Groups of genes that are frequently observed in each other's genomic neighborhood.
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Experiments
Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
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Fusion
Genes that are sometimes fused into single open reading frames.
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Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A1O9_05554
Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (430 aa)
A1O9_03355
Uncharacterized protein. (448 aa)
Your Current Organism:
Exophiala aquamarina
NCBI taxonomy Id: 1182545 Other names: E. aquamarina CBS 119918, Exophiala aquamarina CBS 119918
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
A1O9_03355
A1O9_05554
A0A072Q1Q2
A0A072PCR0
Uncharacterized protein.
Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
0.979
A1O9_05554
A1O9_03355
A0A072PCR0
A0A072Q1Q2
Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
Uncharacterized protein.
0.979
[ The below analysis is limited to the network nodes included in the specified statistical background ]
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