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| | ESE87276.1 | Fructose-like phosphotransferase system subunit EIIA; COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type). (44 aa) |
| | rhaB | Rhamnulokinase; Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1- hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate. Belongs to the rhamnulokinase family. (489 aa) |
| | cpxA | Two-component sensor protein; COG0642 Signal transduction histidine kinase. (457 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa) |
| | slyX | Phi X174 lysis protein; COG2900 Uncharacterized protein conserved in bacteria; Belongs to the SlyX family. (72 aa) |
| | anmK | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (373 aa) |
| | pdxY | Pyridoxamine kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (286 aa) |
| | pssA | COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes. (451 aa) |
| | nanK | N-acetylmannosamine kinase; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily. (291 aa) |
| | ESE86741.1 | Aerobic respiration control sensor protein ArcB; COG0642 Signal transduction histidine kinase. (778 aa) |
| | ESE86744.1 | Phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr); COG1925 Phosphotransferase system, HPr-related proteins. (90 aa) |
| | ESE86746.1 | PTS system nitrogen regulatory protein IIA(Ntr); COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type). (163 aa) |
| | ESE86748.1 | RNA polymerase factor sigma-54; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (477 aa) |
| | pnp | Polynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (711 aa) |
| | ESE86806.1 | Hypothetical protein; COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific. (523 aa) |
| | ESE86810.1 | COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. (144 aa) |
| | ESE86813.1 | COG3444 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB. (157 aa) |
| | ESE86820.1 | COG1929 Glycerate kinase; Belongs to the glycerate kinase type-1 family. (381 aa) |
| | ESE86476.1 | COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase. (300 aa) |
| | pduW | COG0282 Acetate kinase. (404 aa) |
| | cobU | Adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (181 aa) |
| | cobS | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (247 aa) |
| | umuC | COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; Belongs to the DNA polymerase type-Y family. (422 aa) |
| | ESE86564.1 | Diguanylate cyclase YedQ; COG2199 FOG: GGDEF domain. (573 aa) |
| | ESE86359.1 | COG1881 Phospholipid-binding protein. (182 aa) |
| | ESE86166.1 | Phosphoenolpyruvate-protein phosphotransferase; COG3605 Signal transduction protein containing GAF and PtsI domains; Belongs to the PEP-utilizing enzyme family. (748 aa) |
| | pgk | COG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (387 aa) |
| | ESE86240.1 | Nucleoside triphosphate hydrolase domain-containing protein; COG1072 Panthothenate kinase. (238 aa) |
| | ESE87888.1 | Hypothetical protein; COG2194 Predicted membrane-associated, metal-dependent hydrolase. (577 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (257 aa) |
| | ulaA | PTS system ascorbate-specific transporter subunit IIC; COG3037 Uncharacterized protein conserved in bacteria. (466 aa) |
| | ESE88254.1 | PTS system L-ascorbate-specific transporter subunit IIB; COG3414 Phosphotransferase system, galactitol-specific IIB component. (101 aa) |
| | ESE88253.1 | PTS system L-ascorbate-specific transporter subunit IIA; COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type). (154 aa) |
| | ESE88212.1 | COG3711 Transcriptional antiterminator. (637 aa) |
| | ESE88206.1 | PTS system trehalose(maltose)-specific transporter subunits IIBC; COG1264 Phosphotransferase system IIB components. (472 aa) |
| | ESE88195.1 | COG0549 Carbamate kinase; Belongs to the carbamate kinase family. (310 aa) |
| | ESE88186.1 | COG2927 DNA polymerase III, chi subunit. (147 aa) |
| | idnK | COG3265 Gluconate kinase. (77 aa) |
| | ESE88166.1 | Hypothetical protein. (980 aa) |
| | ESE88118.1 | Sigma-54 dependent DNA-binding response regulator; COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain. (921 aa) |
| | ESE88117.1 | Hypothetical protein; COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. (140 aa) |
| | ESE88116.1 | PTS system transporter subunit IIB; COG3444 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB. (153 aa) |
