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leuA-2 leuA-2 BN6_04490 BN6_04490 BN6_05270 BN6_05270 serC serC BN6_07740 BN6_07740 metB metB serB serB BN6_14410 BN6_14410 ilvE ilvE metF metF BN6_23200 BN6_23200 leuA leuA trpB2 trpB2 BN6_26530 BN6_26530 metH metH BN6_30650 BN6_30650 metE1 metE1 BN6_37290 BN6_37290 BN6_37660 BN6_37660 BN6_39490 BN6_39490 BN6_40770 BN6_40770 cysK cysK BN6_45280 BN6_45280 BN6_47830 BN6_47830 mdlC mdlC metE3 metE3 BN6_51430 BN6_51430 BN6_57100 BN6_57100 sam27 sam27 metK metK ilvB1 ilvB1 cysA1 cysA1 leuD leuD leuC leuC BN6_71960 BN6_71960 leuB leuB serA serA ilvC ilvC ilvH ilvH ilvB3 ilvB3 ilvD ilvD BN6_72450 BN6_72450 thrB thrB thrC thrC hom hom metX metX metY metY sdaA sdaA ahcY ahcY BN6_80570 BN6_80570
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
leuA-2Putative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (597 aa)
BN6_04490Putative threo-3-hydroxyaspartate ammonia-lyase. (311 aa)
BN6_05270Pyridoxal-5'-phosphate-dependent protein, beta subunit. (296 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (377 aa)
BN6_07740Putative cystathionine beta-synthase. (414 aa)
metBCystathionine gamma-synthase. (385 aa)
serBPhosphoserine phosphatase. (408 aa)
BN6_14410Putative threonine synthase. (420 aa)
ilvEBranched-chain-amino-acid aminotransferase. (366 aa)
metF5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (294 aa)
BN6_23200Hypothetical protein; Belongs to the AB hydrolase superfamily. MetX family. (347 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (586 aa)
trpB2Tryptophan synthase beta chain 2; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (455 aa)
BN6_26530Sulfide-quinone reductase. (432 aa)
metHMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1213 aa)
BN6_30650Methionine gamma-lyase. (410 aa)
metE15-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase. (354 aa)
BN6_37290Benzoylformate decarboxylase; Belongs to the TPP enzyme family. (522 aa)
BN6_37660Putative methionine gamma-lyase. (428 aa)
BN6_39490Putative cysteine synthase A. (379 aa)
BN6_40770Pyridoxal-5'-phosphate-dependent protein, beta subunit. (312 aa)
cysKCysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (325 aa)
BN6_45280Putative homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine. (385 aa)
BN6_47830Branched-chain amino acid aminotransferase. (360 aa)
mdlCBenzoylformate decarboxylase; Belongs to the TPP enzyme family. (538 aa)
metE35-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (744 aa)
BN6_51430Pyridoxal-5'-phosphate-dependent protein, beta subunit. (419 aa)
BN6_57100Hypothetical protein. (307 aa)
sam27L-threonine synthase. (430 aa)
metKS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (400 aa)
ilvB1Acetolactate synthase I/II/III large subunit; Belongs to the TPP enzyme family. (551 aa)
cysA1Putative cystathionine gamma-lyase. (354 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa)
BN6_71960Putative transferase, AIPM/Hcit synthase family; Belongs to the alpha-IPM synthase/homocitrate synthase family. (528 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (345 aa)
serAD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
ilvHAcetolactate synthase small subunit. (168 aa)
ilvB3Acetolactate synthase. (612 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (614 aa)
BN6_72450Ectoine utilization protein. (289 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (329 aa)
thrCThreonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (358 aa)
homHomoserine dehydrogenase. (432 aa)
metXHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (365 aa)
metYO-acetylhomoserine (thiol)-lyase. (429 aa)
sdaAL-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (487 aa)
BN6_80570Pyridoxal-5'-phosphate-dependent protein, beta subunit. (348 aa)
Your Current Organism:
Saccharothrix espanaensis
NCBI taxonomy Id: 1179773
Other names: S. espanaensis DSM 44229, Saccharothrix espanaensis ATCC 51144, Saccharothrix espanaensis DSM 44229, Saccharothrix espanaensis NRRL 15764, Saccharothrix espanaensis str. DSM 44229, Saccharothrix espanaensis strain DSM 44229
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