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| | Py04_0006 | Hypothetical protein. (153 aa) |
| | Py04_0009 | Putative oxidoreductase; COG0493. (476 aa) |
| | tpiA | Putative triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (229 aa) |
| | Py04_0019 | Putative phosphoserine phosphatase; COG0560. (208 aa) |
| | Py04_0021 | Putative Fe-S oxidoreductase; COG1032. (532 aa) |
| | Py04_0033 | Bifunctional inositol-1 monophosphatase/fructose-1,6-bisphosphatase; COG0483. (254 aa) |
| | Py04_0042 | Anaerobic glycerol 3-phosphate dehydrogenase; COG0579. (495 aa) |
| | gcvPB | Glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (502 aa) |
| | gcvPA | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (448 aa) |
| | apgM | Cofactor-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (410 aa) |
| | Py04_0141 | L-asparaginase; COG0252. (328 aa) |
| | Py04_0144 | Glycogen synthase; COG0297. (447 aa) |
| | Py04_0173 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (816 aa) |
| | Py04_0178 | Putative prephenate dehydratase; COG0077. (268 aa) |
| | Py04_0181 | Fructose 1,6-bisphosphate aldolase; COG1830. (281 aa) |
| | Py04_0274 | Aspartate aminotransferase; COG1167. (413 aa) |
| | Py04_0296 | L-asparagine amidohydrolase; COG1446. (305 aa) |
| | Py04_0301 | Short chain dehydrogenase; COG1028. (263 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; COG0152; Belongs to the SAICAR synthetase family. (234 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (442 aa) |
| | pgiA | Glucose-6-phosphate isomerase; COG2140; Belongs to the archaeal-type GPI family. (189 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to as [...] (80 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (223 aa) |
| | purL | Hosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (704 aa) |
| | Py04_0356 | Aconitate hydratase; COG0538. (836 aa) |
| | Py04_0357 | Isocitrate dehydrogenase; COG0372. (400 aa) |
| | Py04_0358 | Citrate synthase. (372 aa) |
| | argG | Argininosuccinate synthase; COG0137; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (414 aa) |
| | argH | Argininosuccinate lyase; COG0165. (447 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa) |
| | Py04_0389 | Glucose-1-phosphate thymidylyltransferase; COG1208. (420 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (278 aa) |
| | Py04_0423 | 4-alpha-Glucanotransferase; COG1449. (643 aa) |
| | guaB | Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (624 aa) |
| | Py04_0445 | Putative aminotransferase; COG0079. (328 aa) |
| | Py04_0455 | Sugar-phosphate nucleotidyltransferase; COG1208. (333 aa) |
| | sat | Sulfate adenylyltransferase; COG2046; Belongs to the sulfate adenylyltransferase family. (379 aa) |
| | Py04_0479 | Glucose-1-phosphate thymidylyltransferase; COG1209. (352 aa) |
| | Py04_0480 | dTDP-glucose 4,6-dehydratase; COG1088. (696 aa) |
| | Py04_0481 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (185 aa) |
| | Py04_0482 | dTDP-4-dehydrorhamnose reductase; COG1091. (288 aa) |
| | Py04_0484 | UTP-glucose-1-phosphate uridylyltransferase; COG1210. (199 aa) |
| | Py04_0506 | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; COG1759. (380 aa) |
| | purD | Phosphoribosylamine-glycine ligase; COG0151; Belongs to the GARS family. (438 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (360 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (173 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (429 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase; COG0150. (333 aa) |
| | Py04_0545 | Putative glycerate kinase; COG2379. (434 aa) |
| | Py04_0564 | 2-hydroxyacid dehydrogenase; COG1052; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (325 aa) |
| | gyaR | Glyoxylate reductase; COG1052. (337 aa) |
| | glkA | ADP-dependent glucokinase; Catalyzes the phosphorylation of D-glucose to D-glucose 6- phosphate using ADP as the phosphate donor. (455 aa) |
| | fbp | Putative fructose-1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (375 aa) |
| | Py04_0732 | Glycerol-3-phosphate cytidyltransferase; COG0615. (121 aa) |
| | Py04_0738 | Ornithine carbamoyltransferase; COG0078; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (325 aa) |
| | Py04_0766 | Adenylosuccinate lyase; COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (450 aa) |
| | Py04_0783 | Putative bifunctional short chain isoprenyl diphosphate synthase; COG0142; Belongs to the FPP/GGPP synthase family. (342 aa) |