| | mdoB | Phosphoglycerol transferase I; Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones; Belongs to the OpgB family. (763 aa) |
| | ESE88101.1 | Diguanylate cyclase; COG2199 FOG: GGDEF domain. (354 aa) |
| | ESE88098.1 | DNA polymerase III subunit psi; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. (145 aa) |
| | lplA | Lipoate-protein ligase A; Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Belongs to the LplA family. (338 aa) |
| | ESE88079.1 | Bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; COG1396 Predicted transcriptional regulators. (410 aa) |
| | ESE88070.1 | COG0642 Signal transduction histidine kinase. (474 aa) |
| | thrA | Bifunctional aspartokinase I/homoserine dehydrogenase I; COG0527 Aspartokinases; In the C-terminal section; belongs to the homoserine dehydrogenase family. (820 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa) |
| | mogA | Molybdenum cofactor biosynthesis protein MogA; COG0521 Molybdopterin biosynthesis enzymes. (196 aa) |
| | ESE88016.1 | Bifunctional riboflavin kinase/FMN adenylyltransferase; COG0196 FAD synthase; Belongs to the ribF family. (312 aa) |
| | ESE88008.1 | Sensory histidine kinase in two-component regulatory system with citB; COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism. (542 aa) |
| | ESE87999.1 | COG3697 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase). (183 aa) |
| | citG-2 | COG1767 Triphosphoribosyl-dephospho-CoA synthetase. (303 aa) |
| | ESE87967.1 | COG0417 DNA polymerase elongation subunit (family B). (783 aa) |
| | araB | Ribulokinase; COG1069 Ribulose kinase. (569 aa) |
| | ESE87890.1 | PTS system fructose-like transporter subunit EIIB; COG1445 Phosphotransferase system fructose-specific component IIB. (117 aa) |
| | ESE86244.1 | COG2213 Phosphotransferase system, mannitol-specific IIBC component. (459 aa) |
| | cmtB | PTS system mannitol-specific transporter subunit IIA; COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type). (147 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (502 aa) |
| | ESE85620.1 | COG3954 Phosphoribulokinase. (289 aa) |
| | aroK | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa) |
| | envZ | Osmolarity sensor protein; COG0642 Signal transduction histidine kinase. (450 aa) |
| | glgC | Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. (431 aa) |
| | gntK | COG3265 Gluconate kinase. (177 aa) |
| | ESE85704.1 | Hypothetical protein; COG3654 Prophage maintenance system killer protein. (122 aa) |
| | ESE85728.1 | holo-ACP synthase; COG2091 Phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily. (192 aa) |
| | ESE85747.1 | Hypothetical protein; COG0524 Sugar kinases, ribokinase family. (281 aa) |
| | ESE85760.1 | 2-dehydro-3-deoxygluconokinase; COG0524 Sugar kinases, ribokinase family. (309 aa) |
| | ESE85783.1 | Phosphoethanolamine transferase; COG2194 Predicted membrane-associated, metal-dependent hydrolase. (563 aa) |
| | xylB | Xylulokinase; COG1070 Sugar (pentulose and hexulose) kinases. (484 aa) |
| | ESE85811.1 | COG1940 Transcriptional regulator/sugar kinase. (293 aa) |
| | ESE85815.1 | PTS system mannitol-specific transporter subunit IICBA; COG2213 Phosphotransferase system, mannitol-specific IIBC component. (638 aa) |
| | ESE85819.1 | Hypothetical protein. (68 aa) |
| | ESE85844.1 | Lipopolysaccharide core heptose(II) kinase RfaY; COG0661 Predicted unusual protein kinase. (232 aa) |
| | ESE85849.1 | Lipopolysaccharide core heptose(I) kinase RfaP; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family. (265 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) |
| | rph | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (238 aa) |
| | ESE85863.1 | Hypothetical protein; COG1561 Uncharacterized stress-induced protein. (287 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (91 aa) |
| | ESE85871.1 | Bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (703 aa) |
| | ESE85897.1 | Putative PTS system protein; COG3444 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB. (161 aa) |
| | ESE85898.1 | PTS system fructose IIA component; COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. (141 aa) |
| | ESE85909.1 | COG3851 Signal transduction histidine kinase, glucose-6-phosphate specific. (500 aa) |
| | rbsK | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (306 aa) |
