEGG: ana:all2934 hypothetical protein; PFAM: Glutaminase; PRIAM: Glutaminase; SPTR: Glutaminase; TIGRFAM: Glutaminase; Belongs to the glutaminase family. (327 aa)
AFZ00477.1KEGG: npu:Npun_F1013 hypothetical protein; SPTR: Putative uncharacterized protein. (136 aa)
AFZ00467.1PFAM: CobB/CobQ-like glutamine amidotransferase domain; COGs: COG3442 glutamine amidotransferase; InterPro IPR011698; KEGG: npu:Npun_R3558 glutamine amidotransferase; PFAM: CobB/CobQ-like glutamine amidotransferase; SPTR: CobB/CobQ domain protein glutamine amidotransferase. (268 aa)
hisGATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (215 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (498 aa)
ppcPhosphoenolpyruvate carboxylase, type 1; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (1017 aa)
AFZ00294.1Amine oxidase; PFAM: Flavin containing amine oxidoreductase; COGs: COG1231 Monoamine oxidase; InterPro IPR002937; KEGG: gvi:gll1123 hypothetical protein; PFAM: Amine oxidase; SPTR: FAD dependent oxidoreductase, putative. (541 aa)
pyrBPFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: aspartate carbamoyltransferase; COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; HAMAP: Aspartate carbamoyltransferase, eukaryotic; InterPro IPR002082:IPR006132:IPR006131; KEGG: ava:Ava_1174 aspartate carbamoyltransferase catalytic subunit; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; PRIAM: Aspartate carbamoyltransferase; SPTR: Asparta [...] (335 aa)
AFZ00292.1InterPro IPR000182; KEGG: cyc:PCC7424_4794 GCN5-related N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase (GNAT) domain; SPTR: GCN5-related N-acetyltransferase. (183 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (308 aa)
AFZ00221.1PFAM: HMGL-like; TIGRFAM: homocitrate synthase NifV; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR013477:IPR000891; KEGG: npu:Npun_F0430 trans-homoaconitate synthase; PFAM: Pyruvate carboxyltransferase; PRIAM: Homocitrate synthase; SPTR: Homocitrate synthase; TIGRFAM: Homocitrate synthase NifV-type; Belongs to the alpha-IPM synthase/homocitrate synthase family. (378 aa)
bioDDethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (229 aa)
anmKAnhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (386 aa)
AFZ00208.1PFAM: PEP-utilising enzyme, mobile domain; Domain of unknown function (DUF205); Pyruvate phosphate dikinase, PEP/pyruvate binding domain; COGs: COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; InterPro IPR002192:IPR008279; KEGG: npu:Npun_F1309 pyruvate phosphate dikinase, PEP/pyruvate-binding; PFAM: Pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile domain; SPTR: Pyruvate phosphate dikinase, PEP/pyruvate-binding. (961 aa)
AFZ00174.1NADPH:quinone reductase; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; COGs: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductase; InterPro IPR013154:IPR013149:IPR020843; KEGG: naz:Aazo_1093 alcohol dehydrogenase zinc-binding domain-containing protein; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like; PRIAM: NADPH:quinone reductase; SMART: Polyketide synthase, enoylreductase; SPTR: Alcohol dehydrogenase zinc-binding domain protein. (331 aa)
AFZ00167.1PFAM: Phytanoyl-CoA dioxygenase (PhyH); InterPro IPR008775; KEGG: npu:Npun_F2449 phytanoyl-CoA dioxygenase; PFAM: Phytanoyl-CoA dioxygenase; SPTR: Phytanoyl-CoA dioxygenase. (299 aa)
AFZ00165.1PFAM: Bacterial transferase hexapeptide (three repeats); TIGRFAM: sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; COGs: COG1045 Serine acetyltransferase; InterPro IPR020019:IPR001451; KEGG: gur:Gura_1700 serine acetyltransferase-like protein; SPTR: Serine acetyltransferase-like protein; TIGRFAM: Sialic acid O-acyltransferase, NeuD. (212 aa)
Your Current Organism:
Calothrix sp. PCC6303
NCBI taxonomy Id: 1170562
Other names: C. sp. PCC 6303, Calothrix sp. (ATCC 29156), Calothrix sp. (PCC 6303), Calothrix sp. ATCC 29156, Calothrix sp. PCC 6303
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