| | Py04_0786 | Homoserine dehydrogenase; COG0460. (320 aa) |
| | Py04_0813 | Putative AMP/CMP kinase; COG1936. (149 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (161 aa) |
| | Py04_0847 | Acetolactate synthase, large subunit; COG0028. (534 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). (499 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (423 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa) |
| | Py04_0852 | 3-isopropylmalate dehydrogenase; COG0473. (353 aa) |
| | Py04_0853 | Alpha-isopropylmalate/homocitrate synthase family transferase; COG0119; Belongs to the alpha-IPM synthase/homocitrate synthase family. (532 aa) |
| | ilvD | Dihydroxy-acid dehydratase; COG0129; Belongs to the IlvD/Edd family. (551 aa) |
| | Py04_0857 | Mannose-6-phosphate isomerase/mannose-1-phosphate guanylyl transferase; COG0836; Belongs to the mannose-6-phosphate isomerase type 2 family. (465 aa) |
| | Py04_0858 | Phospho-sugar mutase; COG1109. (456 aa) |
| | Py04_0870 | Sugar-phosphate nucleotidyl transferase; COG1208. (413 aa) |
| | metE | Methionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. (338 aa) |
| | Py04_0897 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; COG0620. (309 aa) |
| | Py04_0899 | Cystathionine gamma-synthase; COG0626. (367 aa) |
| | Py04_0933 | Acetylornithine deacetylase; COG0624. (351 aa) |
| | gcvT | Putative glycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. (398 aa) |
| | Py04_0962 | 3-methyl-2-oxobutanoate hydroxymethyltransferase; COG0413. (219 aa) |
| | Py04_0990 | Putative glutamate synthase (NADPH/NADH) small chain; COG0493. (469 aa) |
| | Py04_0997 | Putative acetolactate synthase small subunit; COG0440. (139 aa) |
| | Py04_1004 | Aspartate kinase; COG0527. (375 aa) |
| | Py04_1005 | Aspartate kinase; COG0527. (358 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (292 aa) |
| | Py04_1007 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (394 aa) |
| | Py04_1008 | Aspartate-semialdehyde dehydrogenase; COG0136. (335 aa) |
| | Py04_1009 | Phosphoglycerate kinase; COG0126. (358 aa) |
| | Py04_1033 | Asparagine synthetase; COG0367. (485 aa) |
| | Py04_1045 | Putative tungsten-containing aldehyde ferredoxin oxidoreductase cofactor modifying protein; COG0535. (373 aa) |
| | ubiX | Putative aromatic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (185 aa) |
| | fni | Isopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (370 aa) |
| | Py04_1076 | Pyruvate ferredoxin oxidoreductase subunit beta; COG1013. (331 aa) |
| | Py04_1077 | Pyruvate ferredoxin oxidoreductase subunit alpha; COG0674. (396 aa) |
| | Py04_1078 | Pyuvate ferredoxin oxidoreductase subunit delta; COG1144. (105 aa) |
| | Py04_1082 | Pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; COG1014. (185 aa) |
| | Py04_1083 | Putative 3-hydroxy-3-methylglutaryl CoA synthase; COG3425; Belongs to the thiolase-like superfamily. UPF0219 family. (350 aa) |
| | Py04_1084 | acetyl-CoA acetyltransferase; COG0183. (388 aa) |
| | Py04_1124 | Pyruvate kinase; COG0469; Belongs to the pyruvate kinase family. (476 aa) |
| | mfnA | L-tyrosine decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (367 aa) |
| | rbcL | Ribulose bisophosphate carboxylase; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (420 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (220 aa) |
| | Py04_1201 | Putative ubiquinone/menaquinone biosynthesis methyl transferase. (139 aa) |
| | rpiA | Ribose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (229 aa) |
| | purP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (333 aa) |
| | Py04_1260 | Alanine aminotransferase; COG0436. (398 aa) |
| | gcvH | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (134 aa) |
| | Py04_1290 | Putative Fructokinase; COG0524. (311 aa) |
| | Py04_1333 | Phosphoglycolate phosphatase; COG0561. (189 aa) |
| | Py04_1345 | Threonine synthase; COG0498. (439 aa) |
| | Py04_1355 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (305 aa) |
| | Py04_1357 | D-3-phosphoglycerate dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (304 aa) |
| | Py04_1358 | Glycogen branching enzyme; COG1543; Belongs to the glycosyl hydrolase 57 family. (632 aa) |
| | Py04_1405 | Alpha-glucan phosphorylase; COG0058. (836 aa) |
| | trpB | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (445 aa) |
