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purK purK AFZ28859.1 AFZ28859.1 AFZ28967.1 AFZ28967.1 AFZ29131.1 AFZ29131.1 guaA guaA apt apt purD purD surE surE purM purM AFZ30175.1 AFZ30175.1 purF purF purL purL AFZ30515.1 AFZ30515.1 AFZ30516.1 AFZ30516.1 purS purS purQ purQ purC purC gmk gmk AFZ31586.1 AFZ31586.1 AFZ31617.1 AFZ31617.1 purA purA AFZ31661.1 AFZ31661.1 AFZ31784.1 AFZ31784.1 purE purE AFZ32397.1 AFZ32397.1 purN purN tmk tmk purH purH
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
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purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (377 aa)
AFZ28859.15'-nucleotidase; PFAM: Survival protein SurE; TIGRFAM: 5'/3'-nucleotidase SurE; COGs: COG0496 acid phosphatase; InterPro IPR002828; KEGG: npu:Npun_R1763 stationary phase survival protein SurE; PFAM: Survival protein SurE-like phosphatase/nucleotidase; SPTR: Stationary-phase survival protein SurE; TIGRFAM: Survival protein SurE-like phosphatase/nucleotidase. (225 aa)
AFZ28967.1PFAM: IMP dehydrogenase / GMP reductase domain; TIGRFAM: IMP dehydrogenase family protein; COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR005992:IPR001093; KEGG: ana:alr0051 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; SPTR: IMP dehydrogenase; TIGRFAM: IMP dehydrogenase related 2; manually curated. (387 aa)
AFZ29131.1PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; COGs: COG0015 Adenylosuccinate lyase; InterPro IPR004769:IPR000362:IPR019468; KEGG: ava:Ava_3410 adenylosuccinate lyase; PFAM: Fumarate lyase; Adenylosuccinate lyase, C-terminal; SPTR: Adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (534 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (173 aa)
purDPhosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; COGs: COG0151 Phosphoribosylamine-glycine ligase; HAMAP: Phosphoribosylglycinamide synthetase; InterPro IPR020562:IPR020561:IPR020560:IPR000115; KEGG: ava:Ava_3227 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthe [...] (427 aa)
surE5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (277 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylaminoimidazole synthetase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR000728:IPR010918:IPR004733; KEGG: naz:Aazo_3150 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, C-terminal; AIR synthase related protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: Phosphoribosylformylglyci [...] (342 aa)
AFZ30175.1PFAM: Thymidylate synthase; TIGRFAM: thymidylate synthase, methanogen type; COGs: COG0207 Thymidylate synthase; InterPro IPR000398; KEGG: cyh:Cyan8802_1276 thymidylate synthase; PFAM: Thymidylate synthase; SPTR: Thymidylate synthase. (498 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (495 aa)
purLPhosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (772 aa)
AFZ30515.1Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (336 aa)
AFZ30516.1PFAM: Permease family; COGs: COG2252 Permease; InterPro IPR006043; KEGG: cyn:Cyan7425_1240 xanthine/uracil/vitamin C permease; PFAM: Xanthine/uracil/vitamin C permease; SPTR: Putative uncharacterized protein. (481 aa)
purSPhosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (89 aa)
purQPhosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (225 aa)
purCPFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; COGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; HAMAP: SAICAR synthetase; InterPro IPR001636; KEGG: ana:alr2268 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: SAICAR synthetase. (248 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa)
AFZ31586.1PFAM: Inosine-uridine preferring nucleoside hydrolase; COGs: COG1957 Inosine-uridine nucleoside N-ribohydrolase; InterPro IPR001910; KEGG: ana:alr3285 inosine-adenosine-guanosine-nucleoside hydrolase; PFAM: Inosine/uridine-preferring nucleoside hydrolase; SPTR: Inosine-adenosine-guanosine-nucleoside hydrolase. (306 aa)
AFZ31617.1Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (200 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (441 aa)
AFZ31661.1PFAM: Adenosine/AMP deaminase; TIGRFAM: adenosine deaminase; COGs: COG1816 Adenosine deaminase; InterPro IPR001365; KEGG: npu:Npun_F3248 adenosine/AMP deaminase; PFAM: Adenosine/AMP deaminase; SPTR: Adenosine/AMP deaminase. (349 aa)
AFZ31784.1MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase domain; TIGRFAM: MazG family protein; COGs: COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain; InterPro IPR004518:IPR011551; KEGG: ava:Ava_2914 nucleoside triphosphate pyrophosphohydrolase; PFAM: NTP pyrophosphohydrolase MazG, putative catalytic core; SPTR: MazG; TIGRFAM: NTP pyrophosphohydrolase MazG, bacterial. (286 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (172 aa)
AFZ32397.1PFAM: 5'-nucleotidase, C-terminal domain; Hemolysin-type calcium-binding repeat (2 copies); COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR008334:IPR001343; KEGG: syf:Synpcc7942_1392 alkaline phosphatase; PFAM: 5'-Nucleotidase, C-terminal; Haemolysin-type calcium-binding repeat; PRIAM: 5'-nucleotidase; SPTR: Alkaline phosphatase. (1339 aa)
purNFormyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (222 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (223 aa)
purHIMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); HAMAP: Bifunctional purine biosynthesis protein purH; InterPro IPR013982:IPR011607:IPR002695; KEGG: npu:Npun_R6316 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; MGS-like; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, transformyla [...] (514 aa)
Your Current Organism:
Gloeocapsa sp. PCC7428
NCBI taxonomy Id: 1173026
Other names: Chroococcus sp. Cey un, G. sp. PCC 7428, Gloeocapsa sp. ATCC 29159, Gloeocapsa sp. PCC 7428
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