STRINGSTRING
ESE83186.1 ESE83186.1 lspA lspA nhaA nhaA ESE88115.1 ESE88115.1 ESE88116.1 ESE88116.1 ESE88117.1 ESE88117.1 ESE88274.1 ESE88274.1 ESE88275.1 ESE88275.1 ESE87562.1 ESE87562.1 ESE87568.1 ESE87568.1 phoR phoR yajC yajC ESE87612.1 ESE87612.1 ESE87627.1 ESE87627.1 ESE87677.1 ESE87677.1 rcsC rcsC ESE87376.1 ESE87376.1 nuoN nuoN ESE87381.1 ESE87381.1 ESE87382.1 ESE87382.1 nuoK nuoK ESE87384.1 ESE87384.1 nuoH nuoH nuoA nuoA ESE87475.1 ESE87475.1 cpxA cpxA tppB tppB ESE86884.1 ESE86884.1 ESE86709.1 ESE86709.1 lptC lptC ESE86756.1 ESE86756.1 ESE86757.1 ESE86757.1 ESE86804.1 ESE86804.1 ESE82142.1 ESE82142.1 tolQ tolQ tolR tolR pntA pntA pntB pntB uppP uppP ESE81727.1 ESE81727.1 ESE81771.1 ESE81771.1 ESE81775.1 ESE81775.1 ESE81553.1 ESE81553.1 ESE81554.1 ESE81554.1 ESE81570.1 ESE81570.1 ESE81571.1 ESE81571.1 ESE81572.1 ESE81572.1 ESE81612.1 ESE81612.1 ESE81462.1 ESE81462.1 ESE81463.1 ESE81463.1 macB macB mscL mscL frdD frdD ESE81184.1 ESE81184.1 motB motB ESE81228.1 ESE81228.1 ESE86810.1 ESE86810.1 ESE86813.1 ESE86813.1 ESE86644.1 ESE86644.1 ESE86340.1 ESE86340.1 ESE86370.1 ESE86370.1 ESE86429.1 ESE86429.1 lgt lgt ESE86180.1 ESE86180.1 ESE86205.1 ESE86205.1 ESE86229.1 ESE86229.1 ESE86231.1 ESE86231.1 tsgA tsgA envZ envZ glpG glpG dtpB dtpB ESE85780.1 ESE85780.1 ESE85815.1 ESE85815.1 ESE85875.1 ESE85875.1 ESE85895.1 ESE85895.1 ESE85897.1 ESE85897.1 ESE85898.1 ESE85898.1 ESE85908.1 ESE85908.1 emrD emrD ESE85936.1 ESE85936.1 pstC pstC actP actP ESE84698.1 ESE84698.1 lapA lapA zntB zntB ESE84766.1 ESE84766.1 ESE84848.1 ESE84848.1 ESE84866.1 ESE84866.1 ESE84874.1 ESE84874.1 kdpB kdpB ESE84893.1 ESE84893.1 ESE84922.1 ESE84922.1 ESE84508.1 ESE84508.1 lnt lnt ESE82095.1 ESE82095.1 ESE84531.1 ESE84531.1 ftsQ ftsQ ftsW ftsW ftsL ftsL ESE84091.1 ESE84091.1 ESE84095.1 ESE84095.1 ESE84107.1 ESE84107.1 malK malK malF malF malG malG ESE83529.1 ESE83529.1 ESE83479.1 ESE83479.1 ESE83204.1 ESE83204.1 rodZ rodZ ESE83252.1 ESE83252.1 ESE83262.1 ESE83262.1 mdoH mdoH mdtG mdtG ESE82774.1 ESE82774.1 ESE82788.1 ESE82788.1 ESE82863.1 ESE82863.1 btuC btuC ESE82575.1 ESE82575.1 ESE82576.1 ESE82576.1 ESE82397.1 ESE82397.1 tatB tatB tatA tatA crcB crcB ESE82075.1 ESE82075.1 ESE82092.1 ESE82092.1 ESE82094.1 ESE82094.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ESE83186.1COG2233 Xanthine/uracil permeases. (429 aa)
lspALipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. (166 aa)
nhaApH-dependent sodium/proton antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. (388 aa)
ESE88115.1Phosphotransferase enzyme II C component; COG3715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC. (259 aa)
ESE88116.1PTS system transporter subunit IIB; COG3444 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB. (153 aa)
ESE88117.1Hypothetical protein; COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. (140 aa)
ESE88274.1FtsH protease regulator HflC; HflC and HflK could regulate a protease. (334 aa)
ESE88275.1FtsH protease regulator HflK; HflC and HflK could encode or regulate a protease. (419 aa)
ESE87562.1Microcin B17 transporter; COG1133 ABC-type long-chain fatty acid transport system, fused permease and ATPase components. (406 aa)
ESE87568.1Drug efflux system protein MdtG; COG0477 Permeases of the major facilitator superfamily. (403 aa)
phoRPhosphate regulon sensor protein; COG0642 Signal transduction histidine kinase. (431 aa)
yajCPreprotein translocase subunit YajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (110 aa)
ESE87612.1Inner membrane transport protein yajR; COG0477 Permeases of the major facilitator superfamily. (455 aa)
ESE87627.1Periplasmic folding chaperone; COG0760 Parvulin-like peptidyl-prolyl isomerase. (623 aa)
ESE87677.1Metal resistance protein; COG0390 ABC-type uncharacterized transport system, permease component. (259 aa)
rcsCHybrid sensory kinase in two-component regulatory system with RcsB and YojN; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (948 aa)
ESE87376.1Hypothetical protein. (103 aa)
nuoNNADH:ubiquinone oxidoreductase subunit N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (485 aa)
ESE87381.1COG1008 NADH:ubiquinone oxidoreductase subunit 4 (chain M). (509 aa)
ESE87382.1COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit. (613 aa)
nuoKNADH:ubiquinone oxidoreductase subunit K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (100 aa)
ESE87384.1NADH:ubiquinone oxidoreductase subunit J; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (184 aa)
nuoHNADH:ubiquinone oxidoreductase subunit H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (325 aa)
nuoANADH:ubiquinone oxidoreductase subunit A; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. (147 aa)
ESE87475.1COG1972 Nucleoside permease; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. (400 aa)
cpxATwo-component sensor protein; COG0642 Signal transduction histidine kinase. (457 aa)
