(20 nodes) Tricarboxylic acid cycle enzyme complex network (Exophiala aquamarina)

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Your Input:
	A1O9_06511	Tartrate dehydrogenase/decarboxylase ttuC. (370 aa)
	A1O9_11460	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (345 aa)
	A1O9_11294	Uncharacterized protein. (134 aa)
	A1O9_10049	Dihydrolipoyllysine-residue succinyltransferase, E2 component. (467 aa)
	A1O9_10650	2-oxoisovalerate dehydrogenase E1 component, beta subunit. (393 aa)
	A1O9_11250	Succinyl-CoA synthetase alpha subunit. (644 aa)
	A1O9_10651	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (361 aa)
	A1O9_09405	Oxoglutarate dehydrogenase (Succinyl-transferring), E1 component. (1050 aa)
	A1O9_11530	D-malate dehydrogenase. (364 aa)
	A1O9_05829	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (333 aa)
	A1O9_03928	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (443 aa)
	A1O9_08839	Iso_dh domain-containing protein. (385 aa)
	A1O9_04366	Uncharacterized protein. (349 aa)
	A1O9_05016	GFA domain-containing protein. (100 aa)
	A1O9_05063	2-oxoisovalerate dehydrogenase E1 component, beta subunit. (391 aa)
	A1O9_03443	Fumarate hydratase, class II. (542 aa)
	A1O9_00201	DUF2183 domain-containing protein. (436 aa)
	A1O9_06301	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (383 aa)
	A1O9_03929	Uncharacterized protein. (232 aa)
	A1O9_01821	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (395 aa)

Your Current Organism:

Exophiala aquamarina

NCBI taxonomy Id: 1182545
Other names: E. aquamarina CBS 119918, Exophiala aquamarina CBS 119918

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A1O9_01821	A1O9_03928	A0A072PWV9	A0A072PG15	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.477
A1O9_01821	A1O9_05063	A0A072PWV9	A0A072PLK5	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	2-oxoisovalerate dehydrogenase E1 component, beta subunit.	0.999
A1O9_01821	A1O9_05829	A0A072PWV9	A0A072PDS1	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.470
A1O9_01821	A1O9_09405	A0A072PWV9	A0A072P293	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Oxoglutarate dehydrogenase (Succinyl-transferring), E1 component.	0.772
A1O9_01821	A1O9_10049	A0A072PWV9	A0A072P0I5	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Dihydrolipoyllysine-residue succinyltransferase, E2 component.	0.940
A1O9_01821	A1O9_10650	A0A072PWV9	A0A072P0I8	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	2-oxoisovalerate dehydrogenase E1 component, beta subunit.	0.999
A1O9_01821	A1O9_11250	A0A072PWV9	A0A072P0Q7	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Succinyl-CoA synthetase alpha subunit.	0.470
A1O9_03443	A1O9_03928	A0A072PPS3	A0A072PG15	Fumarate hydratase, class II.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.851
A1O9_03443	A1O9_05016	A0A072PPS3	A0A072PJV4	Fumarate hydratase, class II.	GFA domain-containing protein.	0.527
A1O9_03443	A1O9_05829	A0A072PPS3	A0A072PDS1	Fumarate hydratase, class II.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.845
A1O9_03443	A1O9_06301	A0A072PPS3	A0A072PS94	Fumarate hydratase, class II.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.733
A1O9_03443	A1O9_06511	A0A072PPS3	A0A072PST2	Fumarate hydratase, class II.	Tartrate dehydrogenase/decarboxylase ttuC.	0.527
A1O9_03443	A1O9_08839	A0A072PPS3	A0A072PI37	Fumarate hydratase, class II.	Iso_dh domain-containing protein.	0.527
A1O9_03443	A1O9_09405	A0A072PPS3	A0A072P293	Fumarate hydratase, class II.	Oxoglutarate dehydrogenase (Succinyl-transferring), E1 component.	0.878
A1O9_03443	A1O9_10049	A0A072PPS3	A0A072P0I5	Fumarate hydratase, class II.	Dihydrolipoyllysine-residue succinyltransferase, E2 component.	0.788
A1O9_03443	A1O9_11250	A0A072PPS3	A0A072P0Q7	Fumarate hydratase, class II.	Succinyl-CoA synthetase alpha subunit.	0.845
A1O9_03443	A1O9_11460	A0A072PPS3	A0A072NYX1	Fumarate hydratase, class II.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.611
A1O9_03443	A1O9_11530	A0A072PPS3	A0A072P9U1	Fumarate hydratase, class II.	D-malate dehydrogenase.	0.527
A1O9_03928	A1O9_01821	A0A072PG15	A0A072PWV9	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.477
A1O9_03928	A1O9_03443	A0A072PG15	A0A072PPS3	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	Fumarate hydratase, class II.	0.851