(35 nodes) Two-component regulatory system, and Histidine kinase domain network (Enterococcus rotai)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ALS35600.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa)
	ALS35608.1	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
	ALS35609.1	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
	ALS35610.1	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
	ALS35756.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (695 aa)
	ALS35757.1	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
	ALS36095.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa)
	ALS36096.1	PhoB family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
	ALS36375.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (668 aa)
	ALS36376.1	Bacteriocin ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
	ALS36377.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
	ALS36378.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa)
	ALS36454.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
	ALS36547.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
	ALS36548.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
	ALS36656.1	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
	ALS36657.1	PhoB family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
	ALS36773.1	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
	ALS36774.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (459 aa)
	ALS36787.1	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
	ALS36788.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
	ALS36873.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
	ALS38775.1	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
	ALS37089.1	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
	ALS37204.1	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
	ALS37205.1	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
	ALS37382.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (498 aa)
	ALS37383.1	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
	ALS37384.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (98 aa)
	ALS37511.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
	ALS37740.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (616 aa)
	ALS37741.1	PhoB family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
	ALS37945.1	HAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
	ALS37946.1	PhoP family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
	ALS37947.1	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (489 aa)

Your Current Organism:

Enterococcus rotai

NCBI taxonomy Id: 118060
Other names: CCM 4630, CCUG 61593, E. rotai, Enterococcus rotai Sedlacek et al. 2013, Enterococcus sp. CCM 4360, LMG 26678, LMG:26678

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALS35600.1	ALS35609.1	ATZ35_00015	ATZ35_00060	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.590
ALS35600.1	ALS35610.1	ATZ35_00015	ATZ35_00065	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.613
ALS35600.1	ALS36095.1	ATZ35_00015	ATZ35_02635	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.657
ALS35600.1	ALS36096.1	ATZ35_00015	ATZ35_02640	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	PhoB family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.689
ALS35600.1	ALS36377.1	ATZ35_00015	ATZ35_04140	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.611
ALS35600.1	ALS36378.1	ATZ35_00015	ATZ35_04145	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.468
ALS35600.1	ALS36547.1	ATZ35_00015	ATZ35_05045	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.751
ALS35600.1	ALS36548.1	ATZ35_00015	ATZ35_05050	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.663
ALS35600.1	ALS36656.1	ATZ35_00015	ATZ35_05610	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.510
ALS35600.1	ALS36774.1	ATZ35_00015	ATZ35_06275	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.654
ALS35600.1	ALS36787.1	ATZ35_00015	ATZ35_06340	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.628
ALS35600.1	ALS36788.1	ATZ35_00015	ATZ35_06345	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.720
ALS35600.1	ALS37089.1	ATZ35_00015	ATZ35_07940	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.560
ALS35600.1	ALS37204.1	ATZ35_00015	ATZ35_08545	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.405
ALS35600.1	ALS37205.1	ATZ35_00015	ATZ35_08550	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.602
ALS35600.1	ALS37382.1	ATZ35_00015	ATZ35_09510	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.513
ALS35600.1	ALS37383.1	ATZ35_00015	ATZ35_09515	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.605
ALS35600.1	ALS37946.1	ATZ35_00015	ATZ35_12565	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	PhoP family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.440
ALS35600.1	ALS37947.1	ATZ35_00015	ATZ35_12570	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.422
ALS35600.1	ALS38775.1	ATZ35_00015	ATZ35_07935	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.662