| | ESE85946.1 | DNA-binding transcriptional regulator TorR; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (230 aa) |
| | ESE85948.1 | Hybrid sensory histidine kinase TorS; COG0642 Signal transduction histidine kinase. (911 aa) |
| | ESE85952.1 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (366 aa) |
| | ESE85961.1 | Hypothetical protein; COG2091 Phosphopantetheinyl transferase. (251 aa) |
| | ESE85382.1 | COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. (471 aa) |
| | ESE85385.1 | GalU regulator GalF; COG1210 UDP-glucose pyrophosphorylase. (297 aa) |
| | ESE85388.1 | Colanic acid biosynthesis protein. (426 aa) |
| | cpsB | COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. (478 aa) |
| | ESE85403.1 | Tyrosine kinase; COG3206 Uncharacterized protein involved in exopolysaccharide biosynthesis. (719 aa) |
| | udk | COG0572 Uridine kinase. (213 aa) |
| | ESE85410.1 | Mase1 domain family protein; COG2202 FOG: PAS/PAC domain. (996 aa) |
| | ESE85417.1 | COG0642 Signal transduction histidine kinase. (467 aa) |
| | yegS | Lipid kinase; Probably phosphorylates lipids; the in vivo substrate is unknown; Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily. (299 aa) |
| | ESE85430.1 | COG0524 Sugar kinases, ribokinase family. (321 aa) |
| | ESE85432.1 | Bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (266 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (262 aa) |
| | ESE85446.1 | Putative sensor kinase; COG3275 Putative regulator of cell autolysis. (561 aa) |
| | ESE85311.1 | COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism. (543 aa) |
| | ESE85321.1 | Metal dependent hydrolase; COG2194 Predicted membrane-associated, metal-dependent hydrolase. (547 aa) |
| | ESE85323.1 | Sensor protein BasS/PmrB; COG0642 Signal transduction histidine kinase. (359 aa) |
| | phnN | Ribose 1,5-bisphosphokinase; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (184 aa) |
| | ESE85207.1 | Hypothetical protein. (114 aa) |
| | ESE85259.1 | COG3395 Uncharacterized protein conserved in bacteria. (420 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (236 aa) |
| | cysC | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (201 aa) |
| | cysN | Sulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (479 aa) |
| | cysD | Sulfate adenylyltransferase subunit 2; COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes. (302 aa) |
| | ESE84709.1 | Secreted effector kinase steC. (325 aa) |
| | ESE84719.1 | DNA-binding transcriptional activator PspC; COG1983 Putative stress-responsive transcriptional regulator. (119 aa) |
| | ESE84749.1 | Putative lipoprotein. (281 aa) |
| | ESE84764.1 | Hypothetical protein; COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain. (375 aa) |
| | ESE84804.1 | PTS system sugar-specific transporter subunit EIIA 2; COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type). (145 aa) |
| | ESE84807.1 | PTS system lactose/cellobiose-specific transporter subunit IIB; COG3414 Phosphotransferase system, galactitol-specific IIB component. (93 aa) |
| | cmk | COG0283 Cytidylate kinase. (227 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (325 aa) |
| | ycaR | Hypothetical protein; Belongs to the UPF0434 family. (60 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (248 aa) |
| | dnaE | COG0587 DNA polymerase III, alpha subunit. (1160 aa) |
| | cdsA | COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. (285 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa) |
| | glnD | PII uridylyl-transferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (890 aa) |
| | pcnB | poly(A) polymerase I; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (472 aa) |
| | ESE84495.1 | COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (163 aa) |
| | ESE84508.1 | COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. (146 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa) |
| | ESE84274.1 | PTS system fructose-specific transporter subunits IIBC; COG3925 N-terminal domain of the phosphotransferase system fructose-specific component IIB. (562 aa) |
| | fruK | 1-phosphofructokinase; COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); Belongs to the carbohydrate kinase PfkB family. (312 aa) |
| | ESE84276.1 | Bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; COG4668 Mannitol/fructose-specific phosphotransferase system, IIA domain. (376 aa) |
