STRINGSTRING
lipA lipA AQG77943.1 AQG77943.1 sucD sucD AQG78003.1 AQG78003.1 AQG78245.1 AQG78245.1 AQG82270.1 AQG82270.1 AQG78367.1 AQG78367.1 AQG78404.1 AQG78404.1 AQG78486.1 AQG78486.1 AQG78543.1 AQG78543.1 AQG78544.1 AQG78544.1 fumC fumC mqo mqo AQG78618.1 AQG78618.1 AQG82313.1 AQG82313.1 AQG78705.1 AQG78705.1 pckA pckA AQG78804.1 AQG78804.1 AQG78871.1 AQG78871.1 AQG78899.1 AQG78899.1 AQG82354.1 AQG82354.1 AQG79202.1 AQG79202.1 AQG79301.1 AQG79301.1 AQG79314.1 AQG79314.1 AQG79326.1 AQG79326.1 AQG82394.1 AQG82394.1 gltD gltD AQG79385.1 AQG79385.1 AQG79386.1 AQG79386.1 sucC sucC AQG79424.1 AQG79424.1 AQG79533.1 AQG79533.1 AQG82419.1 AQG82419.1 AQG79715.1 AQG79715.1 AQG79756.1 AQG79756.1 AQG79757.1 AQG79757.1 AQG79824.1 AQG79824.1 AQG79878.1 AQG79878.1 AQG79879.1 AQG79879.1 AQG79956.1 AQG79956.1 AQG80234.1 AQG80234.1 AQG80407.1 AQG80407.1 AQG80409.1 AQG80409.1 AQG80446.1 AQG80446.1 AQG80458.1 AQG80458.1 AQG80469.1 AQG80469.1 AQG80761.1 AQG80761.1 AQG82538.1 AQG82538.1 AQG80772.1 AQG80772.1 AQG80773.1 AQG80773.1 gltA gltA AQG80893.1 AQG80893.1 AQG80894.1 AQG80894.1 lipB lipB AQG81120.1 AQG81120.1 AQG81122.1 AQG81122.1 AQG81202.1 AQG81202.1 AQG81203.1 AQG81203.1 AQG81233.1 AQG81233.1 AQG81263.1 AQG81263.1 AQG81275.1 AQG81275.1 sdhA sdhA AQG81277.1 AQG81277.1 AQG81284.1 AQG81284.1 AQG81305.1 AQG81305.1 proC proC AQG81374.1 AQG81374.1 AQG81443.1 AQG81443.1 AQG81456.1 AQG81456.1 pdhA pdhA AQG81536.1 AQG81536.1 AQG81556.1 AQG81556.1 AQG81705.1 AQG81705.1 AQG81711.1 AQG81711.1 AQG81712.1 AQG81712.1 AQG81824.1 AQG81824.1 AQG81829.1 AQG81829.1 purU purU AQG81996.1 AQG81996.1 AQG82172.1 AQG82172.1 AQG82688.1 AQG82688.1 mdh mdh
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (297 aa)
AQG77943.1Cytochrome P450; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cytochrome P450 family. (460 aa)
sucDsuccinate--CoA ligase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa)
AQG78003.1Malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (754 aa)
AQG78245.1hydroxymethylglutaryl-CoA lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
AQG82270.1Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
AQG78367.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (476 aa)
AQG78404.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (512 aa)
AQG78486.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
AQG78543.1Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
AQG78544.1Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (320 aa)
fumCClass II fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (468 aa)
mqoMalate:quinone oxidoreductase; Malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (510 aa)
AQG78618.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
AQG82313.13-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
AQG78705.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (265 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (547 aa)
AQG78804.1Aconitate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (760 aa)
AQG78871.1Diapophytoene dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
AQG78899.1enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (279 aa)
AQG82354.1Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (631 aa)
AQG79202.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
AQG79301.14-hydroxybutyrate CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa)
AQG79314.1Malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (755 aa)
AQG79326.1Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (584 aa)
AQG82394.1Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1532 aa)
gltDGlutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (496 aa)
AQG79385.1Aminoglycoside phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
AQG79386.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (423 aa)
sucCsuccinate--CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (405 aa)
AQG79424.1Aminotransferase class III; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (425 aa)
AQG79533.1Isocitrate dehydrogenase; Catalyzes the formation of 2-oxoglutarate from isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (481 aa)
AQG82419.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (702 aa)
AQG79715.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (563 aa)
AQG79756.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (729 aa)
AQG79757.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (342 aa)
AQG79824.15-oxoprolinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1269 aa)
AQG79878.14-aminobutyrate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (438 aa)
AQG79879.1Succinate-semialdehyde dehydrogenase; In Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (452 aa)
AQG79956.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
AQG80234.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa)
AQG80407.1NADPH:quinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
AQG80409.1Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
AQG80446.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (430 aa)
AQG80458.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (606 aa)
AQG80469.1Gamma-glutamyltranspeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (603 aa)
AQG80761.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1147 aa)
AQG82538.1Proline dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (411 aa)
AQG80772.1Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (2229 aa)
AQG80773.1Non-ribosomal peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1340 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (426 aa)
AQG80893.12-oxoglutarate dehydrogenase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (549 aa)
AQG80894.12-oxoglutarate dehydrogenase subunit E1; Derived by automated computational analysis using gene prediction method: Protein Homology. (924 aa)
lipBOctanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (247 aa)
AQG81120.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
AQG81122.13-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (721 aa)
AQG81202.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
AQG81203.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (604 aa)
AQG81233.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (452 aa)
AQG81263.13-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (816 aa)
AQG81275.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (645 aa)
AQG81277.1Fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
AQG81284.1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
AQG81305.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (801 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (267 aa)
AQG81374.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (597 aa)
AQG81443.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (554 aa)
AQG81456.11-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (543 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (353 aa)
AQG81536.1Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
AQG81556.1Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (326 aa)
AQG81705.1Amino acid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (424 aa)
AQG81711.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
AQG81712.1Dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (156 aa)
AQG81824.1Long-chain fatty acid--CoA ligase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. (566 aa)
AQG81829.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (275 aa)
AQG81996.1Catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (466 aa)
AQG82172.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (466 aa)
AQG82688.1acetoacetyl-CoA synthetase; AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (656 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (311 aa)
Your Current Organism:
Spirosoma montaniterrae
NCBI taxonomy Id: 1178516
Other names: JCM 18492, KCTC 23999, KEMB 9004-162, KEMB:9004-162, S. montaniterrae, Spirosoma montaniterrae Lee et al. 2017, Spirosoma sp. DY10, strain DY10
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