73 items (Exophiala aquamarina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A1O9_02547	RAN protein kinase; Belongs to the protein kinase superfamily. (414 aa)
	A1O9_02987	CAMK protein kinase. (469 aa)
	A1O9_07060	CAMK/CAMKL/CHK1 protein kinase. (537 aa)
	A1O9_05093	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (607 aa)
	A1O9_02691	HAL protein kinase; Belongs to the protein kinase superfamily. (469 aa)
	A1O9_06824	NACHT domain-containing protein. (1585 aa)
	A1O9_02431	Uncharacterized protein. (880 aa)
	A1O9_01896	HAL protein kinase; Belongs to the protein kinase superfamily. (450 aa)
	A1O9_04994	Uncharacterized protein. (354 aa)
	A1O9_04869	Endo/exonuclease/phosphatase domain-containing protein. (337 aa)
	A1O9_04777	Uncharacterized protein. (639 aa)
	A1O9_04477	BRCT domain-containing protein. (752 aa)
	SLX1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (408 aa)
	A1O9_03995	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2300 aa)
	A1O9_08176	Uncharacterized protein. (510 aa)
	A1O9_08139	UBX domain-containing protein. (550 aa)
	A1O9_13158	Uncharacterized protein. (1577 aa)
	A1O9_09488	CAMK protein kinase. (1049 aa)
	A1O9_09817	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (767 aa)
	A1O9_10766	Uncharacterized protein. (188 aa)
	A1O9_10046	Histone H2B; Belongs to the histone H2B family. (140 aa)
	A1O9_11125	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (99 aa)
	A1O9_10469	FHA domain-containing protein. (415 aa)
	A1O9_10449	Uncharacterized protein. (508 aa)
	A1O9_01344	Uncharacterized protein. (360 aa)
	A1O9_01644	DNA_LIGASE_A3 domain-containing protein. (1136 aa)
	A1O9_01774	Uncharacterized protein. (381 aa)
	A1O9_01996	Uncharacterized protein. (452 aa)
	A1O9_02016	Uncharacterized protein. (1226 aa)
	A1O9_02961	ERCC4 domain-containing protein. (614 aa)
	A1O9_03300	Uncharacterized protein. (612 aa)
	A1O9_00613	Ubiquitin-40S ribosomal protein S27a. (154 aa)
	A1O9_00803	DUF1767 domain-containing protein. (290 aa)
	A1O9_03894	AAA domain-containing protein. (523 aa)
	A1O9_05966	Uncharacterized protein. (540 aa)
	A1O9_06477	FHA domain-containing protein. (740 aa)
	A1O9_06005	Uncharacterized protein. (1098 aa)
	A1O9_10070	CAMK protein kinase. (695 aa)
	A1O9_10330	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2921 aa)
	A1O9_06958	Uncharacterized protein. (390 aa)
	A1O9_10983	Uncharacterized protein. (624 aa)
	A1O9_07799	Uncharacterized protein. (824 aa)
	A1O9_07094	Uncharacterized protein. (562 aa)
	A1O9_08053	BZIP domain-containing protein. (262 aa)
	A1O9_07842	DNA repair protein RAD50. (1305 aa)
	A1O9_08060	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (352 aa)
	A1O9_00639	RECA_2 domain-containing protein. (427 aa)
	A1O9_11411	Replication fork protection complex subunit Tof1/Swi1. (1180 aa)
	A1O9_00888	Adenosinetriphosphatase. (1122 aa)
	A1O9_03994	Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (451 aa)
	A1O9_01893	Poly [ADP-ribose] polymerase. (706 aa)
	A1O9_02500	Uncharacterized protein. (375 aa)
	A1O9_08341	HAL protein kinase. (674 aa)
	A1O9_08791	Cyclin N-terminal domain-containing protein. (438 aa)
	A1O9_08502	DNA ligase. (1032 aa)
	A1O9_08417	DNA polymerase delta subunit 4. (225 aa)
	A1O9_08512	Serine/threonine-protein phosphatase. (452 aa)
	A1O9_08533	Serine/threonine-protein phosphatase. (329 aa)
	A1O9_07840	Uncharacterized protein. (432 aa)
	A1O9_10994	Uncharacterized protein. (908 aa)
	A1O9_11325	Bloom syndrome protein. (1510 aa)
	A1O9_10817	Poly [ADP-ribose] polymerase. (465 aa)
	A1O9_10796	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (484 aa)
	A1O9_11161	Protein kinase domain-containing protein. (84 aa)
	A1O9_11126	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (462 aa)
	A1O9_11809	Asparaginyl-tRNA synthetase. (572 aa)
	A1O9_11977	Uncharacterized protein. (461 aa)
	A1O9_12628	RECA_2 domain-containing protein. (484 aa)
	A1O9_12327	C2H2-type domain-containing protein. (300 aa)
	A1O9_12597	Phosphate system cyclin PHO80. (305 aa)
	A1O9_13169	Helicase C-terminal domain-containing protein. (425 aa)
	A1O9_00213	Uncharacterized protein. (682 aa)
	A1O9_03526	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (503 aa)