| | lpxT | Putative permease; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (232 aa) |
| | ESE84121.1 | Tricarboxylic transport regulatory protein; COG0642 Signal transduction histidine kinase. (471 aa) |
| | ESE83813.1 | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (122 aa) |
| | ESE83831.1 | Bifunctional PTS system maltose and glucose-specific transporter subunits IICB; COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific. (524 aa) |
| | ESE83838.1 | Aspartate kinase III; COG0527 Aspartokinases; Belongs to the aspartokinase family. (449 aa) |
| | aceK | Bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (581 aa) |
| | tdcD | Propionate/acetate kinase; Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. (402 aa) |
| | ESE83514.1 | Inner membrane diguanylate cyclase; COG2199 FOG: GGDEF domain. (406 aa) |
| | ppnK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (292 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1342 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1407 aa) |
| | ESE83468.1 | Sulfur carrier protein ThiS adenylyltransferase; COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. (251 aa) |
| | ESE83479.1 | Sensor protein ZraS; COG0642 Signal transduction histidine kinase. (460 aa) |
| | ESE83155.1 | COG4766 Ethanolamine utilization protein. (229 aa) |
| | ESE83156.1 | COG4917 Ethanolamine utilization protein; Belongs to the EutP/PduV family. (159 aa) |
| | ESE83167.1 | Nitrate/nitrite sensor protein NarQ; COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific. (566 aa) |
| | ESE83179.1 | COG1929 Glycerate kinase; Belongs to the glycerate kinase type-1 family. (379 aa) |
| | ppk | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (688 aa) |
| | ndk | Multifunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-phosphodiesterase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | ESE83248.1 | COG0642 Signal transduction histidine kinase. (461 aa) |
| | ESE83253.1 | Phosphotransferase system, eiic; COG1264 Phosphotransferase system IIB components. (454 aa) |
| | acpS | 4'-phosphopantetheinyl transferase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (126 aa) |
| | coaA | COG1072 Panthothenate kinase. (316 aa) |
| | clsC | Putative phospholipase; Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE); Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsC sub-subfamily. (495 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (213 aa) |
| | ESE82772.1 | DNA polymerase III subunit delta; COG0470 ATPase involved in DNA replication. (334 aa) |
| | ESE82774.1 | PTS glucose-specific subunit IIBC; COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific. (477 aa) |
| | thiK | Thiamine kinase; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (274 aa) |
| | nagK | N-acetyl-D-glucosamine kinase; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. (303 aa) |
| | ESE82800.1 | Sensor protein PhoQ; COG0642 Signal transduction histidine kinase. (487 aa) |
| | ESE82833.1 | Aminoglycoside resistance protein; Mediates bacterial resistance to the antibiotics streptomycin and spectomycin. (262 aa) |
| | ESE82836.1 | Biofilm development protein YmgB/AriR. (82 aa) |
| | ESE82851.1 | Hypothetical protein; COG2199 FOG: GGDEF domain. (496 aa) |
| | ESE82853.1 | PrkA family serine protein kinase; COG2766 Putative Ser protein kinase. (644 aa) |
| | selD | Selenophosphate synthetase; Synthesizes selenophosphate from selenide and ATP. (347 aa) |
| | ESE82880.1 | PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB; COG1440 Phosphotransferase system cellobiose-specific component IIB. (106 aa) |
| | ESE82881.1 | PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (452 aa) |
| | ESE82892.1 | COG3001 Fructosamine-3-kinase. (286 aa) |
| | ESE82894.1 | 6-phosphofructokinase 2; COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); Belongs to the carbohydrate kinase PfkB family. (310 aa) |
| | selO | Hypothetical protein; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). Belongs to the SELO family. (480 aa) |
| | ppsR | PEP synthetase regulatory protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (277 aa) |
| | ESE82915.1 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa) |
| | ESE82930.1 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (470 aa) |
| | rbsK-2 | Regulatory protein, DeoR family; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (408 aa) |