| | Py04_1492 | Myo-inositol-1-phosphate synthase; COG1260. (383 aa) |
| | Py04_1517 | Acetylglutamate kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. (254 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (333 aa) |
| | Py04_1520 | Threonine synthase; COG0498. (311 aa) |
| | Py04_1522 | Putative eno-like enolase; COG0148. (341 aa) |
| | pfkC | ADP-specific phosphofructokinase; Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor. (458 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (427 aa) |
| | Py04_1549 | 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; COG1014. (180 aa) |
| | Py04_1550 | 2-oxoglutarate ferredoxin oxidoreductase subunit beta; COG1013. (281 aa) |
| | Py04_1551 | 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; COG0674. (385 aa) |
| | Py04_1552 | 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; COG1014. (170 aa) |
| | Py04_1553 | 2-oxoglutarate ferredoxin oxidoreductase subunit beta; COG1013. (280 aa) |
| | Py04_1554 | 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; COG0674. (397 aa) |
| | Py04_1555 | 2-oxoglutarate ferredoxin oxidoreductase, subunit delta; COG1146. (89 aa) |
| | Py04_1574 | Fumarate hydratase (fumarase) alpha subunit; COG1951. (276 aa) |
| | Py04_1575 | Fumarate hydratase (fumarase) beta subunit; COG1838. (166 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (572 aa) |
| | Py04_1589 | Mannose-1-phosphate guanyltransferase; COG1208. (361 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (267 aa) |
| | trpC | Indole-3-glycerol-phosphate synthase; COG0134; Belongs to the TrpC family. (227 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (326 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (345 aa) |
| | Py04_1607 | Anthranilate synthase component II; COG0512. (190 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; COG0135; Belongs to the TrpF family. (208 aa) |
| | trpB-2 | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (388 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (253 aa) |
| | Py04_1612 | Prephenate dehydrogenase (pdh); COG0287. (263 aa) |
| | Py04_1613 | Aspartate aminotransferase; COG0436. (344 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (357 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (402 aa) |
| | aroK | Shikimate kinase; COG1685. (274 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (273 aa) |
| | aroD | Putative 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (215 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (334 aa) |
| | Py04_1629 | Putative transketolase C-terminal section; COG3958. (306 aa) |
| | Py04_1630 | Putative transketolaseN-terminal section; COG3959. (206 aa) |
| | Py04_1633 | Acetylornithine/acetyl-lysine aminotransferase; COG4992; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (347 aa) |
| | lysZ | Acetylglutamate/acetylaminoadipate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (249 aa) |
| | lysY | N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (330 aa) |
| | Py04_1638 | 3-isopropylmalate dehydrogenase; COG0473. (346 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (380 aa) |
| | Py04_1642 | Aspartate aminotransferase; COG1167. (384 aa) |
| | hisC | Putative histidinol-phosphate aminotransferase HisC; COG0079. (341 aa) |
| | hisI | Putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase His IE; COG0139; In the N-terminal section; belongs to the PRA-CH family. (189 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; COG0106. (229 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (191 aa) |
| | Py04_1655 | Imidazoleglycerol-phosphate dehydratase HisB; COG0131. (139 aa) |
| | hisD | Histidinol dehydrogenase HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (375 aa) |
| | hisG | ATP phosphoribosyltransferase catalytic subunit HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (204 aa) |
| | Py04_1658 | Putative histidyl-tRNA synthetase; COG0124. (301 aa) |
| | adkA | Adenylate kinase; COG2019; Belongs to the archaeal adenylate kinase family. (196 aa) |
| | Py04_1729 | 3-hydroxy-3-methylglutaryl coenzyme A reductase; COG1257; Belongs to the HMG-CoA reductase family. (408 aa) |
| | Py04_1734 | Putative glutamate synthase subunit beta; COG0493. (348 aa) |
| | mat | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (401 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase; COG0057. (334 aa) |
