(16 nodes) DNA ligase activity, and AP endonuclease 1 network (Saccharothrix espanaensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nth	Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (255 aa)
	lig-2	Putative DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (515 aa)
	BN6_18810	DNA polymerase LigD, polymerase domain protein. (333 aa)
	ligC	ATP-dependent DNA ligase. (357 aa)
	BN6_24570	DNA polymerase LigD, polymerase domain-containing protein. (258 aa)
	BN6_24580	DNA polymerase LigD, ligase domain-containing protein. (388 aa)
	lig	ATP-dependent DNA ligase. (708 aa)
	ku	Putative DNA repair protein, Ku family; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (264 aa)
	ku-2	Putative DNA repair protein, Ku family; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (298 aa)
	BN6_42910	Putative DNA ligase. (492 aa)
	BN6_42920	Putative DNA polymerase, LigD family. (342 aa)
	ligA1	DNA ligase 1; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (663 aa)
	BN6_58390	DNA polymerase LigD, polymerase domain-containing protein. (318 aa)
	BN6_65040	PHP family phosphoesterase. (329 aa)
	BN6_77620	Exodeoxyribonuclease III Xth. (327 aa)
	BN6_81740	Exodeoxyribonuclease III Xth. (338 aa)

Your Current Organism:

Saccharothrix espanaensis

NCBI taxonomy Id: 1179773
Other names: S. espanaensis DSM 44229, Saccharothrix espanaensis ATCC 51144, Saccharothrix espanaensis DSM 44229, Saccharothrix espanaensis NRRL 15764, Saccharothrix espanaensis str. DSM 44229, Saccharothrix espanaensis strain DSM 44229

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN6_18810	BN6_24580	BN6_18810	BN6_24580	DNA polymerase LigD, polymerase domain protein.	DNA polymerase LigD, ligase domain-containing protein.	0.901
BN6_18810	BN6_42910	BN6_18810	BN6_42910	DNA polymerase LigD, polymerase domain protein.	Putative DNA ligase.	0.977
BN6_18810	BN6_65040	BN6_18810	BN6_65040	DNA polymerase LigD, polymerase domain protein.	PHP family phosphoesterase.	0.422
BN6_18810	ku	BN6_18810	BN6_42890	DNA polymerase LigD, polymerase domain protein.	Putative DNA repair protein, Ku family; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.850
BN6_18810	ku-2	BN6_18810	BN6_42900	DNA polymerase LigD, polymerase domain protein.	Putative DNA repair protein, Ku family; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.850
BN6_18810	lig-2	BN6_18810	BN6_08010	DNA polymerase LigD, polymerase domain protein.	Putative DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.	0.747
BN6_18810	ligC	BN6_18810	BN6_18930	DNA polymerase LigD, polymerase domain protein.	ATP-dependent DNA ligase.	0.878
BN6_24570	BN6_24580	BN6_24570	BN6_24580	DNA polymerase LigD, polymerase domain-containing protein.	DNA polymerase LigD, ligase domain-containing protein.	0.942
BN6_24570	BN6_42910	BN6_24570	BN6_42910	DNA polymerase LigD, polymerase domain-containing protein.	Putative DNA ligase.	0.977
BN6_24570	ku	BN6_24570	BN6_42890	DNA polymerase LigD, polymerase domain-containing protein.	Putative DNA repair protein, Ku family; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.850
BN6_24570	ku-2	BN6_24570	BN6_42900	DNA polymerase LigD, polymerase domain-containing protein.	Putative DNA repair protein, Ku family; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.850
BN6_24570	lig-2	BN6_24570	BN6_08010	DNA polymerase LigD, polymerase domain-containing protein.	Putative DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.	0.731
BN6_24570	ligC	BN6_24570	BN6_18930	DNA polymerase LigD, polymerase domain-containing protein.	ATP-dependent DNA ligase.	0.872
BN6_24580	BN6_18810	BN6_24580	BN6_18810	DNA polymerase LigD, ligase domain-containing protein.	DNA polymerase LigD, polymerase domain protein.	0.901
BN6_24580	BN6_24570	BN6_24580	BN6_24570	DNA polymerase LigD, ligase domain-containing protein.	DNA polymerase LigD, polymerase domain-containing protein.	0.942
BN6_24580	BN6_42920	BN6_24580	BN6_42920	DNA polymerase LigD, ligase domain-containing protein.	Putative DNA polymerase, LigD family.	0.919
BN6_24580	BN6_58390	BN6_24580	BN6_58390	DNA polymerase LigD, ligase domain-containing protein.	DNA polymerase LigD, polymerase domain-containing protein.	0.847
BN6_24580	BN6_65040	BN6_24580	BN6_65040	DNA polymerase LigD, ligase domain-containing protein.	PHP family phosphoesterase.	0.867
BN6_24580	BN6_77620	BN6_24580	BN6_77620	DNA polymerase LigD, ligase domain-containing protein.	Exodeoxyribonuclease III Xth.	0.531
BN6_24580	BN6_81740	BN6_24580	BN6_81740	DNA polymerase LigD, ligase domain-containing protein.	Exodeoxyribonuclease III Xth.	0.531

page 1 of 7

Server load: low (34%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About