| | ESE82938.1 | Putative histidine kinase, two component regulatory protein; COG0642 Signal transduction histidine kinase. (592 aa) |
| | ESE82945.1 | Two component system sensor kinase SsrA; COG0642 Signal transduction histidine kinase. (920 aa) |
| | galK | Galactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (382 aa) |
| | ESE82536.1 | COG1085 Galactose-1-phosphate uridylyltransferase. (348 aa) |
| | ESE82553.1 | Kinase inhibitor protein; COG1881 Phospholipid-binding protein. (158 aa) |
| | ESE82561.1 | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (302 aa) |
| | clsB | Cardiolipin synthase 2; Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (413 aa) |
| | ESE82593.1 | COG2194 Predicted membrane-associated, metal-dependent hydrolase. (526 aa) |
| | ESE82603.1 | Molybdopterin biosynthesis protein MoeB; COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. (249 aa) |
| | ESE82633.1 | PTS system ascorbate-specific transporter subunit IIC; COG3037 Uncharacterized protein conserved in bacteria. (447 aa) |
| | ESE82634.1 | COG3414 Phosphotransferase system, galactitol-specific IIB component. (106 aa) |
| | ubiB | Ubiquinone biosynthesis protein UbiB; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (546 aa) |
| | ESE82451.1 | Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (293 aa) |
| | wzzE | Lipopolysaccharide biosynthesis protein WzzE; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family. (348 aa) |
| | wecA | Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (367 aa) |
| | nadD | Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (213 aa) |
| | holA | COG1466 DNA polymerase III, delta subunit. (343 aa) |
| | ESE82113.1 | DNA-binding transcriptional dual regulator NagC; COG1940 Transcriptional regulator/sugar kinase. (406 aa) |
| | ESE82116.1 | COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific. (650 aa) |
| | ESE82138.1 | Sensor protein KdpD; COG2205 Osmosensitive K+ channel histidine kinase. (894 aa) |
| | ESE81942.1 | Hypothetical protein. (146 aa) |
| | ESE81947.1 | Bifunctional PTS system maltose and glucose-specific transporter subunits IICB; COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific. (530 aa) |
| | ESE81954.1 | Sensor protein RstB; COG0642 Signal transduction histidine kinase. (433 aa) |
| | ESE81971.1 | DNA-binding transcriptional repressor DgsA; COG1940 Transcriptional regulator/sugar kinase. (406 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (581 aa) |
| | cca | 2',3'-cyclic phosphodiesterase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. (413 aa) |
| | glnE | Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] (947 aa) |
| | hldE | Bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (477 aa) |
| | ESE81754.1 | Sensor protein QseC; COG0642 Signal transduction histidine kinase. (449 aa) |
| | ESE81572.1 | PTS system mannose-specific transporter subunits IIAB; COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. (322 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | ipk | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily. (283 aa) |
| | ESE81628.1 | Hypothetical protein. (269 aa) |
| | ESE81635.1 | Nitrate/nitrite sensor protein NarX; COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific. (598 aa) |
| | tsaC | tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. (190 aa) |
| | rpoA | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (329 aa) |
| | ESE81168.1 | DNA polymerase III subunit theta. (76 aa) |
| | ESE81180.1 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (480 aa) |
| | ESE81226.1 | COG0643 Chemotaxis protein histidine kinase and related kinases. (668 aa) |
| | pgsA | Phosphatidylglycerophosphate synthetase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (182 aa) |
| | fliA | Flagellar biosynthesis sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (239 aa) |
| | dnaQ | DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (243 aa) |
| | relA | (p)ppGpp synthetase I/GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (744 aa) |
| | ESE81008.1 | Hybrid sensory histidine kinase BarA; COG0642 Signal transduction histidine kinase. (918 aa) |
| | ESE81009.1 | COG1929 Glycerate kinase; Belongs to the glycerate kinase type-1 family. (380 aa) |
| | fucK | L-fuculokinase; Catalyzes the phosphorylation of L-fuculose. Belongs to the FGGY kinase family. (472 aa) |
