STRINGSTRING
uvrB uvrB ALS38718.1 ALS38718.1 ALS35695.1 ALS35695.1 ALS35936.1 ALS35936.1 kdpB kdpB ALS36126.1 ALS36126.1 ALS36132.1 ALS36132.1 smc smc recG recG ALS36503.1 ALS36503.1 ALS36556.1 ALS36556.1 ALS36635.1 ALS36635.1 ychF ychF ALS36659.1 ALS36659.1 mutL mutL ruvA ruvA ruvB ruvB ALS36852.1 ALS36852.1 ALS37009.1 ALS37009.1 ftsH ftsH cshA cshA ALS37147.1 ALS37147.1 ftsA ftsA ALS37450.1 ALS37450.1 ATZ35_09940 ATZ35_09940 ALS37485.1 ALS37485.1 ALS37575.1 ALS37575.1 clpX clpX ALS37713.1 ALS37713.1 cshB cshB ALS37786.1 ALS37786.1 ALS37882.1 ALS37882.1 dbpA dbpA hslU hslU ALS38115.1 ALS38115.1 addA addA rexB rexB mutS2 mutS2 ALS38246.1 ALS38246.1 clpB clpB ALS38340.1 ALS38340.1 ALS38426.1 ALS38426.1 ALS38433.1 ALS38433.1 ALS38567.1 ALS38567.1 ALS38568.1 ALS38568.1 recD2 recD2 uvrA uvrA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (664 aa)
ALS38718.1ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology. (746 aa)
ALS35695.1ATP-dependent Clp protease ATP-binding subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ClpA/ClpB family. (751 aa)
ALS35936.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (524 aa)
kdpBPotassium-transporting ATPase subunit B; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (686 aa)
ALS36126.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa)
ALS36132.1Metal-transporting ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (654 aa)
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1192 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (678 aa)
ALS36503.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)
ALS36556.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (456 aa)
ALS36635.1Sporulation initiation inhibitor Soj; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
ychFGTP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (366 aa)
ALS36659.1ATP-dependent Clp protease ATP-binding subunit ClpC; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ClpA/ClpB family. (829 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (693 aa)
ruvAHolliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (203 aa)
ruvBATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (337 aa)
ALS36852.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (821 aa)
ALS37009.1AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
ftsHCell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (720 aa)
cshADEAD/DEAH box helicase; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. (513 aa)
ALS37147.1Magnesium-transporting ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (878 aa)
ftsACell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (440 aa)
ALS37450.1Recombinase RarA; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
ATZ35_09940Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
ALS37485.1Daunorubicin resistance protein DrrC; Derived by automated computational analysis using gene prediction method: Protein Homology. (743 aa)
ALS37575.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (903 aa)
clpXATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (417 aa)
ALS37713.1Magnesium-translocating P-type ATPase; P-type; involved in magnesium transport into the cytoplasm; Derived by automated computational analysis using gene prediction method: Protein Homology. (870 aa)
cshBDEAD/DEAH box helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (450 aa)
ALS37786.1Bifunctional P-type ATPase/ATP:dephospho-CoA triphosphoribosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (876 aa)
ALS37882.1Aromatic ring hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (113 aa)
dbpARNA helicase; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes. (482 aa)
hslUATP-dependent protease; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (467 aa)
ALS38115.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (778 aa)
addADNA helicase UvrD; ATP-dependent DNA helicase. (1265 aa)
rexBATP-dependent helicase; ATP-dependent DNA helicase; Belongs to the helicase family. AddB/RexB type 2 subfamily. (1192 aa)
mutS2DNA mismatch repair protein MutS; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (788 aa)
ALS38246.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (637 aa)
clpBATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (867 aa)
ALS38340.1Copper-transporting ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (688 aa)
ALS38426.1Magnesium-translocating P-type ATPase; P-type; involved in magnesium transport into the cytoplasm; Derived by automated computational analysis using gene prediction method: Protein Homology. (884 aa)
ALS38433.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (459 aa)
ALS38567.1Cobalt ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (596 aa)
ALS38568.1Magnesium-transporting ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (822 aa)
recD2Exodeoxyribonuclease V subunit alpha; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (863 aa)
uvrAABC-ATPase UvrA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (938 aa)
Your Current Organism:
Enterococcus rotai
NCBI taxonomy Id: 118060
Other names: CCM 4630, CCUG 61593, E. rotai, Enterococcus rotai Sedlacek et al. 2013, Enterococcus sp. CCM 4360, LMG 26678, LMG:26678
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