Your Current Organism:

Exophiala aquamarina

NCBI taxonomy Id: 1182545
Other names: E. aquamarina CBS 119918, Exophiala aquamarina CBS 119918

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A1O9_00213	A1O9_00613	A0A072PQV6	A0A072Q401	Uncharacterized protein.	Ubiquitin-40S ribosomal protein S27a.	0.461
A1O9_00213	A1O9_01644	A0A072PQV6	A0A072PUY4	Uncharacterized protein.	DNA_LIGASE_A3 domain-containing protein.	0.761
A1O9_00213	A1O9_01774	A0A072PQV6	A0A072PVC4	Uncharacterized protein.	Uncharacterized protein.	0.463
A1O9_00213	A1O9_02961	A0A072PQV6	A0A072Q0I7	Uncharacterized protein.	ERCC4 domain-containing protein.	0.654
A1O9_00213	A1O9_04477	A0A072PQV6	A0A072PIC3	Uncharacterized protein.	BRCT domain-containing protein.	0.614
A1O9_00213	A1O9_04777	A0A072PQV6	A0A072PII6	Uncharacterized protein.	Uncharacterized protein.	0.500
A1O9_00213	A1O9_04869	A0A072PQV6	A0A072PIR7	Uncharacterized protein.	Endo/exonuclease/phosphatase domain-containing protein.	0.476
A1O9_00213	A1O9_06005	A0A072PQV6	A0A072PE78	Uncharacterized protein.	Uncharacterized protein.	0.458
A1O9_00213	A1O9_06477	A0A072PQV6	A0A072PF96	Uncharacterized protein.	FHA domain-containing protein.	0.454
A1O9_00213	A1O9_07799	A0A072PQV6	A0A072PAC6	Uncharacterized protein.	Uncharacterized protein.	0.463
A1O9_00213	A1O9_07842	A0A072PQV6	A0A072P8V7	Uncharacterized protein.	DNA repair protein RAD50.	0.673
A1O9_00213	A1O9_08053	A0A072PQV6	A0A072P9N0	Uncharacterized protein.	BZIP domain-containing protein.	0.461
A1O9_00213	A1O9_08502	A0A072PQV6	A0A072P7E7	Uncharacterized protein.	DNA ligase.	0.830
A1O9_00213	A1O9_08512	A0A072PQV6	A0A072P7I0	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.573
A1O9_00213	A1O9_08533	A0A072PQV6	A0A072P7V8	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.573
A1O9_00213	A1O9_09817	A0A072PQV6	A0A072P2U6	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.773
A1O9_00213	A1O9_10046	A0A072PQV6	A0A072P1D9	Uncharacterized protein.	Histone H2B; Belongs to the histone H2B family.	0.540
A1O9_00213	A1O9_10330	A0A072PQV6	A0A072PCT0	Uncharacterized protein.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.640
A1O9_00213	A1O9_10469	A0A072PQV6	A0A072P046	Uncharacterized protein.	FHA domain-containing protein.	0.454
A1O9_00213	A1O9_10766	A0A072PQV6	A0A072P242	Uncharacterized protein.	Uncharacterized protein.	0.463