tppBTripeptide transporter permease; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily. (501 aa)
ESE86884.1cysteine/O-acetylserine exporter; COG1280 Putative threonine efflux protein. (195 aa)
ESE86709.1COG3164 Predicted membrane protein. (1266 aa)
lptCLipopolysaccharide exporter periplasmic protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. (191 aa)
ESE86756.1Toluene ABC transporter permease; COG0767 ABC-type transport system involved in resistance to organic solvents, permease component. (260 aa)
ESE86757.1Mce family protein; COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component. (183 aa)
ESE86804.1COG3716 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID. (81 aa)
ESE82142.1K+-transporting ATPase, F subunit. (29 aa)
tolQColicin uptake protein TolQ; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (230 aa)
tolRColicin uptake protein TolR; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (142 aa)
pntANAD(P) transhydrogenase subunit alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. (509 aa)
pntBPyridine nucleotide transhydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. (462 aa)
uppPUndecaprenyl pyrophosphate phosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (273 aa)
ESE81727.1COG3103 SH3 domain protein. (204 aa)
ESE81771.1COG0586 Uncharacterized membrane-associated protein. (219 aa)
ESE81775.1COG0848 Biopolymer transport protein. (141 aa)
ESE81553.1Mce-like protein; COG3008 Paraquat-inducible protein B. (873 aa)
ESE81554.1Integral membrane protein, PqiA family; COG2995 Uncharacterized paraquat-inducible protein A. (427 aa)
ESE81570.1PTS system mannose-specific transporter subunit IID; COG3716 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID. (286 aa)
ESE81571.1PTS system mannose-specific transporter subunit IIC; COG3715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC. (266 aa)
ESE81572.1PTS system mannose-specific transporter subunits IIAB; COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. (322 aa)
ESE81612.1COG1969 Ni,Fe-hydrogenase I cytochrome b subunit. (243 aa)
ESE81462.1Cysteine/glutathione ABC transporter membrane/ATP-binding component; COG4988 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components. (588 aa)
ESE81463.1Cysteine/glutathione ABC transporter membrane/ATP-binding component; COG4987 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components. (573 aa)
macBMacrolide transporter ATP-binding /permease protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (648 aa)
mscLLarge-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. (137 aa)
frdDFumarate reductase subunit D; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (119 aa)
ESE81184.1Putative sugar transporter subunit; COG1175 ABC-type sugar transport systems, permease components. (429 aa)
motBCOG1360 Flagellar motor protein. (309 aa)
ESE81228.1COG1291 Flagellar motor component. (295 aa)
ESE86810.1COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. (144 aa)
ESE86813.1COG3444 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB. (157 aa)
ESE86644.1COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins. (1319 aa)
ESE86340.1COG2995 Uncharacterized paraquat-inducible protein A. (417 aa)
ESE86370.1Hypothetical protein; COG0477 Permeases of the major facilitator superfamily. (403 aa)
ESE86429.1Proline:sodium symporter PutP; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (502 aa)
lgtProlipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (291 aa)
ESE86180.1Arabinose-proton symporter; COG0477 Permeases of the major facilitator superfamily; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (471 aa)
ESE86205.1Hypothetical protein. (137 aa)
ESE86229.1Oxidative stress defense protein. (248 aa)
ESE86231.1COG0668 Small-conductance mechanosensitive channel. (286 aa)
tsgATransporter; COG0477 Permeases of the major facilitator superfamily. (393 aa)
envZOsmolarity sensor protein; COG0642 Signal transduction histidine kinase. (450 aa)
glpGIntramembrane serine protease GlpG; Rhomboid-type serine protease that catalyzes intramembrane proteolysis. (276 aa)
dtpBDipeptide/tripeptide permease B; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily. (490 aa)
ESE85780.1COG2233 Xanthine/uracil permeases. (441 aa)
ESE85815.1PTS system mannitol-specific transporter subunit IICBA; COG2213 Phosphotransferase system, mannitol-specific IIBC component. (638 aa)
ESE85875.1COG2233 Xanthine/uracil permeases. (463 aa)
ESE85895.1PTS system protein; COG3716 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID. (285 aa)
ESE85897.1Putative PTS system protein; COG3444 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB. (161 aa)
ESE85898.1PTS system fructose IIA component; COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. (141 aa)
ESE85908.1Regulatory protein UhpC; COG2271 Sugar phosphate permease. (442 aa)
