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| | BN6_00210 | Anthranilate synthase component 2. (214 aa) |
| | pheA | Prephenate dehydratase. (311 aa) |
| | hisC1 | Histidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (355 aa) |
| | BN6_02220 | Putative prephenate dehydrogenase. (318 aa) |
| | leuA-2 | Putative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (597 aa) |
| | lysC | Aspartate kinase; Belongs to the aspartokinase family. (421 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (353 aa) |
| | BN6_03170 | Hypothetical protein. (270 aa) |
| | BN6_04490 | Putative threo-3-hydroxyaspartate ammonia-lyase. (311 aa) |
| | BN6_05270 | Pyridoxal-5'-phosphate-dependent protein, beta subunit. (296 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (377 aa) |
| | BN6_07740 | Putative cystathionine beta-synthase. (414 aa) |
| | metB | Cystathionine gamma-synthase. (385 aa) |
| | BN6_08550 | 4Fe-4S ferredoxin iron-sulfur binding domain protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (108 aa) |
| | dapC | N-succinyldiaminopimelate aminotransferase. (360 aa) |
| | dapD | 2,3,4, 5-tetrahydropyridine-2-carboxylateN-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (323 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase. (355 aa) |
| | serB | Phosphoserine phosphatase. (408 aa) |
| | BN6_14410 | Putative threonine synthase. (420 aa) |
| | ilvE | Branched-chain-amino-acid aminotransferase. (366 aa) |
| | trpB1 | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (351 aa) |
| | aroH | Phospho-2-dehydro-3-deoxyheptonate aldolase; Belongs to the class-II DAHP synthase family. (462 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (294 aa) |
| | dapF1 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (266 aa) |
| | BN6_23200 | Hypothetical protein; Belongs to the AB hydrolase superfamily. MetX family. (347 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (586 aa) |
| | trpB2 | Tryptophan synthase beta chain 2; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (455 aa) |
| | BN6_26530 | Sulfide-quinone reductase. (432 aa) |
| | metH | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1213 aa) |
| | BN6_30650 | Methionine gamma-lyase. (410 aa) |
| | hisE | Hypothetical protein. (93 aa) |
| | lysA1 | Diaminopimelate decarboxylase. (435 aa) |
| | metE1 | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase. (354 aa) |
| | BN6_32940 | Sugar phosphate isomerase/epimerase. (252 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (287 aa) |
| | dapA1 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (310 aa) |
| | BN6_37290 | Benzoylformate decarboxylase; Belongs to the TPP enzyme family. (522 aa) |
| | BN6_37660 | Putative methionine gamma-lyase. (428 aa) |
| | BN6_39180 | Hypothetical protein; Chorismate mutase. (94 aa) |
| | BN6_39490 | Putative cysteine synthase A. (379 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (198 aa) |
| | BN6_40770 | Pyridoxal-5'-phosphate-dependent protein, beta subunit. (312 aa) |
| | dapF3 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (280 aa) |
| | cysK | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (325 aa) |
| | BN6_45280 | Putative homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine. (385 aa) |
| | BN6_47830 | Branched-chain amino acid aminotransferase. (360 aa) |
| | mdlC | Benzoylformate decarboxylase; Belongs to the TPP enzyme family. (538 aa) |
| | metE3 | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (744 aa) |
| | pab | Para-aminobenzoate synthase. (695 aa) |
| | BN6_51430 | Pyridoxal-5'-phosphate-dependent protein, beta subunit. (419 aa) |
| | hisF1 | Imidazole glycerol phosphate synthase subunit HisF; Belongs to the HisA/HisF family. (257 aa) |
| | BN6_57100 | Hypothetical protein. (307 aa) |
| | sam27 | L-threonine synthase. (430 aa) |
| | metK | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (400 aa) |
| | aroQ | 3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (142 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (368 aa) |
| | aroK | Hypothetical protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (170 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (399 aa) |
| | aroE | Shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (314 aa) |
| | BN6_64330 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase-like protein. (362 aa) |
| | dapA3 | Dihydrodipicolinate synthase; Belongs to the DapA family. (283 aa) |
| | ilvB1 | Acetolactate synthase I/II/III large subunit; Belongs to the TPP enzyme family. (551 aa) |
| | BN6_67720 | Para-aminobenzoate synthase. (668 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (261 aa) |
| | trpB3 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (407 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (269 aa) |
| | trpE | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (610 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (150 aa) |
| | hisF3 | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (280 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (243 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (212 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (199 aa) |
| | hisC3 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (367 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (465 aa) |
| | dapA5 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (277 aa) |
| | cysA1 | Putative cystathionine gamma-lyase. (354 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa) |
| | BN6_71960 | Putative transferase, AIPM/Hcit synthase family; Belongs to the alpha-IPM synthase/homocitrate synthase family. (528 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (345 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa) |
| | ilvH | Acetolactate synthase small subunit. (168 aa) |
| | ilvB3 | Acetolactate synthase. (612 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (614 aa) |
| | BN6_72450 | Ectoine utilization protein. (289 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (329 aa) |
| | thrC | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (358 aa) |
| | hom | Homoserine dehydrogenase. (432 aa) |
| | lysA3 | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (474 aa) |
| | metX | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (365 aa) |
| | metY | O-acetylhomoserine (thiol)-lyase. (429 aa) |
| | sdaA | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (426 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (487 aa) |
| | BN6_78320 | Hypothetical protein. (89 aa) |
| | aspC | Aspartate aminotransferase. (414 aa) |
| | BN6_80570 | Pyridoxal-5'-phosphate-dependent protein, beta subunit. (348 aa) |
| | BN6_81420 | Aminotransferase class I and II. (390 aa) |
| | lysA5 | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (416 aa) |
| | BN6_83190 | Xylose isomerase domain-containing protein. (256 aa) |
