(56 nodes) Polyketide synthase, phosphopantetheine-binding domain, and MbtH-like domain network (Saccharothrix espanaensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BN6_07080	Putative ligase. (529 aa)
	BN6_21380	AMP-binding enzyme. (476 aa)
	BN6_21390	Putative thioesterase. (264 aa)
	nrps1-a3	Amino acid adenylation domain-containing protein. (508 aa)
	nrps1-c2	Condensation domain-containing protein. (484 aa)
	nrps1-t3	Amino acid thiolation domain containing protein. (99 aa)
	BN6_22450	Hypothetical protein; Non-ribosomal peptide synthetase modules and related proteins. (385 aa)
	BN6_26890	Putative MbtH-like protein. (68 aa)
	nrps2-2	Non-ribosomal peptide synthetase. (6716 aa)
	nrps2-1	Non-ribosomal peptide synthase-modules containing protein. (720 aa)
	nrps3-3	Non-ribosomal peptide synthetase. (4893 aa)
	BN6_32500	Uncharacterized protein conserved in bacteria. (75 aa)
	BN6_32550	MbtH-like protein. (63 aa)
	nrps3-2	Non-ribosomal peptide synthetase. (6194 aa)
	nrps3-1	Non-ribosomal peptide synthetase. (2519 aa)
	pks4-1	Polyketide synthase. (2130 aa)
	pks4-3	Polyketide synthase. (2420 aa)
	pks5	Polyketide synthase type I. (1140 aa)
	nrps5-a5	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family. (518 aa)
	nrps5-4	Non-ribosomal peptide synthetase; Belongs to the ATP-dependent AMP-binding enzyme family. (1462 aa)
	nrps5-2	Non-ribosomal peptide synthetase. (1035 aa)
	nrps5-1	Non-ribosomal peptide synthetase. (1917 aa)
	BN6_35640	Uncharacterized protein conserved in bacteria. (71 aa)
	nrps6-c	Non-ribosomal peptide synthetase-like protein. (459 aa)
	nrps6	Non-ribosomal peptide synthetase-like protein. (646 aa)
	nrps7	Non-ribosomal peptide synthetase. (2098 aa)
	BN6_45590	MbtH-like protein. (72 aa)
	pks8-4	Modular polyketide synthase. (2230 aa)
	BN6_46050	PfaD family protein. (784 aa)
	nrpks8	Hybrid nonribosomal peptide synthetase / polyketide synthase. (2223 aa)
	BN6_46070	Thioesterase. (202 aa)
	pks8-2	Polyketide synthase. (6706 aa)
	pks8-1	Polyketide synthase. (1999 aa)
	BN6_46220	PfaD family protein. (741 aa)
	pks9-3	Polyketide synthase. (1844 aa)
	pks9-2	Polyketide synthase. (1549 aa)
	pks9-7	Polyketide synthase. (1984 aa)
	pks9-6	Polyketide synthase. (2743 aa)
	pks9-5	Polyketide synthase. (1589 aa)
	nrps10-1	Putative non-ribosomal peptide synthase. (2324 aa)
	nrps10-4	Putative non-ribosomal peptide synthase. (963 aa)
	nrps10-3	Putative non-ribosomal peptide synthase. (1314 aa)
	BN6_47920	Putative oxidoreductase. (341 aa)
	pks10	Putative polyketide synthase. (1394 aa)
	nrps10-2	Amino acid adenylation domain-containing protein. (567 aa)
	BN6_47950	Putative MbtH-like protein. (63 aa)
	pks11-3	Putative polyketide synthase. (2069 aa)
	pks11-2	Putative polyketide synthase. (3151 aa)
	BN6_48370	Hypothetical protein; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (603 aa)
	nrps12-2	Non-ribosomal peptide synthetase. (1396 aa)
	BN6_53050	Non-ribosomal peptide synthetase. (988 aa)
	BN6_53360	Peptide synthetase. (400 aa)
	nrps14-1	Non-ribosomal peptide synthetase. (1918 aa)
	pks14	Polyketide synthase type I. (1463 aa)
	nrps14-3	Non-ribosomal peptide synthetase. (1109 aa)
	nrps14-5	Non-ribosomal peptide synthetase. (996 aa)

Your Current Organism:

Saccharothrix espanaensis

NCBI taxonomy Id: 1179773
Other names: S. espanaensis DSM 44229, Saccharothrix espanaensis ATCC 51144, Saccharothrix espanaensis DSM 44229, Saccharothrix espanaensis NRRL 15764, Saccharothrix espanaensis str. DSM 44229, Saccharothrix espanaensis strain DSM 44229

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN6_07080	BN6_22450	BN6_07080	BN6_22450	Putative ligase.	Hypothetical protein; Non-ribosomal peptide synthetase modules and related proteins.	0.520
BN6_07080	BN6_53050	BN6_07080	BN6_53050	Putative ligase.	Non-ribosomal peptide synthetase.	0.622
BN6_07080	BN6_53360	BN6_07080	BN6_53360	Putative ligase.	Peptide synthetase.	0.882
BN6_07080	nrpks8	BN6_07080	BN6_46060	Putative ligase.	Hybrid nonribosomal peptide synthetase / polyketide synthase.	0.488
BN6_07080	nrps1-a3	BN6_07080	BN6_22370	Putative ligase.	Amino acid adenylation domain-containing protein.	0.576
BN6_07080	nrps1-t3	BN6_07080	BN6_22390	Putative ligase.	Amino acid thiolation domain containing protein.	0.465
BN6_07080	nrps10-1	BN6_07080	BN6_47680	Putative ligase.	Putative non-ribosomal peptide synthase.	0.484
BN6_07080	nrps10-2	BN6_07080	BN6_47940	Putative ligase.	Amino acid adenylation domain-containing protein.	0.804
BN6_07080	nrps10-3	BN6_07080	BN6_47910	Putative ligase.	Putative non-ribosomal peptide synthase.	0.835
BN6_07080	nrps10-4	BN6_07080	BN6_47890	Putative ligase.	Putative non-ribosomal peptide synthase.	0.654
BN6_07080	nrps12-2	BN6_07080	BN6_51330	Putative ligase.	Non-ribosomal peptide synthetase.	0.432
BN6_07080	nrps14-1	BN6_07080	BN6_56580	Putative ligase.	Non-ribosomal peptide synthetase.	0.524
BN6_07080	nrps14-3	BN6_07080	BN6_56790	Putative ligase.	Non-ribosomal peptide synthetase.	0.844
BN6_07080	nrps14-5	BN6_07080	BN6_56850	Putative ligase.	Non-ribosomal peptide synthetase.	0.835
BN6_07080	nrps2-1	BN6_07080	BN6_26940	Putative ligase.	Non-ribosomal peptide synthase-modules containing protein.	0.499
BN6_07080	nrps2-2	BN6_07080	BN6_26930	Putative ligase.	Non-ribosomal peptide synthetase.	0.529
BN6_07080	nrps3-1	BN6_07080	BN6_32580	Putative ligase.	Non-ribosomal peptide synthetase.	0.663
BN6_07080	nrps3-3	BN6_07080	BN6_32470	Putative ligase.	Non-ribosomal peptide synthetase.	0.535
BN6_07080	nrps5-1	BN6_07080	BN6_35630	Putative ligase.	Non-ribosomal peptide synthetase.	0.489
BN6_07080	nrps5-2	BN6_07080	BN6_35610	Putative ligase.	Non-ribosomal peptide synthetase.	0.760

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