| | ESE87893.1 | PTS system fructose-like transporter subunit EIIB; COG1445 Phosphotransferase system fructose-specific component IIB. (106 aa) |
| | ESE87894.1 | PTS system fructose-like transporter subunit EIIC; COG1299 Phosphotransferase system, fructose-specific IIC component. (359 aa) |
| | ESE87895.1 | Multifunctional phosphoenolpyruvate-protein phosphotransferase subunit IIA; COG1925 Phosphotransferase system, HPr-related proteins. (833 aa) |
| | metL | Bifunctional aspartate kinase II/homoserine dehydrogenase II; COG0527 Aspartokinases; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa) |
| | dinB | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (351 aa) |
| | proB | Gamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa) |
| | adrA | Diguanylate cyclase AdrA; COG2199 FOG: GGDEF domain. (370 aa) |
| | aroL | Shikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (181 aa) |
| | ESE87579.1 | Fructokinase; COG1940 Transcriptional regulator/sugar kinase. (302 aa) |
| | phoR | Phosphate regulon sensor protein; COG0642 Signal transduction histidine kinase. (431 aa) |
| | thiL | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa) |
| | thiI | tRNA s(4)U8 sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa) |
| | dnaX | DNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (642 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | ESE87665.1 | COG0524 Sugar kinases, ribokinase family. (434 aa) |
| | ESE87714.1 | Sensor kinase CusS; Member of a two-component regulatory system. (483 aa) |
| | ESE87734.1 | Phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; COG2977 Phosphopantetheinyl transferase component of siderophore synthetase; Belongs to the P-Pant transferase superfamily. (229 aa) |
| | ESE87739.1 | LPS O-antigen length regulator; COG3765 Chain length determinant protein. (378 aa) |
| | entE | Enterobactin synthase subunit E; COG1021 Peptide arylation enzymes. (536 aa) |
| | ESE87760.1 | COG0589 Universal stress protein UspA and related nucleotide-binding proteins. (142 aa) |
| | rnk | Nucleoside diphosphate kinase regulator; May act as an anti-Gre factor; Belongs to the Rnk family. (136 aa) |
| | citG | COG1767 Triphosphoribosyl-dephospho-CoA synthetase. (298 aa) |
| | citX | 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase; Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein; Belongs to the CitX family. (183 aa) |
| | dpiB | COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism. (553 aa) |
| | rcsD | Phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (889 aa) |
| | rcsC | Hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (948 aa) |
| | arnC | Undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (327 aa) |
| | ackA | Acetate kinase A/propionate kinase 2; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | ulaA-2 | PTS system ascorbate-specific transporter subunit IIC; COG3037 Uncharacterized protein conserved in bacteria. (463 aa) |
| | ESE87406.1 | PTS system lactose/cellobiose-specific transporter subunit IIB; COG3414 Phosphotransferase system, galactitol-specific IIB component. (90 aa) |
| | ESE87464.1 | Multifunctional phosphoenolpyruvate-protein phosphotransferase subunit IIA; COG1925 Phosphotransferase system, HPr-related proteins; Belongs to the PEP-utilizing enzyme family. (831 aa) |
| | ESE87467.1 | PTS system IIC component; COG1299 Phosphotransferase system, fructose-specific IIC component. (415 aa) |
| | ESE87468.1 | Hypothetical protein; COG1445 Phosphotransferase system fructose-specific component IIB. (108 aa) |
| | glk | COG0837 Glucokinase; Belongs to the bacterial glucokinase family. (321 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein MobA; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (194 aa) |
| | srkA | Serine/threonine protein kinase; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. (328 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (928 aa) |
| | glnL | Nitrogen regulation protein NR(II); COG3852 Signal transduction histidine kinase, nitrogen specific. (349 aa) |
| | ESE87255.1 | Putative sugar kinase; Phosphorylates 6-deoxy-6-sulfo-D-fructose (SF) to 6-deoxy-6- sulfo-D-fructose 1-phosphate (SFP); Belongs to the carbohydrate kinase PfkB family. (298 aa) |
| | ESE87272.1 | Frv operon regulatory protein. (130 aa) |
| | ESE87274.1 | PTS subunit IIBC; COG1299 Phosphotransferase system, fructose-specific IIC component. (96 aa) |