emrDMultidrug resistance protein D; COG0477 Permeases of the major facilitator superfamily. (394 aa)
ESE85936.1Heme lyase subunit CcmF; COG1138 Cytochrome c biogenesis factor. (643 aa)
pstCPhosphate transporter permease subunit PstC; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (319 aa)
actPAcetate permease; Transports acetate; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (549 aa)
ESE84698.1COG0671 Membrane-associated phospholipid phosphatase. (254 aa)
lapAInner membrane protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. (102 aa)
zntBZinc transporter; Mediates efflux of zinc ions; Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. (327 aa)
ESE84766.1Putative multidrug transporter; COG2076 Membrane transporters of cations and cationic drugs. (112 aa)
ESE84848.1Aromatic amino acid exporter; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily. (293 aa)
ESE84866.1COG0477 Permeases of the major facilitator superfamily. (413 aa)
ESE84874.1COG1969 Ni,Fe-hydrogenase I cytochrome b subunit. (247 aa)
kdpBPotassium-transporting ATPase subunit B; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (682 aa)
ESE84893.1O-acetylserine/cysteine export protein; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily. (299 aa)
ESE84922.1COG2116 Formate/nitrite family of transporters. (285 aa)
ESE84508.1COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. (146 aa)
lntApolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (512 aa)
ESE82095.1Putative molecular chaperone. (385 aa)
ESE84531.1Aromatic amino acid transporter; COG1113 Gamma-aminobutyrate permease and related permeases. (456 aa)
ftsQCell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (276 aa)
ftsWCell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (414 aa)
ftsLCell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (121 aa)
ESE84091.1Multidrug efflux system protein EmrA; COG1566 Multidrug resistance efflux pump. (390 aa)
ESE84095.1Glycine betaine transporter membrane protein; COG4176 ABC-type proline/glycine betaine transport system, permease component. (354 aa)
ESE84107.1Inner membrane protein ygaP; COG0607 Rhodanese-related sulfurtransferase. (175 aa)
malKMaltose/maltodextrin transporter ATP-binding protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family. (369 aa)
malFMaltose transporter membrane protein; COG1175 ABC-type sugar transport systems, permease components. (514 aa)
malGCOG3833 ABC-type maltose transport systems, permease component. (296 aa)
ESE83529.1VCBS repeat-containing protein. (3824 aa)
ESE83479.1Sensor protein ZraS; COG0642 Signal transduction histidine kinase. (460 aa)
ESE83204.1COG2976 Uncharacterized protein conserved in bacteria. (206 aa)
rodZCytoskeletal protein RodZ; Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis. (334 aa)
ESE83252.1Hypothetical protein; COG0560 Phosphoserine phosphatase. (211 aa)
ESE83262.1COG0681 Signal peptidase I; Belongs to the peptidase S26 family. (324 aa)
mdoHGlucosyltransferase MdoH; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). (847 aa)
mdtGDrug efflux system protein MdtG; COG0477 Permeases of the major facilitator superfamily. (404 aa)
ESE82774.1PTS glucose-specific subunit IIBC; COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific. (477 aa)
ESE82788.1Outer membrane-specific lipoprotein transporter subunit LolC; COG4591 ABC-type transport system, involved in lipoprotein release, permease component. (399 aa)
ESE82863.1Protease 4; COG0616 Periplasmic serine proteases (ClpP class). (618 aa)
btuCVtamin B12-transporter permease; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane. (326 aa)
ESE82575.1COG0842 ABC-type multidrug transport system, permease component. (368 aa)
ESE82576.1Inner membrane transport permease YbhS; COG0842 ABC-type multidrug transport system, permease component. (376 aa)
ESE82397.1Potassium transporter; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA; Belongs to the TrkH potassium transport family. (483 aa)
tatBSec-independent translocase; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (182 aa)
tatATwin arginine translocase protein A; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (84 aa)
crcBChromosome condensation membrane protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. (127 aa)
ESE82075.1COG1686 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (403 aa)
ESE82092.1DnaJ domain-containing protein; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. (477 aa)
ESE82094.1DnaJ domain-containing protein; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. (96 aa)
Your Current Organism:
Salmonella enterica indica
NCBI taxonomy Id: 1173950
Other names: S. enterica subsp. indica serovar 6,14,25:z10:1,(2),7 str. 1121, Salmonella enterica subsp. indica serovar 6,14,25:z10:1,(2),7 str. 1121
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