(30 nodes) Homologous recombination network (Enterococcus rotai)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	dnaE	DNA polymerase III subunit alpha; Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria; Derived by automated computational analysis using gene prediction method: Protein Homology. (1110 aa)
	ALS38252.1	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (343 aa)
	recO	DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (269 aa)
	polC	DNA polymerase III subunit alpha; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1450 aa)
	ALS38090.1	single-stranded-DNA-specific exonuclease RecJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (769 aa)
	ATZ35_12350	Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
	ALS37789.1	Alkaline phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
	dinG	DNA polymerase III subunit epsilon; 3'-5' exonuclease. (921 aa)
	ALS37486.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (301 aa)
	prsA	Peptidylprolyl isomerase; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins. (350 aa)
	ruvB	ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (337 aa)
	ruvA	Holliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (203 aa)
	ALS36107.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
	ALS36330.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
	recG	ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (678 aa)
	priA	Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (810 aa)
	ALS36560.1	Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (183 aa)
	ALS35684.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
	ALS35738.1	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
	ALS35769.1	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
	recR	Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa)
	dnaX	DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (584 aa)
	ALS38700.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
	ALS35683.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
	recA	DNA recombination/repair protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (350 aa)
	ALS36583.1	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (376 aa)
	recF	Recombinase RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (375 aa)
	recD2	Exodeoxyribonuclease V subunit alpha; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (863 aa)
	polA	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (881 aa)
	ALS38327.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa)

Your Current Organism:

Enterococcus rotai

NCBI taxonomy Id: 118060
Other names: CCM 4630, CCUG 61593, E. rotai, Enterococcus rotai Sedlacek et al. 2013, Enterococcus sp. CCM 4360, LMG 26678, LMG:26678

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALS35683.1	ALS35684.1	ATZ35_00475	ATZ35_00480	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.952
ALS35683.1	dinG	ATZ35_00475	ATZ35_11580	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit epsilon; 3'-5' exonuclease.	0.726
ALS35684.1	ALS35683.1	ATZ35_00480	ATZ35_00475	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.952
ALS35684.1	dinG	ATZ35_00480	ATZ35_11580	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit epsilon; 3'-5' exonuclease.	0.726
ALS35738.1	ALS35769.1	ATZ35_00760	ATZ35_00920	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.848
ALS35738.1	ALS36583.1	ATZ35_00760	ATZ35_05225	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.954
ALS35738.1	ALS38252.1	ATZ35_00760	ATZ35_14175	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.922
ALS35738.1	dnaE	ATZ35_00760	ATZ35_14270	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit alpha; Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.959
ALS35738.1	dnaX	ATZ35_00760	ATZ35_00975	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.958
ALS35738.1	polA	ATZ35_00760	ATZ35_14640	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.721
ALS35738.1	polC	ATZ35_00760	ATZ35_13835	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit alpha; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.809
ALS35769.1	ALS35738.1	ATZ35_00920	ATZ35_00760	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.848
ALS35769.1	ALS36583.1	ATZ35_00920	ATZ35_05225	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.998
ALS35769.1	ALS38252.1	ATZ35_00920	ATZ35_14175	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
ALS35769.1	dinG	ATZ35_00920	ATZ35_11580	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit epsilon; 3'-5' exonuclease.	0.961
ALS35769.1	dnaE	ATZ35_00920	ATZ35_14270	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit alpha; Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.996
ALS35769.1	dnaX	ATZ35_00920	ATZ35_00975	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.998
ALS35769.1	polA	ATZ35_00920	ATZ35_14640	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.986
ALS35769.1	polC	ATZ35_00920	ATZ35_13835	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit alpha; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.926
ALS35769.1	recA	ATZ35_00920	ATZ35_06040	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA recombination/repair protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.664