STRINGSTRING
BN6_43200 BN6_43200 BN6_41210 BN6_41210 BN6_41180 BN6_41180 BN6_38300 BN6_38300 BN6_37530 BN6_37530 BN6_37520 BN6_37520 BN6_35400 BN6_35400 BN6_34870 BN6_34870 BN6_34660 BN6_34660 BN6_34390 BN6_34390 BN6_32320 BN6_32320 fadB2 fadB2 BN6_30100 BN6_30100 BN6_29630 BN6_29630 BN6_27560 BN6_27560 BN6_23070 BN6_23070 BN6_22150 BN6_22150 ribD1 ribD1 BN6_19030 BN6_19030 BN6_18530 BN6_18530 BN6_17270 BN6_17270 BN6_08000 BN6_08000 hbd hbd BN6_05070 BN6_05070 BN6_04260 BN6_04260 BN6_02890 BN6_02890 BN6_00600 BN6_00600 BN6_00030 BN6_00030 tdh tdh BN6_83040 BN6_83040 BN6_82420 BN6_82420 murB murB guaB guaB BN6_78540 BN6_78540 mdh mdh icd icd BN6_77050 BN6_77050 rfbD rfbD BN6_75500 BN6_75500 BN6_75110 BN6_75110 hom hom paaH paaH ilvC ilvC serA serA leuB leuB gpsA2 gpsA2 dxr dxr hisD hisD BN6_68150 BN6_68150 BN6_67950 BN6_67950 BN6_64900 BN6_64900 aroE aroE ribD3 ribD3 zwf zwf BN6_61440 BN6_61440 BN6_60420 BN6_60420 sam22 sam22 BN6_56140 BN6_56140 BN6_54820 BN6_54820 fdh3 fdh3 BN6_52630 BN6_52630 BN6_52620 BN6_52620 BN6_52160 BN6_52160 BN6_51110 BN6_51110 fdh1 fdh1 rkpK rkpK vanH vanH BN6_44820 BN6_44820
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BN6_43200Hypothetical protein. (337 aa)
BN6_41210L-threonine 3-dehydrogenase. (326 aa)
BN6_41180Putative riboflavin-specific deaminase. (227 aa)
BN6_38300NAD-dependent epimerase/dehydratase. (293 aa)
BN6_37530Oxidoreductase domain-containing protein. (319 aa)
BN6_37520Nucleotide sugar dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (415 aa)
BN6_354003-hydroxybutyryl-CoA dehydrogenase. (286 aa)
BN6_34870Aldo/keto reductase. (327 aa)
BN6_346603-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein. (352 aa)
BN6_34390Mycothiol-dependent formaldehyde dehydrogenase. (370 aa)
BN6_32320Putative oxidoreductase. (171 aa)
fadB23-hydroxybutyryl-CoA dehydrogenase. (287 aa)
BN6_30100Hypothetical protein; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (423 aa)
BN6_29630UDP-glucose/GDP-mannose dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (436 aa)
BN6_27560Aldo/keto reductase. (342 aa)
BN6_23070Mycothiol-dependent formaldehyde dehydrogenase. (369 aa)
BN6_22150Ketopantoate reductase ApbA/PanE. (321 aa)
ribD1Riboflavin biosynthesis protein. (304 aa)
BN6_19030Bifunctional deaminase-reductase domain protein. (255 aa)
BN6_185303-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein. (703 aa)
BN6_17270Glycoside hydrolase family 4. (423 aa)
BN6_08000Putative oxidoreductase. (479 aa)
hbd3-hydroxybutyryl-CoA dehydrogenase. (274 aa)
BN6_05070NAD-dependent malic enzyme. (462 aa)
BN6_042606-phospho-beta-glucosidase. (424 aa)
BN6_02890Oxidoreductase domain-containing protein. (296 aa)
BN6_00600UDP-glucose 6-dehydrogenase. (431 aa)
BN6_000306-phosphogluconate dehydrogenase-like protein. (304 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (344 aa)
BN6_83040Aldo/keto reductase. (312 aa)
BN6_82420Alcohol dehydrogenase GroES domain protein. (392 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (376 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (503 aa)
BN6_78540Putative oxidoreductase. (377 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
icdIsocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (406 aa)
BN6_77050Hypothetical protein. (319 aa)
rfbDdTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (296 aa)
BN6_75500NAD-dependent malic enzyme. (394 aa)
BN6_75110Putative oxidoreductase. (339 aa)
homHomoserine dehydrogenase. (432 aa)
paaH3-hydroxybutyryl-CoA dehydrogenase. (591 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
serAD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (345 aa)
gpsA2Glycerol-3-phosphate dehydrogenase [NAD(P)+] 2; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (334 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (406 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (465 aa)
BN6_681506-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (479 aa)
BN6_679503-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein. (703 aa)
BN6_64900Putative oxidoreductase. (331 aa)
aroEShikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (314 aa)
ribD3Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (334 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (513 aa)
BN6_61440Putative oxidoreductase. (301 aa)
BN6_60420Hypothetical protein. (221 aa)
sam22Aldo/keto reductase. (330 aa)
BN6_56140Zinc-containing dehydrogenase. (345 aa)
BN6_54820Aldo/keto reductase. (299 aa)
fdh3Glutathione-dependent formaldehyde dehydrogenase. (391 aa)
BN6_52630Cyclitol dehydrogenase. (377 aa)
BN6_52620Alcohol dehydrogenase, GroES domain protein. (348 aa)
BN6_52160Hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (333 aa)
BN6_51110Alcohol dehydrogenase. (385 aa)
fdh1S-(hydroxymethyl)glutathione dehydrogenase. (392 aa)
rkpKUDP-glucose 6-dehydrogenase. (419 aa)
vanHD-specific alpha-keto acid dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (350 aa)
BN6_448203-hydroxybutyryl-CoA dehydrogenase. (261 aa)
Your Current Organism:
Saccharothrix espanaensis
NCBI taxonomy Id: 1179773
Other names: S. espanaensis DSM 44229, Saccharothrix espanaensis ATCC 51144, Saccharothrix espanaensis DSM 44229, Saccharothrix espanaensis NRRL 15764, Saccharothrix espanaensis str. DSM 44229, Saccharothrix espanaensis strain DSM 44229
Server load: low (24%) [HD]