(56 nodes) Ubiquinone and other terpenoid-quinone biosynthesis network (Capronia epimyces)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A1O3_01017	Uncharacterized protein. (605 aa)
	COQ3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (309 aa)
	A1O3_08422	AP_endonuc_2 domain-containing protein. (334 aa)
	A1O3_08623	Uncharacterized protein. (576 aa)
	A1O3_07973	Uncharacterized protein. (579 aa)
	A1O3_08092	Uncharacterized protein. (319 aa)
	A1O3_06911	Uncharacterized protein. (564 aa)
	A1O3_09964	Uncharacterized protein. (301 aa)
	A1O3_06912	Uncharacterized protein. (1121 aa)
	A1O3_06927	Uncharacterized protein. (141 aa)
	A1O3_09154	Uncharacterized protein. (574 aa)
	A1O3_07231	Uncharacterized protein. (491 aa)
	A1O3_06542	FAD_binding_3 domain-containing protein. (453 aa)
	A1O3_08672	2,4-dichlorophenol 6-monooxygenase. (660 aa)
	A1O3_08210	FAD_binding_3 domain-containing protein. (638 aa)
	A1O3_08346	Uncharacterized protein. (570 aa)
	A1O3_08211	Fungal_trans domain-containing protein. (488 aa)
	A1O3_07428	Uncharacterized protein. (569 aa)
	A1O3_04920	Flavodoxin_2 domain-containing protein. (220 aa)
	A1O3_07591	Aminotran_1_2 domain-containing protein. (408 aa)
	A1O3_05227	PKS_PP domain-containing protein. (1051 aa)
	A1O3_05583	Uncharacterized protein. (480 aa)
	A1O3_05788	4HBT domain-containing protein. (142 aa)
	A1O3_03898	Aromatic amino acid aminotransferase I. (560 aa)
	A1O3_06474	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (298 aa)
	A1O3_03423	AB hydrolase-1 domain-containing protein. (326 aa)
	A1O3_06753	FAD_binding_3 domain-containing protein. (629 aa)
	A1O3_03716	AP_endonuc_2 domain-containing protein. (358 aa)
	A1O3_03556	Minor allergen Cla h 7. (204 aa)
	A1O3_04331	Aminotran_1_2 domain-containing protein. (533 aa)
	A1O3_04603	Uncharacterized protein. (552 aa)
	A1O3_04547	FAD_binding_3 domain-containing protein. (607 aa)
	A1O3_05103	Acyl-CoA thioester hydrolase. (159 aa)
	A1O3_09690	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (413 aa)
	COQ6	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (549 aa)
	A1O3_08665	FAD_binding_3 domain-containing protein. (569 aa)
	A1O3_02655	4HBT domain-containing protein. (153 aa)
	A1O3_03977	Uncharacterized protein. (265 aa)
	A1O3_04529	FAD_binding_3 domain-containing protein. (689 aa)
	A1O3_04098	FAD_binding_3 domain-containing protein. (183 aa)
	A1O3_06887	FAD_binding_3 domain-containing protein. (552 aa)
	A1O3_07212	4-hydroxyphenylpyruvate dioxygenase. (421 aa)
	A1O3_02696	FAD_binding_3 domain-containing protein. (467 aa)
	A1O3_00267	Uncharacterized protein. (605 aa)
	A1O3_02064	AP_endonuc_2 domain-containing protein. (369 aa)
	A1O3_06067	Uncharacterized protein. (145 aa)
	A1O3_02722	Aminotran_1_2 domain-containing protein. (421 aa)
	COQ5	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (302 aa)
	A1O3_02448	Uncharacterized protein. (547 aa)
	A1O3_03103	AB hydrolase-1 domain-containing protein. (257 aa)
	A1O3_01750	Uncharacterized protein. (555 aa)
	A1O3_04359	4HBT domain-containing protein. (172 aa)
	A1O3_05021	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family. (360 aa)
	A1O3_05198	Uncharacterized protein. (555 aa)
	A1O3_00685	Aminotran_1_2 domain-containing protein. (611 aa)
	COQ7	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. (238 aa)

Your Current Organism:

Capronia epimyces

NCBI taxonomy Id: 1182542
Other names: C. epimyces CBS 606.96, Capronia epimyces CBS 606.96

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A1O3_00685	A1O3_02064	W9YR33	W9YH66	Aminotran_1_2 domain-containing protein.	AP_endonuc_2 domain-containing protein.	0.411
A1O3_00685	A1O3_03716	W9YR33	W9Y1S2	Aminotran_1_2 domain-containing protein.	AP_endonuc_2 domain-containing protein.	0.411
A1O3_00685	A1O3_07212	W9YR33	W9YF57	Aminotran_1_2 domain-containing protein.	4-hydroxyphenylpyruvate dioxygenase.	0.659
A1O3_00685	A1O3_08422	W9YR33	W9XEL1	Aminotran_1_2 domain-containing protein.	AP_endonuc_2 domain-containing protein.	0.411
A1O3_01017	A1O3_05198	W9YT89	W9YQI8	Uncharacterized protein.	Uncharacterized protein.	0.645
A1O3_01750	A1O3_03977	W9YKU3	W9YBJ0	Uncharacterized protein.	Uncharacterized protein.	0.517
A1O3_01750	A1O3_08092	W9YKU3	W9XH13	Uncharacterized protein.	Uncharacterized protein.	0.517
A1O3_01750	A1O3_09690	W9YKU3	W9Y4U2	Uncharacterized protein.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.420
A1O3_01750	COQ3	W9YKU3	W9XC83	Uncharacterized protein.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.517
A1O3_01750	COQ5	W9YKU3	W9YJC8	Uncharacterized protein.	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).	0.450
A1O3_02064	A1O3_00685	W9YH66	W9YR33	AP_endonuc_2 domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.411
A1O3_02064	A1O3_03898	W9YH66	W9YXC7	AP_endonuc_2 domain-containing protein.	Aromatic amino acid aminotransferase I.	0.486
A1O3_02064	A1O3_04331	W9YH66	W9Y3K9	AP_endonuc_2 domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.486
A1O3_02064	A1O3_07212	W9YH66	W9YF57	AP_endonuc_2 domain-containing protein.	4-hydroxyphenylpyruvate dioxygenase.	0.668
A1O3_02448	A1O3_05198	W9YJH6	W9YQI8	Uncharacterized protein.	Uncharacterized protein.	0.635
A1O3_02655	A1O3_04920	W9YAN9	W9XVI8	4HBT domain-containing protein.	Flavodoxin_2 domain-containing protein.	0.617
A1O3_02655	A1O3_05103	W9YAN9	W9Y481	4HBT domain-containing protein.	Acyl-CoA thioester hydrolase.	0.720
A1O3_02696	A1O3_03977	W9Z554	W9YBJ0	FAD_binding_3 domain-containing protein.	Uncharacterized protein.	0.517
A1O3_02696	A1O3_08092	W9Z554	W9XH13	FAD_binding_3 domain-containing protein.	Uncharacterized protein.	0.517
A1O3_02696	A1O3_09690	W9Z554	W9Y4U2	FAD_binding_3 domain-containing protein.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.420